{ "api_version": "1", "request": { "url": "https://clinicaltrialsfind.com/api/v1/search.json?intervention=Aviptadil", "query": { "intervention": "Aviptadil" }, "page_size": 10 }, "pagination": { "page": 1, "page_size": 10, "total_count": 6, "total_pages": 1, "next_page_url": null, "previous_page_url": null }, "source": "remote", "last_synced_at": "2026-09-07T04:32:56.203Z", "attribution": "Data derived from public ClinicalTrials.gov records. The official record at https://clinicaltrials.gov/ remains the source of truth for current availability, contacts, and full study details.", "notes": [ "This endpoint exposes only public summary fields — no participant contact emails, phone numbers, or scraped investigator contact details.", "For contact information and full protocol detail, follow each trial's `official_url` to the ClinicalTrials.gov record.", "This API is a navigational aid. It does not provide medical advice, eligibility determinations, or compensation guarantees." ], "trials": [ { "nct_id": "NCT04360096", "title": "Inhaled ZYESAMI™ (Aviptadil Acetate) for the Treatment of Severe COVID-19", "overall_status": "TERMINATED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE2", "PHASE3" ], "conditions": [ "SARS-CoV 2", "COVID", "ARDS", "ALI", "Acute Lung Injury/Acute Respiratory Distress Syndrome (ARDS)", "Dyspnea" ], "interventions": [ { "name": "ZYESAMI™ (aviptadil acetate)", "type": "DRUG" }, { "name": "Placebo", "type": "DRUG" }, { "name": "Nebulized administration of ZYESAMI™ or Placebo", "type": "DEVICE" } ], "intervention_types": [ "DRUG", "DEVICE" ], "sponsor": "APR Applied Pharma Research s.a.", "sponsor_class": "OTHER", "healthy_volunteers": false, "eligibility": { "minimum_age": "18 Years", "maximum_age": "85 Years", "sex": "ALL", "summary": "18 Years to 85 Years" }, "enrollment_count": 144, "start_date": "2021-02-15", "completion_date": "2021-12-31", "has_results": false, "last_update_posted_date": "2023-02-03", "last_synced_at": "2026-09-07T04:32:56.203Z", "location_count": 13, "location_summary": "Fullerton, California • Irvine, California • Miami, Florida + 10 more", "locations": [ { "city": "Fullerton", "state": "California" }, { "city": "Irvine", "state": "California" }, { "city": "Miami", "state": "Florida" }, { "city": "Orlando", "state": "Florida" }, { "city": "Winfield", "state": "Illinois" } ], "official_url": "https://clinicaltrials.gov/study/NCT04360096" }, { "nct_id": "NCT04311697", "title": "Intravenous Aviptadil for Critical COVID-19 With Respiratory Failure", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE2", "PHASE3" ], "conditions": [ "Critical COVID-19 With Respiratory Failure", "Acute Respiratory Distress Syndrome (ARDS)", "Corona Virus Infection", "Acute Lung Injury" ], "interventions": [ { "name": "Aviptadil by intravenous infusion + standard of care", "type": "DRUG" }, { "name": "Normal Saline Infusion + standard of care", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "APR Applied Pharma Research s.a.", "sponsor_class": "OTHER", "healthy_volunteers": false, "eligibility": { "minimum_age": "18 Years", "maximum_age": "100 Years", "sex": "ALL", "summary": "18 Years to 100 Years" }, "enrollment_count": 203, "start_date": "2020-05-15", "completion_date": "2021-02-22", "has_results": true, "last_update_posted_date": "2023-07-24", "last_synced_at": "2026-09-07T04:32:56.203Z", "location_count": 10, "location_summary": "Fullerton, California • Irvine, California • Miami, Florida + 6 more", "locations": [ { "city": "Fullerton", "state": "California" }, { "city": "Irvine", "state": "California" }, { "city": "Miami", "state": "Florida" }, { "city": "Miami", "state": "Florida" }, { "city": "Louisville", "state": "Kentucky" } ], "official_url": "https://clinicaltrials.gov/study/NCT04311697" }, { "nct_id": "NCT04488081", "title": "I-SPY COVID-19 TRIAL: An Adaptive Platform Trial for Critically Ill Patients", "overall_status": "ACTIVE_NOT_RECRUITING", "study_type": "INTERVENTIONAL", "phases": [ "PHASE2" ], "conditions": [ "COVID-19" ], "interventions": [ { "name": "Remdesivir", "type": "DRUG" }, { "name": "Imatinib Mesylate", "type": "DRUG" }, { "name": "Dexamethasone", "type": "DRUG" }, { "name": "Cenicriviroc", "type": "DRUG" }, { "name": "Icatibant", "type": "DRUG" }, { "name": "Apremilast", "type": "DRUG" }, { "name": "dornase alfa", "type": "BIOLOGICAL" }, { "name": "Celecoxib", "type": "DRUG" }, { "name": "Famotidine", "type": "DRUG" }, { "name": "IC14", "type": "BIOLOGICAL" }, { "name": "Aviptadil", "type": "DRUG" }, { "name": "narsoplimab", "type": "BIOLOGICAL" }, { "name": "Cyproheptadine", "type": "DRUG" }, { "name": "Cyclosporine", "type": "DRUG" } ], "intervention_types": [ "DRUG", "BIOLOGICAL" ], "sponsor": "QuantumLeap