{ "api_version": "1", "request": { "url": "https://clinicaltrialsfind.com/api/v1/search.json?intervention=Cyclobenzaprine+HCl", "query": { "intervention": "Cyclobenzaprine HCl" }, "page_size": 10 }, "pagination": { "page": 1, "page_size": 10, "total_count": 34, "total_pages": 4, "next_page_url": "https://clinicaltrialsfind.com/api/v1/search.json?intervention=Cyclobenzaprine+HCl&page=2&page_size=10", "previous_page_url": null }, "source": "remote", "last_synced_at": "2026-09-16T05:00:05.544Z", "attribution": "Data derived from public ClinicalTrials.gov records. The official record at https://clinicaltrials.gov/ remains the source of truth for current availability, contacts, and full study details.", "notes": [ "This endpoint exposes only public summary fields — no participant contact emails, phone numbers, or scraped investigator contact details.", "For contact information and full protocol detail, follow each trial's `official_url` to the ClinicalTrials.gov record.", "This API is a navigational aid. It does not provide medical advice, eligibility determinations, or compensation guarantees." ], "trials": [ { "nct_id": "NCT04990804", "title": "Opioid Free vs. Standard Perioperative Pain Regimen for Anterior Cervical Discectomy and Fusion (ACDF) Surgery", "overall_status": "TERMINATED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE4" ], "conditions": [ "Opioid Use", "Spinal Diseases", "Surgery--Complications", "Surgery", "Postoperative Pain" ], "interventions": [ { "name": "Opioid Analgesic", "type": "DRUG" }, { "name": "Opioid-Free Postoperative Pain Regimen", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "Vanderbilt University Medical Center", "sponsor_class": "OTHER", "healthy_volunteers": false, "eligibility": { "minimum_age": "18 Years", "maximum_age": null, "sex": "ALL", "summary": "18 Years and older" }, "enrollment_count": 8, "start_date": "2021-08-01", "completion_date": "2022-02-01", "has_results": true, "last_update_posted_date": "2024-01-31", "last_synced_at": "2026-09-16T05:00:05.544Z", "location_count": 1, "location_summary": "Nashville, Tennessee", "locations": [ { "city": "Nashville", "state": "Tennessee" } ], "official_url": "https://clinicaltrials.gov/study/NCT04990804" }, { "nct_id": "NCT04771741", "title": "Opiate Free Multimodal Pain Pathway in Elective Foot and Ankle Surgery: A Prospective Study", "overall_status": "COMPLETED", "study_type": "OBSERVATIONAL", "phases": [], "conditions": [ "Bunion of Unspecified Foot", "Bunionette of Unspecified Foot", "Hammertoe", "Ankle Fractures", "Achilles Tendon Surgery" ], "interventions": [ { "name": "Acetominophen", "type": "DRUG" }, { "name": "Toradol", "type": "DRUG" }, { "name": "Meloxicam", "type": "DRUG" }, { "name": "Cyclobenzaprine", "type": "DRUG" }, { "name": "Lyrica", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "Prisma Health-Midlands", "sponsor_class": "OTHER", "healthy_volunteers": false, "eligibility": { "minimum_age": "18 Years", "maximum_age": "99 Years", "sex": "ALL", "summary": "18 Years to 99 Years" }, "enrollment_count": 72, "start_date": "2020-12-01", "completion_date": "2023-04-26", "has_results": false, "last_update_posted_date": "2023-04-27", "last_synced_at": "2026-09-16T05:00:05.544Z", "location_count": 1, "location_summary": "Columbia, South Carolina", "locations": [ { "city": "Columbia", "state": "South Carolina" } ], "official_url": "https://clinicaltrials.gov/study/NCT04771741" }, { "nct_id": "NCT03110575", "title": "12-Week Open-Label Extension Study of TNX-102 SL in PTSD Patients", "overall_status": "TERMINATED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE3" ], "conditions": [ "PTSD" ], "interventions": [ { "name": "TNX-102 SL", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "Tonix Pharmaceuticals, Inc.", "sponsor_class": "INDUSTRY", "healthy_volunteers": false, "eligibility": { "minimum_age": "18 Years", "maximum_age": "75 Years", "sex": "ALL", "summary": "18 Years to 75 Years" }, "enrollment_count": 190, "start_date": "2017-06-20", "completion_date": "2018-07-27", "has_results": true, "last_update_posted_date": "2025-02-06", "last_synced_at": "2026-09-16T05:00:05.544Z", "location_count": 32, "location_summary": "Phoenix, Arizona • Rogers, Arkansas • Beverly Hills, California + 28 more", "locations": [ { "city": "Phoenix", "state": "Arizona" }, { "city": "Rogers", "state": "Arkansas" }, { "city": "Beverly Hills", "state": "California" }, { "city": "Glendale", "state": "California" }, { "city": "Oakland", "state": "California" } ], "official_url": "https://clinicaltrials.gov/study/NCT03110575" }, { "nct_id": "NCT03062540", "title": "Safety and Efficacy Study of TNX-102 SL in Patients With Military-related PTSD", "overall_status": "TERMINATED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE3" ], "conditions": [ "PTSD" ], "interventions": [ { "name": "TNX-102 SL", "type": "DRUG" }, { "name": "Placebo SL Tablet", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "Tonix Pharmaceuticals, Inc.", "sponsor_class": "INDUSTRY", "healthy_volunteers": false, "eligibility": { "minimum_age": "18 Years", "maximum_age": "75 Years", "sex": "ALL", "summary": "18 Years to 75 Years" }, "enrollment_count": 358, "start_date": "2017-03-27", "completion_date": "2018-07-27", "has_results": true, "last_update_posted_date": "2024-05-22", "last_synced_at": "2026-09-16T05:00:05.544Z", "location_count": 44, "location_summary": "Phoenix, Arizona • Little Rock, Arkansas • Rogers, Arkansas + 40 more", "locations": [ { "city": "Phoenix", "state": "Arizona" }, { "city": "Little Rock", "state": "Arkansas" }, { "city": "Rogers", "state": "Arkansas" }, { "city": "Beverly Hills", "state": "California" }, { "city": "Glendale", "state": "California" } ], "official_url": "https://clinicaltrials.gov/study/NCT03062540" }, { "nct_id": "NCT01041495", "title": "Cyclobenzaprine Extended Release (ER) for Fibromyalgia", "overall_status": "TERMINATED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE4" ], "conditions": [ "Fibromyalgia", "Pain", "Sleep", "Fatigue" ], "interventions": [ { "name": "cyclobenzaprine ER (AMRIX)", "type": "DRUG" }, { "name": "placebo", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "State University of New York - Upstate Medical University", "sponsor_class": "OTHER", "healthy_volunteers": false, "eligibility": { "minimum_age": "18 Years", "maximum_age": "65 Years", "sex": "ALL", "summary": "18 Years to 65 Years" }, "enrollment_count": 37, "start_date": "2009-06", "completion_date": "2013-03", "has_results": true, "last_update_posted_date": "2024-11-27", "last_synced_at": "2026-09-16T05:00:05.544Z", "location_count": 1, "location_summary": "Syracuse, New York", "locations": [ { "city": "Syracuse", "state": "New York" } ], "official_url": "https://clinicaltrials.gov/study/NCT01041495" }, { "nct_id": "NCT04407377", "title": "Effects of Tolperisone on Measures of Drowsiness and Cognitive Function", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE1" ], "conditions": [ "Healthy" ], "interventions": [ { "name": "Tolperisone Hydrochloride", "type": "DRUG" }, { "name": "Cyclobenzaprine Hydrochloride 10 MG", "type": "DRUG" }, { "name": "Placebo", "type": "OTHER" } ], "intervention_types": [ "DRUG", "OTHER" ], "sponsor": "Neurana Pharmaceuticals, Inc.", "sponsor_class": "INDUSTRY", "healthy_volunteers": true, "eligibility": { "minimum_age": "21 Years", "maximum_age": "65 Years", "sex": "ALL", "summary": "21 Years to 65 Years" }, "enrollment_count": 39, "start_date": "2020-06-20", "completion_date": "2021-03-31", "has_results": false, "last_update_posted_date": "2022-02-01", "last_synced_at": "2026-09-16T05:00:05.544Z", "location_count": 2, "location_summary": "Long Beach, California • Berlin, New Jersey", "locations": [ { "city": "Long Beach", "state": "California" }, { "city": "Berlin", "state": "New Jersey" } ], "official_url": "https://clinicaltrials.gov/study/NCT04407377" }, { "nct_id": "NCT01028014", "title": "Medication Effects on Periurethral Sensation,Urethral Sphincter Activity and Pressure Flow Parameters", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "NA" ], "conditions": [ "Urethral Sphincter Activity" ], "interventions": [ { "name": "Pseudoephedrine", "type": "DRUG" }, { "name": "Tamsulosin", "type": "DRUG" }, { "name": "Imipramine", "type": "DRUG" }, { "name": "Cyclobenzaprine", "type": "DRUG" }, { "name": "Lactose capsule", "type": "DRUG" }, { "name": "Solifenacin", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "University of Alabama at Birmingham", "sponsor_class": "OTHER", "healthy_volunteers": true, "eligibility": { "minimum_age": "19 Years", "maximum_age": "51 