{ "api_version": "1", "request": { "url": "https://clinicaltrialsfind.com/api/v1/search.json?intervention=Bivalent+COVID-19+Booster", "query": { "intervention": "Bivalent COVID-19 Booster" }, "page_size": 10 }, "pagination": { "page": 1, "page_size": 10, "total_count": 15, "total_pages": 2, "next_page_url": "https://clinicaltrialsfind.com/api/v1/search.json?intervention=Bivalent+COVID-19+Booster&page=2&page_size=10", "previous_page_url": null }, "source": "remote", "last_synced_at": "2026-09-25T09:37:12.791Z", "attribution": "Data derived from public ClinicalTrials.gov records. The official record at https://clinicaltrials.gov/ remains the source of truth for current availability, contacts, and full study details.", "notes": [ "This endpoint exposes only public summary fields — no participant contact emails, phone numbers, or scraped investigator contact details.", "For contact information and full protocol detail, follow each trial's `official_url` to the ClinicalTrials.gov record.", "This API is a navigational aid. It does not provide medical advice, eligibility determinations, or compensation guarantees." ], "trials": [ { "nct_id": "NCT05541861", "title": "Safety and Effects of an Investigational COVID-19 Vaccine as Booster in Healthy People", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE1" ], "conditions": [ "SARS-CoV-2 Infection", "COVID-19" ], "interventions": [ { "name": "BNT162b2 Bivalent (original/Omicron BA.4/BA.5) 30 mcg", "type": "BIOLOGICAL" }, { "name": "BNT162b4 5 mcg", "type": "BIOLOGICAL" }, { "name": "BNT162b4 10 mcg", "type": "BIOLOGICAL" }, { "name": "BNT162b4 15 mcg", "type": "BIOLOGICAL" }, { "name": "BNT162b4 30 mcg", "type": "BIOLOGICAL" }, { "name": "BNT162b2 Monovalent (OMI XBB.1.5) 30 mcg", "type": "BIOLOGICAL" } ], "intervention_types": [ "BIOLOGICAL" ], "sponsor": "BioNTech SE", "sponsor_class": "INDUSTRY", "healthy_volunteers": true, "eligibility": { "minimum_age": "18 Years", "maximum_age": null, "sex": "ALL", "summary": "18 Years and older" }, "enrollment_count": 383, "start_date": "2022-11-08", "completion_date": "2024-11-22", "has_results": true, "last_update_posted_date": "2026-01-13", "last_synced_at": "2026-09-25T09:37:12.791Z", "location_count": 17, "location_summary": "Tempe, Arizona • Newport Beach, California • San Diego, California + 13 more", "locations": [ { "city": "Tempe", "state": "Arizona" }, { "city": "Newport Beach", "state": "California" }, { "city": "San Diego", "state": "California" }, { "city": "Walnut Creek", "state": "California" }, { "city": "Milford", "state": "Connecticut" } ], "official_url": "https://clinicaltrials.gov/study/NCT05541861" }, { "nct_id": "NCT05586204", "title": "Boost Intentions and Facilitate Action to Promote COVID-19 Booster Take-up", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "NA" ], "conditions": [ "COVID-19", "Vaccines" ], "interventions": [ { "name": "Eligibility reminder", "type": "BEHAVIORAL" }, { "name": "Link to a narrow set of vaccine venues", "type": "BEHAVIORAL" }, { "name": "Link to a broad set of vaccine venues", "type": "BEHAVIORAL" }, { "name": "Doctors' recommendation and value of vaccine", "type": "BEHAVIORAL" } ], "intervention_types": [ "BEHAVIORAL" ], "sponsor": "University of California, Los Angeles", "sponsor_class": "OTHER", "healthy_volunteers": true, "eligibility": { "minimum_age": "18 Years", "maximum_age": null, "sex": "ALL", "summary": "18 Years and older" }, "enrollment_count": 154977, "start_date": "2022-10-18", "completion_date": "2023-12-31", "has_results": false, "last_update_posted_date": "2024-12-09", "last_synced_at": "2026-09-25T09:37:12.791Z", "location_count": 1, "location_summary": "Los Angeles, California", "locations": [ { "city": "Los