{
  "api_version": "1",
  "request": {
    "url": "https://clinicaltrialsfind.com/api/v1/search.json?intervention=DiRECT&page=38",
    "query": {
      "intervention": "DiRECT",
      "page": 38
    },
    "page_size": 10
  },
  "pagination": {
    "page": 38,
    "page_size": 10,
    "total_count": 3416,
    "total_pages": 342,
    "next_page_url": "https://clinicaltrialsfind.com/api/v1/search.json?intervention=DiRECT&page=39&page_size=10",
    "previous_page_url": "https://clinicaltrialsfind.com/api/v1/search.json?intervention=DiRECT&page=37&page_size=10"
  },
  "source": "remote",
  "last_synced_at": "2026-10-27T11:35:07.855Z",
  "attribution": "Data derived from public ClinicalTrials.gov records. The official record at https://clinicaltrials.gov/ remains the source of truth for current availability, contacts, and full study details.",
  "notes": [
    "This endpoint exposes only public summary fields — no participant contact emails, phone numbers, or scraped investigator contact details.",
    "For contact information and full protocol detail, follow each trial's `official_url` to the ClinicalTrials.gov record.",
    "This API is a navigational aid. It does not provide medical advice, eligibility determinations, or compensation guarantees."
  ],
  "trials": [
    {
      "nct_id": "NCT04810130",
      "title": "Physiological Effects of Soccer Heading",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Repeated Head Impacts"
      ],
      "interventions": [
        {
          "name": "Soccer Kicking",
          "type": "OTHER"
        },
        {
          "name": "Soccer Heading (Frontal)",
          "type": "OTHER"
        },
        {
          "name": "Soccer Heading (Oblique)",
          "type": "OTHER"
        }
      ],
      "intervention_types": [
        "OTHER"
      ],
      "sponsor": "Children's Hospital of Philadelphia",
      "sponsor_class": "OTHER",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "13 Years",
        "maximum_age": "18 Years",
        "sex": "ALL",
        "summary": "13 Years to 18 Years"
      },
      "enrollment_count": 27,
      "start_date": "2020-12-15",
      "completion_date": "2021-12-19",
      "has_results": false,
      "last_update_posted_date": "2022-11-10",
      "last_synced_at": "2026-10-27T11:35:07.855Z",
      "location_count": 1,
      "location_summary": "Philadelphia, Pennsylvania",
      "locations": [
        {
          "city": "Philadelphia",
          "state": "Pennsylvania"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT04810130"
    },
    {
      "nct_id": "NCT00308165",
      "title": "Topotecan by Intracerebral Clysis for Recurrent Primary Malignant Brain Tumors",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE1"
      ],
      "conditions": [
        "Brain Neoplasms, Primary Malignant"
      ],
      "interventions": [
        {
          "name": "Convection-Enhanced Delivery",
          "type": "PROCEDURE"
        },
        {
          "name": "Topotecan",
          "type": "DRUG"
        }
      ],
      "intervention_types": [
        "PROCEDURE",
        "DRUG"
      ],
      "sponsor": "Columbia University",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "1 Year",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "1 Year and older"
      },
      "enrollment_count": 16,
      "start_date": "2004-03",
      "completion_date": "2016-01",
      "has_results": true,
      "last_update_posted_date": "2026-06-25",
      "last_synced_at": "2026-10-27T11:35:07.855Z",
      "location_count": 1,
      "location_summary": "New York, New York",
      "locations": [
        {
          "city": "New York",
          "state": "New York"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT00308165"
    },
    {
      "nct_id": "NCT07219628",
      "title": "Radicle Calm RDH: A Study Assessing the Impact of Health and Wellness Products on Feelings of Anxiety and Related Health Outcomes",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Anxiety"
      ],
      "interventions": [
        {
          "name": "Calm Product Placebo Control",
          "type": "DIETARY_SUPPLEMENT"
        },
        {
          "name": "Calm Active Product 1",
          "type": "DIETARY_SUPPLEMENT"
        }
      ],
      "intervention_types": [
        "DIETARY_SUPPLEMENT"
      ],
      "sponsor": "Radicle Science",
      "sponsor_class": "INDUSTRY",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "21 Years",
        "maximum_age": "105 Years",
        "sex": "ALL",
        "summary": "21 Years to 105 Years"
      },
      "enrollment_count": 500,
      "start_date": "2025-09-23",
      "completion_date": "2025-12-14",
      "has_results": false,
      "last_update_posted_date": "2026-01-14",
      "last_synced_at": "2026-10-27T11:35:07.855Z",
