{ "api_version": "1", "request": { "url": "https://clinicaltrialsfind.com/api/v1/search.json?intervention=Caffeine+formulation", "query": { "intervention": "Caffeine formulation" }, "page_size": 10 }, "pagination": { "page": 1, "page_size": 10, "total_count": 8, "total_pages": 1, "next_page_url": null, "previous_page_url": null }, "source": "remote", "last_synced_at": "2026-09-10T13:47:53.144Z", "attribution": "Data derived from public ClinicalTrials.gov records. The official record at https://clinicaltrials.gov/ remains the source of truth for current availability, contacts, and full study details.", "notes": [ "This endpoint exposes only public summary fields — no participant contact emails, phone numbers, or scraped investigator contact details.", "For contact information and full protocol detail, follow each trial's `official_url` to the ClinicalTrials.gov record.", "This API is a navigational aid. It does not provide medical advice, eligibility determinations, or compensation guarantees." ], "trials": [ { "nct_id": "NCT01842633", "title": "Clinical Study to Evaluate Efficacy of New Paracetamol Formulation Compared to Ibuprofen in Headache", "overall_status": "TERMINATED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE3" ], "conditions": [ "Pain" ], "interventions": [ { "name": "Paracetamol and Caffeine", "type": "DRUG" }, { "name": "Ibuprofen", "type": "DRUG" }, { "name": "Placebo", "type": "OTHER" } ], "intervention_types": [ "DRUG", "OTHER" ], "sponsor": "GlaxoSmithKline", "sponsor_class": "INDUSTRY", "healthy_volunteers": true, "eligibility": { "minimum_age": "18 Years", "maximum_age": "65 Years", "sex": "ALL", "summary": "18 Years to 65 Years" }, "enrollment_count": 365, "start_date": "2013-04-01", "completion_date": "2015-03-31", "has_results": true, "last_update_posted_date": "2017-09-01", "last_synced_at": "2026-09-10T13:47:53.144Z", "location_count": 1, "location_summary": "Waltham, Massachusetts", "locations": [ { "city": "Waltham", "state": "Massachusetts" } ], "official_url": "https://clinicaltrials.gov/study/NCT01842633" }, { "nct_id": "NCT04197427", "title": "Determination of the Safety and Efficacy of a Novel Oral Rinse on Oral Health", "overall_status": "UNKNOWN", "study_type": "INTERVENTIONAL", "phases": [ "NA" ], "conditions": [ "Plaque", "Gingivitis" ], "interventions": [ { "name": "Experimental Oral Rinse", "type": "DEVICE" }, { "name": "Placebo", "type": "DEVICE" } ], "intervention_types": [ "DEVICE" ], "sponsor": "You First Services", "sponsor_class": "INDUSTRY", "healthy_volunteers": true, "eligibility": { "minimum_age": "18 Years", "maximum_age": "75 Years", "sex": "ALL", "summary": "18 Years to 75 Years" }, "enrollment_count": 62, "start_date": "2020-03-01", "completion_date": "2020-12-31", "has_results": false, "last_update_posted_date": "2019-12-17", "last_synced_at": "2026-09-10T13:47:53.144Z", "location_count": 1, "location_summary": "Buffalo, New York", "locations": [ { "city": "Buffalo", "state": "New York" } ], "official_url": "https://clinicaltrials.gov/study/NCT04197427" }, { "nct_id": "NCT01755702", "title": "Paracetamol With Caffeine to Treat Episodic Tension Type Headache", "overall_status": "TERMINATED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE2", "PHASE3" ], "conditions": [ "Headache, Tension-Type" ], "interventions": [ { "name": "Placebo", "type": "DRUG" }, { "name": "Experimental paracetamol + caffeine formulation", "type": "DRUG" }, { "name": "ibuprofen marketed