{
  "api_version": "1",
  "request": {
    "url": "https://clinicaltrialsfind.com/api/v1/search.json?intervention=Definity+Perflutren+Lipid+Microsphere+Ultrasound+Contrast",
    "query": {
      "intervention": "Definity Perflutren Lipid Microsphere Ultrasound Contrast"
    },
    "page_size": 10
  },
  "pagination": {
    "page": 1,
    "page_size": 10,
    "total_count": 29,
    "total_pages": 3,
    "next_page_url": "https://clinicaltrialsfind.com/api/v1/search.json?intervention=Definity+Perflutren+Lipid+Microsphere+Ultrasound+Contrast&page=2&page_size=10",
    "previous_page_url": null
  },
  "source": "remote",
  "last_synced_at": "2026-09-27T01:48:15.184Z",
  "attribution": "Data derived from public ClinicalTrials.gov records. The official record at https://clinicaltrials.gov/ remains the source of truth for current availability, contacts, and full study details.",
  "notes": [
    "This endpoint exposes only public summary fields — no participant contact emails, phone numbers, or scraped investigator contact details.",
    "For contact information and full protocol detail, follow each trial's `official_url` to the ClinicalTrials.gov record.",
    "This API is a navigational aid. It does not provide medical advice, eligibility determinations, or compensation guarantees."
  ],
  "trials": [
    {
      "nct_id": "NCT01631318",
      "title": "Pilot 3D Contrast-Enhanced Ultrasound Imaging to Predict Treatment Response in Liver Metastases",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Liver Metastases",
        "Colon Cancer"
      ],
      "interventions": [
        {
          "name": "Dynamic contrast-enhanced ultrasound imaging",
          "type": "PROCEDURE"
        },
        {
          "name": "Optical Tracking Device",
          "type": "DEVICE"
        },
        {
          "name": "Electromagnetic Tracking Device",
          "type": "DEVICE"
        },
        {
          "name": "Perflutren",
          "type": "DRUG"
        }
      ],
      "intervention_types": [
        "PROCEDURE",
        "DEVICE",
        "DRUG"
      ],
      "sponsor": "Stanford University",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "18 Years and older"
      },
      "enrollment_count": 34,
      "start_date": "2012-11-01",
      "completion_date": "2020-09-30",
      "has_results": false,
      "last_update_posted_date": "2022-06-10",
      "last_synced_at": "2026-09-27T01:48:15.184Z",
      "location_count": 1,
      "location_summary": "Stanford, California",
      "locations": [
        {
          "city": "Stanford",
          "state": "California"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT01631318"
    },
    {
      "nct_id": "NCT03297112",
      "title": "Contrast-Enhanced Subharmonic Ultrasound Imaging in Improving Characterization of Adnexal Masses in Patients Undergoing Surgery",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "EARLY_PHASE1"
      ],
      "conditions": [
        "Adnexal Mass"
      ],
      "interventions": [
        {
          "name": "Perflutren Lipid Microspheres",
          "type": "DRUG"
        },
        {
          "name": "Contrast-Enhanced Subharmonic Ultrasound Imaging",
          "type": "PROCEDURE"
        }
      ],
      "intervention_types": [
        "DRUG",
        "PROCEDURE"
      ],
      "sponsor": "Sidney Kimmel Comprehensive Cancer Center at Thomas Jefferson University",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "21 Years",
        "maximum_age": null,
        "sex": "FEMALE",
        "summary": "21 Years and older · Female only"
      },
      "enrollment_count": 12,
      "start_date": "2017-08-01",
      "completion_date": "2018-09-04",
      "has_results": true,
      "last_update_posted_date": "2025-05-15",
      "last_synced_at": "2026-09-27T01:48:15.184Z",
      "location_count": 1,
      "location_summary": "Philadelphia, Pennsylvania",
      "locations": [
        {
          "city": "Philadelphia",
          "state": "Pennsylvania"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT03297112"
    },
    {
      "nct_id": "NCT02880137",
      "title": "Real Time Myocardial Perfusion Echocardiography for Coronary Allograft Vasculopathy",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE4"
      ],
      "conditions": [
        "Cardiac Allograft Vasculopathy"
      ],
      "interventions": [
        {
          "name": "Perflutren Lipid Microsphere",
          "type": "DRUG"
        },
        {
          "name": "RTMPE",
          "type": "PROCEDURE"
        }
      ],
      "intervention_types": [
        "DRUG",
        "PROCEDURE"
      ],
      "sponsor": "Mayo Clinic",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "1 Year",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "1 Year and older"
      },
      "enrollment_count": 36,
      "start_date": "2016-09",
      "completion_date": "2018-06-30",