      "location_count": 1,
      "location_summary": "Del Mar, California",
      "locations": [
        {
          "city": "Del Mar",
          "state": "California"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT07219628"
    },
    {
      "nct_id": "NCT04831372",
      "title": "On-Table Versus Off-Table Total Hip Arthroplasty",
      "overall_status": "UNKNOWN",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Arthroplasty, Replacement, Hip",
        "Osteoarthritis, Hip"
      ],
      "interventions": [
        {
          "name": "Off Table Group",
          "type": "PROCEDURE"
        },
        {
          "name": "On Table Group",
          "type": "PROCEDURE"
        }
      ],
      "intervention_types": [
        "PROCEDURE"
      ],
      "sponsor": "Carilion Clinic",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "18 Years and older"
      },
      "enrollment_count": 93,
      "start_date": "2021-04-07",
      "completion_date": "2025-01-25",
      "has_results": false,
      "last_update_posted_date": "2024-02-16",
      "last_synced_at": "2026-10-27T11:35:07.855Z",
      "location_count": 1,
      "location_summary": "Roanoke, Virginia",
      "locations": [
        {
          "city": "Roanoke",
          "state": "Virginia"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT04831372"
    },
    {
      "nct_id": "NCT00607477",
      "title": "Pilot Study of the Treatment of Vascular Endothelial Growth Factor(VEGF)Signaling Pathway Inhibitor-Induced Hypertension",
      "overall_status": "TERMINATED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Treatment Induced Hypertension"
      ],
      "interventions": [
        {
          "name": "Minoxidil",
          "type": "DRUG"
        },
        {
          "name": "Hydralazine",
          "type": "DRUG"
        }
      ],
      "intervention_types": [
        "DRUG"
      ],
      "sponsor": "University of Chicago",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "18 Years and older"
      },
      "enrollment_count": 2,
      "start_date": "2008-01",
      "completion_date": "2009-01",
      "has_results": true,
      "last_update_posted_date": "2014-06-10",
      "last_synced_at": "2026-10-27T11:35:07.855Z",
      "location_count": 1,
      "location_summary": "Chicago, Illinois",
      "locations": [
        {
          "city": "Chicago",
          "state": "Illinois"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT00607477"
    },
    {
      "nct_id": "NCT01010412",
      "title": "Ultrasound Visualization Versus Electrical Nerve Stimulation",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE4"
      ],
      "conditions": [
        "Trauma to the Arm, Shoulder, Elbow, Forearm, or Hand"
      ],
      "interventions": [
        {
          "name": "Ultrasound (Sonosite Titan T-shaped ultrasound probe)",
          "type": "DEVICE"
        },
        {
          "name": "Electrical Nerve Stimulation (Stimuplex (B Braun) needle)",
          "type": "DEVICE"
        }
      ],
      "intervention_types": [
        "DEVICE"
      ],
      "sponsor": "Allentown Anesthesia Associates",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "18 Years and older"
      },
      "enrollment_count": 158,
      "start_date": "2009-02",
      "completion_date": "2011-10",
      "has_results": false,
      "last_update_posted_date": "2012-08-30",
      "last_synced_at": "2026-10-27T11:35:07.855Z",
      "location_count": 1,
      "location_summary": "Allentown, Pennsylvania",
      "locations": [
        {
          "city": "Allentown",
          "state": "Pennsylvania"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT01010412"
    },
    {
      "nct_id": "NCT02123212",
      "title": "Birth-Cohort Evaluation to Advance Screening and Testing for Hepatitis C",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Hepatitis C",
        "Chronic Hepatitis C"
      ],
      "interventions": [
        {
          "name": "Mailer",
          "type": "OTHER"
        },
        {
          "name": "In-person recruitment",
          "type": "OTHER"
        },
        {
          "name": "EHR Alert",
          "type": "OTHER"
        }
      ],
      "intervention_types": [
        "OTHER"
      ],
      "sponsor": "National Opinion Research Center",
      "sponsor_class": "OTHER",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "47 Years",
        "maximum_age": "69 Years",
        "sex": "ALL",
        "summary": "47 Years to 69 Years"
      },
      "enrollment_count": 29607,
      "start_date": "2013-02",
      "completion_date": "2014-03",
      "has_results": false,
      "last_update_posted_date": "2015-03-26",
      "last_synced_at": "2026-10-27T11:35:07.855Z",
      "location_count": 3,
