{ "api_version": "1", "request": { "url": "https://clinicaltrialsfind.com/api/v1/search.json?intervention=Arginine+%28Continuous%29", "query": { "intervention": "Arginine (Continuous)" }, "page_size": 10 }, "pagination": { "page": 1, "page_size": 10, "total_count": 24, "total_pages": 3, "next_page_url": "https://clinicaltrialsfind.com/api/v1/search.json?intervention=Arginine+%28Continuous%29&page=2&page_size=10", "previous_page_url": null }, "source": "remote", "last_synced_at": "2026-09-13T09:10:23.105Z", "attribution": "Data derived from public ClinicalTrials.gov records. The official record at https://clinicaltrials.gov/ remains the source of truth for current availability, contacts, and full study details.", "notes": [ "This endpoint exposes only public summary fields — no participant contact emails, phone numbers, or scraped investigator contact details.", "For contact information and full protocol detail, follow each trial's `official_url` to the ClinicalTrials.gov record.", "This API is a navigational aid. It does not provide medical advice, eligibility determinations, or compensation guarantees." ], "trials": [ { "nct_id": "NCT03449901", "title": "ADI-PEG 20 in Combination With Gemcitabine and Docetaxel for the Treatment of Soft Tissue Sarcoma, Osteosarcoma, Ewing's Sarcoma, and Small Cell Lung Cancer", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE2" ], "conditions": [ "Soft Tissue Sarcoma" ], "interventions": [ { "name": "pegylated arginine deiminase", "type": "DRUG" }, { "name": "Gemcitabine", "type": "DRUG" }, { "name": "Docetaxel", "type": "DRUG" }, { "name": "Tumor biopsy", "type": "PROCEDURE" }, { "name": "Research blood draw", "type": "PROCEDURE" } ], "intervention_types": [ "DRUG", "PROCEDURE" ], "sponsor": "Washington University School of Medicine", "sponsor_class": "OTHER", "healthy_volunteers": false, "eligibility": { "minimum_age": "10 Years", "maximum_age": null, "sex": "ALL", "summary": "10 Years and older" }, "enrollment_count": 98, "start_date": "2018-05-09", "completion_date": "2022-07-08", "has_results": true, "last_update_posted_date": "2025-12-11", "last_synced_at": "2026-09-13T09:10:23.105Z", "location_count": 4, "location_summary": "Palo Alto, California • Santa Monica, California • St Louis, Missouri + 1 more", "locations": [ { "city": "Palo Alto", "state": "California" }, { "city": "Santa Monica", "state": "California" }, { "city": "St Louis", "state": "Missouri" }, { "city": "New York", "state": "New York" } ], "official_url": "https://clinicaltrials.gov/study/NCT03449901" }, { "nct_id": "NCT03236935", "title": "Phase Ib of L-NMMA and Pembrolizumab", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE1" ], "conditions": [ "Non-Small Cell Lung Cancer", "Malignant Melanoma", "Head and Neck Squamous Cell Carcinoma", "Classical Hodgkin Lymphoma", "Urothelial Carcinoma Bladder", "DNA Repair-Deficiency Disorders" ], "interventions": [ { "name": "L-NMMA", "type": "DRUG" }, { "name": "Pembrolizumab", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "The Methodist Hospital Research Institute", "sponsor_class": "OTHER", "healthy_volunteers": false, "eligibility": { "minimum_age": "18 Years", "maximum_age": null, "sex": "ALL", "summary": "18 Years and older" }, "enrollment_count": 12, "start_date": "2018-08-27", "completion_date": "2022-04-22", "has_results": true, "last_update_posted_date": "2026-04-09", "last_synced_at": "2026-09-13T09:10:23.105Z", "location_count": 1, "location_summary": "Houston, Texas", "locations": [ { "city": "Houston", "state": "Texas" } ], "official_url": "https://clinicaltrials.gov/study/NCT03236935" }, { "nct_id": "NCT05813327", "title": "Neoadjuvant ADI-PEG 20 + Ifosfamide + Radiotherapy in Soft Tissue Sarcoma", "overall_status": "TERMINATED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE1" ], "conditions": [ "Soft Tissue Sarcoma", "Sts", "Sarcoma,Soft Tissue" ], "interventions": [ { "name": "ADI PEG20", "type": "DRUG" }, { "name": "Ifosfamide", "type": "DRUG" }, { "name": "Radiotherapy", "type": "RADIATION" }, { "name": "Mesna", "type": "DRUG" } ], "intervention_types": [ "DRUG", "RADIATION" ], "sponsor": "Washington University School of Medicine", "sponsor_class": "OTHER", "healthy_volunteers": false, "eligibility": { "minimum_age": "18 Years", "maximum_age": null, "sex": "ALL", "summary": "18 