{
  "api_version": "1",
  "request": {
    "url": "https://clinicaltrialsfind.com/api/v1/search.json?intervention=Cigarette+Reduced+Nicotine",
    "query": {
      "intervention": "Cigarette Reduced Nicotine"
    },
    "page_size": 10
  },
  "pagination": {
    "page": 1,
    "page_size": 10,
    "total_count": 123,
    "total_pages": 13,
    "next_page_url": "https://clinicaltrialsfind.com/api/v1/search.json?intervention=Cigarette+Reduced+Nicotine&page=2&page_size=10",
    "previous_page_url": null
  },
  "source": "remote",
  "last_synced_at": "2026-09-13T10:56:15.918Z",
  "attribution": "Data derived from public ClinicalTrials.gov records. The official record at https://clinicaltrials.gov/ remains the source of truth for current availability, contacts, and full study details.",
  "notes": [
    "This endpoint exposes only public summary fields — no participant contact emails, phone numbers, or scraped investigator contact details.",
    "For contact information and full protocol detail, follow each trial's `official_url` to the ClinicalTrials.gov record.",
    "This API is a navigational aid. It does not provide medical advice, eligibility determinations, or compensation guarantees."
  ],
  "trials": [
    {
      "nct_id": "NCT05370313",
      "title": "The Impact of Innovative Tax Proposals on Purchase Patterns",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Cigarette Smoking"
      ],
      "interventions": [
        {
          "name": "Market Price Condition (control)",
          "type": "BEHAVIORAL"
        },
        {
          "name": "Tobacco Parity Tax Condition",
          "type": "BEHAVIORAL"
        },
        {
          "name": "Nicotine-Content Tax Condition",
          "type": "BEHAVIORAL"
        },
        {
          "name": "Harm-Reduction Tax Condition",
          "type": "BEHAVIORAL"
        },
        {
          "name": "Modified Risk Tobacco Product (MRTP) Tax Condition",
          "type": "BEHAVIORAL"
        }
      ],
      "intervention_types": [
        "BEHAVIORAL"
      ],
      "sponsor": "Virginia Polytechnic Institute and State University",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "21 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "21 Years and older"
      },
      "enrollment_count": 285,
      "start_date": "2023-04-11",
      "completion_date": "2025-06-10",
      "has_results": false,
      "last_update_posted_date": "2025-09-18",
      "last_synced_at": "2026-09-13T10:56:15.918Z",
      "location_count": 2,
      "location_summary": "Buffalo, New York • Roanoke, Virginia",
      "locations": [
        {
          "city": "Buffalo",
          "state": "New York"
        },
        {
          "city": "Roanoke",
          "state": "Virginia"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT05370313"
    },
    {
      "nct_id": "NCT02592772",
      "title": "Manipulating Tobacco Constituents in Male Menthol Smokers",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Nicotine Dependence"
      ],
      "interventions": [
        {
          "name": "Reduced Nicotine Non-Menthol (RNC)",
          "type": "OTHER"
        },
        {
          "name": "Reduced Nicotine Menthol (RNC-Men)",
          "type": "OTHER"
        },
        {
          "name": "Conventional Nicotine Non-Menthol (CN)",
          "type": "OTHER"
        }
      ],
      "intervention_types": [
        "OTHER"
      ],
      "sponsor": "UConn Health",
      "sponsor_class": "OTHER",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": "45 Years",
        "sex": "MALE",
        "summary": "18 Years to 45 Years · Male only"
      },
      "enrollment_count": 118,
      "start_date": "2016-02-04",
      "completion_date": "2019-06",
      "has_results": false,
      "last_update_posted_date": "2020-04-09",
      "last_synced_at": "2026-09-13T10:56:15.918Z",
      "location_count": 2,
      "location_summary": "Farmington, Connecticut • Hartford, Connecticut",
      "locations": [
        {
          "city": "Farmington",
          "state": "Connecticut"
        },
        {
          "city": "Hartford",
          "state": "Connecticut"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT02592772"
    },
    {
      "nct_id": "NCT06554873",
      "title": "Adaptive Use of Nicotine Substitution to Maintain Smoking Reduction/Abstinence in Nicotine Responders",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE3"
      ],
      "conditions": [
        "Smoking Cessation",
        "Harm Reduction"
      ],
      "interventions": [
        {
          "name": "Nicoderm",
          "type": "DRUG"
        },
        {
          "name": "Nicorette 4Mg Chewing Gum",
          "type": "DRUG"
        },
        {
          "name": "Nicorette Lozenge Product",
          "type": "DRUG"
        },
        {
          "name": "NJOY e-cigarette",
          "type": "OTHER"
        },
        {
          "name": "on!",
          "type": "OTHER"
        }
      ],
      "intervention_types": [
        "DRUG",
        "OTHER"
      ],
      "sponsor": "Rose Research Center, LLC",
      "sponsor_class": "INDUSTRY",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "22 Years",
        "maximum_age": "65 Years",
        "sex": "ALL",
