{
  "api_version": "1",
  "request": {
    "url": "https://clinicaltrialsfind.com/api/v1/search.json?intervention=Calcium+hydroxylapatite",
    "query": {
      "intervention": "Calcium hydroxylapatite"
    },
    "page_size": 10
  },
  "pagination": {
    "page": 1,
    "page_size": 10,
    "total_count": 20,
    "total_pages": 2,
    "next_page_url": "https://clinicaltrialsfind.com/api/v1/search.json?intervention=Calcium+hydroxylapatite&page=2&page_size=10",
    "previous_page_url": null
  },
  "source": "remote",
  "last_synced_at": "2026-09-03T08:24:44.472Z",
  "attribution": "Data derived from public ClinicalTrials.gov records. The official record at https://clinicaltrials.gov/ remains the source of truth for current availability, contacts, and full study details.",
  "notes": [
    "This endpoint exposes only public summary fields — no participant contact emails, phone numbers, or scraped investigator contact details.",
    "For contact information and full protocol detail, follow each trial's `official_url` to the ClinicalTrials.gov record.",
    "This API is a navigational aid. It does not provide medical advice, eligibility determinations, or compensation guarantees."
  ],
  "trials": [
    {
      "nct_id": "NCT00510055",
      "title": "Treatment of Acne Scarring With a Novel Procedure Combination",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Acne Scarring"
      ],
      "interventions": [
        {
          "name": "subdermal manipulation ONLY",
          "type": "PROCEDURE"
        },
        {
          "name": "subdermal manipulation AND injection of a filler",
          "type": "PROCEDURE"
        }
      ],
      "intervention_types": [
        "PROCEDURE"
      ],
      "sponsor": "Northwestern University",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "18 Years and older"
      },
      "enrollment_count": 30,
      "start_date": "2007-06",
      "completion_date": "2009-07",
      "has_results": false,
      "last_update_posted_date": "2021-12-02",
      "last_synced_at": "2026-09-03T08:24:44.472Z",
      "location_count": 1,
      "location_summary": "Chicago, Illinois",
      "locations": [
        {
          "city": "Chicago",
          "state": "Illinois"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT00510055"
    },
    {
      "nct_id": "NCT04933331",
      "title": "Early Caries Lesion Management Observational Study",
      "overall_status": "UNKNOWN",
      "study_type": "OBSERVATIONAL",
      "phases": [],
      "conditions": [
        "Initial Caries",
        "Arrested Dental Caries",
        "Cavitated Caries",
        "Dental Caries",
        "Dental Caries in Children"
      ],
      "interventions": [
        {
          "name": "Curodont Repair Fluoride Plus",
          "type": "DRUG"
        },
        {
          "name": "Silver Diamine Fluoride",
          "type": "DEVICE"
        },
        {
          "name": "Glass Ionomer Sealant",
          "type": "DEVICE"
        },
        {
          "name": "Fluoride varnish",
          "type": "DEVICE"
        },
        {
          "name": "Fluoride toothpaste",
          "type": "DRUG"
        }
      ],
      "intervention_types": [
        "DRUG",
        "DEVICE"
      ],
      "sponsor": "CareQuest Institute for Oral Health",
      "sponsor_class": "OTHER",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "4 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "4 Years and older"
      },
      "enrollment_count": 744,
      "start_date": "2020-12-07",
      "completion_date": "2024-03-31",
      "has_results": false,
      "last_update_posted_date": "2023-11-24",
      "last_synced_at": "2026-09-03T08:24:44.472Z",
      "location_count": 4,
      "location_summary": "Dothan, Alabama • Westborough, Massachusetts • Bend, Oregon + 1 more",
      "locations": [
        {
          "city": "Dothan",
          "state": "Alabama"
        },
        {
          "city": "Westborough",
          "state": "Massachusetts"
        },
        {
          "city": "Bend",
          "state": "Oregon"
        },
        {
          "city": "Dallas",
          "state": "Texas"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT04933331"
    },
    {
      "nct_id": "NCT06984835",
      "title": "Safety and Effectiveness of ELLANSÉ®-S Dermal Filler in the Treatment of Nasolabial Folds",
      "overall_status": "ACTIVE_NOT_RECRUITING",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Nasolabial Folds"
      ],
      "interventions": [
        {
          "name": "Ellanse S",
          "type": "DEVICE"
        },
        {
          "name": "Calcium Hydroxylapatite-based filler",
          "type": "DEVICE"
        }
      ],
      "intervention_types": [
        "DEVICE"
      ],
      "sponsor": "AQTIS Medical B.V.",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "22 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "22 Years and older"
      },
      "enrollment_count": 126,
      "start_date": "2025-03-31",
