{
  "api_version": "1",
  "request": {
    "url": "https://clinicaltrialsfind.com/api/v1/search.json?intervention=Circadin&page=7",
    "query": {
      "intervention": "Circadin",
      "page": 7
    },
    "page_size": 10
  },
  "pagination": {
    "page": 7,
    "page_size": 10,
    "total_count": 208,
    "total_pages": 21,
    "next_page_url": "https://clinicaltrialsfind.com/api/v1/search.json?intervention=Circadin&page=8&page_size=10",
    "previous_page_url": "https://clinicaltrialsfind.com/api/v1/search.json?intervention=Circadin&page=6&page_size=10"
  },
  "source": "remote",
  "last_synced_at": "2026-11-07T22:32:40.902Z",
  "attribution": "Data derived from public ClinicalTrials.gov records. The official record at https://clinicaltrials.gov/ remains the source of truth for current availability, contacts, and full study details.",
  "notes": [
    "This endpoint exposes only public summary fields — no participant contact emails, phone numbers, or scraped investigator contact details.",
    "For contact information and full protocol detail, follow each trial's `official_url` to the ClinicalTrials.gov record.",
    "This API is a navigational aid. It does not provide medical advice, eligibility determinations, or compensation guarantees."
  ],
  "trials": [
    {
      "nct_id": "NCT05521243",
      "title": "An Exploratory Investigation of a Supplement to Enhance Sleep Quality and Quantity",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Sleep",
        "Sleep Disturbance",
        "Sleep Hygiene"
      ],
      "interventions": [
        {
          "name": "Beam Organics Dream Powder",
          "type": "DIETARY_SUPPLEMENT"
        },
        {
          "name": "Beam Organics Dream Powder Extra Strength",
          "type": "DIETARY_SUPPLEMENT"
        },
        {
          "name": "Placebo",
          "type": "DIETARY_SUPPLEMENT"
        }
      ],
      "intervention_types": [
        "DIETARY_SUPPLEMENT"
      ],
      "sponsor": "Beam",
      "sponsor_class": "INDUSTRY",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "24 Years",
        "maximum_age": "50 Years",
        "sex": "ALL",
        "summary": "24 Years to 50 Years"
      },
      "enrollment_count": 64,
      "start_date": "2022-05-09",
      "completion_date": "2022-09-30",
      "has_results": false,
      "last_update_posted_date": "2022-11-08",
      "last_synced_at": "2026-11-07T22:32:40.902Z",
      "location_count": 1,
      "location_summary": "Santa Monica, California",
      "locations": [
        {
          "city": "Santa Monica",
          "state": "California"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT05521243"
    },
    {
      "nct_id": "NCT07769164",
      "title": "A Double-Blind, Randomized, Placebo-Controlled Study of the Safety and Effects of Various Cannabinoids on Sleep Quality",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Sleep Disturbance",
        "Sleep Quality"
      ],
      "interventions": [
        {
          "name": "2 mg THC + 2 mg CBN + 2 mg CBG + 10 mg CBD + 1 mg Melatonin",
          "type": "DIETARY_SUPPLEMENT"
        },
        {
          "name": "10 mg THC + 5 mg CBN + 5 mg CBG + 20 mg CBD",
          "type": "DIETARY_SUPPLEMENT"
        },
        {
          "name": "10 mg THC + 20 mg CBN + 5 mg CBG",
          "type": "DIETARY_SUPPLEMENT"
        },
        {
          "name": "Stay Asleep Placebo",
          "type": "DIETARY_SUPPLEMENT"
        },
        {
          "name": "Fast Asleep Placebo",
          "type": "DIETARY_SUPPLEMENT"
        }
      ],
      "intervention_types": [
        "DIETARY_SUPPLEMENT"
      ],
      "sponsor": "Cannabis Science Innovations, LLC",
      "sponsor_class": "INDUSTRY",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "21 Years",
        "maximum_age": "55 Years",
        "sex": "ALL",
        "summary": "21 Years to 55 Years"
      },
      "enrollment_count": 332,
      "start_date": "2023-12-01",
      "completion_date": "2024-08-31",
      "has_results": false,
      "last_update_posted_date": "2026-08-19",
      "last_synced_at": "2026-11-07T22:32:40.902Z",
      "location_count": 1,
      "location_summary": "Sarasota, Florida",
      "locations": [
        {
          "city": "Sarasota",
          "state": "Florida"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT07769164"
    },
    {
      "nct_id": "NCT03464084",
      "title": "Interaction of Melatonin With MTNR1B Genotype on Glucose Control - Study 2",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Glucose",
        "Circadian Rhythm",
        "Melatonin",
        "Genes",
        "Light"
      ],
      "interventions": [
        {
          "name": "placebo",
          "type": "DRUG"
        },
        {
          "name": "melatonin",
          "type": "DIETARY_SUPPLEMENT"
        },
        {
          "name": "bright light",
          "type": "OTHER"
        },
        {
          "name": "dim light",
          "type": "OTHER"
        }
      ],
      "intervention_types": [
        "DRUG",
        "DIETARY_SUPPLEMENT",
        "OTHER"
      ],
      "sponsor": "Brigham and Women's Hospital",
      "sponsor_class": "OTHER",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "21 Years",
