{ "api_version": "1", "request": { "url": "https://clinicaltrialsfind.com/api/v1/search.json?intervention=Articaine+Hydrochloride+%2B+Epinephrine", "query": { "intervention": "Articaine Hydrochloride + Epinephrine" }, "page_size": 10 }, "pagination": { "page": 1, "page_size": 10, "total_count": 10, "total_pages": 1, "next_page_url": null, "previous_page_url": null }, "source": "remote", "last_synced_at": "2026-10-08T01:24:50.609Z", "attribution": "Data derived from public ClinicalTrials.gov records. The official record at https://clinicaltrials.gov/ remains the source of truth for current availability, contacts, and full study details.", "notes": [ "This endpoint exposes only public summary fields — no participant contact emails, phone numbers, or scraped investigator contact details.", "For contact information and full protocol detail, follow each trial's `official_url` to the ClinicalTrials.gov record.", "This API is a navigational aid. It does not provide medical advice, eligibility determinations, or compensation guarantees." ], "trials": [ { "nct_id": "NCT07863882", "title": "Keratinized Tissue Augmentation Using Augmented Gingival Matrix Compared to Free Gingival Graft Around Implants", "overall_status": "NOT_YET_RECRUITING", "study_type": "INTERVENTIONAL", "phases": [ "NA" ], "conditions": [ "Keratinized Tissue Augmentation Around Dental Implants" ], "interventions": [ { "name": "Augmented Gingival Matrix graft", "type": "DEVICE" }, { "name": "Free Gingival Graft", "type": "PROCEDURE" } ], "intervention_types": [ "DEVICE", "PROCEDURE" ], "sponsor": "The Forsyth Institute", "sponsor_class": "OTHER", "healthy_volunteers": false, "eligibility": { "minimum_age": "18 Years", "maximum_age": null, "sex": "ALL", "summary": "18 Years and older" }, "enrollment_count": 50, "start_date": "2026-11-01", "completion_date": "2028-10-31", "has_results": false, "last_update_posted_date": "2026-10-07", "last_synced_at": "2026-10-08T01:24:50.609Z", "location_count": 1, "location_summary": "Somerville, Massachusetts", "locations": [ { "city": "Somerville", "state": "Massachusetts" } ], "official_url": "https://clinicaltrials.gov/study/NCT07863882" }, { "nct_id": "NCT01862614", "title": "Testing the Anesthetic Effectiveness of Buffered Articaine Injected Next to a Lower First Molar.", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE4" ], "conditions": [ "Anesthetic Effectiveness" ], "interventions": [ { "name": "Articaine Hydrochloride + Epinephrine", "type": "DRUG" }, { "name": "Buffered Articaine Hydrochloride + Epinephrine", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "Ohio State University", "sponsor_class": "OTHER", "healthy_volunteers": true, "eligibility": { "minimum_age": "18 Years", "maximum_age": "65 Years", "sex": "ALL", "summary": "18 Years to 65 Years" }, "enrollment_count": 80, "start_date": "2013-04", "completion_date": "2014-05", "has_results": true, "last_update_posted_date": "2021-05-26", "last_synced_at": "2026-10-08T01:24:50.609Z", "location_count": 1, "location_summary": "Columbus, Ohio", "locations": [ { "city": "Columbus", "state": "Ohio" } ], "official_url": "https://clinicaltrials.gov/study/NCT01862614" }, { "nct_id": "NCT04865848", "title": "Comparison of Articaine Mandibular Infiltration to Lidocaine Inferior Alveolar Nerve Block in Pediatric Patients", "overall_status": "TERMINATED", "study_type": "INTERVENTIONAL", "phases": [ "NA" ], "conditions": [ "Anesthesia" ], "interventions": [ { "name": "Dental local anesthesia", "type": "PROCEDURE" } ], "intervention_types": [ "PROCEDURE" ], "sponsor": "University of Illinois at Chicago", "sponsor_class": "OTHER", "healthy_volunteers": true, "eligibility": { "minimum_age": "4 Years", "maximum_age": "10 Years", "sex": "ALL", "summary": "4 Years to 10 Years" }, "enrollment_count": 42, "start_date": "2019-06-05", "completion_date": "2022-05-05", "has_results": false, "last_update_posted_date": "2024-05-09", "last_synced_at": "2026-10-08T01:24:50.609Z", "location_count": 1, "location_summary": "Chicago, Illinois", "locations": [ { "city": "Chicago", "state": "Illinois" } ], "official_url": "https://clinicaltrials.gov/study/NCT04865848" }, { "nct_id": "NCT03318952", "title": "Articaine vs Lidocaine for Pediatric Dental Procedures", "overall_status": "WITHDRAWN", "study_type": "INTERVENTIONAL", "phases": [ "PHASE4" ], "conditions": [ "Anesthesia, Dental", "Pain, Postoperative" ], "interventions": [ { "name": "lidocaine", "type": "DRUG" }, { "name": "articaine", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "Boston University", "sponsor_class": "OTHER", "healthy_volunteers": false, "eligibility": { "minimum_age": "4 Years", "maximum_age": "14 Years", "sex": "ALL", "summary": "4 Years to 14 Years" }, "enrollment_count": 0, "start_date": "2022-09", "completion_date": "2023-06", "has_results": false, "last_update_posted_date": "2022-11-03", "last_synced_at": "2026-10-08T01:24:50.609Z", "location_count": 1, "location_summary": "Boston, Massachusetts", "locations": [ { "city": "Boston", "state": "Massachusetts" } ], "official_url": "https://clinicaltrials.gov/study/NCT03318952" }, { "nct_id": "NCT02726620", "title": "Decision Support for Intraoperative Low Blood Pressure", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "NA" ], "conditions": [ "Hypotension" ], "interventions": [ { "name": "Attending real-time decision support", "type": "PROCEDURE" }, { "name": "In-room real-time decision support", "type": "PROCEDURE" }, { "name": "Attending feedback emails", "type": "PROCEDURE" }, { "name": "In-room provider feedback emails", "type": "PROCEDURE" }, { "name": "Anesthesia Information Management System (AIMS)", "type": "DEVICE" }, { "name": "Perioperative Data Warehouse (PDW)", "type": "DEVICE" }, { "name": "General anesthesia", "type": "PROCEDURE" }, { "name": "Pager system", "type": "DEVICE" }, { "name": "Central neuraxial anesthesia", "type": "PROCEDURE" }, { "name": "Non-cardiac surgery", "type": "PROCEDURE" }, { "name": "Propofol", "type": "DRUG" }, { "name": "Sevoflurane", "type": "DRUG" }, { "name": "Desflurane", "type": "DRUG" }, { "name": "Isoflurane", "type": "DRUG" }, { "name": "Ephedrine", "type": "DRUG" }, { "name": "Phenylephrine", "type": "DRUG" }, { "name": "Norepinephrine", "type": "DRUG" }, { "name": "Epinephrine", "type": "DRUG" }, { "name": "Dobutamine", "type": "DRUG" }, { "name": "Dopamine", "type": "DRUG" }, { "name": "Isoproterenol", "type": "DRUG" }, { "name": "Milrinone", "type": "DRUG" }, { "name": "Atropine", "type": "DRUG" }, { "name": "Glycopyrrolate", "type": "DRUG" }, { "name": "Vasopressin", "type": "DRUG" }, { "name": "Terlipressin", "type": "DRUG" }, { "name": "Sodium Chloride 0.9%", "type": "DRUG" }, { "name": "Ringer's lactate", "type": "DRUG" }, { "name": "Hydroxyethyl starch solutions", "type": "DRUG" }, { "name": "Fresh Frozen Plasma", "type": "DRUG" }, { "name": "Packed Red Blood Cells", "type": "DRUG" }, { "name": "Albumin solutions", "type": "DRUG" }, { "name": "Plasma-Lyte", "type": "DRUG" }, { "name": "Lidocaine", "type": "DRUG" }, { "name": "Bupivacaine", "type": "DRUG" }, { "name": "Levobupivacaine", "type": "DRUG" }, { "name": "Ropivacaine", "type": "DRUG" }, { "name": "Mepivacaine", "type": "DRUG" }, { "name": "Tetracaine", "type": "DRUG" }, { "name": "Prilocaine", "type": "DRUG" }, { "name": "Procaine", "type": "DRUG" }, { "name": "Chloroprocaine", "type": "DRUG" }, { "name": "Benzocaine", "type": "DRUG" }, { "name": "Articaine", "type": "DRUG" } ], "intervention_types": [ "PROCEDURE", "DEVICE", "DRUG" ], "sponsor": "Vanderbilt University Medical Center", "sponsor_class": "OTHER", "healthy_volunteers": false, "eligibility": { "minimum_age": "60 Years", "maximum_age": "100 Years", "sex": "ALL", "summary": "60 Years to 100 Years" }, "enrollment_count": 22435, "start_date": "2017-01-05", "completion_date": "2018-12-29", "has_results": true, "last_update_posted_date": "2019-05-16", "last_synced_at": "2026-10-08T01:24:50.609Z", "location_count": 1, "location_summary": "Nashville, Tennessee", "locations": [ { "city": "Nashville", "state": "Tennessee" } ], "official_url": "https://clinicaltrials.gov/study/NCT02726620" }, { "nct_id": "NCT06314425", "title": "Zirconia Implants: Practice-based Evidence", "overall_status": "ACTIVE_NOT_RECRUITING", "study_type": "INTERVENTIONAL", "phases": [ "NA" ], "conditions": [ "Dental Implants", "Ceramic Implant" ], "interventions": [ { "name": "Immediate dental implants placements on fresh sockets after tooth extraction", "type": "PROCEDURE" } ], "intervention_types": [ "PROCEDURE" ], "sponsor": "Swiss Dental Solutions", "sponsor_class": "INDUSTRY", "healthy_volunteers": true, "eligibility": { "minimum_age": "18 Years", "maximum_age": "85 Years", "sex": "ALL", "summary": "18 Years to 85 Years" }, "enrollment_count": 