{ "api_version": "1", "request": { "url": "https://clinicaltrialsfind.com/api/v1/search.json?intervention=Bupivacaine-Meloxicam", "query": { "intervention": "Bupivacaine-Meloxicam" }, "page_size": 10 }, "pagination": { "page": 1, "page_size": 10, "total_count": 32, "total_pages": 4, "next_page_url": "https://clinicaltrialsfind.com/api/v1/search.json?intervention=Bupivacaine-Meloxicam&page=2&page_size=10", "previous_page_url": null }, "source": "remote", "last_synced_at": "2026-09-28T09:57:21.868Z", "attribution": "Data derived from public ClinicalTrials.gov records. The official record at https://clinicaltrials.gov/ remains the source of truth for current availability, contacts, and full study details.", "notes": [ "This endpoint exposes only public summary fields — no participant contact emails, phone numbers, or scraped investigator contact details.", "For contact information and full protocol detail, follow each trial's `official_url` to the ClinicalTrials.gov record.", "This API is a navigational aid. It does not provide medical advice, eligibility determinations, or compensation guarantees." ], "trials": [ { "nct_id": "NCT07775248", "title": "Novel Extended-Release Bupivacaine Polymer for Sustained Pain Relief Following Total Knee Arthroplasty", "overall_status": "RECRUITING", "study_type": "INTERVENTIONAL", "phases": [ "PHASE4" ], "conditions": [ "Osteoarthritis (OA) of the Knee" ], "interventions": [ { "name": "Periarticular Injection", "type": "DRUG" }, { "name": "Adductor Canal Block", "type": "DRUG" }, { "name": "Bupivacaine-Meloxicam", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "Henry Ford Health System", "sponsor_class": "OTHER", "healthy_volunteers": false, "eligibility": { "minimum_age": "18 Years", "maximum_age": null, "sex": "ALL", "summary": "18 Years and older" }, "enrollment_count": 150, "start_date": "2025-02-11", "completion_date": "2026-10-20", "has_results": false, "last_update_posted_date": "2026-08-20", "last_synced_at": "2026-09-28T09:57:21.868Z", "location_count": 1, "location_summary": "Grosse Pointe Farms, Michigan", "locations": [ { "city": "Grosse Pointe Farms", "state": "Michigan" } ], "official_url": "https://clinicaltrials.gov/study/NCT07775248" }, { "nct_id": "NCT03237481", "title": "Phase 3 Herniorrhaphy Study for Postoperative Analgesia (EPOCH 2)", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE3" ], "conditions": [ "Postoperative Pain" ], "interventions": [ { "name": "HTX-011", "type": "DRUG" }, { "name": "Bupivacaine HCl", "type": "DRUG" }, { "name": "Saline placebo", "type": "DRUG" }, { "name": "Luer-lock applicator", "type": "DEVICE" }, { "name": "Vial access device", "type": "DEVICE" } ], "intervention_types": [ "DRUG", "DEVICE" ], "sponsor": "Heron Therapeutics", "sponsor_class": "INDUSTRY", "healthy_volunteers": false, "eligibility": { "minimum_age": "18 Years", "maximum_age": null, "sex": "ALL", "summary": "18 Years and older" }, "enrollment_count": 418, "start_date": "2017-07-31", "completion_date": "2018-01-16", "has_results": true, "last_update_posted_date": "2026-03-02", "last_synced_at": "2026-09-28T09:57:21.868Z", "location_count": 22, "location_summary": "Florence, Alabama • Sheffield, Alabama • Phoenix, Arizona + 18 more", "locations": [ { "city": "Florence", "state": "Alabama" }, { "city": "Sheffield", "state": "Alabama" }, { "city": "Phoenix", "state": "Arizona" }, { "city": "Anaheim", "state": "California" }, { "city": "Bakersfield", "state": "California" } ], "official_url": "https://clinicaltrials.gov/study/NCT03237481" }, { "nct_id": "NCT03974932", "title": "Total