Angeles", "state": "California" } ], "official_url": "https://clinicaltrials.gov/study/NCT05586204" }, { "nct_id": "NCT04977479", "title": "The Safety of Administering a Second Dose of a COVID-19 mRNA Vaccine in Individuals Who Experienced a Systemic Allergic Reaction to an Initial Dose", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE2" ], "conditions": [ "Systemic Allergic Reaction" ], "interventions": [ { "name": "Pfizer-BioNTech COVID-19 Vaccine (Comirnaty)", "type": "BIOLOGICAL" }, { "name": "Placebo", "type": "OTHER" }, { "name": "Pfizer-BioNTech COVID-19 Vaccine, Bivalent", "type": "BIOLOGICAL" } ], "intervention_types": [ "BIOLOGICAL", "OTHER" ], "sponsor": "National Institute of Allergy and Infectious Diseases (NIAID)", "sponsor_class": "NIH", "healthy_volunteers": false, "eligibility": { "minimum_age": "16 Years", "maximum_age": "69 Years", "sex": "ALL", "summary": "16 Years to 69 Years" }, "enrollment_count": 20, "start_date": "2021-09-08", "completion_date": "2023-02-22", "has_results": true, "last_update_posted_date": "2023-10-16", "last_synced_at": "2026-09-25T09:37:12.791Z", "location_count": 1, "location_summary": "Bethesda, Maryland", "locations": [ { "city": "Bethesda", "state": "Maryland" } ], "official_url": "https://clinicaltrials.gov/study/NCT04977479" }, { "nct_id": "NCT05586178", "title": "Information Provision and Consistency Framing to Increase COVID-19 Booster Uptake", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "NA" ], "conditions": [ "COVID-19", "Vaccines" ], "interventions": [ { "name": "Reminder that facilitates action", "type": "BEHAVIORAL" }, { "name": "Consistency framing", "type": "BEHAVIORAL" }, { "name": "Information provision about the uniqueness of the bivalent booster", "type": "BEHAVIORAL" }, { "name": "Information provision about bivalent booster eligibility", "type": "BEHAVIORAL" }, { "name": "Information provision about the severity of COVID-19 symptoms", "type": "BEHAVIORAL" } ], "intervention_types": [ "BEHAVIORAL" ], "sponsor": "University of California, Los Angeles", "sponsor_class": "OTHER", "healthy_volunteers": true, "eligibility": { "minimum_age": "18 Years", "maximum_age": null, "sex": "ALL", "summary": "18 Years and older" }, "enrollment_count": 177720, "start_date": "2022-10-18", "completion_date": "2023-12-31", "has_results": false, "last_update_posted_date": "2024-12-05", "last_synced_at": "2026-09-25T09:37:12.791Z", "location_count": 1, "location_summary": "Los Angeles, California", "locations": [ { "city": "Los Angeles", "state": "California" } ], "official_url": "https://clinicaltrials.gov/study/NCT05586178" }, { "nct_id": "NCT04904549", "title": "Study of Monovalent and Bivalent Recombinant Protein Vaccines Against COVID-19 in Adults 18 Years of Age and Older", "overall_status": "TERMINATED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE3" ], "conditions": [ "COVID-19" ], "interventions": [ { "name": "SARS-CoV-2 adjuvanted recombinant protein vaccine (monovalent D614) (primary series)", "type": "BIOLOGICAL" }, { "name": "SARS-CoV-2 adjuvanted recombinant protein vaccine (bivalent D614 + B.1.351) (primary series)", "type": "BIOLOGICAL" }, { "name": "Placebo", "type": "BIOLOGICAL" }, { "name": "SARS-CoV-2 adjuvanted recombinant protein vaccine (monovalent B.1.351) (booster dose) >= 4 months after last vaccination", "type": "BIOLOGICAL" }, { "name": "SARS-CoV-2 adjuvanted recombinant protein vaccine(monovalent D614)(primary series)& SARS-CoV-2 adjuvanted recombinant protein vaccine(monovalent B.1.351)(booster dose)>=4 months after last vaccination", "type": "BIOLOGICAL" } ], "intervention_types": [ "BIOLOGICAL" ], "sponsor": "Sanofi Pasteur, a Sanofi Company", "sponsor_class": "INDUSTRY", "healthy_volunteers": true, "eligibility": { "minimum_age": "18 Years", "maximum_age": null, "sex": "ALL", "summary": "18 