{
  "api_version": "1",
  "request": {
    "url": "https://clinicaltrialsfind.com/api/v1/search.json?intervention=Caries+Active+-+Placebo",
    "query": {
      "intervention": "Caries Active - Placebo"
    },
    "page_size": 10
  },
  "pagination": {
    "page": 1,
    "page_size": 10,
    "total_count": 6,
    "total_pages": 1,
    "next_page_url": null,
    "previous_page_url": null
  },
  "source": "remote",
  "last_synced_at": "2026-09-08T21:27:35.161Z",
  "attribution": "Data derived from public ClinicalTrials.gov records. The official record at https://clinicaltrials.gov/ remains the source of truth for current availability, contacts, and full study details.",
  "notes": [
    "This endpoint exposes only public summary fields — no participant contact emails, phone numbers, or scraped investigator contact details.",
    "For contact information and full protocol detail, follow each trial's `official_url` to the ClinicalTrials.gov record.",
    "This API is a navigational aid. It does not provide medical advice, eligibility determinations, or compensation guarantees."
  ],
  "trials": [
    {
      "nct_id": "NCT00357877",
      "title": "Prevention of Adult Caries Study (PACS)",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE3"
      ],
      "conditions": [
        "Caries, Dental"
      ],
      "interventions": [
        {
          "name": "10% w/v chlorhexidine acetate coating FDA IND #45466",
          "type": "DRUG"
        },
        {
          "name": "Placebo",
          "type": "OTHER"
        }
      ],
      "intervention_types": [
        "DRUG",
        "OTHER"
      ],
      "sponsor": "Tufts University",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "18 Years and older"
      },
      "enrollment_count": 983,
      "start_date": "2006-07",
      "completion_date": "2010-06",
      "has_results": true,
      "last_update_posted_date": "2017-06-14",
      "last_synced_at": "2026-09-08T21:27:35.161Z",
      "location_count": 4,
      "location_summary": "Tuba City, Arizona • Boston, Massachusetts • Portland, Oregon",
      "locations": [
        {
          "city": "Tuba City",
          "state": "Arizona"
        },
        {
          "city": "Boston",
          "state": "Massachusetts"
        },
        {
          "city": "Boston",
          "state": "Massachusetts"
        },
        {
          "city": "Portland",
          "state": "Oregon"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT00357877"
    },
    {
      "nct_id": "NCT01176396",
      "title": "CAMBRA - PBRN Caries Management By Risk Assessment In A Practice-Based Research Network",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Dental Caries"
      ],
      "interventions": [
        {
          "name": "Caries prevention active intervention",
          "type": "OTHER"
        },
        {
          "name": "control treatment",
          "type": "OTHER"
        }
      ],
      "intervention_types": [
        "OTHER"
      ],
      "sponsor": "University of California, San Francisco",
      "sponsor_class": "OTHER",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "12 Years",
        "maximum_age": "65 Years",
        "sex": "ALL",
        "summary": "12 Years to 65 Years"
      },
      "enrollment_count": 460,
      "start_date": "2012-04",
      "completion_date": "2017-05",
      "has_results": false,
      "last_update_posted_date": "2020-04-10",
      "last_synced_at": "2026-09-08T21:27:35.161Z",
      "location_count": 1,
      "location_summary": "San Francisco, California",
      "locations": [
        {
          "city": "San Francisco",
          "state": "California"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT01176396"
    },
    {
      "nct_id": "NCT01147835",
      "title": "Herbal Lollipops on Oral Bacterial Levels and DMFT/Dmft Scores of Children With Asthma Using Inhalers",
      "overall_status": "TERMINATED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Asthma",
        "Dental Caries"
      ],
      "interventions": [
        {
          "name": "Chinese Licorice Root",
          "type": "DIETARY_SUPPLEMENT"
        }
      ],
      "intervention_types": [
        "DIETARY_SUPPLEMENT"
      ],
      "sponsor": "University of Nebraska",
      "sponsor_class": "OTHER",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "4 Years",
        "maximum_age": "16 Years",