      "has_results": true,
      "last_update_posted_date": "2019-06-20",
      "last_synced_at": "2026-09-27T01:48:15.184Z",
      "location_count": 1,
      "location_summary": "Rochester, Minnesota",
      "locations": [
        {
          "city": "Rochester",
          "state": "Minnesota"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT02880137"
    },
    {
      "nct_id": "NCT03907657",
      "title": "Contrast-enhanced Ultrasound as a Screening Tool for Kidney Cancer in Patients With Von-Hippel Lindau",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE2"
      ],
      "conditions": [
        "Von-Hippel Lindau",
        "Kidney Disease, Chronic"
      ],
      "interventions": [
        {
          "name": "Perflutren lipid microsphere",
          "type": "DRUG"
        },
        {
          "name": "Sulfur hexafluoride lipid microspheres",
          "type": "DRUG"
        }
      ],
      "intervention_types": [
        "DRUG"
      ],
      "sponsor": "UNC Lineberger Comprehensive Cancer Center",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "16 Years",
        "maximum_age": "99 Years",
        "sex": "ALL",
        "summary": "16 Years to 99 Years"
      },
      "enrollment_count": 15,
      "start_date": "2019-09-23",
      "completion_date": "2023-03-13",
      "has_results": true,
      "last_update_posted_date": "2024-05-21",
      "last_synced_at": "2026-09-27T01:48:15.184Z",
      "location_count": 1,
      "location_summary": "Chapel Hill, North Carolina",
      "locations": [
        {
          "city": "Chapel Hill",
          "state": "North Carolina"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT03907657"
    },
    {
      "nct_id": "NCT02967458",
      "title": "Detection of High Grade Prostate Cancer With Subharmonic Ultrasound Imaging, A Pilot Study",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE2"
      ],
      "conditions": [
        "Prostatic Neoplasm"
      ],
      "interventions": [
        {
          "name": "Perflutren Lipid Microsphere Intravenous Suspension",
          "type": "DRUG"
        }
      ],
      "intervention_types": [
        "DRUG"
      ],
      "sponsor": "Thomas Jefferson University",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": null,
        "sex": "MALE",
        "summary": "18 Years and older · Male only"
      },
      "enrollment_count": 55,
      "start_date": "2017-02-01",
      "completion_date": "2018-09-20",
      "has_results": true,
      "last_update_posted_date": "2025-04-30",
      "last_synced_at": "2026-09-27T01:48:15.184Z",
      "location_count": 1,
      "location_summary": "Philadelphia, Pennsylvania",
      "locations": [
        {
          "city": "Philadelphia",
          "state": "Pennsylvania"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT02967458"
    },
    {
      "nct_id": "NCT04056988",
      "title": "tSCI Contrast Enhanced Ultrasound Study",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE4"
      ],
      "conditions": [
        "Acute Spinal Cord Injury"
      ],
      "interventions": [
        {
          "name": "Perflutren Lipid Microsphere",
          "type": "DRUG"
        }
      ],
      "intervention_types": [
        "DRUG"
      ],
      "sponsor": "University of Washington",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "18 Years and older"
      },
      "enrollment_count": 27,
      "start_date": "2018-07-31",
      "completion_date": "2023-11-20",
      "has_results": true,
      "last_update_posted_date": "2026-07-13",
      "last_synced_at": "2026-09-27T01:48:15.184Z",
      "location_count": 1,
      "location_summary": "Seattle, Washington",
      "locations": [
        {
          "city": "Seattle",
          "state": "Washington"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT04056988"
    },
    {
      "nct_id": "NCT02067884",
      "title": "Contrast Enhanced Ultrasound and Shear Wave Elastography in Measuring Response in Patients With Breast Cancer Receiving Chemotherapy Before Surgery",
      "overall_status": "TERMINATED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE1"
      ],
      "conditions": [
        "Breast Cancer"
      ],
      "interventions": [
        {
          "name": "dynamic contrast-enhanced ultrasound imaging",
          "type": "PROCEDURE"
        },
        {
          "name": "shear wave elastography",
          "type": "PROCEDURE"
        },
        {
          "name": "Definity, (Lipid Microspheres) Intravenous Suspension",
          "type": "DRUG"
        },
        {
          "name": "Philips Shear Wave Elastography",
          "type": "DEVICE"
        }
      ],
      "intervention_types": [
        "PROCEDURE",
        "DRUG",
        "DEVICE"
      ],
      "sponsor": "University of Southern California",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": null,
        "sex": "FEMALE",
