{
  "api_version": "1",
  "request": {
    "url": "https://clinicaltrialsfind.com/api/v1/search.json?intervention=Bicarbonate",
    "query": {
      "intervention": "Bicarbonate"
    },
    "page_size": 10
  },
  "pagination": {
    "page": 1,
    "page_size": 10,
    "total_count": 211,
    "total_pages": 22,
    "next_page_url": "https://clinicaltrialsfind.com/api/v1/search.json?intervention=Bicarbonate&page=2&page_size=10",
    "previous_page_url": null
  },
  "source": "remote",
  "last_synced_at": "2026-09-11T16:17:13.132Z",
  "attribution": "Data derived from public ClinicalTrials.gov records. The official record at https://clinicaltrials.gov/ remains the source of truth for current availability, contacts, and full study details.",
  "notes": [
    "This endpoint exposes only public summary fields — no participant contact emails, phone numbers, or scraped investigator contact details.",
    "For contact information and full protocol detail, follow each trial's `official_url` to the ClinicalTrials.gov record.",
    "This API is a navigational aid. It does not provide medical advice, eligibility determinations, or compensation guarantees."
  ],
  "trials": [
    {
      "nct_id": "NCT02082717",
      "title": "The Impact of Neut During Potassium Chloride Replacement on Pain and Incidence of Phlebitis",
      "overall_status": "TERMINATED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE4"
      ],
      "conditions": [
        "Hypokalemia"
      ],
      "interventions": [
        {
          "name": "potassium chloride replacement",
          "type": "DRUG"
        },
        {
          "name": "Experimental - 4% Sodium Bicarbonate",
          "type": "DRUG"
        }
      ],
      "intervention_types": [
        "DRUG"
      ],
      "sponsor": "Baptist Health South Florida",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "21 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "21 Years and older"
      },
      "enrollment_count": 17,
      "start_date": "2014-02-25",
      "completion_date": "2018-08-03",
      "has_results": true,
      "last_update_posted_date": "2021-04-01",
      "last_synced_at": "2026-09-11T16:17:13.132Z",
      "location_count": 1,
      "location_summary": "Miami, Florida",
      "locations": [
        {
          "city": "Miami",
          "state": "Florida"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT02082717"
    },
    {
      "nct_id": "NCT01846429",
      "title": "Oral Bicarbonate as Adjuvant for Pain Reduction in Patients With Tumor Related Pain",
      "overall_status": "TERMINATED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE1"
      ],
      "conditions": [
        "Tumor",
        "Cancer",
        "Pain",
        "Malignant Solid Tumor",
        "Unresectable Malignant Neoplasm",
        "Hematologic Malignancy",
        "Multiple Myeloma",
        "Lymphoma",
        "Neoplasm Metastasis"
      ],
      "interventions": [
        {
          "name": "Sodium Bicarbonate",
          "type": "DRUG"
        }
      ],
      "intervention_types": [
        "DRUG"
      ],
      "sponsor": "H. Lee Moffitt Cancer Center and Research Institute",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "18 Years and older"
      },
      "enrollment_count": 9,
      "start_date": "2013-09",
      "completion_date": "2015-05",
      "has_results": false,
      "last_update_posted_date": "2015-06-04",
      "last_synced_at": "2026-09-11T16:17:13.132Z",
      "location_count": 1,
      "location_summary": "Tampa, Florida",
      "locations": [
        {
          "city": "Tampa",
          "state": "Florida"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT01846429"
    },
    {
      "nct_id": "NCT04055116",
      "title": "Buffered Lidocaine in the Pediatric Dental Patient",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE4"
      ],
      "conditions": [
        "Pediatric Dentistry"
      ],
      "interventions": [
        {
          "name": "Buffered Lidocaine",
          "type": "DRUG"
        }
      ],
      "intervention_types": [
        "DRUG"
      ],
      "sponsor": "Geisinger Clinic",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "4 Years",
        "maximum_age": "17 Years",
        "sex": "ALL",
