{
  "api_version": "1",
  "request": {
    "url": "https://clinicaltrialsfind.com/api/v1/search.json?intervention=Cryoneurolysis&page=2",
    "query": {
      "intervention": "Cryoneurolysis",
      "page": 2
    },
    "page_size": 10
  },
  "pagination": {
    "page": 2,
    "page_size": 10,
    "total_count": 26,
    "total_pages": 3,
    "next_page_url": "https://clinicaltrialsfind.com/api/v1/search.json?intervention=Cryoneurolysis&page=3&page_size=10",
    "previous_page_url": "https://clinicaltrialsfind.com/api/v1/search.json?intervention=Cryoneurolysis&page=1&page_size=10"
  },
  "source": "remote",
  "last_synced_at": "2026-10-05T05:40:17.798Z",
  "attribution": "Data derived from public ClinicalTrials.gov records. The official record at https://clinicaltrials.gov/ remains the source of truth for current availability, contacts, and full study details.",
  "notes": [
    "This endpoint exposes only public summary fields — no participant contact emails, phone numbers, or scraped investigator contact details.",
    "For contact information and full protocol detail, follow each trial's `official_url` to the ClinicalTrials.gov record.",
    "This API is a navigational aid. It does not provide medical advice, eligibility determinations, or compensation guarantees."
  ],
  "trials": [
    {
      "nct_id": "NCT03688477",
      "title": "Iovera° to Treat Pain Associated With ACL Reconstruction and Rehabilitation",
      "overall_status": "WITHDRAWN",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Anterior Cruciate Ligament Reconstruction"
      ],
      "interventions": [
        {
          "name": "iovera°",
          "type": "DEVICE"
        }
      ],
      "intervention_types": [
        "DEVICE"
      ],
      "sponsor": "Pacira Pharmaceuticals, Inc",
      "sponsor_class": "INDUSTRY",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": "49 Years",
        "sex": "ALL",
        "summary": "18 Years to 49 Years"
      },
      "enrollment_count": 0,
      "start_date": "2018-10",
      "completion_date": "2019-06",
      "has_results": false,
      "last_update_posted_date": "2019-01-14",
      "last_synced_at": "2026-10-05T05:40:17.798Z",
      "location_count": 1,
      "location_summary": "New York, New York",
      "locations": [
        {
          "city": "New York",
          "state": "New York"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT03688477"
    },
    {
      "nct_id": "NCT03818022",
      "title": "Pain Control With Pre-operative Cryoneurolysis Following TKA",
      "overall_status": "WITHDRAWN",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Osteo Arthritis Knee"
      ],
      "interventions": [
        {
          "name": "Cryoneurolysis (Iovera)",
          "type": "PROCEDURE"
        }
      ],
      "intervention_types": [
        "PROCEDURE"
      ],
      "sponsor": "Fondren Orthopedic Group L.L.P.",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": "90 Years",
        "sex": "ALL",
        "summary": "18 Years to 90 Years"
      },
      "enrollment_count": 0,
      "start_date": "2019-02-01",
      "completion_date": "2020-12",
      "has_results": false,
      "last_update_posted_date": "2024-02-23",
      "last_synced_at": "2026-10-05T05:40:17.798Z",
      "location_count": 1,
      "location_summary": "Houston, Texas",
      "locations": [
        {
          "city": "Houston",
          "state": "Texas"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT03818022"
    },
    {
      "nct_id": "NCT06069154",
      "title": "Ultrasound-Guided Percutaneous Cryoneurolysis to Treat Pain Following Thoracic Trauma",
      "overall_status": "ENROLLING_BY_INVITATION",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Rib Fracture",
        "Rib Fracture Multiple"
      ],
      "interventions": [
        {
          "name": "Cryoneurolysis",
          "type": "DEVICE"
        },
        {
          "name": "Local anesthetic peripheral nerve block",
          "type": "PROCEDURE"
        },
        {
          "name": "Sham Cryoneurolysis",
          "type": "DEVICE"
        },
        {
          "name": "Sham peripheral nerve block",
          "type": "PROCEDURE"
        }
      ],
      "intervention_types": [
        "DEVICE",
        "PROCEDURE"
      ],
      "sponsor": "University of California, San Diego",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "18 Years and older"
      },
      "enrollment_count": 120,
      "start_date": "2023-10-30",
      "completion_date": "2028-12",
      "has_results": false,
      "last_update_posted_date": "2026-08-24",
      "last_synced_at": "2026-10-05T05:40:17.798Z",
