{ "api_version": "1", "request": { "url": "https://clinicaltrialsfind.com/api/v1/search.json?intervention=CONCERTA+%28methylphenidate+HCl%29+or+placebo", "query": { "intervention": "CONCERTA (methylphenidate HCl) or placebo" }, "page_size": 10 }, "pagination": { "page": 1, "page_size": 10, "total_count": 48, "total_pages": 5, "next_page_url": "https://clinicaltrialsfind.com/api/v1/search.json?intervention=CONCERTA+%28methylphenidate+HCl%29+or+placebo&page=2&page_size=10", "previous_page_url": null }, "source": "remote", "last_synced_at": "2026-10-03T11:33:04.317Z", "attribution": "Data derived from public ClinicalTrials.gov records. The official record at https://clinicaltrials.gov/ remains the source of truth for current availability, contacts, and full study details.", "notes": [ "This endpoint exposes only public summary fields — no participant contact emails, phone numbers, or scraped investigator contact details.", "For contact information and full protocol detail, follow each trial's `official_url` to the ClinicalTrials.gov record.", "This API is a navigational aid. It does not provide medical advice, eligibility determinations, or compensation guarantees." ], "trials": [ { "nct_id": "NCT02822937", "title": "Sensitivity of Project: EVO Monitor Cognitive Measurements to Pharmacological Agents", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "NA" ], "conditions": [ "Healthy" ], "interventions": [ { "name": "Methylphenidate", "type": "DRUG" }, { "name": "Triazolam", "type": "DRUG" }, { "name": "Project: EVO", "type": "OTHER" }, { "name": "Placebo", "type": "DRUG" } ], "intervention_types": [ "DRUG", "OTHER" ], "sponsor": "Akili Interactive Labs, Inc.", "sponsor_class": "INDUSTRY", "healthy_volunteers": true, "eligibility": { "minimum_age": "40 Years", "maximum_age": "55 Years", "sex": "ALL", "summary": "40 Years to 55 Years" }, "enrollment_count": 18, "start_date": "2016-07", "completion_date": "2016-11", "has_results": false, "last_update_posted_date": "2016-11-07", "last_synced_at": "2026-10-03T11:33:04.317Z", "location_count": 1, "location_summary": "San Antonio, Texas", "locations": [ { "city": "San Antonio", "state": "Texas" } ], "official_url": "https://clinicaltrials.gov/study/NCT02822937" }, { "nct_id": "NCT01993108", "title": "Control of Cognition (Naltrexone, Methylphenidate, and ADHD Study (NMAS))", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE4" ], "conditions": [ "Healthy", "Attention Deficit Hyperactivity Disorder" ], "interventions": [ { "name": "Methylphenidate", "type": "DRUG" }, { "name": "Naltrexone", "type": "DRUG" }, { "name": "Placebo", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "University of Michigan", "sponsor_class": "OTHER", "healthy_volunteers": true, "eligibility": { "minimum_age": "18 Years", "maximum_age": "35 Years", "sex": "ALL", "summary": "18 Years to 35 Years" }, "enrollment_count": 23, "start_date": "2013-10", "completion_date": "2017-02", "has_results": true, "last_update_posted_date": "2018-06-18", "last_synced_at": "2026-10-03T11:33:04.317Z", "location_count": 1, "location_summary": "Ann Arbor, Michigan", "locations": [ { "city": "Ann Arbor", "state": "Michigan" } ], "official_url": "https://clinicaltrials.gov/study/NCT01993108" }, { "nct_id": "NCT00794040", "title": "A Controlled Trial of Serotonin Reuptake Inhibitors Added to Stimulant Medication in Youth With Severe Mood Dysregulation", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE2" ], "conditions": [ "Mood Disorder", "Mental Disorder Diagnosed in Childhood", "Attention Deficit and Disruptive Behavior Disorder", "Attention Deficit Hyperactivity Disorder" ], "interventions": [ { "name": "Add-on citalopram following optimized methylphenidate", "type": "DRUG" }, { "name": "Add-on placebo following optimized methylphenidate", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "National Institute of Mental Health (NIMH)", "sponsor_class": "NIH", "healthy_volunteers": false, "eligibility": { "minimum_age": "7 Years", "maximum_age": "17 Years", "sex": "ALL", "summary": "7 Years to 17 Years" }, "enrollment_count": 103, "start_date": "2008-11-17", "completion_date": "2018-02-01", "has_results": true, "last_update_posted_date": "2019-05-07", "last_synced_at": "2026-10-03T11:33:04.317Z", "location_count": 1, "location_summary": "Bethesda, Maryland", "locations": [ { "city": "Bethesda", "state": "Maryland" } ], "official_url": "https://clinicaltrials.gov/study/NCT00794040" }, { "nct_id": "NCT01416948", "title": "Cognitive REmediation After Trauma Exposure Trial = CREATE Trial", "overall_status": "TERMINATED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE2" ], "conditions": [ "Posttraumatic Stress Disorder", "Traumatic Brain Injury" ], "interventions": [ { "name": "Methylphenidate Hydrochloride 20 mg", "type": "DRUG" }, { "name": "Placebo Capsule", "type": "DRUG" }, { "name": "Galantamine 12 mg", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "INTRuST, Post-Traumatic Stress Disorder - Traumatic Brain Injury Clinical Consortium", "sponsor_class": "OTHER", "healthy_volunteers": false, "eligibility": { "minimum_age": "18 Years", "maximum_age": "55 Years", "sex": "ALL", "summary": "18 Years to 55 Years" }, "enrollment_count": 32, "start_date": "2011-08", "completion_date": "2013-03", "has_results": false, "last_update_posted_date": "2013-04-26", "last_synced_at": "2026-10-03T11:33:04.317Z", "location_count": 7, "location_summary": "San Diego, California • Boston, Massachusetts • Manchester, New Hampshire + 4 more", "locations": [ { "city": "San Diego", "state": "California" }, { "city": "Boston", "state": "Massachusetts" }, { "city": "Manchester", "state": "New Hampshire" }, { "city": "Durham", "state": "North Carolina" }, { "city": "Cincinnati", "state": "Ohio" } ], "official_url": "https://clinicaltrials.gov/study/NCT01416948" }, { "nct_id": "NCT04781972", "title": "Multimodal Brain Imaging of the Neural Effects of Methylphenidate in Patients With ADHD", "overall_status": "RECRUITING", "study_type": "INTERVENTIONAL", "phases": [ "PHASE4" ], "conditions": [ "ADHD - Combined Type" ], "interventions": [ { "name": "Methylphenidate", "type": "DRUG" }, { "name": "Placebo", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "Johns Hopkins University", "sponsor_class": "OTHER", "healthy_volunteers": false, "eligibility": { "minimum_age": "6 Years", "maximum_age": "40 Years", "sex": "ALL", "summary": "6 Years to 40 Years" }, "enrollment_count": 30, "start_date": "2021-07-27", "completion_date": "2029-04-30", "has_results": false, "last_update_posted_date": "2025-10-16", "last_synced_at": "2026-10-03T11:33:04.317Z", "location_count": 1, "location_summary": "Baltimore, Maryland", "locations": [ { "city": "Baltimore", "state": "Maryland" } ], "official_url": "https://clinicaltrials.gov/study/NCT04781972" }, { "nct_id": "NCT02148783", "title": "Dopamine Receptor Imaging to Predict Response to Stimulant Therapy in Chronic TBI", "overall_status": "TERMINATED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE2" ], "conditions": [ "Traumatic Brain Injury" ], "interventions": [ { "name": "methylphenidate", "type": "DRUG" }, { "name": "Placebo", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "Uniformed Services University of the Health Sciences", "sponsor_class": "FED", "healthy_volunteers": false, "eligibility": { "minimum_age": "18 Years", "maximum_age": "55 Years", "sex": "ALL", "summary": "18 Years to 55 Years" }, "enrollment_count": 11, "start_date": "2014-09", "completion_date": "2018-08", "has_results": false, "last_update_posted_date": "2018-10-04", "last_synced_at": "2026-10-03T11:33:04.317Z", "location_count": 1, "location_summary": "Bethesda, Maryland", "locations": [ { "city": "Bethesda", "state": "Maryland" } ], "official_url": "https://clinicaltrials.gov/study/NCT02148783" }, { "nct_id": "NCT00129467", "title": "Methylphenidate for Depressed Cancer Patients Receiving Palliative Care", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "NA" ], "conditions": [ "Depression", "Palliative Care", "Cancer", "Mental Disorder" ], "interventions": [ { "name": "Methylphenidate", "type": "DRUG" }, { "name": "Placebo", "type": "DRUG" }, { "name": "Selective Serotonin Uptake Inhibitor (SSRI)", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "US Department of Veterans Affairs", "sponsor_class": "FED", "healthy_volunteers": false, "eligibility": { "minimum_age": "18 Years", "maximum_age": null, "sex": "ALL", "summary": "18 Years and older" }, "enrollment_count": 47, "start_date": "2005-02", "completion_date": "2010-12", "has_results": true, "last_update_posted_date": "2015-04-24", "last_synced_at": "2026-10-03T11:33:04.317Z", "location_count": 1, "location_summary": "Portland, Oregon", "locations": [ { "city": "Portland", "state": "Oregon" } ], "official_url": "https://clinicaltrials.gov/study/NCT00129467" }, { "nct_id": "NCT00844090", "title": "The Role of Apathy in Glycemic Control", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "NA" ], "conditions": [ "Apathy", "Diabetes" ], "interventions": [ { "name": "methylphenidate or placebo", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "US Department of Veterans Affairs", "sponsor_class": "FED", "healthy_volunteers": false, "eligibility": { "minimum_age": "21 Years", "maximum_age": "75 Years", "sex": "ALL", "summary": "21 Years to 75 Years" }, "enrollment_count": 106, "start_date": "2009-07", "completion_date": "2012-10", "has_results": true, "last_update_posted_date": "2014-04-21", "last_synced_at": "2026-10-03T11:33:04.317Z", "location_count": 1, "location_summary": "Omaha, Nebraska", "locations": [ { "city": "Omaha", "state": "Nebraska" } ], "official_url": "https://clinicaltrials.gov/study/NCT00844090" }, { "nct_id": "NCT00223691", "title": "Treatment of Orthostatic Hypotension in Autonomic Failure", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE1" ], "conditions": [ "Autonomic Failure", "Orthostatic Hypotension" ], "interventions": [ { "name": "Atomoxetine", "type": "DRUG" }, { "name": "Acarbose", "type": "DRUG" }, { "name": "Pyridostigmine Bromide", "type": "DRUG" }, { "name": "Yohimbine", "type": "DRUG" }, { "name": "Midodrine HCl", "type": "DRUG" }, { "name": "placebo", "type": "DRUG" }, { "name": "Modafinil", "type": "DRUG" }, { "name": "Octreotide", "type": "DRUG" }, { "name": "water intake", "type": "OTHER" }, { "name": "Diphenhydramine Hydrochloride", "type": "DRUG" }, { "name": "Ranitidine HCL", "type": "DRUG" }, { "name": "Tranylcypromine", "type": "DRUG" }, { "name": "Ergotamine/ Caffeine", "type": "DRUG" }, { "name": "Celecoxib", "type": "DRUG" }, { "name": "Pseudoephedrine", "type": "DRUG" }, { "name": "Methylphenidate", "type": "DRUG" }, { "name": "Indomethacin", "type": "DRUG" }, { "name": "Ibuprofen", "type": "DRUG" }, { "name": "Oxymetazoline 0.05% nasal solution", "type": "DRUG" }, { "name": "Bovril", "type": "DIETARY_SUPPLEMENT" }, { "name": "Acetazolamide", "type": "DRUG" }, { "name": "Rivastigmine tartrate", "type": "DRUG" }, { "name": "Carbidopa/levodopa", "type": "DRUG" }, { "name": "Inflatable abdominal binder", "type": "DEVICE" }, { "name": "inflatable abdominal binder (sham)", "type": "DEVICE" } ], "intervention_types": [ "DRUG", "OTHER", "DIETARY_SUPPLEMENT", "DEVICE" ], "sponsor": "Vanderbilt University", "sponsor_class": "OTHER", "healthy_volunteers": false, "eligibility": { "minimum_age": "18 Years", "maximum_age": "85 Years", "sex": "ALL", "summary": "18 Years to 85 Years" }, "enrollment_count": 389, "start_date": "2002-03", "completion_date": "2017-01", "has_results": false, "last_update_posted_date": "2017-01-18", "last_synced_at": "2026-10-03T11:33:04.317Z", "location_count": 1, "location_summary": "Nashville, Tennessee", "locations": [ { "city": "Nashville", "state": "Tennessee" } ], "official_url": "https://clinicaltrials.gov/study/NCT00223691" }, { "nct_id": "NCT01074294", "title": "Study of the Safety and Efficacy of OPC-34712 as a Complementary Therapy in the Treatment of Adult Attention Deficit/Hyperactivity Disorder", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE2" ], "conditions": [ "Attention Deficit Hyperactivity Disorder" ], "interventions": [ { "name": "OPDC-34712", "type": "DRUG" }, { "name": "Placebo", "type": "DRUG" }, { "name": "Stimulant Therapy", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "Otsuka Pharmaceutical Development & Commercialization, Inc.", "sponsor_class": "INDUSTRY", "healthy_volunteers": false, "eligibility": { "minimum_age": "18 Years", "maximum_age": "55 Years", "sex": "ALL", "summary": "18 Years to 55 Years" }, "enrollment_count": 740, "start_date": "2010-03-16", "completion_date": "2011-06-20", "has_results": true, "last_update_posted_date": "2023-02-02", "last_synced_at": "2026-10-03T11:33:04.317Z", "location_count": 35, "location_summary": "Little Rock, Arkansas • Beverly Hills, California • Irvine, California + 32 more", "locations": [ { "city": "Little Rock", "state": "Arkansas" }, { "city": "Beverly Hills", "state": "California" }, { "city": "Irvine", "state": "California" }, { "city": "Pasadena", "state": "California" }, { "city": "San Francisco", "state": "California" } ], "official_url": "https://clinicaltrials.gov/study/NCT01074294" } ] }