        "summary": "4 Years to 17 Years"
      },
      "enrollment_count": 64,
      "start_date": "2019-11-11",
      "completion_date": "2022-03-01",
      "has_results": true,
      "last_update_posted_date": "2023-04-07",
      "last_synced_at": "2026-09-11T16:17:13.132Z",
      "location_count": 1,
      "location_summary": "Danville, Pennsylvania",
      "locations": [
        {
          "city": "Danville",
          "state": "Pennsylvania"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT04055116"
    },
    {
      "nct_id": "NCT00758394",
      "title": "Clinical Study to Compare Dental Plaque Control",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE3"
      ],
      "conditions": [
        "Dental Plaque"
      ],
      "interventions": [
        {
          "name": "Fluoride",
          "type": "DRUG"
        },
        {
          "name": "Triclosan/Fluoride",
          "type": "DRUG"
        }
      ],
      "intervention_types": [
        "DRUG"
      ],
      "sponsor": "Colgate Palmolive",
      "sponsor_class": "INDUSTRY",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": "53 Years",
        "sex": "ALL",
        "summary": "18 Years to 53 Years"
      },
      "enrollment_count": 29,
      "start_date": "2007-09",
      "completion_date": "2007-11",
      "has_results": true,
      "last_update_posted_date": "2013-08-15",
      "last_synced_at": "2026-09-11T16:17:13.132Z",
      "location_count": 1,
      "location_summary": "New York, New York",
      "locations": [
        {
          "city": "New York",
          "state": "New York"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT00758394"
    },
    {
      "nct_id": "NCT04794439",
      "title": "Plaque Removal Efficacy of Four Dentifrices Following a Single Brushing",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE2"
      ],
      "conditions": [
        "Plaque, Dental"
      ],
      "interventions": [
        {
          "name": "Dentifrices",
          "type": "DRUG"
        }
      ],
      "intervention_types": [
        "DRUG"
      ],
      "sponsor": "Church & Dwight Company, Inc.",
      "sponsor_class": "INDUSTRY",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": "69 Years",
        "sex": "ALL",
        "summary": "18 Years to 69 Years"
      },
      "enrollment_count": 70,
      "start_date": "2020-11-16",
      "completion_date": "2020-12-18",
      "has_results": false,
      "last_update_posted_date": "2021-03-12",
      "last_synced_at": "2026-09-11T16:17:13.132Z",
      "location_count": 1,
      "location_summary": "Fort Wayne, Indiana",
      "locations": [
        {
          "city": "Fort Wayne",
          "state": "Indiana"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT04794439"
    },
    {
      "nct_id": "NCT00496964",
      "title": "Botox for Non-surgical Lateral Release in Patellofemoral Pain",
      "overall_status": "TERMINATED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE3"
      ],
      "conditions": [
        "Patellofemoral Pain Syndrome"
      ],
      "interventions": [
        {
          "name": "Botulinum toxin A + exercise",
          "type": "DRUG"
        },
        {
          "name": "Placebo",
          "type": "DRUG"
        }
      ],
      "intervention_types": [
        "DRUG"
      ],
      "sponsor": "Virginia Commonwealth University",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": "40 Years",
        "sex": "ALL",
        "summary": "18 Years to 40 Years"
      },
      "enrollment_count": 5,
      "start_date": "2005-05",
      "completion_date": "2008-06",
      "has_results": true,
      "last_update_posted_date": "2017-10-23",
      "last_synced_at": "2026-09-11T16:17:13.132Z",
      "location_count": 1,
      "location_summary": "Richmond, Virginia",
      "locations": [
        {
          "city": "Richmond",
          "state": "Virginia"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT00496964"
    },
    {
      "nct_id": "NCT00392405",
      "title": "Prevention of Contrast Induced Nephropathy With Sodium Bicarbonate",
      "overall_status": "UNKNOWN",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE2"
      ],
      "conditions": [
        "Contrast Induced Nephropathy"
      ],