        "maximum_age": "55 Years",
        "sex": "ALL",
        "summary": "21 Years to 55 Years"
      },
      "enrollment_count": 24,
      "start_date": "2018-02-17",
      "completion_date": "2022-07-19",
      "has_results": false,
      "last_update_posted_date": "2022-07-26",
      "last_synced_at": "2026-11-07T22:32:40.902Z",
      "location_count": 1,
      "location_summary": "Boston, Massachusetts",
      "locations": [
        {
          "city": "Boston",
          "state": "Massachusetts"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT03464084"
    },
    {
      "nct_id": "NCT02597231",
      "title": "Melatonin and Sleep in Preventing Delirium in the Hospital",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE1",
        "PHASE2"
      ],
      "conditions": [
        "Delirium"
      ],
      "interventions": [
        {
          "name": "Melatonin",
          "type": "DIETARY_SUPPLEMENT"
        },
        {
          "name": "Placebo",
          "type": "OTHER"
        }
      ],
      "intervention_types": [
        "DIETARY_SUPPLEMENT",
        "OTHER"
      ],
      "sponsor": "Scripps Health",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "65 Years",
        "maximum_age": "100 Years",
        "sex": "ALL",
        "summary": "65 Years to 100 Years"
      },
      "enrollment_count": 94,
      "start_date": "2015-11",
      "completion_date": "2016-12-31",
      "has_results": false,
      "last_update_posted_date": "2017-10-04",
      "last_synced_at": "2026-11-07T22:32:40.902Z",
      "location_count": 1,
      "location_summary": "La Jolla, California",
      "locations": [
        {
          "city": "La Jolla",
          "state": "California"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT02597231"
    },
    {
      "nct_id": "NCT04731974",
      "title": "Acute Concussion and Melatonin",
      "overall_status": "UNKNOWN",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE2"
      ],
      "conditions": [
        "Concussion, Mild",
        "Concussion, Brain",
        "Pediatric ALL"
      ],
      "interventions": [
        {
          "name": "Melatonin 3 MG",
          "type": "DRUG"
        },
        {
          "name": "Placebo",
          "type": "OTHER"
        }
      ],
      "intervention_types": [
        "DRUG",
        "OTHER"
      ],
      "sponsor": "Children's National Research Institute",
      "sponsor_class": "OTHER",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "12 Years",
        "maximum_age": "18 Years",
        "sex": "ALL",
        "summary": "12 Years to 18 Years"
      },
      "enrollment_count": 254,
      "start_date": "2023-03-01",
      "completion_date": "2024-06-30",
      "has_results": false,
      "last_update_posted_date": "2024-02-07",
      "last_synced_at": "2026-11-07T22:32:40.902Z",
      "location_count": 1,
      "location_summary": "Washington D.C., District of Columbia",
      "locations": [
        {
          "city": "Washington D.C.",
          "state": "District of Columbia"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT04731974"
    },
    {
      "nct_id": "NCT00869869",
      "title": "Melatonin Supplementation to Improve Sleep in Patients With Heart Failure",
      "overall_status": "WITHDRAWN",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE2"
      ],
      "conditions": [
        "Heart Failure",
        "Sleep Disorders"
      ],
      "interventions": [
        {
          "name": "melatonin",
          "type": "DRUG"
        },
        {
          "name": "placebo",
          "type": "DRUG"
        }
      ],
      "intervention_types": [
        "DRUG"
      ],
      "sponsor": "Brigham and Women's Hospital",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "35 Years",
        "maximum_age": "75 Years",
        "sex": "ALL",
        "summary": "35 Years to 75 Years"
      },
      "enrollment_count": 0,
      "start_date": "2009-03",
      "completion_date": "2011-03",
      "has_results": false,
      "last_update_posted_date": "2018-01-19",
      "last_synced_at": "2026-11-07T22:32:40.902Z",
      "location_count": 1,
      "location_summary": "Boston, Massachusetts",
      "locations": [
        {
          "city": "Boston",
          "state": "Massachusetts"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT00869869"
    },
    {
      "nct_id": "NCT06104280",
      "title": "Medications for Opioid Use Disorder Photosensitive Retinal Ganglion Cell Function, Sleep, and Circadian Rhythms: Implications for Treatment",
      "overall_status": "RECRUITING",
      "study_type": "OBSERVATIONAL",
      "phases": [],
      "conditions": [
        "Opioid Use Disorder",
        "Sleep Disturbance"
      ],
      "interventions": [
        {
          "name": "Post-Illumination Pupillary Response (PIPR)",
          "type": "OTHER"
        },
        {
          "name": "Polysomnography",
          "type": "OTHER"
        },
        {
          "name": "Multiple Sleep Latency Test",
          "type": "OTHER"
        },
        {
          "name": "Ecological Momentary Assessments",
          "type": "BEHAVIORAL"
        },
        {
