{
  "api_version": "1",
  "request": {
    "url": "https://clinicaltrialsfind.com/api/v1/search.json?intervention=Circadin&page=5",
    "query": {
      "intervention": "Circadin",
      "page": 5
    },
    "page_size": 10
  },
  "pagination": {
    "page": 5,
    "page_size": 10,
    "total_count": 208,
    "total_pages": 21,
    "next_page_url": "https://clinicaltrialsfind.com/api/v1/search.json?intervention=Circadin&page=6&page_size=10",
    "previous_page_url": "https://clinicaltrialsfind.com/api/v1/search.json?intervention=Circadin&page=4&page_size=10"
  },
  "source": "remote",
  "last_synced_at": "2026-11-07T20:07:23.688Z",
  "attribution": "Data derived from public ClinicalTrials.gov records. The official record at https://clinicaltrials.gov/ remains the source of truth for current availability, contacts, and full study details.",
  "notes": [
    "This endpoint exposes only public summary fields — no participant contact emails, phone numbers, or scraped investigator contact details.",
    "For contact information and full protocol detail, follow each trial's `official_url` to the ClinicalTrials.gov record.",
    "This API is a navigational aid. It does not provide medical advice, eligibility determinations, or compensation guarantees."
  ],
  "trials": [
    {
      "nct_id": "NCT07840560",
      "title": "Sleep Harmonization Via Bundled Team-Based Interventions in the ICU",
      "overall_status": "NOT_YET_RECRUITING",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Sleep Deprivation",
        "Critical Illness",
        "Sleep-Wake Disorders",
        "Bundle Care",
        "Implementation Science",
        "Delirium"
      ],
      "interventions": [
        {
          "name": "Nighttime noise & light reduction",
          "type": "BEHAVIORAL"
        },
        {
          "name": "Clustering patient-care interactions",
          "type": "BEHAVIORAL"
        },
        {
          "name": "Non-pharmacologic sleep aids",
          "type": "BEHAVIORAL"
        },
        {
          "name": "Daytime light exposure",
          "type": "BEHAVIORAL"
        },
        {
          "name": "Encourage out-of-bed activity",
          "type": "BEHAVIORAL"
        },
        {
          "name": "Medication management to support nighttime sleep",
          "type": "OTHER"
        }
      ],
      "intervention_types": [
        "BEHAVIORAL",
        "OTHER"
      ],
      "sponsor": "University of California, San Diego",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "18 Years and older"
      },
      "enrollment_count": 62500,
      "start_date": "2026-10-01",
      "completion_date": "2031-03",
      "has_results": false,
      "last_update_posted_date": "2026-09-25",
      "last_synced_at": "2026-11-07T20:07:23.688Z",
      "location_count": 7,
      "location_summary": "La Jolla, California • San Francisco, California • Orlando, Florida + 4 more",
      "locations": [
        {
          "city": "La Jolla",
          "state": "California"
        },
        {
          "city": "San Francisco",
          "state": "California"
        },
        {
          "city": "Orlando",
          "state": "Florida"
        },
        {
          "city": "Boston",
          "state": "Massachusetts"
        },
        {
          "city": "Nashville",
          "state": "Tennessee"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT07840560"
    },
    {
      "nct_id": "NCT03178396",
      "title": "Effects and Mechanisms of Melatonin on Blood Pressure, Insulin Resistance, and Platelets",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Prehypertension",
        "Healthy"
      ],
      "interventions": [
        {
          "name": "melatonin",
          "type": "DIETARY_SUPPLEMENT"
        }
      ],
      "intervention_types": [
        "DIETARY_SUPPLEMENT"
      ],
      "sponsor": "Thomas Jefferson University",
      "sponsor_class": "OTHER",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "18 Years and older"
      },
      "enrollment_count": 31,
      "start_date": "2015-12-07",
      "completion_date": "2016-08-09",
      "has_results": false,
      "last_update_posted_date": "2017-06-08",
      "last_synced_at": "2026-11-07T20:07:23.688Z",
      "location_count": 1,
      "location_summary": "Philadelphia, Pennsylvania",
      "locations": [
        {
          "city": "Philadelphia",
          "state": "Pennsylvania"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT03178396"
    },
    {
      "nct_id": "NCT05829044",
      "title": "Impact of Sex and Age on Non-visual Light Input That Affects Sleep and Circadian Rhythms",
      "overall_status": "RECRUITING",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Normal Physiology"
      ],
      "interventions": [
        {
          "name": "Pupillometry",
          "type": "DEVICE"
        },
        {
          "name": "Light box exposure",
          "type": "DEVICE"
        }
      ],
      "intervention_types": [
        "DEVICE"
      ],
      "sponsor": "Massachusetts General Hospital",
      "sponsor_class": "OTHER",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": "85 Years",
        "sex": "ALL",
        "summary": "18 Years to 85 Years"
      },
      "enrollment_count": 48,