Years and older" }, "enrollment_count": 23670, "start_date": "2021-05-26", "completion_date": "2024-08-31", "has_results": true, "last_update_posted_date": "2026-06-03", "last_synced_at": "2026-09-25T09:37:12.791Z", "location_count": 23, "location_summary": "Birmingham, Alabama • Huntsville, Alabama • Rolling Hills Estates, California + 20 more", "locations": [ { "city": "Birmingham", "state": "Alabama" }, { "city": "Huntsville", "state": "Alabama" }, { "city": "Rolling Hills Estates", "state": "California" }, { "city": "Centennial", "state": "Colorado" }, { "city": "Melbourne", "state": "Florida" } ], "official_url": "https://clinicaltrials.gov/study/NCT04904549" }, { "nct_id": "NCT05543993", "title": "COVID Booster in Pregnancy and Lactation", "overall_status": "COMPLETED", "study_type": "OBSERVATIONAL", "phases": [], "conditions": [ "COVID-19" ], "interventions": [ { "name": "Bivalent COVID-19 Booster", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "Thomas Jefferson University", "sponsor_class": "OTHER", "healthy_volunteers": true, "eligibility": { "minimum_age": "13 Years", "maximum_age": "55 Years", "sex": "FEMALE", "summary": "13 Years to 55 Years · Female only" }, "enrollment_count": 150, "start_date": "2022-09-29", "completion_date": "2024-06-10", "has_results": false, "last_update_posted_date": "2025-12-02", "last_synced_at": "2026-09-25T09:37:12.791Z", "location_count": 1, "location_summary": "Philadelphia, Pennsylvania", "locations": [ { "city": "Philadelphia", "state": "Pennsylvania" } ], "official_url": "https://clinicaltrials.gov/study/NCT05543993" }, { "nct_id": "NCT05765578", "title": "An Observational Study of Moderna COVID-19 Bivalent Vaccines (Original and Omicron BA.4/BA.5) and 2023 Updated mRNA COVID-19 Vaccines (XBB.1.5)", "overall_status": "COMPLETED", "study_type": "OBSERVATIONAL", "phases": [], "conditions": [ "COVID-19" ], "interventions": [ { "name": "Moderna COVID-19 Vaccine", "type": "BIOLOGICAL" }, { "name": "Moderna mRNA1273.222 Booster", "type": "BIOLOGICAL" }, { "name": "Pfizer COVID-19 Vaccine", "type": "BIOLOGICAL" }, { "name": "Moderna 2023 Updated COVID-19 vaccine (XBB.1.5)", "type": "BIOLOGICAL" }, { "name": "Pfizer 2023 Updated COVID-19 vaccine (XBB.1.5)", "type": "BIOLOGICAL" } ], "intervention_types": [ "BIOLOGICAL" ], "sponsor": "ModernaTX, Inc.", "sponsor_class": "INDUSTRY", "healthy_volunteers": true, "eligibility": { "minimum_age": "18 Years", "maximum_age": null, "sex": "ALL", "summary": "18 Years and older" }, "enrollment_count": 1713, "start_date": "2023-03-08", "completion_date": "2024-06-17", "has_results": false, "last_update_posted_date": "2024-07-31", "last_synced_at": "2026-09-25T09:37:12.791Z", "location_count": 1, "location_summary": "Culver City, California", "locations": [ { "city": "Culver City", "state": "California" } ], "official_url": "https://clinicaltrials.gov/study/NCT05765578" }, { "nct_id": "NCT04762680", "title": "Study of Recombinant Protein Vaccines With Adjuvant as a Primary Series and as a Booster Dose Against COVID-19 in Adults 18 Years of Age and Older", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE2", "PHASE3" ], "conditions": [ "COVID-19" ], "interventions": [ { "name": "SARS-CoV-2 recombinant protein vaccine Phase 2 Formulation 1", "type": "BIOLOGICAL" }, { "name": "SARS-CoV-2 recombinant protein vaccine Phase 2 Formulation 2", "type": "BIOLOGICAL" }, { "name": "SARS-CoV-2 recombinant protein vaccine Phase 2 Formulation 3", "type": "BIOLOGICAL" }, { "name": "SARS-CoV-2 adjuvanted recombinant protein vaccine, monovalent (D614)-AS03, Dosage A", "type": "BIOLOGICAL" }, { "name": "SARS-CoV-2 adjuvanted recombinant protein vaccine, monovalent (B.1.351)-AS03", "type": "BIOLOGICAL" }, { "name": "SARS-CoV-2 adjuvanted recombinant