{ "api_version": "1", "request": { "url": "https://clinicaltrialsfind.com/api/v1/search.json?intervention=Combination+Therapy+placebo&page=5", "query": { "intervention": "Combination Therapy placebo", "page": 5 }, "page_size": 10 }, "pagination": { "page": 5, "page_size": 10, "total_count": 1668, "total_pages": 167, "next_page_url": "https://clinicaltrialsfind.com/api/v1/search.json?intervention=Combination+Therapy+placebo&page=6&page_size=10", "previous_page_url": "https://clinicaltrialsfind.com/api/v1/search.json?intervention=Combination+Therapy+placebo&page=4&page_size=10" }, "source": "remote", "last_synced_at": "2026-10-06T18:49:50.311Z", "attribution": "Data derived from public ClinicalTrials.gov records. The official record at https://clinicaltrials.gov/ remains the source of truth for current availability, contacts, and full study details.", "notes": [ "This endpoint exposes only public summary fields — no participant contact emails, phone numbers, or scraped investigator contact details.", "For contact information and full protocol detail, follow each trial's `official_url` to the ClinicalTrials.gov record.", "This API is a navigational aid. It does not provide medical advice, eligibility determinations, or compensation guarantees." ], "trials": [ { "nct_id": "NCT00573443", "title": "Safety and Efficacy of AVP-923 in PBA Patients With ALS or MS", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE3" ], "conditions": [ "Pseudobulbar Affect (PBA)" ], "interventions": [ { "name": "dextromethorphan hydrobromide 20 mg and quinidine sulfate 10 mg", "type": "DRUG" }, { "name": "dextromethorphan hydrobromide 30 mg and quinidine sulfate 10 mg", "type": "DRUG" }, { "name": "Placebo", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "Avanir Pharmaceuticals", "sponsor_class": "INDUSTRY", "healthy_volunteers": false, "eligibility": { "minimum_age": "18 Years", "maximum_age": "80 Years", "sex": "ALL", "summary": "18 Years to 80 Years" }, "enrollment_count": 326, "start_date": "2007-12", "completion_date": "2009-09", "has_results": true, "last_update_posted_date": "2017-04-12", "last_synced_at": "2026-10-06T18:49:50.311Z", "location_count": 45, "location_summary": "Phoenix, Arizona • Scottsdale, Arizona • Anaheim, California + 39 more", "locations": [ { "city": "Phoenix", "state": "Arizona" }, { "city": "Scottsdale", "state": "Arizona" }, { "city": "Anaheim", "state": "California" }, { "city": "Irvine", "state": "California" }, { "city": "La Jolla", "state": "California" } ], "official_url": "https://clinicaltrials.gov/study/NCT00573443" }, { "nct_id": "NCT05353257", "title": "A Study to Evaluate the Efficacy and Safety of Serplulimab in Combination With Chemotherapy and Concurrent Radiotherapy in Patients With Limited-Stage Small Cell Lung Cancer", "overall_status": "ACTIVE_NOT_RECRUITING", "study_type": "INTERVENTIONAL", "phases": [ "PHASE3" ], "conditions": [ "Limited-Stage Small Cell Lung Cancer" ], "interventions": [ { "name": "HLX10", "type": "DRUG" }, { "name": "carboplatin/cisplatin-etoposide", "type": "DRUG" }, { "name": "Thoracic radiotherapy", "type": "RADIATION" }, { "name": "Placebo", "type": "DRUG" }, { "name": "Prophylactic Cranial Irradiation (PCI)", "type": "RADIATION" } ], "intervention_types": [ "DRUG", "RADIATION" ], "sponsor": "Shanghai Henlius Biotech", "sponsor_class": "INDUSTRY", "healthy_volunteers": false, "eligibility": { "minimum_age": "18 Years", "maximum_age": null, "sex": "ALL", "summary": "18 Years and older" }, "enrollment_count": 511, "start_date": "2022-05-17", "completion_date": "2028-05-30", "has_results": false, "last_update_posted_date": "2026-01-13", "last_synced_at": "2026-10-06T18:49:50.311Z", "location_count": 31, "location_summary": "Arcadia, California • Los Alamitos, California • Los Angeles, California + 26 more", "locations": [ { "city": "Arcadia", "state": "California" }, { "city": "Los Alamitos", "state": "California" }, { "city": "Los Angeles", "state": "California" }, { "city": "Redlands", "state": "California" }, { "city": "Santa Rosa", "state": "California" } ], "official_url": "https://clinicaltrials.gov/study/NCT05353257" }, { "nct_id": "NCT03862430", "title": "A Study of NanO2™ Combined With Radiation and Temozolomide in Patients With Newly Diagnosed GBM", "overall_status": "ACTIVE_NOT_RECRUITING", "study_type": "INTERVENTIONAL", "phases": [ "PHASE2" ], "conditions": [ "Glioblastoma Multiforme" ], "interventions": [ { "name": "NanO2TM", "type": "DRUG" }, { "name": "Placebo Saline Infusion", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "NuvOx