      "location_count": 5,
      "location_summary": "La Jolla, California • Bethesda, Maryland • Boston, Massachusetts + 1 more",
      "locations": [
        {
          "city": "La Jolla",
          "state": "California"
        },
        {
          "city": "Bethesda",
          "state": "Maryland"
        },
        {
          "city": "Boston",
          "state": "Massachusetts"
        },
        {
          "city": "Boston",
          "state": "Massachusetts"
        },
        {
          "city": "Houston",
          "state": "Texas"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT06069154"
    },
    {
      "nct_id": "NCT05330611",
      "title": "Treatment of Adult Traumatic Rib Fractures With Percutaneous Cryoneurolysis",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Rib Fractures"
      ],
      "interventions": [
        {
          "name": "Cryoneurolysis of Intercostal Nerves",
          "type": "DEVICE"
        },
        {
          "name": "Standard of Care",
          "type": "OTHER"
        }
      ],
      "intervention_types": [
        "DEVICE",
        "OTHER"
      ],
      "sponsor": "Stanford University",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": "64 Years",
        "sex": "ALL",
        "summary": "18 Years to 64 Years"
      },
      "enrollment_count": 43,
      "start_date": "2023-02-21",
      "completion_date": "2026-02-02",
      "has_results": true,
      "last_update_posted_date": "2026-04-24",
      "last_synced_at": "2026-10-05T05:40:17.798Z",
      "location_count": 1,
      "location_summary": "Palo Alto, California",
      "locations": [
        {
          "city": "Palo Alto",
          "state": "California"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT05330611"
    },
    {
      "nct_id": "NCT07637370",
      "title": "FROST-STERN Trial: A Trial of Intraoperative Cryoablation for Post Operative Pain Management After Full Sternotomy",
      "overall_status": "NOT_YET_RECRUITING",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Pulmonary Dysfunction",
        "Median Sternotomy Recovery",
        "Postoperative Pain"
      ],
      "interventions": [
        {
          "name": "Intercostal Nerve Cryoablation",
          "type": "DEVICE"
        }
      ],
      "intervention_types": [
        "DEVICE"
      ],
      "sponsor": "Rutgers, The State University of New Jersey",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "40 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "40 Years and older"
      },
      "enrollment_count": 100,
      "start_date": "2026-07-15",
      "completion_date": "2028-08",
      "has_results": false,
      "last_update_posted_date": "2026-06-09",
      "last_synced_at": "2026-10-05T05:40:17.798Z",
      "location_count": 1,
      "location_summary": "New Brunswick, New Jersey",
      "locations": [
        {
          "city": "New Brunswick",
          "state": "New Jersey"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT07637370"
    },
    {
      "nct_id": "NCT06908538",
      "title": "Cryo NerVe Block Extremity AmputatioN RegIStry for Post Operative and pHantom Limb Pain",
      "overall_status": "RECRUITING",
      "study_type": "OBSERVATIONAL",
      "phases": [],
      "conditions": [
        "Amputation",
        "Amputation of Lower Limb",
        "Amputation of Upper Limb",
        "Amputation, Limb Loss",
        "Amputation, Traumatic/Surgery",
        "Cryo Analgesia"
      ],
      "interventions": [
        {
          "name": "cryoablation",
          "type": "DEVICE"
        }
      ],
      "intervention_types": [
        "DEVICE"
      ],
      "sponsor": "AtriCure, Inc.",
      "sponsor_class": "INDUSTRY",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "18 Years and older"
      },
      "enrollment_count": 2000,
      "start_date": "2025-04-01",
      "completion_date": "2035-04",
      "has_results": false,
      "last_update_posted_date": "2026-08-26",
      "last_synced_at": "2026-10-05T05:40:17.798Z",
      "location_count": 6,
      "location_summary": "Pittsfield, Massachusetts • Manchester, New Hampshire • New York, New York + 3 more",
      "locations": [
        {
          "city": "Pittsfield",
          "state": "Massachusetts"
        },
        {
          "city": "Manchester",
          "state": "New Hampshire"
        },
        {
          "city": "New York",
          "state": "New York"
        },
        {
          "city": "Columbus",
          "state": "Ohio"
        },
        {
          "city": "Greenville",
          "state": "South Carolina"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT06908538"