formulation", "type": "DRUG" }, { "name": "Paracetamol marketed formulation", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "GlaxoSmithKline", "sponsor_class": "INDUSTRY", "healthy_volunteers": false, "eligibility": { "minimum_age": "18 Years", "maximum_age": "65 Years", "sex": "ALL", "summary": "18 Years to 65 Years" }, "enrollment_count": 66, "start_date": "2009-07", "completion_date": "2010-03", "has_results": true, "last_update_posted_date": "2015-03-27", "last_synced_at": "2026-09-10T13:47:53.144Z", "location_count": 7, "location_summary": "Pembroke Pines, Florida • Springfield, Massachusetts • Wellesley Hills, Massachusetts + 4 more", "locations": [ { "city": "Pembroke Pines", "state": "Florida" }, { "city": "Springfield", "state": "Massachusetts" }, { "city": "Wellesley Hills", "state": "Massachusetts" }, { "city": "Lake Success", "state": "New York" }, { "city": "Mount Vernon", "state": "New York" } ], "official_url": "https://clinicaltrials.gov/study/NCT01755702" }, { "nct_id": "NCT04972123", "title": "The Effect of CPC on Aborting Tilt Induced Syncope in Patients With a History of Vasovagal Syncope or Near Syncope", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE2" ], "conditions": [ "Syncope, Vasovagal" ], "interventions": [ { "name": "CPC - Capsaicin, Phenylephrine, Caffeine", "type": "DRUG" }, { "name": "Tilt Table Test", "type": "DIAGNOSTIC_TEST" }, { "name": "Placebo", "type": "DRUG" } ], "intervention_types": [ "DRUG", "DIAGNOSTIC_TEST" ], "sponsor": "University of Wisconsin, Madison", "sponsor_class": "OTHER", "healthy_volunteers": false, "eligibility": { "minimum_age": "18 Years", "maximum_age": "50 Years", "sex": "ALL", "summary": "18 Years to 50 Years" }, "enrollment_count": 143, "start_date": "2021-07-20", "completion_date": "2023-08-31", "has_results": true, "last_update_posted_date": "2024-07-17", "last_synced_at": "2026-09-10T13:47:53.144Z", "location_count": 1, "location_summary": "Madison, Wisconsin", "locations": [ { "city": "Madison", "state": "Wisconsin" } ], "official_url": "https://clinicaltrials.gov/study/NCT04972123" }, { "nct_id": "NCT02655614", "title": "A Study of GDC-0134 to Determine Initial Safety, Tolerability, and Pharmacokinetic Parameters in Participants With Amyotrophic Lateral Sclerosis", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE1" ], "conditions": [ "Amyotrophic Lateral Sclerosis" ], "interventions": [ { "name": "GDC-0134", "type": "DRUG" }, { "name": "Placebo", "type": "DRUG" }, { "name": "Rabeprazole", "type": "DRUG" }, { "name": "Midazolam", "type": "DRUG" }, { "name": "Caffeine", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "Genentech, Inc.", "sponsor_class": "INDUSTRY", "healthy_volunteers": false, "eligibility": { "minimum_age": "18 Years", "maximum_age": null, "sex": "ALL", "summary": "18 Years and older" }, "enrollment_count": 54, "start_date": "2016-05-31", "completion_date": "2020-03-16", "has_results": false, "last_update_posted_date": "2020-08-06", "last_synced_at": "2026-09-10T13:47:53.144Z", "location_count": 8, "location_summary": "San Francisco, California • Jacksonville, Florida • Miami, Florida + 5 more", "locations": [ { "city": "San Francisco", "state": "California" }, { "city": "Jacksonville", "state": "Florida" }, { "city": "Miami", "state": "Florida" }, { "city": "Atlanta", "state": "Georgia" }, { "city": "Baltimore", "state": "Maryland" } ], "official_url": "https://clinicaltrials.gov/study/NCT02655614" }, { "nct_id": "NCT03556592", "title": "Drug-drug