{ "api_version": "1", "request": { "url": "https://clinicaltrialsfind.com/api/v1/search.json?intervention=DCA+%28dichloroacetate%29", "query": { "intervention": "DCA (dichloroacetate)" }, "page_size": 10 }, "pagination": { "page": 1, "page_size": 10, "total_count": 19, "total_pages": 2, "next_page_url": "https://clinicaltrialsfind.com/api/v1/search.json?intervention=DCA+%28dichloroacetate%29&page=2&page_size=10", "previous_page_url": null }, "source": "remote", "last_synced_at": "2026-09-27T13:51:56.529Z", "attribution": "Data derived from public ClinicalTrials.gov records. The official record at https://clinicaltrials.gov/ remains the source of truth for current availability, contacts, and full study details.", "notes": [ "This endpoint exposes only public summary fields — no participant contact emails, phone numbers, or scraped investigator contact details.", "For contact information and full protocol detail, follow each trial's `official_url` to the ClinicalTrials.gov record.", "This API is a navigational aid. It does not provide medical advice, eligibility determinations, or compensation guarantees." ], "trials": [ { "nct_id": "NCT01386632", "title": "Study of DCA (Dichloroacetate) in Combination With Cisplatin and Definitive Radiation in Head and Neck Carcinoma", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE2" ], "conditions": [ "Squamous Cell Carcinoma of the Head and Neck" ], "interventions": [ { "name": "DCA (dichloroacetate)", "type": "DRUG" }, { "name": "Placebo", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "Sanford Health", "sponsor_class": "OTHER", "healthy_volunteers": false, "eligibility": { "minimum_age": "18 Years", "maximum_age": null, "sex": "ALL", "summary": "18 Years and older" }, "enrollment_count": 50, "start_date": "2011-05", "completion_date": "2020-06-01", "has_results": true, "last_update_posted_date": "2020-10-27", "last_synced_at": "2026-09-27T13:51:56.529Z", "location_count": 2, "location_summary": "Fargo, North Dakota • Sioux Falls, South Dakota", "locations": [ { "city": "Fargo", "state": "North Dakota" }, { "city": "Sioux Falls", "state": "South Dakota" } ], "official_url": "https://clinicaltrials.gov/study/NCT01386632" }, { "nct_id": "NCT00015015", "title": "Dichloroacetate Kinetics, Metabolism and Toxicology", "overall_status": "COMPLETED", "study_type": "OBSERVATIONAL", "phases": [], "conditions": [ "Lactic Acidosis" ], "interventions": [ { "name": "Dichloroacetate", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "National Institute of Environmental Health Sciences (NIEHS)", "sponsor_class": "NIH", "healthy_volunteers": true, "eligibility": { "minimum_age": "3 Months", "maximum_age": "65 Years", "sex": "ALL", "summary": "3 Months to 65 Years" }, "enrollment_count": 100, "start_date": "1994-12", "completion_date": "2002-10", "has_results": false, "last_update_posted_date": "2006-09-04", "last_synced_at": "2026-09-27T13:51:56.529Z", "location_count": 1, "location_summary": "Gainesville, Florida", "locations": [ { "city": "Gainesville", "state": "Florida" } ], "official_url": "https://clinicaltrials.gov/study/NCT00015015" }, { "nct_id": "NCT01807702", "title": "13C-Pyruvate Breath Test", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE1" ], "conditions": [ "Healthy" ], "interventions": [ { "name": "13C-Pyruvate 13C-lactate and dichloroacetate", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "University of Florida", "sponsor_class": "OTHER", "healthy_volunteers": true, "eligibility": { "minimum_age": "21 Years", "maximum_age": "50 Years", "sex": "ALL", "summary": "21 Years to 50 Years" }, "enrollment_count": 