{
  "api_version": "1",
  "request": {
    "url": "https://clinicaltrialsfind.com/api/v1/search.json?intervention=Chewing&page=4",
    "query": {
      "intervention": "Chewing",
      "page": 4
    },
    "page_size": 10
  },
  "pagination": {
    "page": 4,
    "page_size": 10,
    "total_count": 232,
    "total_pages": 24,
    "next_page_url": "https://clinicaltrialsfind.com/api/v1/search.json?intervention=Chewing&page=5&page_size=10",
    "previous_page_url": "https://clinicaltrialsfind.com/api/v1/search.json?intervention=Chewing&page=3&page_size=10"
  },
  "source": "remote",
  "last_synced_at": "2026-10-21T18:51:08.821Z",
  "attribution": "Data derived from public ClinicalTrials.gov records. The official record at https://clinicaltrials.gov/ remains the source of truth for current availability, contacts, and full study details.",
  "notes": [
    "This endpoint exposes only public summary fields — no participant contact emails, phone numbers, or scraped investigator contact details.",
    "For contact information and full protocol detail, follow each trial's `official_url` to the ClinicalTrials.gov record.",
    "This API is a navigational aid. It does not provide medical advice, eligibility determinations, or compensation guarantees."
  ],
  "trials": [
    {
      "nct_id": "NCT03559751",
      "title": "Evaluation of the Abuse Liability of Very Low Nicotine (VLN) Cigarettes",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE1"
      ],
      "conditions": [
        "Tobacco Use"
      ],
      "interventions": [
        {
          "name": "VLN cigarettes (A)",
          "type": "OTHER"
        },
        {
          "name": "Usual Brand Cigarettes (B)",
          "type": "OTHER"
        },
        {
          "name": "Nicotine gum (C)",
          "type": "DRUG"
        }
      ],
      "intervention_types": [
        "OTHER",
        "DRUG"
      ],
      "sponsor": "22nd Century Group, Inc.",
      "sponsor_class": "INDUSTRY",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "22 Years",
        "maximum_age": "65 Years",
        "sex": "ALL",
        "summary": "22 Years to 65 Years"
      },
      "enrollment_count": 66,
      "start_date": "2018-04-13",
      "completion_date": "2018-09-06",
      "has_results": false,
      "last_update_posted_date": "2020-03-26",
      "last_synced_at": "2026-10-21T18:51:08.821Z",
      "location_count": 1,
      "location_summary": "Overland Park, Kansas",
      "locations": [
        {
          "city": "Overland Park",
          "state": "Kansas"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT03559751"
    },
    {
      "nct_id": "NCT05091801",
      "title": "Particle Size Project",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Test if Increased Chewing Will Increased Microbiota SCFA Production"
      ],
      "interventions": [
        {
          "name": "Intervention",
          "type": "BEHAVIORAL"
        }
      ],
      "intervention_types": [
        "BEHAVIORAL"
      ],
      "sponsor": "Duke University",
      "sponsor_class": "OTHER",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "18 Years and older"
      },
      "enrollment_count": 41,
      "start_date": "2021-10-26",
      "completion_date": "2022-04-01",
      "has_results": false,
      "last_update_posted_date": "2022-04-14",
      "last_synced_at": "2026-10-21T18:51:08.821Z",
      "location_count": 1,
      "location_summary": "Durham, North Carolina",
      "locations": [
        {
          "city": "Durham",
          "state": "North Carolina"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT05091801"
    },
    {
      "nct_id": "NCT05154669",
      "title": "Integrating Financial Coaching and Smoking Cessation Coaching",
      "overall_status": "RECRUITING",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE3"
      ],
      "conditions": [
        "Smoking"
      ],
      "interventions": [
        {
          "name": "Financial counseling",
          "type": "OTHER"
        },
        {
          "name": "Nicotine Replacement Therapy Agent - Patches",
          "type": "DRUG"
        },
        {
          "name": "Nicotine Replacement Therapy Agent - Lozenges",
          "type": "DRUG"
        },
        {
          "name": "Nicotine Replacement Therapy Agent - Gum",
          "type": "DRUG"
        }
      ],
      "intervention_types": [
        "OTHER",
        "DRUG"
      ],
      "sponsor": "NYU Langone Health",
      "sponsor_class": "OTHER",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": "100 Years",
        "sex": "ALL",
        "summary": "18 Years to 100 Years"
      },