        "summary": "18 Years and older · Female only"
      },
      "enrollment_count": 34,
      "start_date": "2013-12-19",
      "completion_date": "2016-09-25",
      "has_results": false,
      "last_update_posted_date": "2019-01-25",
      "last_synced_at": "2026-09-27T01:48:15.184Z",
      "location_count": 1,
      "location_summary": "Los Angeles, California",
      "locations": [
        {
          "city": "Los Angeles",
          "state": "California"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT02067884"
    },
    {
      "nct_id": "NCT07436364",
      "title": "Application of Contrast-enhanced Ultrasound in Monitoring Soft Tissue Sarcoma Response to Neoadjuvant Radiotherapy",
      "overall_status": "RECRUITING",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "EARLY_PHASE1"
      ],
      "conditions": [
        "Soft Tissue Sarcoma"
      ],
      "interventions": [
        {
          "name": "Definity",
          "type": "DRUG"
        },
        {
          "name": "Contrast-Enhanced Ultrasound",
          "type": "DIAGNOSTIC_TEST"
        }
      ],
      "intervention_types": [
        "DRUG",
        "DIAGNOSTIC_TEST"
      ],
      "sponsor": "Thomas Jefferson University",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "18 Years and older"
      },
      "enrollment_count": 10,
      "start_date": "2026-03-23",
      "completion_date": "2027-05",
      "has_results": false,
      "last_update_posted_date": "2026-04-14",
      "last_synced_at": "2026-09-27T01:48:15.184Z",
      "location_count": 1,
      "location_summary": "Philadelphia, Pennsylvania",
      "locations": [
        {
          "city": "Philadelphia",
          "state": "Pennsylvania"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT07436364"
    },
    {
      "nct_id": "NCT02384473",
      "title": "Real-Time Contrast-Enhanced Ultrasonography and Shear Wave Elastography in Predicting Treatment Response in Patients With Soft Tissue Sarcoma",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "EARLY_PHASE1"
      ],
      "conditions": [
        "Adult Soft Tissue Sarcoma",
        "Bone Sarcoma",
        "Retroperitoneal Sarcoma"
      ],
      "interventions": [
        {
          "name": "Real-Time CEUS",
          "type": "PROCEDURE"
        },
        {
          "name": "SWE",
          "type": "PROCEDURE"
        },
        {
          "name": "Definity Suspension for Injection",
          "type": "DRUG"
        },
        {
          "name": "Philips Shear Wave Elastography",
          "type": "DEVICE"
        }
      ],
      "intervention_types": [
        "PROCEDURE",
        "DRUG",
        "DEVICE"
      ],
      "sponsor": "University of Southern California",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "18 Years and older"
      },
      "enrollment_count": 25,
      "start_date": "2014-12-24",
      "completion_date": "2024-01-19",
      "has_results": false,
      "last_update_posted_date": "2024-01-23",
      "last_synced_at": "2026-09-27T01:48:15.184Z",
      "location_count": 1,
      "location_summary": "Los Angeles, California",
      "locations": [
        {
          "city": "Los Angeles",
          "state": "California"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT02384473"
    },
    {
      "nct_id": "NCT03300401",
      "title": "Contrast-Enhanced Ultrasound in Diagnosing Patients With Liver Cancer Undergoing Yttrium-90 Radioembolization",
      "overall_status": "WITHDRAWN",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Hepatocellular Carcinoma"
      ],
      "interventions": [
        {
          "name": "Perflutren Lipid Microspheres",
          "type": "DRUG"
        },
        {
          "name": "Sulfur Hexafluoride Lipid Microspheres",
          "type": "DRUG"
        },
        {
          "name": "Dynamic Contrast-Enhanced Ultrasound Imaging",
          "type": "DEVICE"
        },
        {
          "name": "Positron Emission Tomography",
          "type": "DEVICE"
        },
        {
          "name": "Computed Tomography",
          "type": "DEVICE"
        },
        {
          "name": "Yttrium-90 (90Y)",
          "type": "BIOLOGICAL"
        }
      ],
      "intervention_types": [
        "DRUG",
        "DEVICE",
        "BIOLOGICAL"
      ],
      "sponsor": "University of Southern California",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "18 Years and older"
      },
      "enrollment_count": 0,
      "start_date": "2017-11-07",
      "completion_date": "2020-11-07",
      "has_results": false,
      "last_update_posted_date": "2019-05-16",
      "last_synced_at": "2026-09-27T01:48:15.184Z",
      "location_count": 1,
      "location_summary": "Los Angeles, California",
      "locations": [
        {
          "city": "Los Angeles",
          "state": "California"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT03300401"
    }
  ]
}