LLC", "sponsor_class": "INDUSTRY", "healthy_volunteers": false, "eligibility": { "minimum_age": "18 Years", "maximum_age": null, "sex": "ALL", "summary": "18 Years and older" }, "enrollment_count": 87, "start_date": "2023-03-31", "completion_date": "2027-09-30", "has_results": false, "last_update_posted_date": "2026-08-06", "last_synced_at": "2026-10-06T18:49:50.311Z", "location_count": 12, "location_summary": "Tucson, Arizona • Orange, California • Santa Monica, California + 8 more", "locations": [ { "city": "Tucson", "state": "Arizona" }, { "city": "Tucson", "state": "Arizona" }, { "city": "Orange", "state": "California" }, { "city": "Santa Monica", "state": "California" }, { "city": "New Haven", "state": "Connecticut" } ], "official_url": "https://clinicaltrials.gov/study/NCT03862430" }, { "nct_id": "NCT00451204", "title": "A Combination Trial of Copaxone Plus Estriol in Relapsing Remitting Multiple Sclerosis (RRMS)", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE2" ], "conditions": [ "Relapsing Remitting Multiple Sclerosis" ], "interventions": [ { "name": "Estriol", "type": "DRUG" }, { "name": "Placebo", "type": "DRUG" }, { "name": "Copaxone", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "University of California, Los Angeles", "sponsor_class": "OTHER", "healthy_volunteers": false, "eligibility": { "minimum_age": "18 Years", "maximum_age": "50 Years", "sex": "FEMALE", "summary": "18 Years to 50 Years · Female only" }, "enrollment_count": 158, "start_date": "2007-03", "completion_date": "2014-07", "has_results": true, "last_update_posted_date": "2016-06-16", "last_synced_at": "2026-10-06T18:49:50.311Z", "location_count": 15, "location_summary": "Scottsdale, Arizona • Los Angeles, California • Aurora, Colorado + 12 more", "locations": [ { "city": "Scottsdale", "state": "Arizona" }, { "city": "Los Angeles", "state": "California" }, { "city": "Aurora", "state": "Colorado" }, { "city": "Chicago", "state": "Illinois" }, { "city": "Kansas City", "state": "Kansas" } ], "official_url": "https://clinicaltrials.gov/study/NCT00451204" }, { "nct_id": "NCT02667587", "title": "An Investigational Immuno-therapy Study of Temozolomide Plus Radiation Therapy With Nivolumab or Placebo, for Newly Diagnosed Patients With Glioblastoma (GBM, a Malignant Brain Cancer)", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE3" ], "conditions": [ "Brain Neoplasms" ], "interventions": [ { "name": "Nivolumab", "type": "DRUG" }, { "name": "Temozolomide", "type": "DRUG" }, { "name": "Radiotherapy", "type": "RADIATION" }, { "name": "Nivolumab Placebo", "type": "OTHER" } ], "intervention_types": [ "DRUG", "RADIATION", "OTHER" ], "sponsor": "Bristol-Myers Squibb", "sponsor_class": "INDUSTRY", "healthy_volunteers": false, "eligibility": { "minimum_age": "18 Years", "maximum_age": null, "sex": "ALL", "summary": "18 Years and older" }, "enrollment_count": 716, "start_date": "2016-05-09", "completion_date": "2024-04-09", "has_results": true, "last_update_posted_date": "2025-06-18", "last_synced_at": "2026-10-06T18:49:50.311Z", "location_count": 35, "location_summary": "Birmingham, Alabama • Phoenix, Arizona • Los Angeles, California + 29 more", "locations": [ { "city": "Birmingham", "state": "Alabama" }, { "city": "Phoenix", "state": "Arizona" }, { "city": "Los Angeles", "state": "California" }, { "city": "Los Angeles", "state": "California" }, { "city": "Sacramento", "state": "California" } ], "official_url": "https://clinicaltrials.gov/study/NCT02667587" }, { "nct_id": "NCT01922921", "title": "Vaccine Therapy With or Without Polysaccharide-K in Patients With Stage IV HER2 Positive Breast Cancer Receiving HER2-Targeted Monoclonal Antibody Therapy", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE1", "PHASE2" ], "conditions": [ "HER2/Neu Positive", "Recurrent Breast Carcinoma", "Stage IV Breast Cancer" ], "interventions": [ { "name": "HER-2/neu Intracellular Domain Protein", "type": "BIOLOGICAL" }, { "name": "Laboratory Biomarker Analysis", "type": "OTHER" }, { "name": "Pertuzumab", "type": "BIOLOGICAL" }, { "name": "Placebo", "type": "OTHER" }, { "name": "Polysaccharide-K", "type": "BIOLOGICAL" }, { "name": "Trastuzumab", "type": "BIOLOGICAL" } ], "intervention_types": [ "BIOLOGICAL", "OTHER" ], "sponsor": "University of Washington", "sponsor_class": "OTHER", "healthy_volunteers": false, "eligibility": { "minimum_age": "18 Years", "maximum_age": null, "sex": "ALL", "summary": "18 Years and older" }, "enrollment_count": 31, "start_date": "2014-02-05", "completion_date": "2021-09-01", "has_results": true, "last_update_posted_date": "2023-04-18", "last_synced_at": "2026-10-06T18:49:50.311Z", "location_count": 