      "completion_date": "2027-12",
      "has_results": false,
      "last_update_posted_date": "2026-07-21",
      "last_synced_at": "2026-09-03T08:24:44.472Z",
      "location_count": 7,
      "location_summary": "Scottsdale, Arizona • Encino, California • Westport, Connecticut + 4 more",
      "locations": [
        {
          "city": "Scottsdale",
          "state": "Arizona"
        },
        {
          "city": "Encino",
          "state": "California"
        },
        {
          "city": "Westport",
          "state": "Connecticut"
        },
        {
          "city": "Miami",
          "state": "Florida"
        },
        {
          "city": "Glenn Dale",
          "state": "Maryland"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT06984835"
    },
    {
      "nct_id": "NCT03847922",
      "title": "Nitrous Oxide for Analgesia During Office Urethral Bulking",
      "overall_status": "TERMINATED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE4"
      ],
      "conditions": [
        "Pain",
        "Stress Incontinence, Female"
      ],
      "interventions": [
        {
          "name": "Nitrous Oxide + Oxygen Gas (Product)",
          "type": "DRUG"
        },
        {
          "name": "lidocaine gel 2%",
          "type": "DRUG"
        },
        {
          "name": "Room air",
          "type": "OTHER"
        }
      ],
      "intervention_types": [
        "DRUG",
        "OTHER"
      ],
      "sponsor": "Baylor Research Institute",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": "100 Years",
        "sex": "FEMALE",
        "summary": "18 Years to 100 Years · Female only"
      },
      "enrollment_count": 2,
      "start_date": "2019-02-15",
      "completion_date": "2020-07-23",
      "has_results": false,
      "last_update_posted_date": "2020-08-20",
      "last_synced_at": "2026-09-03T08:24:44.472Z",
      "location_count": 1,
      "location_summary": "Temple, Texas",
      "locations": [
        {
          "city": "Temple",
          "state": "Texas"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT03847922"
    },
    {
      "nct_id": "NCT04176068",
      "title": "Combined Focused Ultrasound and Calcium Hydroxylapatitie Filler for Skin Laxity and Volume Restoration",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE1"
      ],
      "conditions": [
        "Skin Laxity"
      ],
      "interventions": [
        {
          "name": "calcium hydroxylapatite (Radiesse) and IFUS (Ulthera)",
          "type": "COMBINATION_PRODUCT"
        }
      ],
      "intervention_types": [
        "COMBINATION_PRODUCT"
      ],
      "sponsor": "University of California, Irvine",
      "sponsor_class": "OTHER",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": "85 Years",
        "sex": "ALL",
        "summary": "18 Years to 85 Years"
      },
      "enrollment_count": 20,
      "start_date": "2019-04-19",
      "completion_date": "2021-12-01",
      "has_results": false,
      "last_update_posted_date": "2024-02-02",
      "last_synced_at": "2026-09-03T08:24:44.472Z",
      "location_count": 1,
      "location_summary": "Irvine, California",
      "locations": [
        {
          "city": "Irvine",
          "state": "California"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT04176068"
    },
    {
      "nct_id": "NCT01034956",
      "title": "Outcomes and Patient Experience After Soft Tissue Dermal Filler Injections",
      "overall_status": "COMPLETED",
      "study_type": "OBSERVATIONAL",
      "phases": [],
      "conditions": [
        "Rhytids",
        "Wrinkles"
      ],
      "interventions": [
        {
          "name": "hyaluronic acid or calcium hydroxylapatite filler",
          "type": "DEVICE"
        }
      ],
      "intervention_types": [
        "DEVICE"
      ],
      "sponsor": "The New York Eye & Ear Infirmary",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": null,
        "maximum_age": null,
        "sex": "ALL",
        "summary": "Not listed"
      },
      "enrollment_count": 20,
      "start_date": "2009-11",
      "completion_date": "2010-05",
      "has_results": false,
      "last_update_posted_date": "2012-05-01",
      "last_synced_at": "2026-09-03T08:24:44.472Z",
      "location_count": 1,
      "location_summary": "New York, New York",
      "locations": [
        {
          "city": "New York",
          "state": "New York"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT01034956"
    },
    {
      "nct_id": "NCT07154693",
      "title": "Wound Healing Following Tooth Extraction and Ridge Preservation Using OsteoGen®",
      "overall_status": "RECRUITING",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Tooth Extraction"
      ],
      "interventions": [
        {
          "name": "Combination 70% FDBA and 30% DFDBA",
          "type": "DEVICE"
        },
        {
          "name": "OsteoGen Plug",
          "type": "DEVICE"
        }
      ],
      "intervention_types": [
        "DEVICE"
      ],
