{
  "api_version": "1",
  "request": {
    "url": "https://clinicaltrialsfind.com/api/v1/search.json?intervention=Collagen+plug+placement",
    "query": {
      "intervention": "Collagen plug placement"
    },
    "page_size": 10
  },
  "pagination": {
    "page": 1,
    "page_size": 10,
    "total_count": 13,
    "total_pages": 2,
    "next_page_url": "https://clinicaltrialsfind.com/api/v1/search.json?intervention=Collagen+plug+placement&page=2&page_size=10",
    "previous_page_url": null
  },
  "source": "remote",
  "last_synced_at": "2026-09-07T08:49:59.002Z",
  "attribution": "Data derived from public ClinicalTrials.gov records. The official record at https://clinicaltrials.gov/ remains the source of truth for current availability, contacts, and full study details.",
  "notes": [
    "This endpoint exposes only public summary fields — no participant contact emails, phone numbers, or scraped investigator contact details.",
    "For contact information and full protocol detail, follow each trial's `official_url` to the ClinicalTrials.gov record.",
    "This API is a navigational aid. It does not provide medical advice, eligibility determinations, or compensation guarantees."
  ],
  "trials": [
    {
      "nct_id": "NCT06447844",
      "title": "OsteoGen Plug vs. Freeze-dried Bone Allograft With Collagen Barrier",
      "overall_status": "ACTIVE_NOT_RECRUITING",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Nonterminal Premolar Needing Extraction"
      ],
      "interventions": [
        {
          "name": "OsteoGen Plug",
          "type": "DEVICE"
        },
        {
          "name": "BioGide",
          "type": "DEVICE"
        }
      ],
      "intervention_types": [
        "DEVICE"
      ],
      "sponsor": "McGuire Institute",
      "sponsor_class": "INDUSTRY",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": "75 Years",
        "sex": "ALL",
        "summary": "18 Years to 75 Years"
      },
      "enrollment_count": 70,
      "start_date": "2024-03-28",
      "completion_date": "2027-11-28",
      "has_results": false,
      "last_update_posted_date": "2026-05-29",
      "last_synced_at": "2026-09-07T08:49:59.002Z",
      "location_count": 9,
      "location_summary": "Aurora, Colorado • Broomfield, Colorado • Boston, Massachusetts + 6 more",
      "locations": [
        {
          "city": "Aurora",
          "state": "Colorado"
        },
        {
          "city": "Broomfield",
          "state": "Colorado"
        },
        {
          "city": "Boston",
          "state": "Massachusetts"
        },
        {
          "city": "Fenton",
          "state": "Michigan"
        },
        {
          "city": "La Vista",
          "state": "Nebraska"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT06447844"
    },
    {
      "nct_id": "NCT03613090",
      "title": "Novel Collagen Scaffold vs Conventional Scaffold in Regeneration of Human Dental Pulp Tissue",
      "overall_status": "WITHDRAWN",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE2"
      ],
      "conditions": [
        "Root Canal Therapy"
      ],
      "interventions": [
        {
          "name": "Collagen-hydroxyapatite scaffold (Syn-Oss)",
          "type": "DRUG"
        },
        {
          "name": "Collagen Scaffold (Colla-Plug)",
          "type": "DRUG"
        }
      ],
      "intervention_types": [
        "DRUG"
      ],
      "sponsor": "University of Alabama at Birmingham",
      "sponsor_class": "OTHER",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "12 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "12 Years and older"
      },
      "enrollment_count": 0,
      "start_date": "2019-04-01",
      "completion_date": "2019-04-01",
      "has_results": false,
      "last_update_posted_date": "2019-05-23",
      "last_synced_at": "2026-09-07T08:49:59.002Z",
      "location_count": 1,
      "location_summary": "Birmingham, Alabama",
      "locations": [
        {
          "city": "Birmingham",
          "state": "Alabama"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT03613090"
    },
    {
      "nct_id": "NCT04527887",
      "title": "Intracanalicular Dexamethasone Insert for the Treatment of Inflammation and Discomfort in Dry Eye Disease (DEcIDED)",
      "overall_status": "TERMINATED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE4"
      ],
      "conditions": [
        "Dry Eye"
      ],
      "interventions": [
        {
          "name": "Dextenza (IDI) (Sustained Release Dexamethasone), (0.4 mg)",
          "type": "DRUG"
        },
        {
          "name": "ProLong™ collagen plugs",