50, "start_date": "2025-01-03", "completion_date": "2026-12-31", "has_results": false, "last_update_posted_date": "2026-07-31", "last_synced_at": "2026-10-08T01:24:50.609Z", "location_count": 1, "location_summary": "Englewood Cliffs, New Jersey", "locations": [ { "city": "Englewood Cliffs", "state": "New Jersey" } ], "official_url": "https://clinicaltrials.gov/study/NCT06314425" }, { "nct_id": "NCT01567839", "title": "Testing the Anesthetic Effectiveness of Three Different Dental Local Anesthetics Injected Next to a Lower First Molar", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE4" ], "conditions": [ "Anesthetic Effectiveness" ], "interventions": [ { "name": "Mandibular buccal Infiltration injection", "type": "PROCEDURE" } ], "intervention_types": [ "PROCEDURE" ], "sponsor": "Ohio State University", "sponsor_class": "OTHER", "healthy_volunteers": true, "eligibility": { "minimum_age": "18 Years", "maximum_age": "65 Years", "sex": "ALL", "summary": "18 Years to 65 Years" }, "enrollment_count": 60, "start_date": "2012-05", "completion_date": "2013-05", "has_results": true, "last_update_posted_date": "2014-01-01", "last_synced_at": "2026-10-08T01:24:50.609Z", "location_count": 1, "location_summary": "Columbus, Ohio", "locations": [ { "city": "Columbus", "state": "Ohio" } ], "official_url": "https://clinicaltrials.gov/study/NCT01567839" }, { "nct_id": "NCT01496846", "title": "Efficacy Study of Articaine Versus Lidocaine as Supplemental Infiltration in Inflamed Molars", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE4" ], "conditions": [ "Irreversible Pulpitis" ], "interventions": [ { "name": "IANB Articaine", "type": "DRUG" }, { "name": "SUP Articaine", "type": "DRUG" }, { "name": "SUP Lidocaine", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "University of Michigan", "sponsor_class": "OTHER", "healthy_volunteers": false, "eligibility": { "minimum_age": "18 Years", "maximum_age": null, "sex": "ALL", "summary": "18 Years and older" }, "enrollment_count": 201, "start_date": "2011-09", "completion_date": "2016-02", "has_results": true, "last_update_posted_date": "2017-10-31", "last_synced_at": "2026-10-08T01:24:50.609Z", "location_count": 1, "location_summary": "Ann Arbor, Michigan", "locations": [ { "city": "Ann Arbor", "state": "Michigan" } ], "official_url": "https://clinicaltrials.gov/study/NCT01496846" }, { "nct_id": "NCT06564987", "title": "Risk of Nerve Damage After Administration of Local Anesthesia", "overall_status": "UNKNOWN", "study_type": "INTERVENTIONAL", "phases": [ "PHASE1" ], "conditions": [ "Inferior Alveolar Nerve Injuries" ], "interventions": [ { "name": "4% Articaine with 1:200,000 epinephrine", "type": "DRUG" }, { "name": "2% lidocaine with 1:100,000 epinephrine", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "Cleveland Dental Institute", "sponsor_class": "OTHER", "healthy_volunteers": true, "eligibility": { "minimum_age": "18 Years", "maximum_age": "55 Years", "sex": "ALL", "summary": "18 Years to 55 Years" }, "enrollment_count": 80, "start_date": "2024-01-01", "completion_date": "2025-03-31", "has_results": false, "last_update_posted_date": "2024-08-26", "last_synced_at": "2026-10-08T01:24:50.609Z", "location_count": 2, "location_summary": "Akron, Ohio • Ashtabula, Ohio", "locations": [ { "city": "Akron", "state": "Ohio" }, { "city": "Ashtabula", "state": "Ohio" } ], "official_url": "https://clinicaltrials.gov/study/NCT06564987" }, { "nct_id": "NCT06047366", "title": "Combination of Buffered Anesthetic to Treat Mandibular Molars", "overall_status": "TERMINATED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE4" ], "conditions": [ "Symptomatic Irreversible Pulpitis" ], "interventions": [ { "name": "Sodium bicarbonate", "type": "DRUG" }, { "name": "Lidocaine w/ epi", "type": "DRUG" }, { "name": "Articaine w/ epi", "type": "DRUG" }, { "name": "Mepivacaine plain", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "Indiana University", "sponsor_class": "OTHER", "healthy_volunteers": true, "eligibility": { "minimum_age": "18 Years", "maximum_age": "80 Years", "sex": "ALL", "summary": "18 Years to 80 Years" }, "enrollment_count": 40, "start_date": "2023-12-05", "completion_date": "2024-05-15", "has_results": true, "last_update_posted_date": "2025-05-13", "last_synced_at": "2026-10-08T01:24:50.609Z", "location_count": 1, "location_summary": "Indianapolis, Indiana", "locations": [ { "city": "Indianapolis", "state": "Indiana" } ], "official_url": "https://clinicaltrials.gov/study/NCT06047366" } ] }