Knee Arthroplasty (TKA) Study of HTX-011 in an Multimodal Analgesic Regimen (MMA) Regimen", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE3" ], "conditions": [ "Analgesia" ], "interventions": [ { "name": "HTX-011", "type": "DRUG" }, { "name": "Ibuprofen", "type": "DRUG" }, { "name": "Acetaminophen", "type": "DRUG" }, { "name": "Celecoxib", "type": "DRUG" }, { "name": "+/- Bupivacaine HCl", "type": "DRUG" }, { "name": "Luer Lock Applicator", "type": "DEVICE" } ], "intervention_types": [ "DRUG", "DEVICE" ], "sponsor": "Heron Therapeutics", "sponsor_class": "INDUSTRY", "healthy_volunteers": false, "eligibility": { "minimum_age": "18 Years", "maximum_age": null, "sex": "ALL", "summary": "18 Years and older" }, "enrollment_count": 116, "start_date": "2019-06-05", "completion_date": "2021-01-07", "has_results": true, "last_update_posted_date": "2026-03-02", "last_synced_at": "2026-09-28T09:57:21.868Z", "location_count": 6, "location_summary": "Sheffield, Alabama • Tamarac, Florida • Dayton, Ohio + 3 more", "locations": [ { "city": "Sheffield", "state": "Alabama" }, { "city": "Tamarac", "state": "Florida" }, { "city": "Dayton", "state": "Ohio" }, { "city": "Bellaire", "state": "Texas" }, { "city": "Plano", "state": "Texas" } ], "official_url": "https://clinicaltrials.gov/study/NCT03974932" }, { "nct_id": "NCT05751421", "title": "Pain Relief After PrimaryTKA", "overall_status": "UNKNOWN", "study_type": "INTERVENTIONAL", "phases": [ "PHASE3" ], "conditions": [ "Pain, Postoperative" ], "interventions": [ { "name": "Zynrelef (Bupivacaine 60 MG / Meloxicam 1.8 MG) Per 2.3 ML Extended Release Solution", "type": "DRUG" }, { "name": "Bupivacaine HCl 0.5% Injectable Solution", "type": "DRUG" }, { "name": "primary total knee replacement", "type": "PROCEDURE" } ], "intervention_types": [ "DRUG", "PROCEDURE" ], "sponsor": "Rothman Institute Orthopaedics", "sponsor_class": "OTHER", "healthy_volunteers": true, "eligibility": { "minimum_age": "18 Years", "maximum_age": null, "sex": "ALL", "summary": "18 Years and older" }, "enrollment_count": 60, "start_date": "2023-02-28", "completion_date": "2024-02-28", "has_results": false, "last_update_posted_date": "2023-03-02", "last_synced_at": "2026-09-28T09:57:21.868Z", "location_count": 1, "location_summary": "Philadelphia, Pennsylvania", "locations": [ { "city": "Philadelphia", "state": "Pennsylvania" } ], "official_url": "https://clinicaltrials.gov/study/NCT05751421" }, { "nct_id": "NCT06109415", "title": "A Multi-surgery Assessment of ZYNRELEF (HTX-011), AMAZE.", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE4" ], "conditions": [ "Postoperative Pain", "Total Shoulder Arthroplasty", "Multimodal Analgesia" ], "interventions": [ { "name": "HTX-011", "type": "DRUG" }, { "name": "Bupivacaine Hydrochloride", "type": "DRUG" }, { "name": "Ibuprofen", "type": "DRUG" }, { "name": "Acetaminophen", "type": "DRUG" }, { "name": "Luer lock applicator", "type": "DEVICE" } ], "intervention_types": [ "DRUG", "DEVICE" ], "sponsor": "Heron Therapeutics", "sponsor_class": "INDUSTRY", "healthy_volunteers": false, "eligibility": { "minimum_age": "18 Years", "maximum_age": null, "sex": "ALL", "summary": "18 Years and older" }, "enrollment_count": 30, "start_date": "2021-10-20", "completion_date": "2022-07-29", "has_results": false, "last_update_posted_date": "2023-10-31", "last_synced_at": "2026-09-28T09:57:21.868Z", "location_count": 