{
  "api_version": "1",
  "request": {
    "url": "https://clinicaltrialsfind.com/api/v1/search.json?intervention=Closed-Loop+Control&page=2",
    "query": {
      "intervention": "Closed-Loop Control",
      "page": 2
    },
    "page_size": 10
  },
  "pagination": {
    "page": 2,
    "page_size": 10,
    "total_count": 10,
    "total_pages": 1,
    "next_page_url": null,
    "previous_page_url": "https://clinicaltrialsfind.com/api/v1/search.json?intervention=Closed-Loop+Control&page=1&page_size=10"
  },
  "source": "remote",
  "last_synced_at": "2026-09-09T02:06:10.149Z",
  "attribution": "Data derived from public ClinicalTrials.gov records. The official record at https://clinicaltrials.gov/ remains the source of truth for current availability, contacts, and full study details.",
  "notes": [
    "This endpoint exposes only public summary fields — no participant contact emails, phone numbers, or scraped investigator contact details.",
    "For contact information and full protocol detail, follow each trial's `official_url` to the ClinicalTrials.gov record.",
    "This API is a navigational aid. It does not provide medical advice, eligibility determinations, or compensation guarantees."
  ],
  "trials": [
    {
      "nct_id": "NCT03534141",
      "title": "Mild Hypothermia and Acute Kidney Injury in Liver Transplantation",
      "overall_status": "TERMINATED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Cirrhosis",
        "End Stage Liver Disease",
        "Acute Kidney Injury",
        "Liver Transplant; Complications",
        "Chronic Kidney Diseases",
        "Hepatitis c",
        "Hepatitis B",
        "NASH - Nonalcoholic Steatohepatitis",
        "Alcoholic Cirrhosis",
        "Hepatocellular Carcinoma"
      ],
      "interventions": [
        {
          "name": "Esophageal cooling/warming device",
          "type": "DEVICE"
        },
        {
          "name": "Mild hypothermia",
          "type": "OTHER"
        },
        {
          "name": "Normothermia",
          "type": "OTHER"
        }
      ],
      "intervention_types": [
        "DEVICE",
        "OTHER"
      ],
      "sponsor": "University of California, San Francisco",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "18 Years and older"
      },
      "enrollment_count": 175,
      "start_date": "2018-07-07",
      "completion_date": "2023-09-14",
      "has_results": true,
      "last_update_posted_date": "2025-05-16",
      "last_synced_at": "2026-09-09T02:06:10.149Z",
      "location_count": 3,
      "location_summary": "San Francisco, California • Aurora, Colorado • Houston, Texas",
      "locations": [
        {
          "city": "San Francisco",
          "state": "California"
        },
        {
          "city": "Aurora",
          "state": "Colorado"
        },
        {
          "city": "Houston",
          "state": "Texas"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT03534141"
    },
    {
      "nct_id": "NCT02705053",
      "title": "At Home Study of a Zone-Model Predictive Control (MPC) Controller and a Health Monitoring System (HMS) With the Diabetes Assistant (DiAs) System and Run-to-Run Adaptation",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE3"
      ],
      "conditions": [
        "Type 1 Diabetes Mellitus"
      ],
      "interventions": [
        {
          "name": "CGM and Insulin Pump",
          "type": "DEVICE"
        },
        {
          "name": "Closed-Loop Control System",
          "type": "DEVICE"
        }
      ],
      "intervention_types": [
        "DEVICE"
      ],
      "sponsor": "Sansum Diabetes Research Institute",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "21 Years",
        "maximum_age": "65 Years",
        "sex": "ALL",
        "summary": "21 Years to 65 Years"
      },
      "enrollment_count": 32,
      "start_date": "2016-02",
      "completion_date": "2016-08",
      "has_results": false,
      "last_update_posted_date": "2016-10-14",
      "last_synced_at": "2026-09-09T02:06:10.149Z",
      "location_count": 3,
      "location_summary": "Santa Barbara, California • Rochester, Minnesota • Charlottesville, Virginia",
      "locations": [
        {
          "city": "Santa Barbara",
          "state": "California"
        },
        {
          "city": "Rochester",
          "state": "Minnesota"
        },
        {
          "city": "Charlottesville",
          "state": "Virginia"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT02705053"
    },
    {
      "nct_id": "NCT05403502",
      "title": "Safety Evaluation of an Advanced Hybrid Closed Loop System Using Lyumjev With the Tandem t:Slim X2 Insulin Pump With Control-IQ Technology in Adults, Adolescents and Children With Type 1 Diabetes",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Type 1 Diabetes"
      ],
      "interventions": [
        {
          "name": "t:slim X2 insulin pump with Control-IQ technology 1.5",
          "type": "DEVICE"
        }
      ],
      "intervention_types": [
        "DEVICE"
      ],
      "sponsor": "Tandem Diabetes Care, Inc.",
      "sponsor_class": "INDUSTRY",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "6 Years",
        "maximum_age": "80 Years",
        "sex": "ALL",
        "summary": "6 Years to 80 Years"
      },
      "enrollment_count": 183,