      "start_date": "2023-12-01",
      "completion_date": "2027-06-30",
      "has_results": false,
      "last_update_posted_date": "2026-07-13",
      "last_synced_at": "2026-11-07T20:07:23.688Z",
      "location_count": 1,
      "location_summary": "Boston, Massachusetts",
      "locations": [
        {
          "city": "Boston",
          "state": "Massachusetts"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT05829044"
    },
    {
      "nct_id": "NCT06292000",
      "title": "Examining the Effects of Morning and Evening Exercise on Glucose Regulation in Adults With Prediabetes",
      "overall_status": "WITHDRAWN",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "PreDiabetes",
        "Obesity",
        "Inactivity/Low Levels of Exercise"
      ],
      "interventions": [
        {
          "name": "AM Exercise",
          "type": "BEHAVIORAL"
        },
        {
          "name": "PM Exercise",
          "type": "BEHAVIORAL"
        }
      ],
      "intervention_types": [
        "BEHAVIORAL"
      ],
      "sponsor": "University of Colorado, Denver",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "20 Years",
        "maximum_age": "40 Years",
        "sex": "ALL",
        "summary": "20 Years to 40 Years"
      },
      "enrollment_count": 0,
      "start_date": "2024-02-01",
      "completion_date": "2026-06",
      "has_results": false,
      "last_update_posted_date": "2025-12-24",
      "last_synced_at": "2026-11-07T20:07:23.688Z",
      "location_count": 1,
      "location_summary": "Aurora, Colorado",
      "locations": [
        {
          "city": "Aurora",
          "state": "Colorado"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT06292000"
    },
    {
      "nct_id": "NCT07542756",
      "title": "A SMART Approach to Evaluating the Benefits of Common Prescription and OTC Medications for Insomnia",
      "overall_status": "RECRUITING",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE4"
      ],
      "conditions": [
        "Insomnia",
        "Insomnia Disorder",
        "Chronic Insomnia",
        "Chronic Insomnia Disorder"
      ],
      "interventions": [
        {
          "name": "Sleep Hygiene Education",
          "type": "OTHER"
        },
        {
          "name": "Melatonin IR, 3 mg",
          "type": "DIETARY_SUPPLEMENT"
        },
        {
          "name": "Melatonin IR, 5 mg",
          "type": "DIETARY_SUPPLEMENT"
        },
        {
          "name": "Diphenhydramine, 25 mg",
          "type": "DRUG"
        },
        {
          "name": "Diphenhydramine, 50 mg",
          "type": "DRUG"
        },
        {
          "name": "Doxepin, 3 mg",
          "type": "DRUG"
        },
        {
          "name": "Doxepin, 6 mg",
          "type": "DRUG"
        },
        {
          "name": "Trazodone, 50 mg",
          "type": "DRUG"
        },
        {
          "name": "Trazodone, 100 mg",
          "type": "DRUG"
        },
        {
          "name": "Placebo",
          "type": "DRUG"
        },
        {
          "name": "Zolpidem, 5 mg",
          "type": "DRUG"
        },
        {
          "name": "Zolpidem, 10 mg",
          "type": "DRUG"
        }
      ],
      "intervention_types": [
        "OTHER",
        "DIETARY_SUPPLEMENT",
        "DRUG"
      ],
      "sponsor": "University of Pennsylvania",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": "80 Years",
        "sex": "ALL",
        "summary": "18 Years to 80 Years"
      },
      "enrollment_count": 1200,
      "start_date": "2026-05-01",
      "completion_date": "2032-01-01",
      "has_results": false,
      "last_update_posted_date": "2026-09-16",
      "last_synced_at": "2026-11-07T20:07:23.688Z",
      "location_count": 1,
      "location_summary": "Philadelphia, Pennsylvania",
      "locations": [
        {
          "city": "Philadelphia",
          "state": "Pennsylvania"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT07542756"
    },
    {
      "nct_id": "NCT04932096",
      "title": "Sleep Management And Recovery After Traumatic Brain Injury in Kids: Pilot Intervention of Melatonin",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE2"
      ],
      "conditions": [
        "Traumatic Brain Injury",
        "Critical Illness",
        "Sleep"
      ],
      "interventions": [
        {
          "name": "melatonin",
          "type": "DRUG"
        },
        {
          "name": "placebo",
          "type": "OTHER"
        }
      ],
      "intervention_types": [
        "DRUG",
        "OTHER"
      ],
      "sponsor": "Oregon Health and Science University",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "6 Years",
        "maximum_age": "18 Years",
        "sex": "ALL",
        "summary": "6 Years to 18 Years"
      },
      "enrollment_count": 21,
      "start_date": "2023-01-02",
      "completion_date": "2025-03-01",
      "has_results": true,
      "last_update_posted_date": "2025-08-20",
      "last_synced_at": "2026-11-07T20:07:23.688Z",
      "location_count": 1,
      "location_summary": "Portland, Oregon",
      "locations": [
        {
          "city": "Portland",
          "state": "Oregon"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT04932096"
    },
    {