Interaction Trial With Tralokinumab in Moderate to Severe Atopic Dermatitis - ECZTRA 4", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE1" ], "conditions": [ "Atopic Dermatitis" ], "interventions": [ { "name": "Tralokinumab", "type": "DRUG" }, { "name": "Caffeine", "type": "DRUG" }, { "name": "Warfarin", "type": "DRUG" }, { "name": "Omeprazole", "type": "DRUG" }, { "name": "Metoprolol", "type": "DRUG" }, { "name": "Midazolam Hydrochloride", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "LEO Pharma", "sponsor_class": "INDUSTRY", "healthy_volunteers": false, "eligibility": { "minimum_age": "18 Years", "maximum_age": null, "sex": "ALL", "summary": "18 Years and older" }, "enrollment_count": 40, "start_date": "2018-08-13", "completion_date": "2020-06-20", "has_results": false, "last_update_posted_date": "2025-02-24", "last_synced_at": "2026-09-10T13:47:53.144Z", "location_count": 9, "location_summary": "Little Rock, Arkansas • Rogers, Arkansas • San Diego, California + 5 more", "locations": [ { "city": "Little Rock", "state": "Arkansas" }, { "city": "Rogers", "state": "Arkansas" }, { "city": "San Diego", "state": "California" }, { "city": "Doral", "state": "Florida" }, { "city": "Miami", "state": "Florida" } ], "official_url": "https://clinicaltrials.gov/study/NCT03556592" }, { "nct_id": "NCT05170113", "title": "Evaluate the Effectiveness and Safety of the Alpinia Galanga Formulation, Theacrine Formulation, and Caffeine Formulation on Fatigue, Mental Acuity, and Cognitive Health", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "NA" ], "conditions": [ "Fatigue" ], "interventions": [ { "name": "Alpinia galanga formulation", "type": "DIETARY_SUPPLEMENT" }, { "name": "Theacrine formulation", "type": "DIETARY_SUPPLEMENT" }, { "name": "Caffeine formulation", "type": "DIETARY_SUPPLEMENT" }, { "name": "Placebo", "type": "DIETARY_SUPPLEMENT" } ], "intervention_types": [ "DIETARY_SUPPLEMENT" ], "sponsor": "Supplement Formulators, Inc.", "sponsor_class": "INDUSTRY", "healthy_volunteers": true, "eligibility": { "minimum_age": "30 Years", "maximum_age": "70 Years", "sex": "ALL", "summary": "30 Years to 70 Years" }, "enrollment_count": 79, "start_date": "2021-11-02", "completion_date": "2022-05-31", "has_results": false, "last_update_posted_date": "2022-07-28", "last_synced_at": "2026-09-10T13:47:53.144Z", "location_count": 1, "location_summary": "Fort Lauderdale, Florida", "locations": [ { "city": "Fort Lauderdale", "state": "Florida" } ], "official_url": "https://clinicaltrials.gov/study/NCT05170113" }, { "nct_id": "NCT01476176", "title": "A Pharmacokinetic Study of an Experimental Paracetamol Formulation", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE1" ], "conditions": [ "Headache, Tension-Type" ], "interventions": [ { "name": "Experimental paracetamol", "type": "DRUG" }, { "name": "Paracetamol marketed formulation", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "GlaxoSmithKline", "sponsor_class": "INDUSTRY", "healthy_volunteers": true, "eligibility": { "minimum_age": "18 Years", "maximum_age": "55 Years", "sex": "ALL", "summary": "18 Years to 55 Years" }, "enrollment_count": 30, "start_date": "2009-07", "completion_date": "2009-08", "has_results": false, "last_update_posted_date": "2014-11-24", "last_synced_at": "2026-09-10T13:47:53.144Z", "location_count": 1, "location_summary": "Phoenix, Arizona", "locations": [ { "city": "Phoenix", "state": "Arizona" } ], "official_url": "https://clinicaltrials.gov/study/NCT01476176" } ] }