          "type": "OTHER"
        }
      ],
      "intervention_types": [
        "DRUG",
        "OTHER"
      ],
      "sponsor": "Tufts Medical Center",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "18 Years and older"
      },
      "enrollment_count": 54,
      "start_date": "2020-09-04",
      "completion_date": "2024-12-31",
      "has_results": false,
      "last_update_posted_date": "2025-01-15",
      "last_synced_at": "2026-09-07T08:49:59.002Z",
      "location_count": 1,
      "location_summary": "Boston, Massachusetts",
      "locations": [
        {
          "city": "Boston",
          "state": "Massachusetts"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT04527887"
    },
    {
      "nct_id": "NCT07023757",
      "title": "Effect of Age on PRF Quality; Assessed by Evaluating Healing Outcomes of ARP",
      "overall_status": "ENROLLING_BY_INVITATION",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Healing Wound"
      ],
      "interventions": [
        {
          "name": "Socket preservation",
          "type": "PROCEDURE"
        }
      ],
      "intervention_types": [
        "PROCEDURE"
      ],
      "sponsor": "University of Michigan",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "20 Years",
        "maximum_age": "80 Years",
        "sex": "ALL",
        "summary": "20 Years to 80 Years"
      },
      "enrollment_count": 44,
      "start_date": "2025-06-12",
      "completion_date": "2027-07-01",
      "has_results": false,
      "last_update_posted_date": "2026-07-15",
      "last_synced_at": "2026-09-07T08:49:59.002Z",
      "location_count": 1,
      "location_summary": "Ann Arbor, Michigan",
      "locations": [
        {
          "city": "Ann Arbor",
          "state": "Michigan"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT07023757"
    },
    {
      "nct_id": "NCT05838651",
      "title": "Socket Preservation With BioHorizon's Striate+ Membrane and MinerOss X Plug",
      "overall_status": "ACTIVE_NOT_RECRUITING",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Socket Preservation"
      ],
      "interventions": [
        {
          "name": "MinerOss® X Plug",
          "type": "DEVICE"
        },
        {
          "name": "Striate+ Membrane",
          "type": "DEVICE"
        }
      ],
      "intervention_types": [
        "DEVICE"
      ],
      "sponsor": "Harvard School of Dental Medicine",
      "sponsor_class": "OTHER",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "18 Years and older"
      },
      "enrollment_count": 20,
      "start_date": "2023-05-01",
      "completion_date": "2025-05",
      "has_results": false,
      "last_update_posted_date": "2025-01-03",
      "last_synced_at": "2026-09-07T08:49:59.002Z",
      "location_count": 1,
      "location_summary": "Boston, Massachusetts",
      "locations": [
        {
          "city": "Boston",
          "state": "Massachusetts"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT05838651"
    },
    {
      "nct_id": "NCT07756112",
      "title": "Dynamics of Wound Healing in Patients With Obesity",
      "overall_status": "NOT_YET_RECRUITING",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Wound Healing"
      ],
      "interventions": [
        {
          "name": "Collagen Plug (standard of care)",
          "type": "PROCEDURE"
        },
        {
          "name": "Platelet-Rich Fibrin Clot",
          "type": "PROCEDURE"
        }
      ],
      "intervention_types": [
        "PROCEDURE"
      ],
      "sponsor": "University of Iowa",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": "70 Years",
        "sex": "ALL",
        "summary": "18 Years to 70 Years"
      },
      "enrollment_count": 104,
      "start_date": "2026-08",
      "completion_date": "2029-08",
      "has_results": false,
      "last_update_posted_date": "2026-08-10",
      "last_synced_at": "2026-09-07T08:49:59.002Z",
      "location_count": 1,
      "location_summary": "Iowa City, Iowa",
      "locations": [
        {
          "city": "Iowa City",
          "state": "Iowa"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT07756112"
    },
    {
      "nct_id": "NCT02702609",
      "title": "Assessment of Ridge Preservation Using Moldable Beta-tricalcium Phosphate Bone Grafting System",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Dental Implants",
        "Alveolar Ridge Preservation"
      ],
      "interventions": [
        {
          "name": "easy-graft CLASSIC",
          "type": "DEVICE"
        },
        {
          "name": "FDBA with collagen plug",
          "type": "DEVICE"
