{
  "api_version": "1",
  "request": {
    "url": "https://clinicaltrialsfind.com/api/v1/search.json?intervention=Closed+loop+auditory+stimulation",
    "query": {
      "intervention": "Closed loop auditory stimulation"
    },
    "page_size": 10
  },
  "pagination": {
    "page": 1,
    "page_size": 10,
    "total_count": 14,
    "total_pages": 2,
    "next_page_url": "https://clinicaltrialsfind.com/api/v1/search.json?intervention=Closed+loop+auditory+stimulation&page=2&page_size=10",
    "previous_page_url": null
  },
  "source": "remote",
  "last_synced_at": "2026-09-06T06:18:26.503Z",
  "attribution": "Data derived from public ClinicalTrials.gov records. The official record at https://clinicaltrials.gov/ remains the source of truth for current availability, contacts, and full study details.",
  "notes": [
    "This endpoint exposes only public summary fields — no participant contact emails, phone numbers, or scraped investigator contact details.",
    "For contact information and full protocol detail, follow each trial's `official_url` to the ClinicalTrials.gov record.",
    "This API is a navigational aid. It does not provide medical advice, eligibility determinations, or compensation guarantees."
  ],
  "trials": [
    {
      "nct_id": "NCT07242105",
      "title": "Optimizing Brain Excitability in Depression",
      "overall_status": "RECRUITING",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Major Depressive Disorder"
      ],
      "interventions": [
        {
          "name": "Active Single-Pulse TMS",
          "type": "DEVICE"
        },
        {
          "name": "Sham Single-Pulse TMS",
          "type": "DEVICE"
        },
        {
          "name": "TARGET-optimized TMS",
          "type": "DEVICE"
        },
        {
          "name": "Non-optimized (Open-Loop) TMS",
          "type": "DEVICE"
        },
        {
          "name": "EEG Recording",
          "type": "OTHER"
        },
        {
          "name": "Intracranial EEG (iEEG) Recording",
          "type": "OTHER"
        }
      ],
      "intervention_types": [
        "DEVICE",
        "OTHER"
      ],
      "sponsor": "Stanford University",
      "sponsor_class": "OTHER",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": "65 Years",
        "sex": "ALL",
        "summary": "18 Years to 65 Years"
      },
      "enrollment_count": 145,
      "start_date": "2025-10-23",
      "completion_date": "2029-11-30",
      "has_results": false,
      "last_update_posted_date": "2026-02-10",
      "last_synced_at": "2026-09-06T06:18:26.503Z",
      "location_count": 2,
      "location_summary": "Iowa City, California • Stanford, California",
      "locations": [
        {
          "city": "Iowa City",
          "state": "California"
        },
        {
          "city": "Stanford",
          "state": "California"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT07242105"
    },
    {
      "nct_id": "NCT04569708",
      "title": "Sleep Spindles and Memory in Rolandic Epilepsy",
      "overall_status": "WITHDRAWN",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Rolandic Epilepsy",
        "Rolandic Epilepsy, Benign",
        "Centrotemporal Epilepsy",
        "Centrotemporal; EEG Spikes, Epilepsy of Childhood",
        "Epilepsy; Seizure",
        "Epilepsy"
      ],
      "interventions": [
        {
          "name": "Closed loop auditory stimulation",
          "type": "OTHER"
        }
      ],
      "intervention_types": [
        "OTHER"
      ],
      "sponsor": "Massachusetts General Hospital",
      "sponsor_class": "OTHER",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "4 Years",
        "maximum_age": "18 Years",
        "sex": "ALL",
        "summary": "4 Years to 18 Years"
      },
      "enrollment_count": 0,
      "start_date": "2021-01-16",
      "completion_date": "2025-06-30",
      "has_results": false,
      "last_update_posted_date": "2026-08-07",
      "last_synced_at": "2026-09-06T06:18:26.503Z",
      "location_count": 1,
      "location_summary": "Charlestown, Massachusetts",
      "locations": [
        {
          "city": "Charlestown",
          "state": "Massachusetts"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT04569708"
    },
    {
      "nct_id": "NCT07705373",
      "title": "A Novel Digital Music-based Autonomous Personalized Walking Intervention to Improve Gait and Walking Automaticity in Parkinson Disease",
      "overall_status": "RECRUITING",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Parkinson's Disease (PD)"
      ],
      "interventions": [
        {
          "name": "MR-005 (MedRhythms, Inc., Portland, ME)",
          "type": "DEVICE"
        }
      ],
      "intervention_types": [
        "DEVICE"
      ],
      "sponsor": "Boston University Charles River Campus",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "40 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "40 Years and older"
