{
  "api_version": "1",
  "request": {
    "url": "https://clinicaltrialsfind.com/api/v1/search.json?intervention=Darkness",
    "query": {
      "intervention": "Darkness"
    },
    "page_size": 10
  },
  "pagination": {
    "page": 1,
    "page_size": 10,
    "total_count": 14,
    "total_pages": 2,
    "next_page_url": "https://clinicaltrialsfind.com/api/v1/search.json?intervention=Darkness&page=2&page_size=10",
    "previous_page_url": null
  },
  "source": "remote",
  "last_synced_at": "2026-09-03T04:45:50.517Z",
  "attribution": "Data derived from public ClinicalTrials.gov records. The official record at https://clinicaltrials.gov/ remains the source of truth for current availability, contacts, and full study details.",
  "notes": [
    "This endpoint exposes only public summary fields — no participant contact emails, phone numbers, or scraped investigator contact details.",
    "For contact information and full protocol detail, follow each trial's `official_url` to the ClinicalTrials.gov record.",
    "This API is a navigational aid. It does not provide medical advice, eligibility determinations, or compensation guarantees."
  ],
  "trials": [
    {
      "nct_id": "NCT03694626",
      "title": "Objectively Diagnose and Monitor Treatment of Light Sensitivity",
      "overall_status": "RECRUITING",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Photophobia",
        "Traumatic Brain Injury",
        "Migraine"
      ],
      "interventions": [
        {
          "name": "Pupillography",
          "type": "DEVICE"
        },
        {
          "name": "Ocular Coherence Tomography (OCT)",
          "type": "DEVICE"
        },
        {
          "name": "Wrist-watch sensor device",
          "type": "DEVICE"
        },
        {
          "name": "Videography",
          "type": "DEVICE"
        },
        {
          "name": "Electrophysiology",
          "type": "DEVICE"
        }
      ],
      "intervention_types": [
        "DEVICE"
      ],
      "sponsor": "Randy Kardon",
      "sponsor_class": "OTHER",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": "80 Years",
        "sex": "ALL",
        "summary": "18 Years to 80 Years"
      },
      "enrollment_count": 120,
      "start_date": "2019-07-11",
      "completion_date": "2028-01-01",
      "has_results": false,
      "last_update_posted_date": "2025-11-24",
      "last_synced_at": "2026-09-03T04:45:50.517Z",
      "location_count": 1,
      "location_summary": "Iowa City, Iowa",
      "locations": [
        {
          "city": "Iowa City",
          "state": "Iowa"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT03694626"
    },
    {
      "nct_id": "NCT02632318",
      "title": "Dawn Simulation and Postural Hypotension",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE4"
      ],
      "conditions": [
        "Orthostatic Hypotension"
      ],
      "interventions": [
        {
          "name": "Light",
          "type": "DEVICE"
        }
      ],
      "intervention_types": [
        "DEVICE"
      ],
      "sponsor": "VA Palo Alto Health Care System",
      "sponsor_class": "FED",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "55 Years",
        "maximum_age": "85 Years",
        "sex": "ALL",
        "summary": "55 Years to 85 Years"
      },
      "enrollment_count": 35,
      "start_date": "2016-09-01",
      "completion_date": "2019-02-01",
      "has_results": false,
      "last_update_posted_date": "2019-10-25",
      "last_synced_at": "2026-09-03T04:45:50.517Z",
      "location_count": 1,
      "location_summary": "Palo Alto, California",
      "locations": [
        {
          "city": "Palo Alto",
          "state": "California"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT02632318"
    },
    {
      "nct_id": "NCT06104280",
      "title": "Medications for Opioid Use Disorder Photosensitive Retinal Ganglion Cell Function, Sleep, and Circadian Rhythms: Implications for Treatment",
      "overall_status": "RECRUITING",
      "study_type": "OBSERVATIONAL",
      "phases": [],
      "conditions": [
        "Opioid Use Disorder",
        "Sleep Disturbance"
      ],
      "interventions": [
        {
          "name": "Post-Illumination Pupillary Response (PIPR)",
          "type": "OTHER"
        },
        {
          "name": "Polysomnography",
          "type": "OTHER"
        },
        {
          "name": "Multiple Sleep Latency Test",
          "type": "OTHER"
        },
        {
          "name": "Ecological Momentary Assessments",
          "type": "BEHAVIORAL"
        },
        {
          "name": "Actigraphy",
          "type": "DEVICE"
        },
        {
          "name": "DLMO",
          "type": "OTHER"
        },
        {
          "name": "Melatonin Suppression Test",
          "type": "OTHER"
        }
      ],
      "intervention_types": [
