{
  "api_version": "1",
  "request": {
    "url": "https://clinicaltrialsfind.com/api/v1/search.json?intervention=BIG+%2B+Treatment+As+Usual&page=2",
    "query": {
      "intervention": "BIG + Treatment As Usual",
      "page": 2
    },
    "page_size": 10
  },
  "pagination": {
    "page": 2,
    "page_size": 10,
    "total_count": 43,
    "total_pages": 5,
    "next_page_url": "https://clinicaltrialsfind.com/api/v1/search.json?intervention=BIG+%2B+Treatment+As+Usual&page=3&page_size=10",
    "previous_page_url": "https://clinicaltrialsfind.com/api/v1/search.json?intervention=BIG+%2B+Treatment+As+Usual&page=1&page_size=10"
  },
  "source": "remote",
  "last_synced_at": "2026-10-08T06:05:49.439Z",
  "attribution": "Data derived from public ClinicalTrials.gov records. The official record at https://clinicaltrials.gov/ remains the source of truth for current availability, contacts, and full study details.",
  "notes": [
    "This endpoint exposes only public summary fields — no participant contact emails, phone numbers, or scraped investigator contact details.",
    "For contact information and full protocol detail, follow each trial's `official_url` to the ClinicalTrials.gov record.",
    "This API is a navigational aid. It does not provide medical advice, eligibility determinations, or compensation guarantees."
  ],
  "trials": [
    {
      "nct_id": "NCT03024112",
      "title": "Impact of Prophylactic High Flow Nasal Oxygen in Post-Operative Thoracic Surgical Patients",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Post-operative Pulmonary Complications"
      ],
      "interventions": [
        {
          "name": "Heated humified high-flow nasal cannula Oxygen",
          "type": "DEVICE"
        },
        {
          "name": "Standard oxygen therapy",
          "type": "OTHER"
        }
      ],
      "intervention_types": [
        "DEVICE",
        "OTHER"
      ],
      "sponsor": "University of Colorado, Denver",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": "100 Years",
        "sex": "ALL",
        "summary": "18 Years to 100 Years"
      },
      "enrollment_count": 51,
      "start_date": "2013-08",
      "completion_date": "2015-06",
      "has_results": true,
      "last_update_posted_date": "2026-07-07",
      "last_synced_at": "2026-10-08T06:05:49.439Z",
      "location_count": 1,
      "location_summary": "Aurora, Colorado",
      "locations": [
        {
          "city": "Aurora",
          "state": "Colorado"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT03024112"
    },
    {
      "nct_id": "NCT06915428",
      "title": "Personalized Care for Prenatal Stress Reduction & Prevention of Preterm Birth (PTB) Disparities",
      "overall_status": "NOT_YET_RECRUITING",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Preterm Birth Complication",
        "Preterm Birth",
        "Preterm Birth Recurrence",
        "Preeclampsia",
        "Preeclampsia (PE)",
        "Hypertensive Disorders of Pregnancy",
        "Support Program",
        "Stress",
        "Resilience, Psychological",
        "Empowerment, Patient",
        "Emotional Stress",
        "Pregnancy",
        "Pregnancy Complications",
        "Pregnancy Induced Hypertension",
        "Neonates and Preterm Infants",
        "Cervical Insufficiency",
        "Social Determinants of Health (SDOH)",
        "Cervical Shortening",
        "Disparities in Pregnancy Complications",
        "Disparities",
        "Prenatal Care",
        "Care Coordination"
      ],
      "interventions": [
        {
          "name": "Care coordination",
          "type": "BEHAVIORAL"
        },
        {
          "name": "Electronic massage",
          "type": "BEHAVIORAL"
        },
        {
          "name": "support gift #1",
          "type": "BEHAVIORAL"
        },
        {
          "name": "Support gift #2",
          "type": "BEHAVIORAL"
        },
        {
          "name": "Support gift #3",
          "type": "BEHAVIORAL"
        },
        {
          "name": "Support gift #4",
          "type": "BEHAVIORAL"
        },
        {
          "name": "Additional PTBCARE+ support",
          "type": "BEHAVIORAL"
        },
        {
          "name": "Stress reduction toolkit - Visit 1 (V1)",
          "type": "BEHAVIORAL"
        },
        {
          "name": "PTBCARE+ mobile application (app) and website",
          "type": "BEHAVIORAL"
        },
        {
          "name": "Sleep, meditation, and Wellness app",