      "nct_id": "NCT06694441",
      "title": "Noradrenergic Dysregulation, Sleep and Cognition in Older Adults With Insomnia",
      "overall_status": "RECRUITING",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Insomnia"
      ],
      "interventions": [
        {
          "name": "Light Exposure",
          "type": "OTHER"
        },
        {
          "name": "Placebo",
          "type": "OTHER"
        }
      ],
      "intervention_types": [
        "OTHER"
      ],
      "sponsor": "Northwestern University",
      "sponsor_class": "OTHER",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "55 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "55 Years and older"
      },
      "enrollment_count": 60,
      "start_date": "2024-09-30",
      "completion_date": "2029-08-31",
      "has_results": false,
      "last_update_posted_date": "2026-03-30",
      "last_synced_at": "2026-11-07T20:07:23.688Z",
      "location_count": 1,
      "location_summary": "Chicago, Illinois",
      "locations": [
        {
          "city": "Chicago",
          "state": "Illinois"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT06694441"
    },
    {
      "nct_id": "NCT06382610",
      "title": "Pharmacokinetics of Melatonin Administered in Oral, Lotion, and Bubble Bath Formulations",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Sleep"
      ],
      "interventions": [
        {
          "name": "Melatonin",
          "type": "DIETARY_SUPPLEMENT"
        }
      ],
      "intervention_types": [
        "DIETARY_SUPPLEMENT"
      ],
      "sponsor": "University of Redlands",
      "sponsor_class": "OTHER",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": "21 Years",
        "sex": "ALL",
        "summary": "18 Years to 21 Years"
      },
      "enrollment_count": 12,
      "start_date": "2024-05-19",
      "completion_date": "2026-07-31",
      "has_results": false,
      "last_update_posted_date": "2026-08-11",
      "last_synced_at": "2026-11-07T20:07:23.688Z",
      "location_count": 1,
      "location_summary": "Redlands, California",
      "locations": [
        {
          "city": "Redlands",
          "state": "California"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT06382610"
    },
    {
      "nct_id": "NCT02487082",
      "title": "Pilot Study of Sleep Therapy and Biomarkers in Children With Autism Spectrum Disorders",
      "overall_status": "TERMINATED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE2"
      ],
      "conditions": [
        "Autism Spectrum Disorder"
      ],
      "interventions": [
        {
          "name": "Melatonin and Donepezil",
          "type": "DRUG"
        },
        {
          "name": "Placebo",
          "type": "OTHER"
        }
      ],
      "intervention_types": [
        "DRUG",
        "OTHER"
      ],
      "sponsor": "Stony Brook University",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "4 Years",
        "maximum_age": "17 Years",
        "sex": "ALL",
        "summary": "4 Years to 17 Years"
      },
      "enrollment_count": 12,
      "start_date": "2015-06",
      "completion_date": "2021-01-29",
      "has_results": true,
      "last_update_posted_date": "2024-06-06",
      "last_synced_at": "2026-11-07T20:07:23.688Z",
      "location_count": 1,
      "location_summary": "Stony Brook, New York",
      "locations": [
        {
          "city": "Stony Brook",
          "state": "New York"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT02487082"
    },
    {
      "nct_id": "NCT01628029",
      "title": "Cognitive Behavioral Therapy and Multimodal Therapy in Treating Sleep Disturbance in Patients With Cancer",
      "overall_status": "ACTIVE_NOT_RECRUITING",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE2"
      ],
      "conditions": [
        "Hematopoietic and Lymphoid Cell Neoplasm",
        "Malignant Solid Neoplasm",
        "Sleep Disorder"
      ],
      "interventions": [
        {
          "name": "Counseling",
          "type": "OTHER"
        },
        {
          "name": "Methylphenidate Hydrochloride",
          "type": "DRUG"
        },
        {
          "name": "Phototherapy",
          "type": "PROCEDURE"
        },
        {
          "name": "Placebo Administration",
          "type": "OTHER"
        },
        {
          "name": "Quality-of-Life Assessment",
          "type": "OTHER"
        },
        {
          "name": "Sham Intervention",
          "type": "PROCEDURE"
        },
        {
          "name": "Therapeutic Melatonin",
          "type": "DRUG"
        }
      ],
      "intervention_types": [
        "OTHER",
        "DRUG",
        "PROCEDURE"
      ],
      "sponsor": "M.D. Anderson Cancer Center",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "18 Years and older"
      },
      "enrollment_count": 68,
      "start_date": "2014-01-15",
      "completion_date": "2028-12-31",
      "has_results": true,
      "last_update_posted_date": "2026-05-22",
      "last_synced_at": "2026-11-07T20:07:23.688Z",
      "location_count": 1,
      "location_summary": "Houston, Texas",
      "locations": [
        {
          "city": "Houston",
          "state": "Texas"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT01628029"
    }
  ]
}