      "start_date": "2022-08-31",
      "completion_date": "2023-08-02",
      "has_results": true,
      "last_update_posted_date": "2024-07-26",
      "last_synced_at": "2026-09-09T02:06:10.149Z",
      "location_count": 13,
      "location_summary": "Orange, California • Palo Alto, California • Aurora, Colorado + 10 more",
      "locations": [
        {
          "city": "Orange",
          "state": "California"
        },
        {
          "city": "Palo Alto",
          "state": "California"
        },
        {
          "city": "Aurora",
          "state": "Colorado"
        },
        {
          "city": "Gainesville",
          "state": "Florida"
        },
        {
          "city": "Tampa",
          "state": "Florida"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT05403502"
    },
    {
      "nct_id": "NCT06397469",
      "title": "Enhancing Attention and Wellbeing Using Digital Therapeutics",
      "overall_status": "RECRUITING",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Aging",
        "MCI",
        "Cognitive Decline"
      ],
      "interventions": [
        {
          "name": "MediTrain",
          "type": "DEVICE"
        },
        {
          "name": "Worder",
          "type": "DEVICE"
        }
      ],
      "intervention_types": [
        "DEVICE"
      ],
      "sponsor": "University of California, San Francisco",
      "sponsor_class": "OTHER",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "60 Years",
        "maximum_age": "99 Years",
        "sex": "ALL",
        "summary": "60 Years to 99 Years"
      },
      "enrollment_count": 4000,
      "start_date": "2024-04-01",
      "completion_date": "2029-06-01",
      "has_results": false,
      "last_update_posted_date": "2026-08-24",
      "last_synced_at": "2026-09-09T02:06:10.149Z",
      "location_count": 1,
      "location_summary": "San Francisco, California",
      "locations": [
        {
          "city": "San Francisco",
          "state": "California"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT06397469"
    },
    {
      "nct_id": "NCT07362862",
      "title": "MyokinE100 System: Closed Loop Electrical Muscle Stimulation to Mitigate ICU Acquired Weakness in Medical ICU Patients",
      "overall_status": "RECRUITING",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Sepsis",
        "Critical Illness",
        "ICU-acquired Muscle Weakness",
        "ICU-acquired Weakness",
        "ICUAW",
        "Sarcopenia",
        "Secondary Sarcopenia"
      ],
      "interventions": [
        {
          "name": "Electrical Muscle Stimulation System",
          "type": "DEVICE"
        }
      ],
      "intervention_types": [
        "DEVICE"
      ],
      "sponsor": "Health Discovery Labs",
      "sponsor_class": "INDUSTRY",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": "85 Years",
        "sex": "ALL",
        "summary": "18 Years to 85 Years"
      },
      "enrollment_count": 50,
      "start_date": "2026-05-05",
      "completion_date": "2027-08-31",
      "has_results": false,
      "last_update_posted_date": "2026-07-10",
      "last_synced_at": "2026-09-09T02:06:10.149Z",
      "location_count": 3,
      "location_summary": "Rochester, Minnesota • Austin, Texas",
      "locations": [
        {
          "city": "Rochester",
          "state": "Minnesota"
        },
        {
          "city": "Austin",
          "state": "Texas"
        },
        {
          "city": "Austin",
          "state": "Texas"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT07362862"
    },
    {
      "nct_id": "NCT04004169",
      "title": "Closed-Loop Deep Brain Stimulation for Major Depression",
      "overall_status": "RECRUITING",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Major Depressive Disorder"
      ],
      "interventions": [
        {
          "name": "Stimulation-ON",
          "type": "DEVICE"
        },
        {
          "name": "Stimulation-OFF",
          "type": "DEVICE"
        },
        {
          "name": "Stimulation-ON Active Control",
          "type": "DEVICE"
        }
      ],
      "intervention_types": [
        "DEVICE"
      ],
      "sponsor": "Andrew Krystal",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "22 Years",
        "maximum_age": "70 Years",
        "sex": "ALL",
        "summary": "22 Years to 70 Years"
      },
      "enrollment_count": 12,
      "start_date": "2019-07-18",
      "completion_date": "2035-06-28",
      "has_results": false,
      "last_update_posted_date": "2026-08-03",
      "last_synced_at": "2026-09-09T02:06:10.149Z",
      "location_count": 1,
      "location_summary": "San Francisco, California",
      "locations": [
        {
          "city": "San Francisco",
          "state": "California"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT04004169"
    },
    {
      "nct_id": "NCT01472406",
      "title": "Feasibility Study Using Zone-MPC Controller (Zone-Model Predictive Control) and Health Monitoring System (HMS)",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "EARLY_PHASE1"
      ],
      "conditions": [
        "Type 1 Diabetes Mellitus"
      ],
      "interventions": [
        {
          "name": "Sansum Closed-Loop Artificial Pancreas",
          "type": "DEVICE"
        },
        {