        "summary": "22 Years to 65 Years"
      },
      "enrollment_count": 150,
      "start_date": "2024-08-29",
      "completion_date": "2025-12-09",
      "has_results": false,
      "last_update_posted_date": "2026-02-06",
      "last_synced_at": "2026-09-13T10:56:15.918Z",
      "location_count": 2,
      "location_summary": "Charlotte, North Carolina • Raleigh, North Carolina",
      "locations": [
        {
          "city": "Charlotte",
          "state": "North Carolina"
        },
        {
          "city": "Raleigh",
          "state": "North Carolina"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT06554873"
    },
    {
      "nct_id": "NCT02232737",
      "title": "Project 3, Study 2: Extended Exposure to Low Nicotine Content Cigarettes in People With Current Affective Disorders",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE1",
        "PHASE2"
      ],
      "conditions": [
        "Tobacco Use Disorder"
      ],
      "interventions": [
        {
          "name": "Very low nicotine content cigarettes",
          "type": "OTHER"
        }
      ],
      "intervention_types": [
        "OTHER"
      ],
      "sponsor": "Brown University",
      "sponsor_class": "OTHER",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": "70 Years",
        "sex": "ALL",
        "summary": "18 Years to 70 Years"
      },
      "enrollment_count": 775,
      "start_date": "2016-10-07",
      "completion_date": "2019-01-14",
      "has_results": true,
      "last_update_posted_date": "2022-12-07",
      "last_synced_at": "2026-09-13T10:56:15.918Z",
      "location_count": 2,
      "location_summary": "Providence, Rhode Island • Burlington, Vermont",
      "locations": [
        {
          "city": "Providence",
          "state": "Rhode Island"
        },
        {
          "city": "Burlington",
          "state": "Vermont"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT02232737"
    },
    {
      "nct_id": "NCT04523948",
      "title": "Comparative Tobacco Interventions for Individuals With Severe and Persisting Behavioral Health Disorders",
      "overall_status": "UNKNOWN",
      "study_type": "OBSERVATIONAL",
      "phases": [],
      "conditions": [
        "Tobacco Use"
      ],
      "interventions": [
        {
          "name": "Behavioral and pharmacological support to reduce combustible tobacco use.",
          "type": "BEHAVIORAL"
        }
      ],
      "intervention_types": [
        "BEHAVIORAL"
      ],
      "sponsor": "Rose Research Center, LLC",
      "sponsor_class": "INDUSTRY",
      "healthy_volunteers": null,
      "eligibility": {
        "minimum_age": "21 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "21 Years and older"
      },
      "enrollment_count": 100,
      "start_date": "2020-01-30",
      "completion_date": "2023-07-31",
      "has_results": false,
      "last_update_posted_date": "2021-09-28",
      "last_synced_at": "2026-09-13T10:56:15.918Z",
      "location_count": 1,
      "location_summary": "San Francisco, California",
      "locations": [
        {
          "city": "San Francisco",
          "state": "California"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT04523948"
    },
    {
      "nct_id": "NCT02870218",
      "title": "Abuse Liability of Reduced Nicotine Content Cigarettes in the Context of Concurrent E-Cigarette Use",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE2"
      ],
      "conditions": [
        "Nicotine Addiction",
        "Cigarette Smoking"
      ],
      "interventions": [
        {
          "name": "Smoking research cigarettes with e-cigarette",
          "type": "DRUG"
        },
        {
          "name": "Nicotine discrimination thresholds",
          "type": "DRUG"
        }
      ],
      "intervention_types": [
        "DRUG"
      ],
      "sponsor": "Rose Research Center, LLC",
      "sponsor_class": "INDUSTRY",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "21 Years",
        "maximum_age": "65 Years",
        "sex": "ALL",
        "summary": "21 Years to 65 Years"
      },
      "enrollment_count": 150,
      "start_date": "2019-05-01",
      "completion_date": "2021-07-28",
      "has_results": false,
      "last_update_posted_date": "2022-01-14",
      "last_synced_at": "2026-09-13T10:56:15.918Z",
      "location_count": 2,
      "location_summary": "Charlotte, North Carolina • Raleigh, North Carolina",
      "locations": [
        {
          "city": "Charlotte",
          "state": "North Carolina"
        },
        {
          "city": "Raleigh",
          "state": "North Carolina"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT02870218"
    },
    {
      "nct_id": "NCT06072547",
      "title": "Effect of Flavored on!® Nicotine Pouch Products on Smoking Behaviors: a SMART Study",
      "overall_status": "UNKNOWN",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Cigarette Smoking Behavior"
      ],
      "interventions": [
        {
          "name": "Access to all varieties of on! 4mg nicotine pouches (Berry, Citrus, Cinnamon, Wintergreen, Mint, Coffee, and Original)",
          "type": "OTHER"
        },
        {
          "name": "Access to Original on! 4mg nicotine pouches",
          "type": "OTHER"
        },
        {