          "type": "BEHAVIORAL"
        },
        {
          "name": "Emergency low blood sugar kit",
          "type": "BEHAVIORAL"
        },
        {
          "name": "Low dose aspirin (LDA)",
          "type": "BEHAVIORAL"
        },
        {
          "name": "Visit #2 Stress Reduction Toolkit",
          "type": "BEHAVIORAL"
        }
      ],
      "intervention_types": [
        "BEHAVIORAL"
      ],
      "sponsor": "University of North Carolina, Chapel Hill",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": null,
        "sex": "FEMALE",
        "summary": "18 Years and older · Female only"
      },
      "enrollment_count": 1228,
      "start_date": "2026-10-01",
      "completion_date": "2029-01",
      "has_results": false,
      "last_update_posted_date": "2026-09-29",
      "last_synced_at": "2026-10-08T06:05:49.439Z",
      "location_count": 1,
      "location_summary": "Chapel Hill, North Carolina",
      "locations": [
        {
          "city": "Chapel Hill",
          "state": "North Carolina"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT06915428"
    },
    {
      "nct_id": "NCT03938883",
      "title": "Ocular Bandage Gel (OBG) Pivotal Trial in Patients Undergoing Photorefractive Keratectomy (\"PRK\")",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Ophthalmology",
        "Photorefractive Keratectomy (\"PRK\")",
        "Laser Assisted Surgery",
        "Refractive Surgery"
      ],
      "interventions": [
        {
          "name": "Ocular Bandage Gel (OBG)",
          "type": "DEVICE"
        },
        {
          "name": "Bandage Contact Lens (BCL)",
          "type": "DEVICE"
        }
      ],
      "intervention_types": [
        "DEVICE"
      ],
      "sponsor": "Eyegate Pharmaceuticals, Inc.",
      "sponsor_class": "INDUSTRY",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "22 Years",
        "maximum_age": "50 Years",
        "sex": "ALL",
        "summary": "22 Years to 50 Years"
      },
      "enrollment_count": 250,
      "start_date": "2019-06-25",
      "completion_date": "2019-10-10",
      "has_results": false,
      "last_update_posted_date": "2019-12-13",
      "last_synced_at": "2026-10-08T06:05:49.439Z",
      "location_count": 1,
      "location_summary": "Sioux Falls, South Dakota",
      "locations": [
        {
          "city": "Sioux Falls",
          "state": "South Dakota"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT03938883"
    },
    {
      "nct_id": "NCT03799341",
      "title": "Neurocognitive Factors in Substance Use Treatment Response: The Ways of Rewarding Abstinence Project",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Cocaine Use Disorder"
      ],
      "interventions": [
        {
          "name": "Prize-Based Contingency Management",
          "type": "BEHAVIORAL"
        },
        {
          "name": "Treatment As Usual Outpatient Substance Use Treatment",
          "type": "BEHAVIORAL"
        }
      ],
      "intervention_types": [
        "BEHAVIORAL"
      ],
      "sponsor": "VA Office of Research and Development",
      "sponsor_class": "FED",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": "75 Years",
        "sex": "ALL",
        "summary": "18 Years to 75 Years"
      },
      "enrollment_count": 63,
      "start_date": "2019-11-13",
      "completion_date": "2024-04-12",
      "has_results": true,
      "last_update_posted_date": "2025-09-30",
      "last_synced_at": "2026-10-08T06:05:49.439Z",
      "location_count": 1,
      "location_summary": "Pittsburgh, Pennsylvania",
      "locations": [
        {
          "city": "Pittsburgh",
          "state": "Pennsylvania"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT03799341"
    },
    {
      "nct_id": "NCT00556933",
      "title": "Improved Induction and Maintenance Immunosuppression in Kidney Transplantation",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE4"
      ],
      "conditions": [
        "End-stage Renal Disease"
      ],
      "interventions": [
        {
          "name": "rabbit anti-thymocyte globulin - single dose",
          "type": "DRUG"
        },
        {
          "name": "mycophenolate mofetil",
          "type": "DRUG"
        },
        {
          "name": "rabbit anti-thymocyte globulin - 4 doses",
          "type": "DRUG"
        },
        {
          "name": "sirolimus",
          "type": "DRUG"
        },
        {
          "name": "tacrolimus",