      "enrollment_count": 602,
      "start_date": "2022-12-08",
      "completion_date": "2029-12-01",
      "has_results": false,
      "last_update_posted_date": "2026-05-04",
      "last_synced_at": "2026-10-21T18:51:08.821Z",
      "location_count": 1,
      "location_summary": "New York, New York",
      "locations": [
        {
          "city": "New York",
          "state": "New York"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT05154669"
    },
    {
      "nct_id": "NCT01544153",
      "title": "Improving Adherence to Web-Based Cessation Programs: A Social Network Approach",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Smoking Cessation"
      ],
      "interventions": [
        {
          "name": "WEB",
          "type": "BEHAVIORAL"
        },
        {
          "name": "Social Network",
          "type": "BEHAVIORAL"
        },
        {
          "name": "Nicotine Replacement Therapy (NRT)",
          "type": "BEHAVIORAL"
        }
      ],
      "intervention_types": [
        "BEHAVIORAL"
      ],
      "sponsor": "Truth Initiative",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "18 Years and older"
      },
      "enrollment_count": 5292,
      "start_date": "2012-02",
      "completion_date": "2017-08",
      "has_results": true,
      "last_update_posted_date": "2026-10-21",
      "last_synced_at": "2026-10-21T18:51:08.821Z",
      "location_count": 1,
      "location_summary": "Washington D.C., District of Columbia",
      "locations": [
        {
          "city": "Washington D.C.",
          "state": "District of Columbia"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT01544153"
    },
    {
      "nct_id": "NCT02020005",
      "title": "Evaluation of Cessation Preferences of Menthol Smoker",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Smoking Cessation"
      ],
      "interventions": [
        {
          "name": "Non-flavored 2mg nicotine gum",
          "type": "OTHER"
        },
        {
          "name": "Non-flavored 4mg nicotine gum",
          "type": "OTHER"
        },
        {
          "name": "Mint-flavored 2mg nicotine gum",
          "type": "OTHER"
        },
        {
          "name": "Mint-flavored 4mg nicotine gum",
          "type": "OTHER"
        },
        {
          "name": "Non-flavored nicotine inhaler",
          "type": "OTHER"
        },
        {
          "name": "Mint-flavored nicotine ihaler",
          "type": "OTHER"
        }
      ],
      "intervention_types": [
        "OTHER"
      ],
      "sponsor": "University of Minnesota",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "18 Years and older"
      },
      "enrollment_count": 60,
      "start_date": "2013-09",
      "completion_date": "2013-12",
      "has_results": false,
      "last_update_posted_date": "2025-10-03",
      "last_synced_at": "2026-10-21T18:51:08.821Z",
      "location_count": 1,
      "location_summary": "Minneapolis, Minnesota",
      "locations": [
        {
          "city": "Minneapolis",
          "state": "Minnesota"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT02020005"
    },
    {
      "nct_id": "NCT06515483",
      "title": "Evaluation of the Efficacy and Safety of a Loop Stretchable Dental Floss",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Gingivitis",
        "Supragingival Plaque"
      ],
      "interventions": [
        {
          "name": "Brushing and Flossing of teeth",
          "type": "DEVICE"
        },
        {
          "name": "Brushing Only",
          "type": "OTHER"
        }
      ],
      "intervention_types": [
        "DEVICE",
        "OTHER"
      ],
      "sponsor": "Indiana University",
      "sponsor_class": "OTHER",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": "65 Years",
        "sex": "ALL",
        "summary": "18 Years to 65 Years"
      },
      "enrollment_count": 64,
      "start_date": "2024-10-15",
      "completion_date": "2024-12-04",
      "has_results": true,
      "last_update_posted_date": "2025-06-13",
      "last_synced_at": "2026-10-21T18:51:08.821Z",
      "location_count": 1,
      "location_summary": "Indianapolis, Indiana",
      "locations": [
        {
          "city": "Indianapolis",
          "state": "Indiana"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT06515483"
    },
    {
      "nct_id": "NCT01100216",
      "title": "Human Laboratory Study of Smokeless Tobacco Products",
      "overall_status": "WITHDRAWN",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Smokeless Tobacco"
      ],
      "interventions": [
        {
          "name": "Nicotine Lozenge",
          "type": "OTHER"
        },