      },
      "enrollment_count": 200,
      "start_date": "2026-08-20",
      "completion_date": "2029-02-28",
      "has_results": false,
      "last_update_posted_date": "2026-08-24",
      "last_synced_at": "2026-09-06T06:18:26.503Z",
      "location_count": 3,
      "location_summary": "Boston, Massachusetts • St Louis, Missouri • Salt Lake City, Utah",
      "locations": [
        {
          "city": "Boston",
          "state": "Massachusetts"
        },
        {
          "city": "St Louis",
          "state": "Missouri"
        },
        {
          "city": "Salt Lake City",
          "state": "Utah"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT07705373"
    },
    {
      "nct_id": "NCT06979570",
      "title": "Personalized Performance Optimization Platform",
      "overall_status": "TERMINATED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Sensory Science",
        "Performance Assessment",
        "Countermeasure Evaluation",
        "Neurocognitive Function",
        "Psychological Factors"
      ],
      "interventions": [
        {
          "name": "AttentivU",
          "type": "DEVICE"
        }
      ],
      "intervention_types": [
        "DEVICE"
      ],
      "sponsor": "Massachusetts General Hospital",
      "sponsor_class": "OTHER",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": "64 Years",
        "sex": "ALL",
        "summary": "18 Years to 64 Years"
      },
      "enrollment_count": 80,
      "start_date": "2021-02-22",
      "completion_date": "2025-09-30",
      "has_results": false,
      "last_update_posted_date": "2026-03-30",
      "last_synced_at": "2026-09-06T06:18:26.503Z",
      "location_count": 2,
      "location_summary": "Cambridge, Massachusetts • Charlestown, Massachusetts",
      "locations": [
        {
          "city": "Cambridge",
          "state": "Massachusetts"
        },
        {
          "city": "Charlestown",
          "state": "Massachusetts"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT06979570"
    },
    {
      "nct_id": "NCT04611828",
      "title": "Slow-wave Enhancement in Adults Aged 30-49",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Sleep"
      ],
      "interventions": [
        {
          "name": "Philips SmartSleep",
          "type": "DEVICE"
        }
      ],
      "intervention_types": [
        "DEVICE"
      ],
      "sponsor": "University of Wisconsin, Madison",
      "sponsor_class": "OTHER",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "30 Years",
        "maximum_age": "49 Years",
        "sex": "ALL",
        "summary": "30 Years to 49 Years"
      },
      "enrollment_count": 28,
      "start_date": "2019-09-16",
      "completion_date": "2020-12-04",
      "has_results": false,
      "last_update_posted_date": "2021-01-28",
      "last_synced_at": "2026-09-06T06:18:26.503Z",
      "location_count": 1,
      "location_summary": "Madison, Wisconsin",
      "locations": [
        {
          "city": "Madison",
          "state": "Wisconsin"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT04611828"
    },
    {
      "nct_id": "NCT05956951",
      "title": "Restoring Spindle and Thalamocortical Efficiency in Early-Course Schizophrenia Patients Using Auditory Stimulation",
      "overall_status": "RECRUITING",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Schizophrenia"
      ],
      "interventions": [
        {
          "name": "Closed-loop auditory stimulation",
          "type": "DEVICE"
        },
        {
          "name": "Sham auditory stimulation",
          "type": "DEVICE"
        }
      ],
      "intervention_types": [
        "DEVICE"
      ],
      "sponsor": "Fabio Ferrarelli",
      "sponsor_class": "OTHER",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": "40 Years",
        "sex": "ALL",
        "summary": "18 Years to 40 Years"
      },
      "enrollment_count": 200,
      "start_date": "2023-07-20",
      "completion_date": "2028-06",
      "has_results": false,
      "last_update_posted_date": "2026-06-04",
      "last_synced_at": "2026-09-06T06:18:26.503Z",
      "location_count": 1,
      "location_summary": "Pittsburgh, Pennsylvania",
      "locations": [
        {
          "city": "Pittsburgh",
          "state": "Pennsylvania"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT05956951"
    },
    {
      "nct_id": "NCT03512002",
      "title": "HIRREM Hot Flashes Study",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Vasomotor Symptoms",
        "Hot Flashes",
        "Menopause"
      ],
      "interventions": [
        {
          "name": "HIRREM",
          "type": "DEVICE"
        },
        {
          "name": "Continued Current Care",
          "type": "OTHER"
        }
      ],