Years and older" }, "enrollment_count": 6, "start_date": "2024-03-14", "completion_date": "2026-07-22", "has_results": false, "last_update_posted_date": "2026-09-03", "last_synced_at": "2026-09-13T09:10:23.105Z", "location_count": 1, "location_summary": "St Louis, Missouri", "locations": [ { "city": "St Louis", "state": "Missouri" } ], "official_url": "https://clinicaltrials.gov/study/NCT05813327" }, { "nct_id": "NCT05498428", "title": "A Study of Amivantamab in Participants With Advanced or Metastatic Solid Tumors Including Epidermal Growth Factor Receptor (EGFR)-Mutated Non-Small Cell Lung Cancer", "overall_status": "RECRUITING", "study_type": "INTERVENTIONAL", "phases": [ "PHASE2" ], "conditions": [ "Carcinoma, Non-small-Cell Lung" ], "interventions": [ { "name": "Amivantamab", "type": "DRUG" }, { "name": "Lazertinib", "type": "DRUG" }, { "name": "Carboplatin", "type": "DRUG" }, { "name": "Pemetrexed", "type": "DRUG" }, { "name": "Direct Oral Anticoagulant (DOAC)", "type": "DRUG" }, { "name": "Low Molecular Weight Heparin (LMWH)", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "Janssen Research & Development, LLC", "sponsor_class": "INDUSTRY", "healthy_volunteers": false, "eligibility": { "minimum_age": "18 Years", "maximum_age": null, "sex": "ALL", "summary": "18 Years and older" }, "enrollment_count": 520, "start_date": "2022-11-11", "completion_date": "2028-08-18", "has_results": false, "last_update_posted_date": "2026-08-28", "last_synced_at": "2026-09-13T09:10:23.105Z", "location_count": 26, "location_summary": "La Jolla, California • Orange, California • Stanford, California + 21 more", "locations": [ { "city": "La Jolla", "state": "California" }, { "city": "Orange", "state": "California" }, { "city": "Stanford", "state": "California" }, { "city": "Washington D.C.", "state": "District of Columbia" }, { "city": "Boca Raton", "state": "Florida" } ], "official_url": "https://clinicaltrials.gov/study/NCT05498428" }, { "nct_id": "NCT07167693", "title": "Phase 1 Trial of Arginine Hydrochloride for the Management of Diabetic Ketoacidosis in Type 2 Diabetes", "overall_status": "RECRUITING", "study_type": "INTERVENTIONAL", "phases": [ "PHASE1", "PHASE2" ], "conditions": [ "Diabetes (DM)", "Diabetic Ketoacidosis", "Ketosis Prone Diabetes", "Hyperglycaemia (Diabetic)" ], "interventions": [ { "name": "Arginine hydrochloride", "type": "DRUG" }, { "name": "Sodium Chloride 0.9%", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "David K Carroll", "sponsor_class": "OTHER", "healthy_volunteers": false, "eligibility": { "minimum_age": "18 Years", "maximum_age": null, "sex": "ALL", "summary": "18 Years and older" }, "enrollment_count": 60, "start_date": "2025-12-19", "completion_date": "2027-12-31", "has_results": false, "last_update_posted_date": "2026-02-12", "last_synced_at": "2026-09-13T09:10:23.105Z", "location_count": 1, "location_summary": "Detroit, Michigan", "locations": [ { "city": "Detroit", "state": "Michigan" } ], "official_url": "https://clinicaltrials.gov/study/NCT07167693" }, { "nct_id": "NCT00004412", "title": "Phase II Randomized Trial:Arginine Butyrate Plus Standard Local Therapy in Patients With Refractory Sickle Cell Ulcers", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE2" ], "conditions": [ "Skin Ulcers", "Sickle Cell Anemia" ], "interventions": [ { "name": "Arginine Butyrate", "type": "DRUG" }, { "name": "Standard local care dressing", "type": "OTHER" } ], "intervention_types": [ "DRUG", "OTHER" ], "sponsor": "Susan P. Perrine", "sponsor_class": "OTHER", "healthy_volunteers": false, "eligibility": { "minimum_age": "16 Years", "maximum_age": "60 Years", "sex": "ALL", "summary": "16 Years to 60 Years" }, "enrollment_count": 23, "start_date": "1997-09", "completion_date": "2005-02", "has_results": true, "last_update_posted_date": "2015-03-31", "last_synced_at": "2026-09-13T09:10:23.105Z", "location_count": 4, "location_summary": "Chicago, Illinois • Boston, Massachusetts • New York, New York + 1 more", "locations": [ { "city": "Chicago", "state": "Illinois" }, { "city": "Boston", "state": "Massachusetts" }, { "city": "New York", "state": "New York" }, { "city": "Memphis", "state": "Tennessee" } ], "official_url": "https://clinicaltrials.gov/study/NCT00004412" }, { "nct_id": "NCT06043310", "title": "Estrogen and Microvascular