{
  "api_version": "1",
  "request": {
    "url": "https://clinicaltrialsfind.com/api/v1/search.json?intervention=Chlorthalidone+%28CTD%29",
    "query": {
      "intervention": "Chlorthalidone (CTD)"
    },
    "page_size": 10
  },
  "pagination": {
    "page": 1,
    "page_size": 10,
    "total_count": 3,
    "total_pages": 1,
    "next_page_url": null,
    "previous_page_url": null
  },
  "source": "remote",
  "last_synced_at": "2026-09-23T22:52:21.080Z",
  "attribution": "Data derived from public ClinicalTrials.gov records. The official record at https://clinicaltrials.gov/ remains the source of truth for current availability, contacts, and full study details.",
  "notes": [
    "This endpoint exposes only public summary fields — no participant contact emails, phone numbers, or scraped investigator contact details.",
    "For contact information and full protocol detail, follow each trial's `official_url` to the ClinicalTrials.gov record.",
    "This API is a navigational aid. It does not provide medical advice, eligibility determinations, or compensation guarantees."
  ],
  "trials": [
    {
      "nct_id": "NCT02185417",
      "title": "Diuretic Comparison Project",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE3"
      ],
      "conditions": [
        "Hypertension"
      ],
      "interventions": [
        {
          "name": "Hydrochlorothiazide (HCTZ)",
          "type": "DRUG"
        },
        {
          "name": "Chlorthalidone (CTD)",
          "type": "DRUG"
        }
      ],
      "intervention_types": [
        "DRUG"
      ],
      "sponsor": "VA Office of Research and Development",
      "sponsor_class": "FED",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "65 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "65 Years and older"
      },
      "enrollment_count": 20723,
      "start_date": "2016-06-15",
      "completion_date": "2022-12-29",
      "has_results": true,
      "last_update_posted_date": "2024-05-22",
      "last_synced_at": "2026-09-23T22:52:21.080Z",
      "location_count": 69,
      "location_summary": "Birmingham, Alabama • Anchorage, Alaska • Fayetteville, Arkansas + 64 more",
      "locations": [
        {
          "city": "Birmingham",
          "state": "Alabama"
        },
        {
          "city": "Anchorage",
          "state": "Alaska"
        },
        {
          "city": "Fayetteville",
          "state": "Arkansas"
        },
        {
          "city": "Little Rock",
          "state": "Arkansas"
        },
        {
          "city": "Fresno",
          "state": "California"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT02185417"
    },
    {
      "nct_id": "NCT07645300",
      "title": "LOw DosE Spironolactone, chlorThAlidone oR Combination in CKD Trial",
      "overall_status": "NOT_YET_RECRUITING",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE2"
      ],
      "conditions": [
        "Hypertension Treated With Antihypertensive Drugs",
        "Chronic Kidney Disease, 3B and 4"
      ],
      "interventions": [
        {
          "name": "phase 2A Chlorthalidone",
          "type": "DRUG"
        },
        {
          "name": "phase 2A Spironolactone",
          "type": "DRUG"
        },
        {
          "name": "phase 2A Chlorthalidone + Spironolactone",
          "type": "DRUG"
        },
        {
          "name": "phase 2B Chlorthalidone LD + Spironolactone LD",
          "type": "DRUG"
        }
      ],
      "intervention_types": [
        "DRUG"
      ],
      "sponsor": "VA Office of Research and Development",
      "sponsor_class": "FED",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": "90 Years",
        "sex": "ALL",
        "summary": "18 Years to 90 Years"
      },
      "enrollment_count": 160,
      "start_date": "2026-10-01",
      "completion_date": "2032-06-30",
      "has_results": false,
      "last_update_posted_date": "2026-06-12",
      "last_synced_at": "2026-09-23T22:52:21.080Z",
      "location_count": 1,
      "location_summary": "Indianapolis, Indiana",
      "locations": [
        {
          "city": "Indianapolis",
          "state": "Indiana"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT07645300"
    },
    {
      "nct_id": "NCT00353652",
      "title": "Effects of Thiazide Diuretics on Sympathetic Nervous System in Hypertension",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE4"
      ],
      "conditions": [
        "Hypertension"
      ],
      "interventions": [
        {
          "name": "Study#1: chlorthalidone (CTD), titrated dose",
          "type": "DRUG"
        },
        {
          "name": "Study #1: spironolactone (SP), titrated dose",
          "type": "DRUG"
        },
        {
          "name": "Study# 2 chlorthalidone (CTD), fixed dose",
          "type": "DRUG"
        },
        {
          "name": "Study# 2 spironolactone (SP), fixed dose",
          "type": "DRUG"
        },
        {
          "name": "Study# 2 irbsesartan (IR), fixed dose",
          "type": "DRUG"
        }
      ],
      "intervention_types": [
        "DRUG"
      ],
      "sponsor": "University of Texas Southwestern Medical Center",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": "65 Years",
        "sex": "ALL",
        "summary": "18 Years to 65 Years"
      },
      "enrollment_count": 166,
      "start_date": "2005-01",
      "completion_date": "2013-01",
      "has_results": true,
      "last_update_posted_date": "2019-02-06",
      "last_synced_at": "2026-09-23T22:52:21.080Z",
      "location_count": 2,
      "location_summary": "Dallas, Texas",
      "locations": [
        {
          "city": "Dallas",
          "state": "Texas"
        },
        {
          "city": "Dallas",
          "state": "Texas"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT00353652"
    }
  ]
}