5, "start_date": "2013-03", "completion_date": "2013-07", "has_results": false, "last_update_posted_date": "2015-12-02", "last_synced_at": "2026-09-27T13:51:56.529Z", "location_count": 1, "location_summary": "Gainesville, Florida", "locations": [ { "city": "Gainesville", "state": "Florida" } ], "official_url": "https://clinicaltrials.gov/study/NCT01807702" }, { "nct_id": "NCT01123005", "title": "Imaging and Biomarkers of Hypoxia in Solid Tumors", "overall_status": "TERMINATED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE1" ], "conditions": [ "Neoplasms" ], "interventions": [ { "name": "PET Scan", "type": "PROCEDURE" }, { "name": "EF5", "type": "DRUG" }, { "name": "Carbogen", "type": "DRUG" }, { "name": "Dichloroacetate", "type": "DRUG" } ], "intervention_types": [ "PROCEDURE", "DRUG" ], "sponsor": "Stanford University", "sponsor_class": "OTHER", "healthy_volunteers": false, "eligibility": { "minimum_age": "18 Years", "maximum_age": null, "sex": "ALL", "summary": "18 Years and older" }, "enrollment_count": 28, "start_date": "2010-12", "completion_date": "2015-08-21", "has_results": false, "last_update_posted_date": "2017-11-06", "last_synced_at": "2026-09-27T13:51:56.529Z", "location_count": 1, "location_summary": "Stanford, California", "locations": [ { "city": "Stanford", "state": "California" } ], "official_url": "https://clinicaltrials.gov/study/NCT01123005" }, { "nct_id": "NCT01111097", "title": "Study of the Safety and Efficacy of Dichloroacetate (DCA) in Glioblastoma and Other Recurrent Brain Tumors", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE1" ], "conditions": [ "Brain Tumor", "Glioblastoma" ], "interventions": [ { "name": "Dichloroacetate", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "University of Florida", "sponsor_class": "OTHER", "healthy_volunteers": false, "eligibility": { "minimum_age": "21 Years", "maximum_age": "90 Years", "sex": "ALL", "summary": "21 Years to 90 Years" }, "enrollment_count": 15, "start_date": "2010-04", "completion_date": "2014-03", "has_results": false, "last_update_posted_date": "2015-09-22", "last_synced_at": "2026-09-27T13:51:56.529Z", "location_count": 1, "location_summary": "Gainesville, Florida", "locations": [ { "city": "Gainesville", "state": "Florida" } ], "official_url": "https://clinicaltrials.gov/study/NCT01111097" }, { "nct_id": "NCT03356457", "title": "Development of Agents to Diminish the Risk of Hypoglycemia-induced Brain Injury in Type 1 Diabetes", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "EARLY_PHASE1" ], "conditions": [ "Hyperglycaemia (Diabetic)" ], "interventions": [ { "name": "Dichloroacetate", "type": "DRUG" }, { "name": "Placebo oral capsule", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "Yale University", "sponsor_class": "OTHER", "healthy_volunteers": true, "eligibility": { "minimum_age": "18 Years", "maximum_age": "65 Years", "sex": "ALL", "summary": "18 Years to 65 Years" }, "enrollment_count": 21, "start_date": "2017-11-30", "completion_date": "2019-03-20", "has_results": false, "last_update_posted_date": "2021-01-22", "last_synced_at": "2026-09-27T13:51:56.529Z", "location_count": 1, "location_summary": "New Haven, Connecticut", "locations": [ { "city": "New Haven", "state": "Connecticut" } ], "official_url": "https://clinicaltrials.gov/study/NCT03356457" }, { "nct_id": "NCT00031161", "title": "Prevention of Dichloroacetate Toxicity", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "NA" ], "conditions": [ "Acidosis, Lactic", "Chronic Disease" ], "interventions": [ { "name": "Nitisinone (NTBC)", "type": "DRUG" }, { "name": "Dichloroacetate", "type": "DRUG" }, { "name": "Low-tyrosin diet", "type": "BEHAVIORAL" } ], "intervention_types": [ "DRUG", "BEHAVIORAL" ], "sponsor": "University of Florida", "sponsor_class": "OTHER", "healthy_volunteers": false, "eligibility": { "minimum_age": "3 Months", "maximum_age": "21 Years", "sex": "ALL", "summary": "3 Months to 21 Years" }, "enrollment_count": 30, "start_date": "2001-09", "completion_date": "2005-09", "has_results": false, "last_update_posted_date": "2015-03-25", "last_synced_at": "2026-09-27T13:51:56.529Z", "location_count": 1, "location_summary": "Gainesville, Florida", "locations": [ { "city": "Gainesville", "state": "Florida" } ], "official_url": "https://clinicaltrials.gov/study/NCT00031161" }, { "nct_id": "NCT05120284", "title": "Trial of Dichloroacetate (DCA) in Glioblastoma Multiforme (GBM)", "overall_status": "ACTIVE_NOT_RECRUITING", "study_type": "INTERVENTIONAL", "phases": [ "PHASE2" ], "conditions": [ "Glioblastoma Multiforme" ], "interventions": [ { "name": "Dichloroacetate (DCA)", "type": "DRUG" }, { "name": "Genotype", "type": "GENETIC" } ], "intervention_types": [ "DRUG", "GENETIC" ], "sponsor": "University of Florida", "sponsor_class": "OTHER", "healthy_volunteers": false, "eligibility": { "minimum_age": "18 Years", "maximum_age": "80 Years", "sex": "ALL", "summary": "18 Years to 80 Years" }, "enrollment_count": 40, "start_date": "2022-07-01", "completion_date": "2026-08-31", "has_results": false, "last_update_posted_date": "2026-06-26", "last_synced_at": "2026-09-27T13:51:56.529Z", "location_count": 2, "location_summary": "Baltimore, Maryland • Winston-Salem, North Carolina", "locations": [ { "city": "Baltimore", "state": "Maryland" }, { "city": "Winston-Salem", "state": "North Carolina" } ], "official_url": "https://clinicaltrials.gov/study/NCT05120284" }, { "nct_id": "NCT05317455", "title": "Regulation of Brain Glucose Metabolism in Type 1 Diabetes", "overall_status": "RECRUITING", "study_type": "INTERVENTIONAL", "phases": [ "EARLY_PHASE1" ], "conditions": [ "Diabetes Mellitus, Type 1", "Hypoglycemia Unawareness" ], "interventions": [ { "name": "Dichloroacetate", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "Yale University", "sponsor_class": "OTHER", "healthy_volunteers": false, "eligibility": { "minimum_age": "18 Years", "maximum_age": "55 Years", "sex": "ALL", "summary": "18 Years to 55 Years" }, "enrollment_count": 16, "start_date": "2025-05-13", "completion_date": "2027-06-30", "has_results": false, "last_update_posted_date": "2026-06-09", "last_synced_at": "2026-09-27T13:51:56.529Z", "location_count": 1, "location_summary": "New Haven, Connecticut", "locations": [ { "city": "New Haven", "state": "Connecticut" } ], "official_url": "https://clinicaltrials.gov/study/NCT05317455" }, { "nct_id": "NCT01029925", "title": "Dichloroacetate (DCA) in Patients With Previously Treated Metastatic Breast or Non-Small Cell Lung Cancer (NSCL)", "overall_status": "TERMINATED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE2" ], "conditions": [ "Metastatic Breast Cancer", "Lung Cancer" ], "interventions": [ { "name": "Dichloroacetate (DCA)", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "Jonsson Comprehensive Cancer Center", "sponsor_class": "OTHER", "healthy_volunteers": false, "eligibility": { "minimum_age": "18 Years", "maximum_age": null, "sex": "ALL", "summary": "18 Years and older" }, "enrollment_count": 7, "start_date": "2009-12", "completion_date": "2011-11", "has_results": true, "last_update_posted_date": "2016-02-12", "last_synced_at": "2026-09-27T13:51:56.529Z", "location_count": 1, "location_summary": "Los Angeles, California", "locations": [ { "city": "Los Angeles", "state": "California" } ], "official_url": "https://clinicaltrials.gov/study/NCT01029925" } ] }