      "intervention_types": [
        "DEVICE",
        "OTHER"
      ],
      "sponsor": "Wake Forest University Health Sciences",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "40 Years",
        "maximum_age": null,
        "sex": "FEMALE",
        "summary": "40 Years and older · Female only"
      },
      "enrollment_count": 8,
      "start_date": "2018-06-01",
      "completion_date": "2020-05-27",
      "has_results": true,
      "last_update_posted_date": "2023-05-23",
      "last_synced_at": "2026-09-06T06:18:26.503Z",
      "location_count": 1,
      "location_summary": "Winston-Salem, North Carolina",
      "locations": [
        {
          "city": "Winston-Salem",
          "state": "North Carolina"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT03512002"
    },
    {
      "nct_id": "NCT03230890",
      "title": "HIRREM in Military Personnel",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Stress Disorders, Post-Traumatic"
      ],
      "interventions": [
        {
          "name": "HIRREM",
          "type": "DEVICE"
        }
      ],
      "intervention_types": [
        "DEVICE"
      ],
      "sponsor": "Wake Forest University Health Sciences",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "18 Years and older"
      },
      "enrollment_count": 32,
      "start_date": "2015-02-16",
      "completion_date": "2021-04-05",
      "has_results": true,
      "last_update_posted_date": "2023-08-14",
      "last_synced_at": "2026-09-06T06:18:26.503Z",
      "location_count": 1,
      "location_summary": "Winston-Salem, North Carolina",
      "locations": [
        {
          "city": "Winston-Salem",
          "state": "North Carolina"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT03230890"
    },
    {
      "nct_id": "NCT04206059",
      "title": "Closed Loop Acoustic Stimulation During Sedation With Dexmedetomidine",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Sleep",
        "Sedation Complication"
      ],
      "interventions": [
        {
          "name": "MRI",
          "type": "RADIATION"
        },
        {
          "name": "Quantitative Sensory Testing (QST)",
          "type": "DIAGNOSTIC_TEST"
        },
        {
          "name": "Home sleep study",
          "type": "DIAGNOSTIC_TEST"
        },
        {
          "name": "Acoustic stimulation (65 decibels or db) up-slope of EEG with QST",
          "type": "OTHER"
        },
        {
          "name": "Acoustic stimulation (65db) down-slope of EEG with QST",
          "type": "OTHER"
        },
        {
          "name": "0 db with QST",
          "type": "OTHER"
        },
        {
          "name": "Dexmedetomidine",
          "type": "DRUG"
        },
        {
          "name": "Breathe-Squeeze Task",
          "type": "OTHER"
        }
      ],
      "intervention_types": [
        "RADIATION",
        "DIAGNOSTIC_TEST",
        "OTHER",
        "DRUG"
      ],
      "sponsor": "Washington University School of Medicine",
      "sponsor_class": "OTHER",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": "40 Years",
        "sex": "ALL",
        "summary": "18 Years to 40 Years"
      },
      "enrollment_count": 18,
      "start_date": "2021-01-20",
      "completion_date": "2023-07-01",
      "has_results": true,
      "last_update_posted_date": "2026-05-01",
      "last_synced_at": "2026-09-06T06:18:26.503Z",
      "location_count": 1,
      "location_summary": "St Louis, Missouri",
      "locations": [
        {
          "city": "St Louis",
          "state": "Missouri"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT04206059"
    },
    {
      "nct_id": "NCT02709369",
      "title": "HIRREM Developmental Study",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Sleep Initiation and Maintenance Disorders",
        "Anxiety",
        "Post-Traumatic Stress Disorder",
        "Hot Flashes",
        "Headache",
        "Traumatic Brain Injury",
        "Post Concussion Symptoms"
      ],
      "interventions": [
        {
          "name": "HIRREM",
          "type": "DEVICE"
        }
      ],
      "intervention_types": [
        "DEVICE"
      ],
      "sponsor": "Wake Forest University Health Sciences",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "11 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "11 Years and older"
      },
      "enrollment_count": 300,
      "start_date": "2011-08-23",
      "completion_date": "2018-10-25",
      "has_results": true,
      "last_update_posted_date": "2019-12-24",
      "last_synced_at": "2026-09-06T06:18:26.503Z",
      "location_count": 1,
      "location_summary": "Winston-Salem, North Carolina",
      "locations": [
        {
          "city": "Winston-Salem",
          "state": "North Carolina"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT02709369"
    }
  ]
}