    },
    {
      "nct_id": "NCT06804551",
      "title": "Cryoneurolysis Versus Radiofrequency Ablation for the Treatment of Chronic Low Back Pain",
      "overall_status": "ACTIVE_NOT_RECRUITING",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Chronic Low-back Pain"
      ],
      "interventions": [
        {
          "name": "iovera system",
          "type": "DEVICE"
        },
        {
          "name": "Radiofrequency ablation alone",
          "type": "DEVICE"
        }
      ],
      "intervention_types": [
        "DEVICE"
      ],
      "sponsor": "University of Kansas Medical Center",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "18 Years and older"
      },
      "enrollment_count": 30,
      "start_date": "2025-05-13",
      "completion_date": "2027-07",
      "has_results": false,
      "last_update_posted_date": "2026-08-13",
      "last_synced_at": "2026-10-05T05:40:17.798Z",
      "location_count": 1,
      "location_summary": "Kansas City, Kansas",
      "locations": [
        {
          "city": "Kansas City",
          "state": "Kansas"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT06804551"
    },
    {
      "nct_id": "NCT06646731",
      "title": "Cryoneurolysis for Painful Diabetic Neuropathy of the Foot",
      "overall_status": "ACTIVE_NOT_RECRUITING",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Painful Diabetic Peripheral Neuropathy (PDPN)"
      ],
      "interventions": [
        {
          "name": "cryoneurolysis",
          "type": "DEVICE"
        },
        {
          "name": "sham cryoneurolysis",
          "type": "DEVICE"
        }
      ],
      "intervention_types": [
        "DEVICE"
      ],
      "sponsor": "University of California, San Diego",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "18 Years and older"
      },
      "enrollment_count": 30,
      "start_date": "2025-08-25",
      "completion_date": "2026-12",
      "has_results": false,
      "last_update_posted_date": "2026-07-06",
      "last_synced_at": "2026-10-05T05:40:17.798Z",
      "location_count": 1,
      "location_summary": "La Jolla, California",
      "locations": [
        {
          "city": "La Jolla",
          "state": "California"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT06646731"
    },
    {
      "nct_id": "NCT06603051",
      "title": "The Effect of Pre-Operative Cryoneurolysis on Post-Operative Narcotic Consumption in Patients Undergoing Autograft ACL Reconstruction",
      "overall_status": "RECRUITING",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "ACL Repair"
      ],
      "interventions": [
        {
          "name": "Cryoneurolysis",
          "type": "PROCEDURE"
        }
      ],
      "intervention_types": [
        "PROCEDURE"
      ],
      "sponsor": "Virtua Health, Inc.",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "14 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "14 Years and older"
      },
      "enrollment_count": 20,
      "start_date": "2024-08-28",
      "completion_date": "2027-10",
      "has_results": false,
      "last_update_posted_date": "2026-05-12",
      "last_synced_at": "2026-10-05T05:40:17.798Z",
      "location_count": 2,
      "location_summary": "Burlington, New Jersey • Cherry Hill, New Jersey",
      "locations": [
        {
          "city": "Burlington",
          "state": "New Jersey"
        },
        {
          "city": "Cherry Hill",
          "state": "New Jersey"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT06603051"
    },
    {
      "nct_id": "NCT03327220",
      "title": "Treatment With Iovera° for Total Knee Arthroplasty (TKA) Post-Operative Pain",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Total Knee Arthroplasty"
      ],
      "interventions": [
        {
          "name": "iovera°",
          "type": "DEVICE"
        }
      ],
      "intervention_types": [
        "DEVICE"
      ],
      "sponsor": "Pacira Pharmaceuticals, Inc",
      "sponsor_class": "INDUSTRY",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "22 Years",
        "maximum_age": "79 Years",
        "sex": "ALL",
        "summary": "22 Years to 79 Years"
      },
      "enrollment_count": 124,
      "start_date": "2017-11-06",
      "completion_date": "2019-03-27",
      "has_results": true,
      "last_update_posted_date": "2021-05-21",
      "last_synced_at": "2026-10-05T05:40:17.798Z",
      "location_count": 1,
      "location_summary": "Germantown, Tennessee",
      "locations": [
        {
          "city": "Germantown",
          "state": "Tennessee"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT03327220"
    }
  ]
}