5, "location_summary": "Little Rock, Arkansas • Jenks, Oklahoma • Bellaire, Texas + 2 more", "locations": [ { "city": "Little Rock", "state": "Arkansas" }, { "city": "Jenks", "state": "Oklahoma" }, { "city": "Bellaire", "state": "Texas" }, { "city": "Carrollton", "state": "Texas" }, { "city": "Salt Lake City", "state": "Utah" } ], "official_url": "https://clinicaltrials.gov/study/NCT06109415" }, { "nct_id": "NCT06109428", "title": "A Multi-surgery Assessment of ZYNRELEF (HTX-011), AMAZE", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE4" ], "conditions": [ "Analgesia" ], "interventions": [ { "name": "HTX-011", "type": "DRUG" }, { "name": "Bupivacaine Hydrochloride", "type": "DRUG" }, { "name": "Ibuprofen", "type": "DRUG" }, { "name": "Acetaminophen", "type": "DRUG" }, { "name": "Luer lock applicator", "type": "DEVICE" } ], "intervention_types": [ "DRUG", "DEVICE" ], "sponsor": "Heron Therapeutics", "sponsor_class": "INDUSTRY", "healthy_volunteers": false, "eligibility": { "minimum_age": "18 Years", "maximum_age": null, "sex": "ALL", "summary": "18 Years and older" }, "enrollment_count": 30, "start_date": "2021-10-12", "completion_date": "2022-04-07", "has_results": false, "last_update_posted_date": "2023-10-31", "last_synced_at": "2026-09-28T09:57:21.868Z", "location_count": 2, "location_summary": "Bellaire, Texas • San Antonio, Texas", "locations": [ { "city": "Bellaire", "state": "Texas" }, { "city": "San Antonio", "state": "Texas" } ], "official_url": "https://clinicaltrials.gov/study/NCT06109428" }, { "nct_id": "NCT03695367", "title": "Phase 2 Herniorrhaphy Study for Opioid Elimination", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE2" ], "conditions": [ "Postoperative Pain" ], "interventions": [ { "name": "HTX-011", "type": "DRUG" }, { "name": "Luer lock applicator", "type": "DEVICE" }, { "name": "Vial access device", "type": "DEVICE" }, { "name": "Ibuprofen", "type": "DRUG" }, { "name": "Acetaminophen", "type": "DRUG" }, { "name": "Ketorolac", "type": "DRUG" } ], "intervention_types": [ "DRUG", "DEVICE" ], "sponsor": "Heron Therapeutics", "sponsor_class": "INDUSTRY", "healthy_volunteers": false, "eligibility": { "minimum_age": "18 Years", "maximum_age": null, "sex": "ALL", "summary": "18 Years and older" }, "enrollment_count": 63, "start_date": "2018-10-01", "completion_date": "2018-12-15", "has_results": true, "last_update_posted_date": "2026-03-02", "last_synced_at": "2026-09-28T09:57:21.868Z", "location_count": 5, "location_summary": "Anaheim, California • Pasadena, California • Draper, Utah + 2 more", "locations": [ { "city": "Anaheim", "state": "California" }, { "city": "Pasadena", "state": "California" }, { "city": "Draper", "state": "Utah" }, { "city": "Murray", "state": "Utah" }, { "city": "Salt Lake City", "state": "Utah" } ], "official_url": "https://clinicaltrials.gov/study/NCT03695367" }, { "nct_id": "NCT04766996", "title": "PROUD Study - Preventing Opioid Use Disorders", "overall_status": "TERMINATED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE4" ], "conditions": [ "Anesthesia", "Opioid Use" ], "interventions": [ { "name": "Guided mindfulness exercises", "type": "BEHAVIORAL" }, { "name": "Self-administered aromatherapy", "type": "OTHER" }, { "name": "Baby