        {
          "name": "Stonewall Dissolvable Tobacco Pieces",
          "type": "OTHER"
        },
        {
          "name": "Camel Snus Frost",
          "type": "OTHER"
        },
        {
          "name": "Skoal Wintergreen",
          "type": "OTHER"
        }
      ],
      "intervention_types": [
        "OTHER"
      ],
      "sponsor": "University of Minnesota",
      "sponsor_class": "OTHER",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": "60 Years",
        "sex": "MALE",
        "summary": "18 Years to 60 Years · Male only"
      },
      "enrollment_count": 0,
      "start_date": "2010-03",
      "completion_date": "2010-12",
      "has_results": false,
      "last_update_posted_date": "2014-12-10",
      "last_synced_at": "2026-10-21T18:51:08.821Z",
      "location_count": 1,
      "location_summary": "Minneapolis, Minnesota",
      "locations": [
        {
          "city": "Minneapolis",
          "state": "Minnesota"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT01100216"
    },
    {
      "nct_id": "NCT01470209",
      "title": "A Phase I Study of BKM120 and Everolimus in Advanced Solid Malignancies",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE1"
      ],
      "conditions": [
        "Solid Tumors",
        "Lung Cancer"
      ],
      "interventions": [
        {
          "name": "BKM120",
          "type": "DRUG"
        },
        {
          "name": "Everolimus",
          "type": "DRUG"
        }
      ],
      "intervention_types": [
        "DRUG"
      ],
      "sponsor": "Emory University",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "18 Years and older"
      },
      "enrollment_count": 43,
      "start_date": "2012-01",
      "completion_date": "2017-05",
      "has_results": false,
      "last_update_posted_date": "2018-03-19",
      "last_synced_at": "2026-10-21T18:51:08.821Z",
      "location_count": 1,
      "location_summary": "Atlanta, Georgia",
      "locations": [
        {
          "city": "Atlanta",
          "state": "Georgia"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT01470209"
    },
    {
      "nct_id": "NCT05433181",
      "title": "ACE2 Chewing Gum on SARS-CoV-2 Viral Load (COVID 19)",
      "overall_status": "WITHDRAWN",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE1",
        "PHASE2"
      ],
      "conditions": [
        "SARS-CoV-2"
      ],
      "interventions": [
        {
          "name": "ACE2 Chewing Gum",
          "type": "DRUG"
        },
        {
          "name": "Placebo Chewing Gum",
          "type": "OTHER"
        }
      ],
      "intervention_types": [
        "DRUG",
        "OTHER"
      ],
      "sponsor": "University of Pennsylvania",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": "65 Years",
        "sex": "ALL",
        "summary": "18 Years to 65 Years"
      },
      "enrollment_count": 0,
      "start_date": "2025-02",
      "completion_date": "2025-04-01",
      "has_results": false,
      "last_update_posted_date": "2025-03-30",
      "last_synced_at": "2026-10-21T18:51:08.821Z",
      "location_count": 1,
      "location_summary": "Philadelphia, Pennsylvania",
      "locations": [
        {
          "city": "Philadelphia",
          "state": "Pennsylvania"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT05433181"
    },
    {
      "nct_id": "NCT05057247",
      "title": "Duvelisib Plus Docetaxel In Recurrent/Metastatic HNSCC",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE2"
      ],
      "conditions": [
        "Squamous Cell Carcinoma of the Head and Neck (SCCHN)",
        "Recurrent Squamous Cell Carcinoma of the Head and Neck",
        "Metastatic Head and Neck Cancer",
        "Advanced Head and Neck Cancer",
        "Advanced Head and Neck Squamous Cell Carcinoma"
      ],
      "interventions": [
        {
          "name": "Duvelisib",
          "type": "DRUG"
        },
        {
          "name": "Docetaxel",
          "type": "DRUG"
        }
      ],
      "intervention_types": [
        "DRUG"
      ],
      "sponsor": "Kartik Sehgal, MD",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "18 Years and older"
      },
      "enrollment_count": 26,
      "start_date": "2021-10-14",
      "completion_date": "2024-06-13",
      "has_results": true,
      "last_update_posted_date": "2026-09-29",
      "last_synced_at": "2026-10-21T18:51:08.821Z",
      "location_count": 1,
      "location_summary": "Boston, Massachusetts",
      "locations": [
        {
          "city": "Boston",
          "state": "Massachusetts"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT05057247"
    }
  ]
}