{ "api_version": "1", "request": { "url": "https://clinicaltrialsfind.com/api/v1/search.json?intervention=Control+Spontaneous+Breathing+Trial+and+Extubation", "query": { "intervention": "Control Spontaneous Breathing Trial and Extubation" }, "page_size": 10 }, "pagination": { "page": 1, "page_size": 10, "total_count": 4, "total_pages": 1, "next_page_url": null, "previous_page_url": null }, "source": "remote", "last_synced_at": "2026-10-01T16:36:10.126Z", "attribution": "Data derived from public ClinicalTrials.gov records. The official record at https://clinicaltrials.gov/ remains the source of truth for current availability, contacts, and full study details.", "notes": [ "This endpoint exposes only public summary fields — no participant contact emails, phone numbers, or scraped investigator contact details.", "For contact information and full protocol detail, follow each trial's `official_url` to the ClinicalTrials.gov record.", "This API is a navigational aid. It does not provide medical advice, eligibility determinations, or compensation guarantees." ], "trials": [ { "nct_id": "NCT04349332", "title": "Early Extubation for Patients With Acute Hypoxemic Respiratory Failure", "overall_status": "WITHDRAWN", "study_type": "INTERVENTIONAL", "phases": [ "NA" ], "conditions": [ "Mechanical Ventilation", "Corona Virus Infection" ], "interventions": [ { "name": "Helmet non-invasive ventilation (NIV)", "type": "DEVICE" } ], "intervention_types": [ "DEVICE" ], "sponsor": "University of Chicago", "sponsor_class": "OTHER", "healthy_volunteers": false, "eligibility": { "minimum_age": "18 Years", "maximum_age": null, "sex": "ALL", "summary": "18 Years and older" }, "enrollment_count": 0, "start_date": "2020-08-13", "completion_date": "2024-01-09", "has_results": false, "last_update_posted_date": "2024-05-02", "last_synced_at": "2026-10-01T16:36:10.126Z", "location_count": 1, "location_summary": "Chicago, Illinois", "locations": [ { "city": "Chicago", "state": "Illinois" } ], "official_url": "https://clinicaltrials.gov/study/NCT04349332" }, { "nct_id": "NCT03951064", "title": "Providing Optimal PEEP During Mechanical Ventilation for Obese Patients Using Esophageal Balloon", "overall_status": "TERMINATED", "study_type": "INTERVENTIONAL", "phases": [ "NA" ], "conditions": [ "Obesity, Morbid", "Ventilator-Induced Lung Injury", "Respiratory Failure" ], "interventions": [ { "name": "Esophageal balloon", "type": "DEVICE" }, { "name": "Intervention Spontaneous Breathing Trial (SBT) and Extubation", "type": "PROCEDURE" }, { "name": "Control Spontaneous Breathing Trial and Extubation", "type": "PROCEDURE" }, { "name": "Intervention Weaning after Tracheostomy", "type": "PROCEDURE" }, { "name": "Control Weaning after Tracheostomy", "type": "PROCEDURE" } ], "intervention_types": [ "DEVICE", "PROCEDURE" ], "sponsor": "University of North Carolina, Chapel Hill", "sponsor_class": "OTHER", "healthy_volunteers": false, "eligibility": { "minimum_age": "18 Years", "maximum_age": null, "sex": "ALL", "summary": "18 Years and older" }, "enrollment_count": 6, "start_date": "2021-03-31", "completion_date": "2022-12-06", "has_results": true, "last_update_posted_date": "2024-06-05", "last_synced_at": "2026-10-01T16:36:10.126Z", "location_count": 2, "location_summary": "Chapel Hill, North Carolina • Greenville, North Carolina", "locations": [ { "city": "Chapel Hill", "state": "North Carolina" }, { "city": "Greenville", "state": "North Carolina" } ], "official_url": "https://clinicaltrials.gov/study/NCT03951064" }, { "nct_id": "NCT05440851", "title": "Platform of Randomized Adaptive Clinical Trials in Critical Illness", "overall_status": "RECRUITING", "study_type": "INTERVENTIONAL", "phases": [ "NA" ], "conditions": [ "Respiratory Insufficiency", "Extracorporeal Membrane Oxygenation Complication", "Mechanical Ventilation Pressure High" ], "interventions": [ { "name": "Ultra-Protective Ventilation Facilitated by Extracorporeal Support", "type": "OTHER" }, { "name": "Lung-Protective Ventilation (LPV)", "type": "OTHER" }, { "name": "Driving Pressure-Limited Ventilation (DPL)", "type": "OTHER" }, { "name": "Lung- and Diaphragm-Protective Ventilation and Sedation (LDPVS)", "type": "OTHER" }, { "name": "Early Cohort corticosteroid dose", "type": "DRUG" }, { "name": "Extended Cohort corticosteroid dose", "type": "DRUG" }, { "name": "Usual care without routine corticosteroids", "type": "DRUG" }, { "name": "Usual care without extending corticosteroids", "type": "DRUG" }, { "name": "Usual care with fludrocortisone", "type": "DRUG" }, { "name": "Usual care without fludrocortisone", "type": "DRUG" }, { "name": "Drug 4 mL:", "type": "DRUG" }, { "name": "Drug 40 mg:", "type": "DRUG" }, { "name": "PEEP-20", "type": "OTHER" }, { "name": "PEEP-AOP", "type": "OTHER" }, { "name": "PEEP-10", "type": "OTHER" }, { "name": "VV ECMO-facilitated strategy of earlier awakening, extubation and rehabilitation", "type": "OTHER" }, { "name": "Electrical impedance tomography (EIT)", "type": "OTHER" }, { "name": "no treatment / intervention arm is involved.", "type": "OTHER" }, { "name": "Usual care", "type": "OTHER" }, { "name": "Early Routine IMT", "type": "OTHER" } ], "intervention_types": [ "OTHER", "DRUG" ], "sponsor": "University Health Network, Toronto", "sponsor_class": "OTHER", "healthy_volunteers": false, "eligibility": { "minimum_age": "18 Years", "maximum_age": null, "sex": "ALL", "summary": "18 Years and older" }, "enrollment_count": 6250, "start_date": "2023-04-30", "completion_date": "2027-03-31", "has_results": false, "last_update_posted_date": "2026-05-07", "last_synced_at": "2026-10-01T16:36:10.126Z", "location_count": 26, "location_summary": "Tucson, Arizona • Los Angeles, California • San Diego, California + 19 more", "locations": [ { "city": "Tucson", "state": "Arizona" }, { "city": "Los Angeles", "state": "California" }, { "city": "San Diego", "state": "California" }, { "city": "San Francisco", "state": "California" }, { "city": "Aurora", "state": "Colorado" } ], "official_url": "https://clinicaltrials.gov/study/NCT05440851" }, { "nct_id": "NCT03266016", "title": "Real-time Effort Driven VENTilator Management", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "NA" ], "conditions": [ "Ventilation Therapy; Complications", "Diaphragm Disease", "Pediatric Respiratory Diseases" ], "interventions": [ { "name": "Computerized Ventilator Protocol", "type": "OTHER" }, { "name": "Esophageal Manometry", "type": "DIAGNOSTIC_TEST" }, { "name": "Respiratory Inductance Plethysmography (RIP)", "type": "DIAGNOSTIC_TEST" }, { "name": "Diaphragm Ultrasound", "type": "DIAGNOSTIC_TEST" }, { "name": "Maximal Inspiratory Pressure", "type": "DIAGNOSTIC_TEST" } ], "intervention_types": [ "OTHER", "DIAGNOSTIC_TEST" ], "sponsor": "Children's Hospital Los Angeles", "sponsor_class": "OTHER", "healthy_volunteers": false, "eligibility": { "minimum_age": "30 Days", "maximum_age": "18 Years", "sex": "ALL", "summary": "30 Days to 18 Years" }, "enrollment_count": 248, "start_date": "2017-10-21", "completion_date": "2024-06-20", "has_results": true, "last_update_posted_date": "2025-09-17", "last_synced_at": "2026-10-01T16:36:10.126Z", "location_count": 1, "location_summary": "Los Angeles, California", "locations": [ { "city": "Los Angeles", "state": "California" } ], "official_url": "https://clinicaltrials.gov/study/NCT03266016" } ] }