aspirin", "type": "DRUG" }, { "name": "Tylenol/Acetaminophen", "type": "DRUG" }, { "name": "Pregabalin", "type": "DRUG" }, { "name": "Prednisone", "type": "DRUG" }, { "name": "Meloxicam", "type": "DRUG" }, { "name": "Prilosec", "type": "DRUG" }, { "name": "Tramadol", "type": "DRUG" }, { "name": "Voltaren", "type": "DRUG" }, { "name": "Zofran", "type": "DRUG" }, { "name": "Pepcid", "type": "DRUG" }, { "name": "Reglan", "type": "DRUG" }, { "name": "Versed", "type": "DRUG" }, { "name": "Lidocaine", "type": "DRUG" }, { "name": "Propofol", "type": "DRUG" }, { "name": "Ancef", "type": "DRUG" }, { "name": "Tranexamic Acid (TXA)", "type": "DRUG" }, { "name": "Decadron", "type": "DRUG" }, { "name": "Bupivacaine hydrochloride", "type": "DRUG" }, { "name": "Toradol", "type": "DRUG" } ], "intervention_types": [ "BEHAVIORAL", "OTHER", "DRUG" ], "sponsor": "Emory University", "sponsor_class": "OTHER", "healthy_volunteers": false, "eligibility": { "minimum_age": "18 Years", "maximum_age": null, "sex": "ALL", "summary": "18 Years and older" }, "enrollment_count": 57, "start_date": "2021-05-17", "completion_date": "2021-12-27", "has_results": true, "last_update_posted_date": "2023-06-22", "last_synced_at": "2026-09-28T09:57:21.868Z", "location_count": 1, "location_summary": "Atlanta, Georgia", "locations": [ { "city": "Atlanta", "state": "Georgia" } ], "official_url": "https://clinicaltrials.gov/study/NCT04766996" }, { "nct_id": "NCT02504580", "title": "Pilot Herniorrhaphy Study for Postoperative Analgesia", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE2" ], "conditions": [ "Postoperative Pain" ], "interventions": [ { "name": "HTX-011", "type": "DRUG" }, { "name": "Placebo", "type": "DRUG" }, { "name": "HTX-002", "type": "DRUG" }, { "name": "Bupivacaine HCI (Marcaine)", "type": "DRUG" }, { "name": "HTX-011A", "type": "DRUG" }, { "name": "HTX-011B", "type": "DRUG" }, { "name": "HTX-009", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "Heron Therapeutics", "sponsor_class": "INDUSTRY", "healthy_volunteers": false, "eligibility": { "minimum_age": "18 Years", "maximum_age": null, "sex": "ALL", "summary": "18 Years and older" }, "enrollment_count": 463, "start_date": "2015-07", "completion_date": "2017-04", "has_results": true, "last_update_posted_date": "2026-03-02", "last_synced_at": "2026-09-28T09:57:21.868Z", "location_count": 3, "location_summary": "Anaheim, California • Houston, Texas", "locations": [ { "city": "Anaheim", "state": "California" }, { "city": "Houston", "state": "Texas" }, { "city": "Houston", "state": "Texas" } ], "official_url": "https://clinicaltrials.gov/study/NCT02504580" }, { "nct_id": "NCT05188053", "title": "Periarticular Bupivacaine + Meloxicam ER Solution Versus Standard Practice During Total Knee Arthroplasty", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE4" ], "conditions": [ "Total Knee Arthroplasty" ], "interventions": [ { "name": "HTX-011", "type": "DRUG" }, { "name": "ropivacaine , epinephrine , ketorolac diluted in sodium chloride", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "Mayo Clinic", "sponsor_class": "OTHER", "healthy_volunteers": false, "eligibility": { "minimum_age": "18 Years", "maximum_age": null, "sex": "ALL", "summary": "18 Years and older" }, "enrollment_count": 209, "start_date": "2022-03-11", "completion_date": "2024-04-18", "has_results": true, "last_update_posted_date": "2025-04-27", "last_synced_at": "2026-09-28T09:57:21.868Z", "location_count": 1, "location_summary": "Rochester, Minnesota", "locations": [ { "city": "Rochester", "state": "Minnesota" } ], "official_url": "https://clinicaltrials.gov/study/NCT05188053" } ] }