          "type": "DRUG"
        }
      ],
      "intervention_types": [
        "DRUG"
      ],
      "sponsor": "University of Nebraska",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": "65 Years",
        "sex": "ALL",
        "summary": "18 Years to 65 Years"
      },
      "enrollment_count": 180,
      "start_date": "2004-04-01",
      "completion_date": "2011-06-01",
      "has_results": true,
      "last_update_posted_date": "2023-09-18",
      "last_synced_at": "2026-10-08T06:05:49.439Z",
      "location_count": 1,
      "location_summary": "Omaha, Nebraska",
      "locations": [
        {
          "city": "Omaha",
          "state": "Nebraska"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT00556933"
    },
    {
      "nct_id": "NCT04046991",
      "title": "Treating Primary Progressive Aphasia (PPA) Using High-definition tDCS",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE2"
      ],
      "conditions": [
        "Primary Progressive Aphasia"
      ],
      "interventions": [
        {
          "name": "high-definition transcranial direct current stimulation",
          "type": "DEVICE"
        },
        {
          "name": "modified constraint-induced language therapy",
          "type": "BEHAVIORAL"
        }
      ],
      "intervention_types": [
        "DEVICE",
        "BEHAVIORAL"
      ],
      "sponsor": "University of Pennsylvania",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "45 Years",
        "maximum_age": "80 Years",
        "sex": "ALL",
        "summary": "45 Years to 80 Years"
      },
      "enrollment_count": 76,
      "start_date": "2020-08-17",
      "completion_date": "2025-06-30",
      "has_results": false,
      "last_update_posted_date": "2025-10-15",
      "last_synced_at": "2026-10-08T06:05:49.439Z",
      "location_count": 1,
      "location_summary": "Philadelphia, Pennsylvania",
      "locations": [
        {
          "city": "Philadelphia",
          "state": "Pennsylvania"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT04046991"
    },
    {
      "nct_id": "NCT03402607",
      "title": "Trial Comparing PLA to HIGRT (PROVE-HCC)",
      "overall_status": "TERMINATED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Hepatocellular Carcinoma"
      ],
      "interventions": [
        {
          "name": "Percutaneous Local Ablation",
          "type": "PROCEDURE"
        },
        {
          "name": "Hypofractionated Image Guided Radiation Therapy",
          "type": "RADIATION"
        }
      ],
      "intervention_types": [
        "PROCEDURE",
        "RADIATION"
      ],
      "sponsor": "Duke University",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "18 Years and older"
      },
      "enrollment_count": 12,
      "start_date": "2018-08-08",
      "completion_date": "2020-03-25",
      "has_results": true,
      "last_update_posted_date": "2022-07-08",
      "last_synced_at": "2026-10-08T06:05:49.439Z",
      "location_count": 2,
      "location_summary": "Durham, North Carolina",
      "locations": [
        {
          "city": "Durham",
          "state": "North Carolina"
        },
        {
          "city": "Durham",
          "state": "North Carolina"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT03402607"
    },
    {
      "nct_id": "NCT02015390",
      "title": "Comparative Efficacy of the Masquelet Versus Titanium Mesh Cage Techniques for the Treatment of Large Long Bone Defects",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Segmental Long Bone Defects"
      ],
      "interventions": [
        {
          "name": "Autogenous RIA bone grafting",
          "type": "PROCEDURE"
        },
        {
          "name": "Allogeneic bone grafting",
          "type": "PROCEDURE"
        }
      ],
      "intervention_types": [
        "PROCEDURE"
      ],
      "sponsor": "The University of Texas Medical Branch, Galveston",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": "99 Years",
        "sex": "ALL",
        "summary": "18 Years to 99 Years"
      },
      "enrollment_count": 16,
      "start_date": "2013-10-01",
      "completion_date": "2019-12-31",
      "has_results": true,
      "last_update_posted_date": "2021-06-28",
      "last_synced_at": "2026-10-08T06:05:49.439Z",
      "location_count": 1,
      "location_summary": "Galveston, Texas",
      "locations": [
        {
          "city": "Galveston",
          "state": "Texas"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT02015390"