        "OTHER",
        "BEHAVIORAL",
        "DEVICE"
      ],
      "sponsor": "University of Alabama at Birmingham",
      "sponsor_class": "OTHER",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": "80 Years",
        "sex": "ALL",
        "summary": "18 Years to 80 Years"
      },
      "enrollment_count": 200,
      "start_date": "2025-01-06",
      "completion_date": "2029-01-01",
      "has_results": false,
      "last_update_posted_date": "2026-08-11",
      "last_synced_at": "2026-09-03T04:45:50.517Z",
      "location_count": 1,
      "location_summary": "Birmingham, Alabama",
      "locations": [
        {
          "city": "Birmingham",
          "state": "Alabama"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT06104280"
    },
    {
      "nct_id": "NCT02884505",
      "title": "Improving the Assessment of Hypersomnolence",
      "overall_status": "COMPLETED",
      "study_type": "OBSERVATIONAL",
      "phases": [],
      "conditions": [
        "Disorders of Excessive Somnolence"
      ],
      "interventions": [
        {
          "name": "Pupillometry",
          "type": "DEVICE"
        },
        {
          "name": "Psychomotor Vigilance Task",
          "type": "BEHAVIORAL"
        },
        {
          "name": "Auditory Evoked Potential",
          "type": "OTHER"
        },
        {
          "name": "Hypersomnia Severity Index",
          "type": "BEHAVIORAL"
        }
      ],
      "intervention_types": [
        "DEVICE",
        "BEHAVIORAL",
        "OTHER"
      ],
      "sponsor": "University of Wisconsin, Madison",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": "89 Years",
        "sex": "ALL",
        "summary": "18 Years to 89 Years"
      },
      "enrollment_count": 132,
      "start_date": "2017-08-25",
      "completion_date": "2019-06-30",
      "has_results": false,
      "last_update_posted_date": "2019-08-22",
      "last_synced_at": "2026-09-03T04:45:50.517Z",
      "location_count": 1,
      "location_summary": "Madison, Wisconsin",
      "locations": [
        {
          "city": "Madison",
          "state": "Wisconsin"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT02884505"
    },
    {
      "nct_id": "NCT04868539",
      "title": "Influence of Nocturnal Light Exposure on the Impairment of Glucose Tolerance Induced by Chronic Sleep Restriction",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Glucose Intolerance",
        "Sleep Deprivation",
        "Sleep"
      ],
      "interventions": [
        {
          "name": "Sleep Restriction with ALAN first, then Sleep Restriction without ALAN",
          "type": "OTHER"
        },
        {
          "name": "Sleep Restriction without ALAN first, then sleep restriction with ALAN",
          "type": "OTHER"
        }
      ],
      "intervention_types": [
        "OTHER"
      ],
      "sponsor": "Brigham and Women's Hospital",
      "sponsor_class": "OTHER",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "20 Years",
        "maximum_age": "40 Years",
        "sex": "ALL",
        "summary": "20 Years to 40 Years"
      },
      "enrollment_count": 14,
      "start_date": "2022-03-15",
      "completion_date": "2024-05-30",
      "has_results": true,
      "last_update_posted_date": "2025-10-14",
      "last_synced_at": "2026-09-03T04:45:50.517Z",
      "location_count": 1,
      "location_summary": "Boston, Massachusetts",
      "locations": [
        {
          "city": "Boston",
          "state": "Massachusetts"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT04868539"
    },
    {
      "nct_id": "NCT02685423",
      "title": "Light-deprivation Utilized to Mitigate Amblyopia",
      "overall_status": "UNKNOWN",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Amblyopia"
      ],
      "interventions": [
        {
          "name": "Binocular deprivation 10 days",
          "type": "BEHAVIORAL"
        },
        {
          "name": "Vision training",
          "type": "BEHAVIORAL"
        }
      ],
      "intervention_types": [
        "BEHAVIORAL"
      ],
      "sponsor": "State University of New York College of Optometry",
      "sponsor_class": "OTHER",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "18 Years and older"
      },
      "enrollment_count": 8,
      "start_date": "2016-12",
      "completion_date": "2019-12-31",
      "has_results": false,
      "last_update_posted_date": "2019-08-29",
      "last_synced_at": "2026-09-03T04:45:50.517Z",
      "location_count": 1,
      "location_summary": "New York, New York",
      "locations": [
        {
          "city": "New York",
          "state": "New York"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT02685423"
    },
    {
      "nct_id": "NCT05460520",
      "title": "DevRobust Treatment for Mal de Débarquement Syndrome",
