{
  "api_version": "1",
  "request": {
    "url": "https://clinicaltrialsfind.com/api/v1/search.json?intervention=Cerebral+vascular+reactivity+to+carbon+dioxide+%28CO2%29",
    "query": {
      "intervention": "Cerebral vascular reactivity to carbon dioxide (CO2)"
    },
    "page_size": 10
  },
  "pagination": {
    "page": 1,
    "page_size": 10,
    "total_count": 5,
    "total_pages": 1,
    "next_page_url": null,
    "previous_page_url": null
  },
  "source": "remote",
  "last_synced_at": "2026-10-11T21:51:58.446Z",
  "attribution": "Data derived from public ClinicalTrials.gov records. The official record at https://clinicaltrials.gov/ remains the source of truth for current availability, contacts, and full study details.",
  "notes": [
    "This endpoint exposes only public summary fields — no participant contact emails, phone numbers, or scraped investigator contact details.",
    "For contact information and full protocol detail, follow each trial's `official_url` to the ClinicalTrials.gov record.",
    "This API is a navigational aid. It does not provide medical advice, eligibility determinations, or compensation guarantees."
  ],
  "trials": [
    {
      "nct_id": "NCT06150989",
      "title": "Black Women's Life Experience On Cardiovascular Health Via Ongoing Monitoring",
      "overall_status": "ACTIVE_NOT_RECRUITING",
      "study_type": "OBSERVATIONAL",
      "phases": [],
      "conditions": [
        "Cardiovascular Diseases",
        "Heart Disease Risk Factors"
      ],
      "interventions": [
        {
          "name": "Observational Group",
          "type": "BEHAVIORAL"
        }
      ],
      "intervention_types": [
        "BEHAVIORAL"
      ],
      "sponsor": "The University of Texas at Arlington",
      "sponsor_class": "OTHER",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": "49 Years",
        "sex": "FEMALE",
        "summary": "18 Years to 49 Years · Female only"
      },
      "enrollment_count": 80,
      "start_date": "2024-03-04",
      "completion_date": "2027-08",
      "has_results": false,
      "last_update_posted_date": "2026-07-07",
      "last_synced_at": "2026-10-11T21:51:58.446Z",
      "location_count": 1,
      "location_summary": "Arlington, Texas",
      "locations": [
        {
          "city": "Arlington",
          "state": "Texas"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT06150989"
    },
    {
      "nct_id": "NCT04258774",
      "title": "The Effect of Respiratory Challenge on the BOLD Signal",
      "overall_status": "ENROLLING_BY_INVITATION",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Hypoxia, Brain",
        "Hyperoxia",
        "Hypercapnia",
        "Hypocapnia"
      ],
      "interventions": [
        {
          "name": "Carbon Dioxide",
          "type": "OTHER"
        }
      ],
      "intervention_types": [
        "OTHER"
      ],
      "sponsor": "Washington University School of Medicine",
      "sponsor_class": "OTHER",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "18 Years and older"
      },
      "enrollment_count": 48,
      "start_date": "2020-01-29",
      "completion_date": "2027-12-31",
      "has_results": false,
      "last_update_posted_date": "2026-01-16",
      "last_synced_at": "2026-10-11T21:51:58.446Z",
      "location_count": 1,
      "location_summary": "St Louis, Missouri",
      "locations": [
        {
          "city": "St Louis",
          "state": "Missouri"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT04258774"
    },
    {
      "nct_id": "NCT04058132",
      "title": "Cerebrovascular Reactivity Assessed With fNIRS as a Biomarker of TCVI After Acute Traumatic Brain Injury in Military",
      "overall_status": "TERMINATED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE2"
      ],
      "conditions": [
        "Traumatic Brain Injury"
      ],
      "interventions": [
        {
          "name": "Sildenafil Citrate 50Mg Tab",
          "type": "DRUG"
        },
        {
          "name": "functional Near-infrared Spectroscopy (fNIRS)",
          "type": "DEVICE"
        },
        {
          "name": "Carbon Dioxide (CO2) 5%",
          "type": "OTHER"
        },
        {
          "name": "Neuropsychological Assessments",
          "type": "OTHER"
        },
        {
          "name": "Gadolinium contrast infusion",
          "type": "DRUG"
        },
        {
          "name": "Blood sample collection for research purposes",
          "type": "PROCEDURE"
        },
        {
          "name": "Structural brain Magnetic Resonance Imaging (MRI",
          "type": "OTHER"
        }
      ],
      "intervention_types": [
        "DRUG",
        "DEVICE",
        "OTHER",
        "PROCEDURE"
      ],
      "sponsor": "Uniformed Services University of the Health Sciences",
      "sponsor_class": "FED",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": "55 Years",
        "sex": "ALL",
        "summary": "18 Years to 55 Years"
      },
      "enrollment_count": 1,
      "start_date": "2019-08-09",
      "completion_date": "2020-03-01",
      "has_results": false,
      "last_update_posted_date": "2024-02-28",
      "last_synced_at": "2026-10-11T21:51:58.446Z",
      "location_count": 1,
      "location_summary": "Bethesda, Maryland",
      "locations": [
        {
          "city": "Bethesda",
          "state": "Maryland"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT04058132"
    },
    {
      "nct_id": "NCT04336852",
      "title": "Development of a Clinically-relevant Test for Assessment of Cerebral Vascular Function",
      "overall_status": "TERMINATED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Cerebrovascular Disorders",
        "Cerebrovascular Disease"
      ],
      "interventions": [
        {
          "name": "Flow mediated dilation (brachial and femoral arteries)",
          "type": "PROCEDURE"
        },
        {
          "name": "Cerebral vascular reactivity to carbon dioxide (CO2)",
          "type": "PROCEDURE"
        },
        {
          "name": "Cerebral vascular function test",
          "type": "PROCEDURE"
        }
      ],
      "intervention_types": [
        "PROCEDURE"
      ],
      "sponsor": "University of Illinois at Chicago",
      "sponsor_class": "OTHER",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": "80 Years",
        "sex": "ALL",
        "summary": "18 Years to 80 Years"
      },
      "enrollment_count": 2,
      "start_date": "2018-09-14",
      "completion_date": "2023-05-12",
      "has_results": false,
      "last_update_posted_date": "2025-05-20",
      "last_synced_at": "2026-10-11T21:51:58.446Z",
      "location_count": 2,
      "location_summary": "Chicago, Illinois • Fort Worth, Texas",
      "locations": [
        {
          "city": "Chicago",
          "state": "Illinois"
        },
        {
          "city": "Fort Worth",
          "state": "Texas"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT04336852"
    },
    {
      "nct_id": "NCT05298709",
      "title": "Functional Magnetic Resonance Imaging (fMRI) Vascular Reactivity in Cerebral Cavernous Malformations (CCM)",
      "overall_status": "TERMINATED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Cerebral Cavernous Malformation"
      ],
      "interventions": [
        {
          "name": "Hyperventilation and CO2 challenge",
          "type": "OTHER"
        }
      ],
      "intervention_types": [
        "OTHER"
      ],
      "sponsor": "University of New Mexico",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "18 Years and older"
      },
      "enrollment_count": 5,
      "start_date": "2023-06-15",
      "completion_date": "2024-07-17",
      "has_results": false,
      "last_update_posted_date": "2025-06-11",
      "last_synced_at": "2026-10-11T21:51:58.446Z",
      "location_count": 1,
      "location_summary": "Albuquerque, New Mexico",
      "locations": [
        {
          "city": "Albuquerque",
          "state": "New Mexico"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT05298709"
    }
  ]
}