{
  "api_version": "1",
  "request": {
    "url": "https://clinicaltrialsfind.com/api/v1/search.json?intervention=Cigarette+Reduced+Nicotine&page=2",
    "query": {
      "intervention": "Cigarette Reduced Nicotine",
      "page": 2
    },
    "page_size": 10
  },
  "pagination": {
    "page": 2,
    "page_size": 10,
    "total_count": 123,
    "total_pages": 13,
    "next_page_url": "https://clinicaltrialsfind.com/api/v1/search.json?intervention=Cigarette+Reduced+Nicotine&page=3&page_size=10",
    "previous_page_url": "https://clinicaltrialsfind.com/api/v1/search.json?intervention=Cigarette+Reduced+Nicotine&page=1&page_size=10"
  },
  "source": "remote",
  "last_synced_at": "2026-09-30T08:03:35.529Z",
  "attribution": "Data derived from public ClinicalTrials.gov records. The official record at https://clinicaltrials.gov/ remains the source of truth for current availability, contacts, and full study details.",
  "notes": [
    "This endpoint exposes only public summary fields — no participant contact emails, phone numbers, or scraped investigator contact details.",
    "For contact information and full protocol detail, follow each trial's `official_url` to the ClinicalTrials.gov record.",
    "This API is a navigational aid. It does not provide medical advice, eligibility determinations, or compensation guarantees."
  ],
  "trials": [
    {
      "nct_id": "NCT02378714",
      "title": "Behavioral Activation and Varenicline for Smoking Cessation in Depressed Smokers",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE4"
      ],
      "conditions": [
        "Nicotine Dependence",
        "Major Depressive Disorder"
      ],
      "interventions": [
        {
          "name": "Varenicline",
          "type": "DRUG"
        },
        {
          "name": "BASC",
          "type": "BEHAVIORAL"
        },
        {
          "name": "Standard treatment",
          "type": "BEHAVIORAL"
        }
      ],
      "intervention_types": [
        "DRUG",
        "BEHAVIORAL"
      ],
      "sponsor": "Northwestern University",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "18 Years and older"
      },
      "enrollment_count": 300,
      "start_date": "2015-07-24",
      "completion_date": "2020-03-13",
      "has_results": true,
      "last_update_posted_date": "2021-07-29",
      "last_synced_at": "2026-09-30T08:03:35.529Z",
      "location_count": 2,
      "location_summary": "Chicago, Illinois • Philadelphia, Pennsylvania",
      "locations": [
        {
          "city": "Chicago",
          "state": "Illinois"
        },
        {
          "city": "Philadelphia",
          "state": "Pennsylvania"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT02378714"
    },
    {
      "nct_id": "NCT05506046",
      "title": "Messages About Reduced Nicotine in Combusted Tobacco Products",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Health Communication",
        "Smoking",
        "Smoking, Tobacco",
        "Smoking Behaviors",
        "Risk Behavior"
      ],
      "interventions": [
        {
          "name": "Reduced nicotine message exposure",
          "type": "BEHAVIORAL"
        },
        {
          "name": "Modified risk message exposure",
          "type": "BEHAVIORAL"
        },
        {
          "name": "Combined message exposure (reduced nicotine + modified risk)",
          "type": "BEHAVIORAL"
        },
        {
          "name": "Control message exposure",
          "type": "BEHAVIORAL"
        }
      ],
      "intervention_types": [
        "BEHAVIORAL"
      ],
      "sponsor": "Georgia State University",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "18 Years and older"
      },
      "enrollment_count": 1901,
      "start_date": "2022-10-12",
      "completion_date": "2023-02-28",
      "has_results": true,
      "last_update_posted_date": "2024-08-28",
      "last_synced_at": "2026-09-30T08:03:35.529Z",
      "location_count": 1,
      "location_summary": "Atlanta, Georgia",
      "locations": [
        {
          "city": "Atlanta",
          "state": "Georgia"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT05506046"
    },
    {
      "nct_id": "NCT06837220",
      "title": "Implementation of Tobacco Cessation Programming at Community Behavioral Health Sites",
      "overall_status": "RECRUITING",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Nicotine Use Disorder",
        "Smoking Cessation",
        "Smoking Cessation Intervention"
      ],
      "interventions": [
        {
          "name": "Enhanced Courage to Quit",
          "type": "BEHAVIORAL"
        }
      ],
      "intervention_types": [
        "BEHAVIORAL"
      ],
      "sponsor": "University of Chicago",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": "26 Years",
        "sex": "ALL",
        "summary": "18 Years to 26 Years"
      },
      "enrollment_count": 24,
      "start_date": "2026-07-20",
      "completion_date": "2027-05",
      "has_results": false,