      "overall_status": "RECRUITING",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Mal de Débarquement Syndrome"
      ],
      "interventions": [
        {
          "name": "VOR Readaptation",
          "type": "BEHAVIORAL"
        },
        {
          "name": "VOR Habituation",
          "type": "BEHAVIORAL"
        },
        {
          "name": "Visual Motion Desensitization",
          "type": "BEHAVIORAL"
        },
        {
          "name": "Opposing visual motion stimulus",
          "type": "BEHAVIORAL"
        }
      ],
      "intervention_types": [
        "BEHAVIORAL"
      ],
      "sponsor": "Icahn School of Medicine at Mount Sinai",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": "78 Years",
        "sex": "ALL",
        "summary": "18 Years to 78 Years"
      },
      "enrollment_count": 200,
      "start_date": "2023-01-01",
      "completion_date": "2027-04-30",
      "has_results": false,
      "last_update_posted_date": "2026-02-17",
      "last_synced_at": "2026-09-03T04:45:50.517Z",
      "location_count": 1,
      "location_summary": "New York, New York",
      "locations": [
        {
          "city": "New York",
          "state": "New York"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT05460520"
    },
    {
      "nct_id": "NCT01330992",
      "title": "Human Circadian Sensitivity to Very Short Light Pulses",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Circadian Rhythm Disorders"
      ],
      "interventions": [
        {
          "name": "Ocular light or darkness exposure",
          "type": "OTHER"
        }
      ],
      "intervention_types": [
        "OTHER"
      ],
      "sponsor": "Brigham and Women's Hospital",
      "sponsor_class": "OTHER",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": "30 Years",
        "sex": "ALL",
        "summary": "18 Years to 30 Years"
      },
      "enrollment_count": 400,
      "start_date": "2009-12",
      "completion_date": "2011-08",
      "has_results": false,
      "last_update_posted_date": "2011-08-23",
      "last_synced_at": "2026-09-03T04:45:50.517Z",
      "location_count": 1,
      "location_summary": "Boston, Massachusetts",
      "locations": [
        {
          "city": "Boston",
          "state": "Massachusetts"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT01330992"
    },
    {
      "nct_id": "NCT06023446",
      "title": "Can (Optical Coherence Tomography) Pictures of the Retina Detect Alzheimer's Disease at Its Earliest Stages?",
      "overall_status": "ENROLLING_BY_INVITATION",
      "study_type": "OBSERVATIONAL",
      "phases": [],
      "conditions": [
        "Alzheimer Disease",
        "Mild Cognitive Impairment"
      ],
      "interventions": [
        {
          "name": "Optical Coherence Tomography",
          "type": "DIAGNOSTIC_TEST"
        }
      ],
      "intervention_types": [
        "DIAGNOSTIC_TEST"
      ],
      "sponsor": "University of California, Davis",
      "sponsor_class": "OTHER",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "50 Years",
        "maximum_age": "89 Years",
        "sex": "ALL",
        "summary": "50 Years to 89 Years"
      },
      "enrollment_count": 100,
      "start_date": "2023-09-29",
      "completion_date": "2028-02-28",
      "has_results": false,
      "last_update_posted_date": "2025-12-05",
      "last_synced_at": "2026-09-03T04:45:50.517Z",
      "location_count": 1,
      "location_summary": "Sacramento, California",
      "locations": [
        {
          "city": "Sacramento",
          "state": "California"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT06023446"
    },
    {
      "nct_id": "NCT04213079",
      "title": "Treatments of Mal de Debarquement Syndrome (MdDS) by Habituation of Velocity Storage",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Mal de Debarquement Syndrome (MdDS)"
      ],
      "interventions": [
        {
          "name": "re-adaptation of the vestibulo-ocular reflex",
          "type": "DEVICE"
        },
        {
          "name": "Habituation of velocity storage of the vestibulo-ocular reflex",
          "type": "DEVICE"
        }
      ],
      "intervention_types": [
        "DEVICE"
      ],
      "sponsor": "Icahn School of Medicine at Mount Sinai",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": "78 Years",
        "sex": "ALL",
        "summary": "18 Years to 78 Years"
      },
      "enrollment_count": 47,
      "start_date": "2020-06-15",
      "completion_date": "2022-11-30",
      "has_results": true,
      "last_update_posted_date": "2024-01-03",
      "last_synced_at": "2026-09-03T04:45:50.517Z",
      "location_count": 1,
      "location_summary": "New York, New York",
      "locations": [
        {
          "city": "New York",
          "state": "New York"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT04213079"
    }
  ]
}