Function", "overall_status": "ACTIVE_NOT_RECRUITING", "study_type": "OBSERVATIONAL", "phases": [], "conditions": [ "Estrogen", "Cardiovascular Diseases", "Microvasculature", "Oral Contraceptive Use" ], "interventions": [ { "name": "Nω-nitro-L-arginine methyl ester (L-NAME)", "type": "DRUG" }, { "name": "Acetylcholine", "type": "DRUG" }, { "name": "Sodium Nitroprusside", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "Medical College of Wisconsin", "sponsor_class": "OTHER", "healthy_volunteers": true, "eligibility": { "minimum_age": "18 Years", "maximum_age": "40 Years", "sex": "FEMALE", "summary": "18 Years to 40 Years · Female only" }, "enrollment_count": 45, "start_date": "2023-10-12", "completion_date": "2031-12", "has_results": false, "last_update_posted_date": "2026-07-29", "last_synced_at": "2026-09-13T09:10:23.105Z", "location_count": 1, "location_summary": "Wauwatosa, Wisconsin", "locations": [ { "city": "Wauwatosa", "state": "Wisconsin" } ], "official_url": "https://clinicaltrials.gov/study/NCT06043310" }, { "nct_id": "NCT05477134", "title": "Arginine Metabolism in Youth With Type 2 Diabetes", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "NA" ], "conditions": [ "Type 2 Diabetes" ], "interventions": [ { "name": "Stable isotope infusion, oral glucose ingestion, intravenous arginine bolus", "type": "OTHER" } ], "intervention_types": [ "OTHER" ], "sponsor": "Baylor College of Medicine", "sponsor_class": "OTHER", "healthy_volunteers": true, "eligibility": { "minimum_age": "12 Years", "maximum_age": "20 Years", "sex": "ALL", "summary": "12 Years to 20 Years" }, "enrollment_count": 30, "start_date": "2023-02-06", "completion_date": "2026-06-18", "has_results": false, "last_update_posted_date": "2026-08-13", "last_synced_at": "2026-09-13T09:10:23.105Z", "location_count": 1, "location_summary": "Houston, Texas", "locations": [ { "city": "Houston", "state": "Texas" } ], "official_url": "https://clinicaltrials.gov/study/NCT05477134" }, { "nct_id": "NCT05616624", "title": "ADI-PEG 20 in Combination With Gemcitabine and Docetaxel After Progression on Frontline Therapy in Non-small Cell and Small Cell Lung Cancers", "overall_status": "TERMINATED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE1", "PHASE2" ], "conditions": [ "Non Small Cell Lung Cancer", "Non-small Cell Lung Cancer", "Small-cell Lung Cancer", "Small Cell Lung Carcinoma" ], "interventions": [ { "name": "ADI-PEG 20", "type": "DRUG" }, { "name": "Gemcitabine", "type": "DRUG" }, { "name": "Docetaxel", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "Washington University School of Medicine", "sponsor_class": "OTHER", "healthy_volunteers": false, "eligibility": { "minimum_age": "18 Years", "maximum_age": null, "sex": "ALL", "summary": "18 Years and older" }, "enrollment_count": 31, "start_date": "2023-04-05", "completion_date": "2026-07-22", "has_results": false, "last_update_posted_date": "2026-07-27", "last_synced_at": "2026-09-13T09:10:23.105Z", "location_count": 3, "location_summary": "Chicago, Illinois • St Louis, Missouri • Fairfax, Virginia", "locations": [ { "city": "Chicago", "state": "Illinois" }, { "city": "St Louis", "state": "Missouri" }, { "city": "Fairfax", "state": "Virginia" } ], "official_url": "https://clinicaltrials.gov/study/NCT05616624" }, { "nct_id": "NCT02285101", "title": "Recombinant Human Arginase 1 (rhArg1) in Patients With Advanced Arginine Auxotrophic Solid Tumors", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE1" ], "conditions": [ "Melanoma", "Prostate Adenocarcinoma" ], "interventions": [ { "name": "PEG-BCT-100", "type": "BIOLOGICAL" } ], "intervention_types": [ "BIOLOGICAL" ], "sponsor": "Bio-Cancer Treatment International Limited", "sponsor_class": "INDUSTRY", "healthy_volunteers": false, "eligibility": { "minimum_age": "18 Years", "maximum_age": null, "sex": "ALL", "summary": "18 Years and older" }, "enrollment_count": 23, "start_date": "2014-11", "completion_date": "2019-02", "has_results": false, "last_update_posted_date": "2020-04-24", "last_synced_at": "2026-09-13T09:10:23.105Z", "location_count": 2, "location_summary": "San Diego, California • Santa Monica, California", "locations": [ { "city": "San Diego", "state": "California" }, { "city": "Santa Monica", "state": "California" } ], "official_url": "https://clinicaltrials.gov/study/NCT02285101" } ] }