          "name": "Non-Flavored then complete flavor on! nicotine pouches",
          "type": "OTHER"
        }
      ],
      "intervention_types": [
        "OTHER"
      ],
      "sponsor": "Altria Client Services LLC",
      "sponsor_class": "INDUSTRY",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "22 Years",
        "maximum_age": "65 Years",
        "sex": "ALL",
        "summary": "22 Years to 65 Years"
      },
      "enrollment_count": 400,
      "start_date": "2023-09-11",
      "completion_date": "2025-06",
      "has_results": false,
      "last_update_posted_date": "2024-07-11",
      "last_synced_at": "2026-09-13T10:56:15.918Z",
      "location_count": 1,
      "location_summary": "Raleigh, North Carolina",
      "locations": [
        {
          "city": "Raleigh",
          "state": "North Carolina"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT06072547"
    },
    {
      "nct_id": "NCT01989923",
      "title": "Smoking Cessation in Women With Gynecological Conditions",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Cervical Dysplasia"
      ],
      "interventions": [
        {
          "name": "Nicotine Replacement Therapy",
          "type": "OTHER"
        },
        {
          "name": "Electronic Cigarettes",
          "type": "DEVICE"
        }
      ],
      "intervention_types": [
        "OTHER",
        "DEVICE"
      ],
      "sponsor": "University of Oklahoma",
      "sponsor_class": "OTHER",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": "65 Years",
        "sex": "FEMALE",
        "summary": "18 Years to 65 Years · Female only"
      },
      "enrollment_count": 31,
      "start_date": "2013-06",
      "completion_date": "2017-04-13",
      "has_results": false,
      "last_update_posted_date": "2026-04-07",
      "last_synced_at": "2026-09-13T10:56:15.918Z",
      "location_count": 1,
      "location_summary": "Oklahoma City, Oklahoma",
      "locations": [
        {
          "city": "Oklahoma City",
          "state": "Oklahoma"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT01989923"
    },
    {
      "nct_id": "NCT03272685",
      "title": "Impact of Very Low Nicotine Content Cigarettes in a Complex Marketplace",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE3"
      ],
      "conditions": [
        "Tobacco Smoking",
        "Nicotine Dependence"
      ],
      "interventions": [
        {
          "name": "Very Low Nicotine Content Cigarettes",
          "type": "DRUG"
        },
        {
          "name": "Normal Nicotine Content Cigarettes",
          "type": "DRUG"
        }
      ],
      "intervention_types": [
        "DRUG"
      ],
      "sponsor": "University of Minnesota",
      "sponsor_class": "OTHER",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "21 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "21 Years and older"
      },
      "enrollment_count": 799,
      "start_date": "2018-06-01",
      "completion_date": "2023-01-10",
      "has_results": true,
      "last_update_posted_date": "2024-08-20",
      "last_synced_at": "2026-09-13T10:56:15.918Z",
      "location_count": 6,
      "location_summary": "San Francisco, California • Minneapolis, Minnesota • Durham, North Carolina + 3 more",
      "locations": [
        {
          "city": "San Francisco",
          "state": "California"
        },
        {
          "city": "Minneapolis",
          "state": "Minnesota"
        },
        {
          "city": "Durham",
          "state": "North Carolina"
        },
        {
          "city": "Winston-Salem",
          "state": "North Carolina"
        },
        {
          "city": "Philadelphia",
          "state": "Pennsylvania"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT03272685"
    },
    {
      "nct_id": "NCT02048852",
      "title": "Manipulating Tobacco Constituents in Female Menthol Smokers",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Nicotine Dependence"
      ],
      "interventions": [
        {
          "name": "Reduced Nicotine Content- Non Menthol",
          "type": "OTHER"
        },
        {
          "name": "Reduced Nicotine Content- Menthol",
          "type": "OTHER"
        },
        {
          "name": "Conventional Nicotine Content- Menthol",
          "type": "OTHER"
        },
        {
          "name": "Conventional Nicotine Content- Non Menthol",
          "type": "OTHER"
        }
      ],
      "intervention_types": [
        "OTHER"
      ],
      "sponsor": "UConn Health",
      "sponsor_class": "OTHER",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": "45 Years",
        "sex": "FEMALE",
        "summary": "18 Years to 45 Years · Female only"
      },
      "enrollment_count": 381,
      "start_date": "2014-07",
      "completion_date": "2020-07",
      "has_results": false,
      "last_update_posted_date": "2021-03-19",
      "last_synced_at": "2026-09-13T10:56:15.918Z",
      "location_count": 2,
      "location_summary": "Farmington, Connecticut • Hartford, Connecticut",
      "locations": [
        {
          "city": "Farmington",
          "state": "Connecticut"
        },
        {
          "city": "Hartford",
          "state": "Connecticut"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT02048852"
    }
  ]
}