        "sex": "ALL",
        "summary": "4 Years to 16 Years"
      },
      "enrollment_count": 39,
      "start_date": "2009-09-23",
      "completion_date": "2011-09-27",
      "has_results": false,
      "last_update_posted_date": "2023-08-23",
      "last_synced_at": "2026-09-08T21:27:35.161Z",
      "location_count": 1,
      "location_summary": "Omaha, Nebraska",
      "locations": [
        {
          "city": "Omaha",
          "state": "Nebraska"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT01147835"
    },
    {
      "nct_id": "NCT02130206",
      "title": "The Microbiology of Caries Resistance",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE2"
      ],
      "conditions": [
        "Dental Caries"
      ],
      "interventions": [
        {
          "name": "Caries Free",
          "type": "OTHER"
        },
        {
          "name": "Caries Active",
          "type": "OTHER"
        },
        {
          "name": "Caries Free - Placebo",
          "type": "OTHER"
        },
        {
          "name": "Caries Active - Placebo",
          "type": "OTHER"
        }
      ],
      "intervention_types": [
        "OTHER"
      ],
      "sponsor": "University of Florida",
      "sponsor_class": "OTHER",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": "65 Years",
        "sex": "ALL",
        "summary": "18 Years to 65 Years"
      },
      "enrollment_count": 79,
      "start_date": "2014-05",
      "completion_date": "2014-11",
      "has_results": false,
      "last_update_posted_date": "2016-11-09",
      "last_synced_at": "2026-09-08T21:27:35.161Z",
      "location_count": 1,
      "location_summary": "Gainesville, Florida",
      "locations": [
        {
          "city": "Gainesville",
          "state": "Florida"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT02130206"
    },
    {
      "nct_id": "NCT02999230",
      "title": "Probiotics That Moderate pH and Antagonize Pathogens to Promote Oral Health",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Dental Caries"
      ],
      "interventions": [
        {
          "name": "Caries Free 1.5% Arginine",
          "type": "OTHER"
        },
        {
          "name": "Caries Free Placebo Sodium Fluoride",
          "type": "OTHER"
        },
        {
          "name": "Caries Active 1.5% Arginine",
          "type": "OTHER"
        },
        {
          "name": "Caries Active- Placebo Sodium Fluoride",
          "type": "OTHER"
        }
      ],
      "intervention_types": [
        "OTHER"
      ],
      "sponsor": "University of Florida",
      "sponsor_class": "OTHER",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": "65 Years",
        "sex": "ALL",
        "summary": "18 Years to 65 Years"
      },
      "enrollment_count": 170,
      "start_date": "2017-02-22",
      "completion_date": "2020-06-25",
      "has_results": false,
      "last_update_posted_date": "2024-10-01",
      "last_synced_at": "2026-09-08T21:27:35.161Z",
      "location_count": 1,
      "location_summary": "Gainesville, Florida",
      "locations": [
        {
          "city": "Gainesville",
          "state": "Florida"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT02999230"
    },
    {
      "nct_id": "NCT04947527",
      "title": "Efficacy and Safety Evaluation of Anti-Caries Varnish",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE2"
      ],
      "conditions": [
        "Dental Caries in Children"
      ],
      "interventions": [
        {
          "name": "Test varnish",
          "type": "DRUG"
        },
        {
          "name": "Placebo",
          "type": "DRUG"
        }
      ],
      "intervention_types": [
        "DRUG"
      ],
      "sponsor": "Advantage Silver Dental Arrest, LLC",
      "sponsor_class": "INDUSTRY",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "10 Months",
        "maximum_age": "20 Months",
        "sex": "ALL",
        "summary": "10 Months to 20 Months"
      },
      "enrollment_count": 274,
      "start_date": "2022-06-04",
      "completion_date": "2024-08-05",
      "has_results": true,
      "last_update_posted_date": "2025-10-09",
      "last_synced_at": "2026-09-08T21:27:35.161Z",
      "location_count": 0,
      "location_summary": "Not listed",
      "locations": [],
      "official_url": "https://clinicaltrials.gov/study/NCT04947527"
    }
  ]
}