      "last_update_posted_date": "2026-07-07",
      "last_synced_at": "2026-09-30T08:03:35.529Z",
      "location_count": 1,
      "location_summary": "Chicago, Illinois",
      "locations": [
        {
          "city": "Chicago",
          "state": "Illinois"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT06837220"
    },
    {
      "nct_id": "NCT05525078",
      "title": "Quit or Switch: E-cigarette Study",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Tobacco Use"
      ],
      "interventions": [
        {
          "name": "e-cigarette",
          "type": "BEHAVIORAL"
        },
        {
          "name": "Nicotine patch, Nicotine lozenge",
          "type": "OTHER"
        }
      ],
      "intervention_types": [
        "BEHAVIORAL",
        "OTHER"
      ],
      "sponsor": "Medical University of South Carolina",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "21 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "21 Years and older"
      },
      "enrollment_count": 30,
      "start_date": "2022-08-01",
      "completion_date": "2023-07-17",
      "has_results": true,
      "last_update_posted_date": "2024-04-26",
      "last_synced_at": "2026-09-30T08:03:35.529Z",
      "location_count": 1,
      "location_summary": "Charleston, South Carolina",
      "locations": [
        {
          "city": "Charleston",
          "state": "South Carolina"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT05525078"
    },
    {
      "nct_id": "NCT00711100",
      "title": "Evaluation of Oral Tobacco as a Harm Reduction Method for Smokers",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Tobacco Use Disorder"
      ],
      "interventions": [
        {
          "name": "Camel Snus",
          "type": "OTHER"
        },
        {
          "name": "Marlboro Snus",
          "type": "OTHER"
        },
        {
          "name": "Stonewall",
          "type": "OTHER"
        },
        {
          "name": "Ariva",
          "type": "OTHER"
        },
        {
          "name": "General Snus",
          "type": "OTHER"
        }
      ],
      "intervention_types": [
        "OTHER"
      ],
      "sponsor": "University of Minnesota",
      "sponsor_class": "OTHER",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": "70 Years",
        "sex": "ALL",
        "summary": "18 Years to 70 Years"
      },
      "enrollment_count": 104,
      "start_date": "2008-08",
      "completion_date": "2010-12",
      "has_results": true,
      "last_update_posted_date": "2019-11-18",
      "last_synced_at": "2026-09-30T08:03:35.529Z",
      "location_count": 2,
      "location_summary": "Minneapolis, Minnesota • Eugene, Oregon",
      "locations": [
        {
          "city": "Minneapolis",
          "state": "Minnesota"
        },
        {
          "city": "Eugene",
          "state": "Oregon"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT00711100"
    },
    {
      "nct_id": "NCT06474299",
      "title": "The Avenues Study: Dual Use Cessation",
      "overall_status": "RECRUITING",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE4"
      ],
      "conditions": [
        "Smoking Cessation",
        "Electronic Cigarette Use"
      ],
      "interventions": [
        {
          "name": "Varenicline",
          "type": "DRUG"
        },
        {
          "name": "Nicotine patch",
          "type": "DRUG"
        },
        {
          "name": "Dual Focused Cessation Counseling",
          "type": "BEHAVIORAL"
        },
        {
          "name": "Smoking Focused Cessation Counseling",
          "type": "BEHAVIORAL"
        },
        {
          "name": "Counseling Intensity: 1 Session",
          "type": "OTHER"
        },
        {
          "name": "Counseling Intensity: 4 Sessions",
          "type": "OTHER"
        }
      ],
      "intervention_types": [
        "DRUG",
        "BEHAVIORAL",
        "OTHER"
      ],
      "sponsor": "University of Wisconsin, Madison",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "21 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "21 Years and older"
      },
      "enrollment_count": 500,
      "start_date": "2024-09-24",
      "completion_date": "2028-07",
      "has_results": false,
      "last_update_posted_date": "2026-04-13",
      "last_synced_at": "2026-09-30T08:03:35.529Z",
      "location_count": 1,
      "location_summary": "Madison, Wisconsin",
      "locations": [
        {
          "city": "Madison",
          "state": "Wisconsin"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT06474299"
    },
    {
      "nct_id": "NCT06372899",
      "title": "Noncombustible Nicotine Delivery Systems as Potential Harm Reduction Tools for Persistent Cigarette Smokers",
      "overall_status": "RECRUITING",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "E-cigarette Use",
        "Cigarette Smoking",
        "Harm Reduction",
        "Tobacco Use"
      ],
      "interventions": [
        {
          "name": "E-cigarettes",
          "type": "OTHER"