      "location_summary": "Birmingham, Alabama • Detroit, Michigan • New York, New York",
      "locations": [
        {
          "city": "Birmingham",
          "state": "Alabama"
        },
        {
          "city": "Detroit",
          "state": "Michigan"
        },
        {
          "city": "New York",
          "state": "New York"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT02123212"
    },
    {
      "nct_id": "NCT01526681",
      "title": "Registry of Avance® Nerve Graft's Utilization and Recovery Outcomes Post Peripheral Nerve Reconstruction",
      "overall_status": "ACTIVE_NOT_RECRUITING",
      "study_type": "OBSERVATIONAL",
      "phases": [],
      "conditions": [
        "Peripheral Nerve Injuries"
      ],
      "interventions": [
        {
          "name": "Processed Human Nerve Graft",
          "type": "OTHER"
        },
        {
          "name": "Standard Treatment, Autogenous Nerve Graft, Direct Suture, etc.",
          "type": "OTHER"
        },
        {
          "name": "Autogenous Nerve Graft",
          "type": "OTHER"
        },
        {
          "name": "Nerve Tube Conduit",
          "type": "DEVICE"
        },
        {
          "name": "Autologous Breast Reconstruction with Neurotization",
          "type": "PROCEDURE"
        },
        {
          "name": "Autologous Breast Reconstruction without Neurotization",
          "type": "PROCEDURE"
        }
      ],
      "intervention_types": [
        "OTHER",
        "DEVICE",
        "PROCEDURE"
      ],
      "sponsor": "Axogen Corporation",
      "sponsor_class": "INDUSTRY",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": null,
        "maximum_age": null,
        "sex": "ALL",
        "summary": "Not listed"
      },
      "enrollment_count": 3126,
      "start_date": "2008-11",
      "completion_date": "2028-11",
      "has_results": false,
      "last_update_posted_date": "2026-01-26",
      "last_synced_at": "2026-10-27T11:35:07.855Z",
      "location_count": 46,
      "location_summary": "Phoenix, Arizona • Orange, California • San Francisco, California + 33 more",
      "locations": [
        {
          "city": "Phoenix",
          "state": "Arizona"
        },
        {
          "city": "Phoenix",
          "state": "Arizona"
        },
        {
          "city": "Orange",
          "state": "California"
        },
        {
          "city": "San Francisco",
          "state": "California"
        },
        {
          "city": "Stanford",
          "state": "California"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT01526681"
    },
    {
      "nct_id": "NCT04289181",
      "title": "A Trial to Evaluate Medically Tailored Meals With Patients With Heart Failure",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Heart Failure"
      ],
      "interventions": [
        {
          "name": "Medically Tailored Meals",
          "type": "OTHER"
        }
      ],
      "intervention_types": [
        "OTHER"
      ],
      "sponsor": "Thomas Jefferson University",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "50 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "50 Years and older"
      },
      "enrollment_count": 30,
      "start_date": "2020-03-05",
      "completion_date": "2021-04-01",
      "has_results": false,
      "last_update_posted_date": "2021-10-05",
      "last_synced_at": "2026-10-27T11:35:07.855Z",
      "location_count": 1,
      "location_summary": "Philadelphia, Pennsylvania",
      "locations": [
        {
          "city": "Philadelphia",
          "state": "Pennsylvania"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT04289181"
    },
    {
      "nct_id": "NCT07083700",
      "title": "Frame Support Study",
      "overall_status": "RECRUITING",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Fertility Issues",
        "Emotional Stress"
      ],
      "interventions": [
        {
          "name": "Frame Access",
          "type": "BEHAVIORAL"
        }
      ],
      "intervention_types": [
        "BEHAVIORAL"
      ],
      "sponsor": "Inception Fertility Research Institute, LLC",
      "sponsor_class": "INDUSTRY",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "22 Years",
        "maximum_age": "44 Years",
        "sex": "FEMALE",
        "summary": "22 Years to 44 Years · Female only"
      },
      "enrollment_count": 400,
      "start_date": "2025-06-23",
      "completion_date": "2027-06",
      "has_results": false,
      "last_update_posted_date": "2026-04-15",
      "last_synced_at": "2026-10-27T11:35:07.855Z",
      "location_count": 1,
      "location_summary": "Houston, Texas",
      "locations": [
        {
          "city": "Houston",
          "state": "Texas"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT07083700"
    }
  ]
}