          "name": "Insulin infusion pump",
          "type": "DEVICE"
        },
        {
          "name": "Continuous Glucose Monitor",
          "type": "DEVICE"
        },
        {
          "name": "zone-Model Predictive Control algorithm",
          "type": "DEVICE"
        },
        {
          "name": "Safety Health Monitoring System",
          "type": "DEVICE"
        }
      ],
      "intervention_types": [
        "DEVICE"
      ],
      "sponsor": "Sansum Diabetes Research Institute",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": "65 Years",
        "sex": "ALL",
        "summary": "18 Years to 65 Years"
      },
      "enrollment_count": 12,
      "start_date": "2011-11",
      "completion_date": "2014-03",
      "has_results": false,
      "last_update_posted_date": "2021-09-14",
      "last_synced_at": "2026-09-09T02:06:10.149Z",
      "location_count": 1,
      "location_summary": "Santa Barbara, California",
      "locations": [
        {
          "city": "Santa Barbara",
          "state": "California"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT01472406"
    },
    {
      "nct_id": "NCT05907343",
      "title": "Closed-Loop Brain Stimulation as a Potential Intervention for Cognitive Decline",
      "overall_status": "RECRUITING",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Mild Cognitive Impairment",
        "Alzheimer Dementia (AD)"
      ],
      "interventions": [
        {
          "name": "Closed-loop TBS",
          "type": "DEVICE"
        },
        {
          "name": "Open-loop TBS",
          "type": "DEVICE"
        }
      ],
      "intervention_types": [
        "DEVICE"
      ],
      "sponsor": "University of Texas at Austin",
      "sponsor_class": "OTHER",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": "90 Years",
        "sex": "ALL",
        "summary": "18 Years to 90 Years"
      },
      "enrollment_count": 180,
      "start_date": "2023-05-31",
      "completion_date": "2027-10-31",
      "has_results": false,
      "last_update_posted_date": "2026-09-02",
      "last_synced_at": "2026-09-09T02:06:10.149Z",
      "location_count": 1,
      "location_summary": "Austin, Texas",
      "locations": [
        {
          "city": "Austin",
          "state": "Texas"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT05907343"
    },
    {
      "nct_id": "NCT00977808",
      "title": "Pilot Study of Closed-Loop Glucose Control in People With Type 1 Diabetes (BPK004)",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Type 1 Diabetes"
      ],
      "interventions": [
        {
          "name": "Closed-Loop, Model Predictive Control (MPC)",
          "type": "DEVICE"
        },
        {
          "name": "Open-Loop",
          "type": "DEVICE"
        }
      ],
      "intervention_types": [
        "DEVICE"
      ],
      "sponsor": "University of Virginia",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "21 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "21 Years and older"
      },
      "enrollment_count": 12,
      "start_date": "2008-05",
      "completion_date": "2009-02",
      "has_results": true,
      "last_update_posted_date": "2014-09-04",
      "last_synced_at": "2026-09-09T02:06:10.149Z",
      "location_count": 1,
      "location_summary": "Charlottesville, Virginia",
      "locations": [
        {
          "city": "Charlottesville",
          "state": "Virginia"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT00977808"
    },
    {
      "nct_id": "NCT00891995",
      "title": "Effect of Metabolic Control at Onset of Diabetes on Progression of Type 1 Diabetes",
      "overall_status": "TERMINATED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE2",
        "PHASE3"
      ],
      "conditions": [
        "Type 1 Diabetes"
      ],
      "interventions": [
        {
          "name": "Closed loop",
          "type": "DEVICE"
        },
        {
          "name": "Home glucose monitoring",
          "type": "DEVICE"
        },
        {
          "name": "Insulin pump",
          "type": "DEVICE"
        },
        {
          "name": "Continuous glucose monitor",
          "type": "DEVICE"
        }
      ],
      "intervention_types": [
        "DEVICE"
      ],
      "sponsor": "Jaeb Center for Health Research",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "6 Years",
        "maximum_age": "45 Years",
        "sex": "ALL",
        "summary": "6 Years to 45 Years"
      },
      "enrollment_count": 71,
      "start_date": "2010-09",
      "completion_date": "2013-10",
      "has_results": true,
      "last_update_posted_date": "2016-12-30",
      "last_synced_at": "2026-09-09T02:06:10.149Z",
      "location_count": 5,
      "location_summary": "Stanford, California • Aurora, Colorado • New Haven, Connecticut + 2 more",
      "locations": [
        {
          "city": "Stanford",
          "state": "California"
        },
        {
          "city": "Aurora",
          "state": "Colorado"
        },
        {
          "city": "New Haven",
          "state": "Connecticut"
        },
        {
          "city": "Indianapolis",
          "state": "Indiana"
        },
        {
          "city": "Nashville",
          "state": "Tennessee"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT00891995"
    }
  ]
}