          "name": "Actigraphy",
          "type": "DEVICE"
        },
        {
          "name": "DLMO",
          "type": "OTHER"
        },
        {
          "name": "Melatonin Suppression Test",
          "type": "OTHER"
        }
      ],
      "intervention_types": [
        "OTHER",
        "BEHAVIORAL",
        "DEVICE"
      ],
      "sponsor": "University of Alabama at Birmingham",
      "sponsor_class": "OTHER",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": "80 Years",
        "sex": "ALL",
        "summary": "18 Years to 80 Years"
      },
      "enrollment_count": 200,
      "start_date": "2025-01-06",
      "completion_date": "2029-01-01",
      "has_results": false,
      "last_update_posted_date": "2026-08-11",
      "last_synced_at": "2026-11-07T22:32:40.902Z",
      "location_count": 1,
      "location_summary": "Birmingham, Alabama",
      "locations": [
        {
          "city": "Birmingham",
          "state": "Alabama"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT06104280"
    },
    {
      "nct_id": "NCT00705003",
      "title": "Efficacy and Safety Study of a Combination Product [Drug:BCI-024 (Buspirone) and Drug:BCI-049 (Melatonin)] to Treat Major Depressive Disorder (MDD)",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE2"
      ],
      "conditions": [
        "Major Depressive Disorder"
      ],
      "interventions": [
        {
          "name": "BCI-024: over-encapsulated Buspirone tablet 15 mg QD and BCI-049: over-encapsulated Melatonin tablet 3 mg QD",
          "type": "DRUG"
        },
        {
          "name": "BCI-024 (Buspirone)",
          "type": "DRUG"
        },
        {
          "name": "Matching placebo",
          "type": "DRUG"
        }
      ],
      "intervention_types": [
        "DRUG"
      ],
      "sponsor": "Massachusetts General Hospital",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": "65 Years",
        "sex": "ALL",
        "summary": "18 Years to 65 Years"
      },
      "enrollment_count": 142,
      "start_date": "2008-05",
      "completion_date": "2008-12",
      "has_results": true,
      "last_update_posted_date": "2014-06-18",
      "last_synced_at": "2026-11-07T22:32:40.902Z",
      "location_count": 9,
      "location_summary": "Garden Grove, California • San Diego, California • Altanta, Georgia + 6 more",
      "locations": [
        {
          "city": "Garden Grove",
          "state": "California"
        },
        {
          "city": "San Diego",
          "state": "California"
        },
        {
          "city": "Altanta",
          "state": "Georgia"
        },
        {
          "city": "Rockville",
          "state": "Maryland"
        },
        {
          "city": "Beachwood",
          "state": "Ohio"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT00705003"
    },
    {
      "nct_id": "NCT00387179",
      "title": "Effectiveness of Combining Light and Non-Light Treatments for Jet Lag and Sleep Disorders",
      "overall_status": "UNKNOWN",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Sleep Disorders, Circadian Rhythm"
      ],
      "interventions": [
        {
          "name": "Melatonin",
          "type": "DRUG"
        },
        {
          "name": "Methylxanthine",
          "type": "DRUG"
        },
        {
          "name": "Light Therapy",
          "type": "PROCEDURE"
        }
      ],
      "intervention_types": [
        "DRUG",
        "PROCEDURE"
      ],
      "sponsor": "National Heart, Lung, and Blood Institute (NHLBI)",
      "sponsor_class": "NIH",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": "40 Years",
        "sex": "ALL",
        "summary": "18 Years to 40 Years"
      },
      "enrollment_count": 48,
      "start_date": "2006-10",
      "completion_date": "2010-03",
      "has_results": false,
      "last_update_posted_date": "2009-08-25",
      "last_synced_at": "2026-11-07T22:32:40.902Z",
      "location_count": 1,
      "location_summary": "Boulder, Colorado",
      "locations": [
        {
          "city": "Boulder",
          "state": "Colorado"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT00387179"
    },
    {
      "nct_id": "NCT04278677",
      "title": "Sleep Quality and Pain Medication Use Following Arthroscopic Rotator Cuff Repair",
      "overall_status": "UNKNOWN",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Sleep Disturbance"
      ],
      "interventions": [
        {
          "name": "melatonin",
          "type": "DIETARY_SUPPLEMENT"
        }
      ],
      "intervention_types": [
        "DIETARY_SUPPLEMENT"
      ],
      "sponsor": "Rothman Institute Orthopaedics",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "18 Years and older"
      },
      "enrollment_count": 80,
      "start_date": "2020-03",
      "completion_date": "2021-03",
      "has_results": false,
      "last_update_posted_date": "2020-02-20",
      "last_synced_at": "2026-11-07T22:32:40.902Z",
      "location_count": 1,
      "location_summary": "Egg Harbor, New Jersey",
      "locations": [
        {
          "city": "Egg Harbor",
          "state": "New Jersey"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT04278677"
    }
  ]
}