        },
        {
          "name": "Oral nicotine pouches",
          "type": "OTHER"
        }
      ],
      "intervention_types": [
        "OTHER"
      ],
      "sponsor": "Abramson Cancer Center at Penn Medicine",
      "sponsor_class": "OTHER",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "21 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "21 Years and older"
      },
      "enrollment_count": 200,
      "start_date": "2024-10-02",
      "completion_date": "2028-03-31",
      "has_results": false,
      "last_update_posted_date": "2026-03-12",
      "last_synced_at": "2026-09-30T08:03:35.529Z",
      "location_count": 1,
      "location_summary": "Philadelphia, Pennsylvania",
      "locations": [
        {
          "city": "Philadelphia",
          "state": "Pennsylvania"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT06372899"
    },
    {
      "nct_id": "NCT02139930",
      "title": "Project 2: Strategies for Reducing Nicotine Content in Cigarettes",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Nicotine Dependence",
        "Tobacco Smoking"
      ],
      "interventions": [
        {
          "name": "Normal Nicotine Control Group",
          "type": "BEHAVIORAL"
        },
        {
          "name": "Immediate Nicotine Reduction Group",
          "type": "BEHAVIORAL"
        },
        {
          "name": "Gradual Nicotine Reduction Group",
          "type": "BEHAVIORAL"
        }
      ],
      "intervention_types": [
        "BEHAVIORAL"
      ],
      "sponsor": "Wake Forest University Health Sciences",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "18 Years and older"
      },
      "enrollment_count": 1250,
      "start_date": "2014-09",
      "completion_date": "2017-03-14",
      "has_results": false,
      "last_update_posted_date": "2018-08-15",
      "last_synced_at": "2026-09-30T08:03:35.529Z",
      "location_count": 10,
      "location_summary": "Phoenix, Arizona • San Francisco, California • Tampa, Florida + 7 more",
      "locations": [
        {
          "city": "Phoenix",
          "state": "Arizona"
        },
        {
          "city": "San Francisco",
          "state": "California"
        },
        {
          "city": "Tampa",
          "state": "Florida"
        },
        {
          "city": "Baltimore",
          "state": "Maryland"
        },
        {
          "city": "Duluth",
          "state": "Minnesota"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT02139930"
    },
    {
      "nct_id": "NCT01372254",
      "title": "Behavioral Intervention for Low Income Depressed Smokers in Drug Treatment",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE1",
        "PHASE2"
      ],
      "conditions": [
        "Cigarette Smoking",
        "Drug Use"
      ],
      "interventions": [
        {
          "name": "Standard Treatment",
          "type": "BEHAVIORAL"
        },
        {
          "name": "BAD-AS",
          "type": "BEHAVIORAL"
        },
        {
          "name": "Transdermal Nicotine Patch",
          "type": "DRUG"
        }
      ],
      "intervention_types": [
        "BEHAVIORAL",
        "DRUG"
      ],
      "sponsor": "University of Maryland, College Park",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": "65 Years",
        "sex": "ALL",
        "summary": "18 Years to 65 Years"
      },
      "enrollment_count": 96,
      "start_date": "2011-12",
      "completion_date": "2015-05",
      "has_results": true,
      "last_update_posted_date": "2022-05-18",
      "last_synced_at": "2026-09-30T08:03:35.529Z",
      "location_count": 1,
      "location_summary": "Washington D.C., District of Columbia",
      "locations": [
        {
          "city": "Washington D.C.",
          "state": "District of Columbia"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT01372254"
    },
    {
      "nct_id": "NCT06472869",
      "title": "Assessing E-Cigarettes for Tobacco Harm Reduction in the Context of Lung Cancer Screening",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Electronic Cigarette Use",
        "Smoking, Cigarette",
        "Nicotine Dependence"
      ],
      "interventions": [
        {
          "name": "NJOY ACE e-cigarette",
          "type": "OTHER"
        }
      ],
      "intervention_types": [
        "OTHER"
      ],
      "sponsor": "Massachusetts General Hospital",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "50 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "50 Years and older"
      },
      "enrollment_count": 15,
      "start_date": "2024-09-23",
      "completion_date": "2025-12-30",
      "has_results": true,
      "last_update_posted_date": "2026-01-16",
      "last_synced_at": "2026-09-30T08:03:35.529Z",
      "location_count": 1,
      "location_summary": "Boston, Massachusetts",
      "locations": [
        {
          "city": "Boston",
          "state": "Massachusetts"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT06472869"
    }
  ]
}