1, "location_summary": "Seattle, Washington", "locations": [ { "city": "Seattle", "state": "Washington" } ], "official_url": "https://clinicaltrials.gov/study/NCT01922921" }, { "nct_id": "NCT00860847", "title": "Firefighter Aged Garlic Extract Investigation With CoQ10 as a Treatment for Heart Disease (FAITH)", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE3" ], "conditions": [ "Coronary Atherosclerosis", "Coronary Artery Calcification", "Coronary Stenosis" ], "interventions": [ { "name": "Aged garlic extract and Coenzyme Q10", "type": "DIETARY_SUPPLEMENT" } ], "intervention_types": [ "DIETARY_SUPPLEMENT" ], "sponsor": "Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center", "sponsor_class": "OTHER", "healthy_volunteers": false, "eligibility": { "minimum_age": "35 Years", "maximum_age": "84 Years", "sex": "MALE", "summary": "35 Years to 84 Years · Male only" }, "enrollment_count": 65, "start_date": "2009-05", "completion_date": "2010-09", "has_results": true, "last_update_posted_date": "2015-03-12", "last_synced_at": "2026-10-06T18:49:50.311Z", "location_count": 1, "location_summary": "Torrance, California", "locations": [ { "city": "Torrance", "state": "California" } ], "official_url": "https://clinicaltrials.gov/study/NCT00860847" }, { "nct_id": "NCT03061734", "title": "Low-Dose Naltrexone and Acetaminophen Combination and Its Components in the Acute Treatment of Migraine", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE2" ], "conditions": [ "Migraine With or Without Aura" ], "interventions": [ { "name": "Naltrexone and Acetaminophen", "type": "DRUG" }, { "name": "Naltrexone and Acetaminophen-High Dose", "type": "DRUG" }, { "name": "Naltrexone Alone (regular dose)", "type": "DRUG" }, { "name": "Acetaminophen Alone", "type": "DRUG" }, { "name": "Matching Placebo", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "Allodynic Therapeutics, Inc", "sponsor_class": "INDUSTRY", "healthy_volunteers": false, "eligibility": { "minimum_age": "18 Years", "maximum_age": null, "sex": "ALL", "summary": "18 Years and older" }, "enrollment_count": 92, "start_date": "2017-02-18", "completion_date": "2018-02-08", "has_results": false, "last_update_posted_date": "2021-04-14", "last_synced_at": "2026-10-06T18:49:50.311Z", "location_count": 1, "location_summary": "North Miami, Florida", "locations": [ { "city": "North Miami", "state": "Florida" } ], "official_url": "https://clinicaltrials.gov/study/NCT03061734" }, { "nct_id": "NCT04830384", "title": "Evaluation of LLLT/Music for Smoking Cessation", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "NA" ], "conditions": [ "Nicotine Dependence, Cigarettes" ], "interventions": [ { "name": "Fully Active", "type": "DEVICE" }, { "name": "LLLT Only", "type": "DEVICE" }, { "name": "Music Only", "type": "DEVICE" }, { "name": "Placebo", "type": "DEVICE" } ], "intervention_types": [ "DEVICE" ], "sponsor": "Freedom Laser, Inc.", "sponsor_class": "INDUSTRY", "healthy_volunteers": true, "eligibility": { "minimum_age": "21 Years", "maximum_age": "65 Years", "sex": "ALL", "summary": "21 Years to 65 Years" }, "enrollment_count": 28, "start_date": "2020-07-01", "completion_date": "2020-12-31", "has_results": false, "last_update_posted_date": "2021-04-05", "last_synced_at": "2026-10-06T18:49:50.311Z", "location_count": 1, "location_summary": "Mendham, New Jersey", "locations": [ { "city": "Mendham", "state": "New Jersey" } ], "official_url": "https://clinicaltrials.gov/study/NCT04830384" }, { "nct_id": "NCT04557215", "title": "Efficacy and Safety of Rifaximin With NAC in IBS-D", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE1", "PHASE2" ], "conditions": [ "Irritable Bowel Syndrome With Diarrhea" ], "interventions": [ { "name": "Rifaximin", "type": "DRUG" }, { "name": "N-acetylcysteine", "type": "DRUG" }, { "name": "Placebo", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "Cedars-Sinai Medical Center", "sponsor_class": "OTHER", "healthy_volunteers": false, "eligibility": { "minimum_age": "18 Years", "maximum_age": "75 Years", "sex": "ALL", "summary": "18 Years to 75 Years" }, "enrollment_count": 45, "start_date": "2020-11-13", "completion_date": "2022-10-30", "has_results": true, "last_update_posted_date": "2023-03-28", "last_synced_at": "2026-10-06T18:49:50.311Z", "location_count": 1, "location_summary": "Los Angeles, California", "locations": [ { "city": "Los Angeles", "state": "California" } ], "official_url": "https://clinicaltrials.gov/study/NCT04557215" } ] }