    },
    {
      "nct_id": "NCT00281879",
      "title": "Donor Stem Cell Transplant or Donor White Blood Cell Infusions in Treating Patients With Hematologic Cancer",
      "overall_status": "TERMINATED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE2"
      ],
      "conditions": [
        "Chronic Myeloproliferative Disorders",
        "Leukemia",
        "Lymphoma",
        "Multiple Myeloma and Plasma Cell Neoplasm",
        "Myelodysplastic Syndromes",
        "Myelodysplastic/Myeloproliferative Neoplasms",
        "Unusual Cancers of Childhood"
      ],
      "interventions": [
        {
          "name": "anti-thymocyte globulin",
          "type": "BIOLOGICAL"
        },
        {
          "name": "filgrastim",
          "type": "BIOLOGICAL"
        },
        {
          "name": "busulfan",
          "type": "DRUG"
        },
        {
          "name": "carmustine",
          "type": "DRUG"
        },
        {
          "name": "cyclophosphamide",
          "type": "DRUG"
        },
        {
          "name": "cyclosporine",
          "type": "DRUG"
        },
        {
          "name": "cytarabine",
          "type": "DRUG"
        },
        {
          "name": "etoposide",
          "type": "DRUG"
        },
        {
          "name": "fludarabine phosphate",
          "type": "DRUG"
        },
        {
          "name": "melphalan",
          "type": "DRUG"
        },
        {
          "name": "methotrexate",
          "type": "DRUG"
        },
        {
          "name": "methylprednisolone",
          "type": "DRUG"
        },
        {
          "name": "mycophenolate mofetil",
          "type": "DRUG"
        },
        {
          "name": "tacrolimus",
          "type": "DRUG"
        },
        {
          "name": "peripheral blood stem cell transplantation",
          "type": "PROCEDURE"
        },
        {
          "name": "umbilical cord blood transplantation",
          "type": "PROCEDURE"
        },
        {
          "name": "radiation therapy",
          "type": "RADIATION"
        }
      ],
      "intervention_types": [
        "BIOLOGICAL",
        "DRUG",
        "PROCEDURE",
        "RADIATION"
      ],
      "sponsor": "OHSU Knight Cancer Institute",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": null,
        "maximum_age": "60 Years",
        "sex": "ALL",
        "summary": "Up to 60 Years"
      },
      "enrollment_count": 200,
      "start_date": "2006-02",
      "completion_date": "2008-03",
      "has_results": true,
      "last_update_posted_date": "2017-09-27",
      "last_synced_at": "2026-10-08T06:05:49.439Z",
      "location_count": 1,
      "location_summary": "Portland, Oregon",
      "locations": [
        {
          "city": "Portland",
          "state": "Oregon"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT00281879"
    },
    {
      "nct_id": "NCT02908932",
      "title": "Ranger Resilience and Improved Performance on Phospholipid Bound Omega-3's",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Nutrition",
        "Fatty Acids, Omega-3",
        "Cognition",
        "Resilience, Psychological",
        "Psychology, Military"
      ],
      "interventions": [
        {
          "name": "Phospholipid-bound omega-3 supplement",
          "type": "DIETARY_SUPPLEMENT"
        },
        {
          "name": "Placebo supplement",
          "type": "DIETARY_SUPPLEMENT"
        }
      ],
      "intervention_types": [
        "DIETARY_SUPPLEMENT"
      ],
      "sponsor": "Medical University of South Carolina",
      "sponsor_class": "OTHER",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": null,
        "maximum_age": null,
        "sex": "ALL",
        "summary": "Not listed"
      },
      "enrollment_count": 555,
      "start_date": "2016-08",
      "completion_date": "2018-06",
      "has_results": false,
      "last_update_posted_date": "2018-07-05",
      "last_synced_at": "2026-10-08T06:05:49.439Z",
      "location_count": 3,
      "location_summary": "Fort Benning, Georgia • Bethesda, Maryland • Charleston, South Carolina",
      "locations": [
        {
          "city": "Fort Benning",
          "state": "Georgia"
        },
        {
          "city": "Bethesda",
          "state": "Maryland"
        },
        {
          "city": "Charleston",
          "state": "South Carolina"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT02908932"
    }
  ]
}