Healthcare Collaborative", "sponsor_class": "OTHER", "healthy_volunteers": false, "eligibility": { "minimum_age": "18 Years", "maximum_age": null, "sex": "ALL", "summary": "18 Years and older" }, "enrollment_count": 1500, "start_date": "2020-07-31", "completion_date": "2030-07-31", "has_results": false, "last_update_posted_date": "2026-03-16", "last_synced_at": "2026-09-07T04:32:56.203Z", "location_count": 36, "location_summary": "Birmingham, Alabama • Davis, California • Irvine, California + 30 more", "locations": [ { "city": "Birmingham", "state": "Alabama" }, { "city": "Davis", "state": "California" }, { "city": "Irvine", "state": "California" }, { "city": "Long Beach", "state": "California" }, { "city": "Los Angeles", "state": "California" } ], "official_url": "https://clinicaltrials.gov/study/NCT04488081" }, { "nct_id": "NCT04843761", "title": "ACTIV-3b: Therapeutics for Severely Ill Inpatients With COVID-19", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE3" ], "conditions": [ "Covid19" ], "interventions": [ { "name": "Remdesivir", "type": "BIOLOGICAL" }, { "name": "Remdesivir Placebo", "type": "DRUG" }, { "name": "Aviptadil", "type": "BIOLOGICAL" }, { "name": "Aviptadil Placebo", "type": "DRUG" }, { "name": "Corticosteroid", "type": "DRUG" } ], "intervention_types": [ "BIOLOGICAL", "DRUG" ], "sponsor": "National Institute of Allergy and Infectious Diseases (NIAID)", "sponsor_class": "NIH", "healthy_volunteers": false, "eligibility": { "minimum_age": "18 Years", "maximum_age": null, "sex": "ALL", "summary": "18 Years and older" }, "enrollment_count": 473, "start_date": "2021-04-20", "completion_date": "2022-11-20", "has_results": true, "last_update_posted_date": "2025-10-24", "last_synced_at": "2026-09-07T04:32:56.203Z", "location_count": 40, "location_summary": "Tucson, Arizona • Fresno, California • Loma Linda, California + 28 more", "locations": [ { "city": "Tucson", "state": "Arizona" }, { "city": "Fresno", "state": "California" }, { "city": "Loma Linda", "state": "California" }, { "city": "Los Angeles", "state": "California" }, { "city": "Los Angeles", "state": "California" } ], "official_url": "https://clinicaltrials.gov/study/NCT04843761" }, { "nct_id": "NCT06729606", "title": "Aviptadil for Severely Ill Inpatients With COVID-19 (An ACTIV-3b/TESICO Treatment Trial)", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE3" ], "conditions": [ "Covid19" ], "interventions": [ { "name": "Aviptadil", "type": "BIOLOGICAL" }, { "name": "Aviptadil Placebo", "type": "BIOLOGICAL" }, { "name": "Corticosteroid", "type": "DRUG" } ], "intervention_types": [ "BIOLOGICAL", "DRUG" ], "sponsor": "National Institute of Allergy and Infectious Diseases (NIAID)", "sponsor_class": "NIH", "healthy_volunteers": false, "eligibility": { "minimum_age": "18 Years", "maximum_age": null, "sex": "ALL", "summary": "18 Years and older" }, "enrollment_count": 471, "start_date": "2021-04-20", "completion_date": "2022-11-20", "has_results": true, "last_update_posted_date": "2025-10-09", "last_synced_at": "2026-09-07T04:32:56.203Z", "location_count": 40, "location_summary": "Tucson, Arizona • Fresno, California • Loma Linda, California + 28 more", "locations": [ { "city": "Tucson", "state": "Arizona" }, { "city": "Fresno", "state": "California" }, { "city": "Loma Linda", "state": "California" }, { "city": "Los Angeles", "state": "California" }, { "city": "Los Angeles", "state": "California" } ], "official_url": "https://clinicaltrials.gov/study/NCT06729606" }, { "nct_id": "NCT04453839", "title": "ZYESAMI (Aviptadil) Intermediate Population Expanded Access Protocol (SAMICARE)", "overall_status": "NO_LONGER_AVAILABLE", "study_type": "EXPANDED_ACCESS", "phases": [], "conditions": [ "Critical COVID-19 With Respiratory Failure" ], "interventions": [ { "name": "ZYESAMI (aviptadil acetate)", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "APR Applied Pharma Research s.a.", "sponsor_class": "OTHER", "healthy_volunteers": null, "eligibility": { "minimum_age": "12 Years", "maximum_age": "100 Years", "sex": "ALL", "summary": "12 Years to 100 Years" }, "enrollment_count": null, "start_date": null, "completion_date": null, "has_results": false, "last_update_posted_date": "2023-02-03", "last_synced_at": "2026-09-07T04:32:56.203Z", "location_count": 25, "location_summary": "Gilbert, Arizona • Scottsdale, Arizona • Baldwin Park, California + 20 more", "locations": [ { "city": "Gilbert", "state": "Arizona" }, { "city": "Scottsdale", "state": "Arizona" }, { "city": "Baldwin Park", "state": "California" }, { "city": "Irvine", "state": "California" }, { "city": "Ft. Pierce", "state": "Florida" } ], "official_url": "https://clinicaltrials.gov/study/NCT04453839" } ] }