      "sponsor": "The University of Texas Health Science Center at San Antonio",
      "sponsor_class": "OTHER",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": "89 Years",
        "sex": "ALL",
        "summary": "18 Years to 89 Years"
      },
      "enrollment_count": 44,
      "start_date": "2025-11-19",
      "completion_date": "2027-12-31",
      "has_results": false,
      "last_update_posted_date": "2026-01-06",
      "last_synced_at": "2026-09-03T08:24:44.472Z",
      "location_count": 1,
      "location_summary": "San Antonio, Texas",
      "locations": [
        {
          "city": "San Antonio",
          "state": "Texas"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT07154693"
    },
    {
      "nct_id": "NCT07419854",
      "title": "Restoring Facial Volume After GLP-1 Weight Loss With Radiesse",
      "overall_status": "RECRUITING",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE4"
      ],
      "conditions": [
        "Volume Loss (Soft Tissue Ptosis or Atrophy )"
      ],
      "interventions": [
        {
          "name": "Hyperdiluted Calcium Hydroxylapatite",
          "type": "DEVICE"
        },
        {
          "name": "Calcium hydroxylapatite",
          "type": "DEVICE"
        },
        {
          "name": "Calcium hydroxylapatite with integral lidocaine",
          "type": "DEVICE"
        }
      ],
      "intervention_types": [
        "DEVICE"
      ],
      "sponsor": "Kalpna Kay Durairaj, MD, FACS",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "21 Years",
        "maximum_age": "65 Years",
        "sex": "ALL",
        "summary": "21 Years to 65 Years"
      },
      "enrollment_count": 48,
      "start_date": "2026-02",
      "completion_date": "2027-09",
      "has_results": false,
      "last_update_posted_date": "2026-02-19",
      "last_synced_at": "2026-09-03T08:24:44.472Z",
      "location_count": 1,
      "location_summary": "Pasadena, California",
      "locations": [
        {
          "city": "Pasadena",
          "state": "California"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT07419854"
    },
    {
      "nct_id": "NCT06826391",
      "title": "Using Calcium Hydroxylapatite To Treat Gum Recession and Tooth Hypersensitivity",
      "overall_status": "ENROLLING_BY_INVITATION",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Gingival Recession, Generalized",
        "Gingival Recession Generalized Moderate",
        "Gingival Recession Localized Moderate",
        "Tooth Sensitivity"
      ],
      "interventions": [
        {
          "name": "Calcium hydroxylapatite",
          "type": "DEVICE"
        }
      ],
      "intervention_types": [
        "DEVICE"
      ],
      "sponsor": "American Academy of Facial Esthetics",
      "sponsor_class": "NETWORK",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "20 Years",
        "maximum_age": "70 Years",
        "sex": "ALL",
        "summary": "20 Years to 70 Years"
      },
      "enrollment_count": 500,
      "start_date": "2025-02-01",
      "completion_date": "2025-12-31",
      "has_results": false,
      "last_update_posted_date": "2025-02-17",
      "last_synced_at": "2026-09-03T08:24:44.472Z",
      "location_count": 1,
      "location_summary": "South Euclid, Ohio",
      "locations": [
        {
          "city": "South Euclid",
          "state": "Ohio"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT06826391"
    },
    {
      "nct_id": "NCT06447844",
      "title": "OsteoGen Plug vs. Freeze-dried Bone Allograft With Collagen Barrier",
      "overall_status": "ACTIVE_NOT_RECRUITING",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Nonterminal Premolar Needing Extraction"
      ],
      "interventions": [
        {
          "name": "OsteoGen Plug",
          "type": "DEVICE"
        },
        {
          "name": "BioGide",
          "type": "DEVICE"
        }
      ],
      "intervention_types": [
        "DEVICE"
      ],
      "sponsor": "McGuire Institute",
      "sponsor_class": "INDUSTRY",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": "75 Years",
        "sex": "ALL",
        "summary": "18 Years to 75 Years"
      },
      "enrollment_count": 70,
      "start_date": "2024-03-28",
      "completion_date": "2027-11-28",
      "has_results": false,
      "last_update_posted_date": "2026-05-29",
      "last_synced_at": "2026-09-03T08:24:44.472Z",
      "location_count": 9,
      "location_summary": "Aurora, Colorado • Broomfield, Colorado • Boston, Massachusetts + 6 more",
      "locations": [
        {
          "city": "Aurora",
          "state": "Colorado"
        },
        {
          "city": "Broomfield",
          "state": "Colorado"
        },
        {
          "city": "Boston",
          "state": "Massachusetts"
        },
        {
          "city": "Fenton",
          "state": "Michigan"
        },
        {
          "city": "La Vista",
          "state": "Nebraska"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT06447844"
    }
  ]
}