        }
      ],
      "intervention_types": [
        "DEVICE"
      ],
      "sponsor": "Sunstar Americas",
      "sponsor_class": "INDUSTRY",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "18 Years and older"
      },
      "enrollment_count": 45,
      "start_date": "2016-08-02",
      "completion_date": "2019-08-19",
      "has_results": true,
      "last_update_posted_date": "2020-10-22",
      "last_synced_at": "2026-09-07T08:49:59.002Z",
      "location_count": 2,
      "location_summary": "Iowa City, Iowa • Baltimore, Maryland",
      "locations": [
        {
          "city": "Iowa City",
          "state": "Iowa"
        },
        {
          "city": "Baltimore",
          "state": "Maryland"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT02702609"
    },
    {
      "nct_id": "NCT05814757",
      "title": "OTX-DED for the Short-term Treatment of the Symptoms of Dry Eye Disease (DED)",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE2"
      ],
      "conditions": [
        "Dry Eye Syndromes",
        "Eye Diseases"
      ],
      "interventions": [
        {
          "name": "OTX-DED",
          "type": "DRUG"
        },
        {
          "name": "Controlled Insertion",
          "type": "DRUG"
        },
        {
          "name": "Collagen Punctal Plug",
          "type": "DRUG"
        }
      ],
      "intervention_types": [
        "DRUG"
      ],
      "sponsor": "Ocular Therapeutix, Inc.",
      "sponsor_class": "INDUSTRY",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "18 Years and older"
      },
      "enrollment_count": 100,
      "start_date": "2023-05-11",
      "completion_date": "2024-05-22",
      "has_results": false,
      "last_update_posted_date": "2024-07-10",
      "last_synced_at": "2026-09-07T08:49:59.002Z",
      "location_count": 1,
      "location_summary": "Memphis, Tennessee",
      "locations": [
        {
          "city": "Memphis",
          "state": "Tennessee"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT05814757"
    },
    {
      "nct_id": "NCT00450671",
      "title": "Treatment of Perirectal Fistula With Cutting Seton vs. Collagen Plug",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE3"
      ],
      "conditions": [
        "Anal Fistula"
      ],
      "interventions": [
        {
          "name": "Collagen Plug Placement",
          "type": "PROCEDURE"
        },
        {
          "name": "Seton placement",
          "type": "PROCEDURE"
        }
      ],
      "intervention_types": [
        "PROCEDURE"
      ],
      "sponsor": "University of Southern California",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "18 Years and older"
      },
      "enrollment_count": 300,
      "start_date": "2007-02",
      "completion_date": "2013-05-09",
      "has_results": false,
      "last_update_posted_date": "2017-03-17",
      "last_synced_at": "2026-09-07T08:49:59.002Z",
      "location_count": 4,
      "location_summary": "Los Angeles, California",
      "locations": [
        {
          "city": "Los Angeles",
          "state": "California"
        },
        {
          "city": "Los Angeles",
          "state": "California"
        },
        {
          "city": "Los Angeles",
          "state": "California"
        },
        {
          "city": "Los Angeles",
          "state": "California"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT00450671"
    },
    {
      "nct_id": "NCT05419778",
      "title": "Alveolar Ridge Preservation Procedures",
      "overall_status": "COMPLETED",
      "study_type": "OBSERVATIONAL",
      "phases": [],
      "conditions": [
        "Alveolar Ridge Preservation"
      ],
      "interventions": [
        {
          "name": "Osteogen plug®",
          "type": "DEVICE"
        },
        {
          "name": "MInerOss®",
          "type": "DEVICE"
        }
      ],
      "intervention_types": [
        "DEVICE"
      ],
      "sponsor": "University of Tennessee",
      "sponsor_class": "OTHER",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "12 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "12 Years and older"
      },
      "enrollment_count": 14,
      "start_date": "2019-02-08",
      "completion_date": "2021-01-11",
      "has_results": false,
      "last_update_posted_date": "2022-07-08",
      "last_synced_at": "2026-09-07T08:49:59.002Z",
      "location_count": 1,
      "location_summary": "Memphis, Tennessee",
      "locations": [
        {
          "city": "Memphis",
          "state": "Tennessee"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT05419778"
    }
  ]
}