Years", "sex": "FEMALE", "summary": "19 Years to 51 Years · Female only" }, "enrollment_count": 56, "start_date": "2010-04", "completion_date": "2011-04", "has_results": true, "last_update_posted_date": "2012-06-08", "last_synced_at": "2026-09-16T05:00:05.544Z", "location_count": 1, "location_summary": "Birmingham, Alabama", "locations": [ { "city": "Birmingham", "state": "Alabama" } ], "official_url": "https://clinicaltrials.gov/study/NCT01028014" }, { "nct_id": "NCT01151787", "title": "Efficacy and Safety of Cyclobenzaprine Hydrochloride Extended Release for the Treatment of Chronic Migraine", "overall_status": "TERMINATED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE3" ], "conditions": [ "Chronic Migraine" ], "interventions": [ { "name": "cyclobenzaprine hydrochloride", "type": "DRUG" }, { "name": "placebo", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "Kennedy Medical Group", "sponsor_class": "OTHER", "healthy_volunteers": false, "eligibility": { "minimum_age": "18 Years", "maximum_age": "65 Years", "sex": "ALL", "summary": "18 Years to 65 Years" }, "enrollment_count": 35, "start_date": "2010-07", "completion_date": "2013-09", "has_results": false, "last_update_posted_date": "2014-07-25", "last_synced_at": "2026-09-16T05:00:05.544Z", "location_count": 1, "location_summary": "Cherry Hill, New Jersey", "locations": [ { "city": "Cherry Hill", "state": "New Jersey" } ], "official_url": "https://clinicaltrials.gov/study/NCT01151787" }, { "nct_id": "NCT04704297", "title": "Trigger Point Injection for Myofascial Pain Syndrome in the Low Back: A Randomized Controlled Trial", "overall_status": "RECRUITING", "study_type": "INTERVENTIONAL", "phases": [ "PHASE4" ], "conditions": [ "Low Back Pain", "Myofascial Pain Syndrome Lower Back" ], "interventions": [ { "name": "Treatment of Myofascial Pain Syndrome in the low back. This intervention will be based on outcomes of the medications listed below.", "type": "DRUG" }, { "name": "Evaluation of functional ability using a patient centered functional score known as the Modified Oswestry Disability Index (MODI). The intervention will be based on outcomes of medications below.", "type": "DRUG" }, { "name": "Following up with participants 60-72 hours after treatment in the Emergency Department. This intervention will be based on outcomes of the medications listed below.", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "Madigan Army Medical Center", "sponsor_class": "FED", "healthy_volunteers": true, "eligibility": { "minimum_age": "18 Years", "maximum_age": null, "sex": "ALL", "summary": "18 Years and older" }, "enrollment_count": 180, "start_date": "2020-12-28", "completion_date": "2022-07-01", "has_results": false, "last_update_posted_date": "2021-01-12", "last_synced_at": "2026-09-16T05:00:05.544Z", "location_count": 1, "location_summary": "Tacoma, Washington", "locations": [ { "city": "Tacoma", "state": "Washington" } ], "official_url": "https://clinicaltrials.gov/study/NCT04704297" }, { "nct_id": "NCT06636786", "title": "Prevention/Reduction of ASRs and PTSD to Sustain Civilian Performance With Sublingual Cyclobenzaprine HCl (TNX-102 SL)", "overall_status": "RECRUITING", "study_type": "INTERVENTIONAL", "phases": [ "PHASE2" ], "conditions": [ "Acute Stress Reaction", "Acute Stress Disorder", "Neurocognitive Function", "Post-traumatic Stress" ], "interventions": [ { "name": "Cyclobenzaprine HCl", "type": "DRUG" }, { "name": "Placebo", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "University of North Carolina, Chapel Hill", "sponsor_class": "OTHER", "healthy_volunteers": false, "eligibility": { "minimum_age": "18 Years", "maximum_age": "55 Years", "sex": "ALL", "summary": "18 Years to 55 Years" }, "enrollment_count": 180, "start_date": "2025-03-25", "completion_date": "2026-09", "has_results": false, "last_update_posted_date": "2026-09-01", "last_synced_at": "2026-09-16T05:00:05.544Z", "location_count": 9, "location_summary": "Birmingham, Alabama • Indianapolis, Indiana • Kansas City, Kansas + 5 more", "locations": [ { "city": "Birmingham", "state": "Alabama" }, { "city": "Indianapolis", "state": "Indiana" }, { "city": "Kansas City", "state": "Kansas" }, { "city": "St Louis", "state": "Missouri" }, { "city": "Camden", "state": "New Jersey" } ], "official_url": "https://clinicaltrials.gov/study/NCT06636786" } ] }