protein vaccine, monovalent (D614)-AS03, Dosage B", "type": "BIOLOGICAL" }, { "name": "SARS-CoV-2 adjuvanted recombinant protein vaccine, monovalent (B.1.351)-AS03 Alternative Exploratory Formulation 1", "type": "BIOLOGICAL" }, { "name": "SARS-CoV-2 adjuvanted recombinant protein vaccine, monovalent (B.1.351)-AS03 Alternative Exploratory Formulation 2", "type": "BIOLOGICAL" }, { "name": "SARS-CoV-2 adjuvanted recombinant protein vaccine, monovalent (B.1.351)-AS03 Alternative Exploratory Formulation 3", "type": "BIOLOGICAL" }, { "name": "SARS-CoV-2 adjuvanted recombinant protein vaccine, monovalent (B.1.351)-AS03 Alternative Exploratory Formulation 4", "type": "BIOLOGICAL" }, { "name": "SARS-CoV-2 adjuvanted recombinant protein vaccine, bivalent (D614+B.1.351)-AS03", "type": "BIOLOGICAL" } ], "intervention_types": [ "BIOLOGICAL" ], "sponsor": "Sanofi Pasteur, a Sanofi Company", "sponsor_class": "INDUSTRY", "healthy_volunteers": true, "eligibility": { "minimum_age": "18 Years", "maximum_age": null, "sex": "ALL", "summary": "18 Years and older" }, "enrollment_count": 3159, "start_date": "2021-02-24", "completion_date": "2023-06-29", "has_results": true, "last_update_posted_date": "2025-09-18", "last_synced_at": "2026-09-25T09:37:12.791Z", "location_count": 30, "location_summary": "Birmingham, Alabama • Chandler, Arizona • Glendale, Arizona + 26 more", "locations": [ { "city": "Birmingham", "state": "Alabama" }, { "city": "Chandler", "state": "Arizona" }, { "city": "Glendale", "state": "Arizona" }, { "city": "Little Rock", "state": "Arkansas" }, { "city": "Los Angeles", "state": "California" } ], "official_url": "https://clinicaltrials.gov/study/NCT04762680" }, { "nct_id": "NCT05529030", "title": "COVID-19 Booster Readiness Survey", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "NA" ], "conditions": [ "Vaccination Refusal" ], "interventions": [ { "name": "Salience of Omicron variant", "type": "BEHAVIORAL" }, { "name": "Self-protection message", "type": "BEHAVIORAL" }, { "name": "Other-protection message", "type": "BEHAVIORAL" } ], "intervention_types": [ "BEHAVIORAL" ], "sponsor": "Geisinger Clinic", "sponsor_class": "OTHER", "healthy_volunteers": true, "eligibility": { "minimum_age": "18 Years", "maximum_age": null, "sex": "ALL", "summary": "18 Years and older" }, "enrollment_count": 12036, "start_date": "2022-09-01", "completion_date": "2022-09-15", "has_results": false, "last_update_posted_date": "2022-09-30", "last_synced_at": "2026-09-25T09:37:12.791Z", "location_count": 1, "location_summary": "Danville, Pennsylvania", "locations": [ { "city": "Danville", "state": "Pennsylvania" } ], "official_url": "https://clinicaltrials.gov/study/NCT05529030" }, { "nct_id": "NCT05586165", "title": "Effects of Prompt to Bundle COVID-19 Booster and Flu Shot", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "NA" ], "conditions": [ "COVID-19", "Vaccines" ], "interventions": [ { "name": "Reminder to boost protection against COVID-19", "type": "BEHAVIORAL" }, { "name": "Flu Tag Along", "type": "BEHAVIORAL" }, { "name": "COVID-19 Booster & Flu Bundle", "type": "BEHAVIORAL" } ], "intervention_types": [ "BEHAVIORAL" ], "sponsor": "University of California, Los Angeles", "sponsor_class": "OTHER", "healthy_volunteers": true, "eligibility": { "minimum_age": "18 Years", "maximum_age": null, "sex": "ALL", "summary": "18 Years and older" }, "enrollment_count": 109493, "start_date": "2022-10-18", "completion_date": "2023-12-31", "has_results": false, "last_update_posted_date": "2024-12-05", "last_synced_at": "2026-09-25T09:37:12.791Z", "location_count": 1, "location_summary": "Los Angeles, California", "locations": [ { "city": "Los Angeles", "state": "California" } ], "official_url": "https://clinicaltrials.gov/study/NCT05586165" } ] }