      "interventions": [
        {
          "name": "3 amps of sodium bicarbonate mixed in one liter of D5W",
          "type": "DRUG"
        }
      ],
      "intervention_types": [
        "DRUG"
      ],
      "sponsor": "Norton Community Hospital",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "18 Years and older"
      },
      "enrollment_count": 656,
      "start_date": "2006-11",
      "completion_date": null,
      "has_results": false,
      "last_update_posted_date": "2006-10-26",
      "last_synced_at": "2026-09-11T16:17:13.132Z",
      "location_count": 1,
      "location_summary": "Norton, Virginia",
      "locations": [
        {
          "city": "Norton",
          "state": "Virginia"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT00392405"
    },
    {
      "nct_id": "NCT00177645",
      "title": "Inhaled Bicarbonate Therapy in Cystic Fibrosis",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE1"
      ],
      "conditions": [
        "Cystic Fibrosis"
      ],
      "interventions": [
        {
          "name": "sodium bicarbonate",
          "type": "PROCEDURE"
        }
      ],
      "intervention_types": [
        "PROCEDURE"
      ],
      "sponsor": "University of Pittsburgh",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "12 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "12 Years and older"
      },
      "enrollment_count": 16,
      "start_date": "2002-03",
      "completion_date": "2006-12",
      "has_results": false,
      "last_update_posted_date": "2023-09-07",
      "last_synced_at": "2026-09-11T16:17:13.132Z",
      "location_count": 1,
      "location_summary": "Pittsburgh, Pennsylvania",
      "locations": [
        {
          "city": "Pittsburgh",
          "state": "Pennsylvania"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT00177645"
    },
    {
      "nct_id": "NCT05813535",
      "title": "8.4% Sodium Bicarbonate Locks in Intestinal Failure",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE2"
      ],
      "conditions": [
        "Intestinal Failure",
        "CRBSI - Catheter Related Bloodstream Infection"
      ],
      "interventions": [
        {
          "name": "Sodium bicarb lock",
          "type": "DRUG"
        }
      ],
      "intervention_types": [
        "DRUG"
      ],
      "sponsor": "Riad Rahhal",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "1 Year",
        "maximum_age": "18 Years",
        "sex": "ALL",
        "summary": "1 Year to 18 Years"
      },
      "enrollment_count": 6,
      "start_date": "2022-12-01",
      "completion_date": "2025-03-01",
      "has_results": true,
      "last_update_posted_date": "2026-05-28",
      "last_synced_at": "2026-09-11T16:17:13.132Z",
      "location_count": 1,
      "location_summary": "Iowa City, Iowa",
      "locations": [
        {
          "city": "Iowa City",
          "state": "Iowa"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT05813535"
    },
    {
      "nct_id": "NCT02870738",
      "title": "Bladder Directed vs. Pelvic Floor Therapy in IC/BPS",
      "overall_status": "ACTIVE_NOT_RECRUITING",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE2"
      ],
      "conditions": [
        "Cystitis, Interstitial",
        "Painful Bladder Syndrome"
      ],
      "interventions": [
        {
          "name": "Pelvic Floor Physical Therapy",
          "type": "PROCEDURE"
        },
        {
          "name": "Bladder Instillations",
          "type": "DRUG"
        }
      ],
      "intervention_types": [
        "PROCEDURE",
        "DRUG"
      ],
      "sponsor": "Corewell Health East",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": "85 Years",
        "sex": "FEMALE",
        "summary": "18 Years to 85 Years · Female only"
      },
      "enrollment_count": 128,
      "start_date": "2017-04-21",
      "completion_date": "2027-08",
      "has_results": false,
      "last_update_posted_date": "2026-07-09",
      "last_synced_at": "2026-09-11T16:17:13.132Z",
      "location_count": 1,
      "location_summary": "Royal Oak, Michigan",
      "locations": [
        {
          "city": "Royal Oak",
          "state": "Michigan"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT02870738"
    }
  ]
}