{
  "api_version": "1",
  "request": {
    "url": "https://clinicaltrialsfind.com/api/v1/search.json?intervention=DiRECT&page=53",
    "query": {
      "intervention": "DiRECT",
      "page": 53
    },
    "page_size": 10
  },
  "pagination": {
    "page": 53,
    "page_size": 10,
    "total_count": 3417,
    "total_pages": 342,
    "next_page_url": "https://clinicaltrialsfind.com/api/v1/search.json?intervention=DiRECT&page=54&page_size=10",
    "previous_page_url": "https://clinicaltrialsfind.com/api/v1/search.json?intervention=DiRECT&page=52&page_size=10"
  },
  "source": "remote",
  "last_synced_at": "2026-10-30T14:12:45.239Z",
  "attribution": "Data derived from public ClinicalTrials.gov records. The official record at https://clinicaltrials.gov/ remains the source of truth for current availability, contacts, and full study details.",
  "notes": [
    "This endpoint exposes only public summary fields — no participant contact emails, phone numbers, or scraped investigator contact details.",
    "For contact information and full protocol detail, follow each trial's `official_url` to the ClinicalTrials.gov record.",
    "This API is a navigational aid. It does not provide medical advice, eligibility determinations, or compensation guarantees."
  ],
  "trials": [
    {
      "nct_id": "NCT06455527",
      "title": "Heart Rate Variability (HRV)-Guided Transcranial Direct Current Stimulation (tDCS)",
      "overall_status": "RECRUITING",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Depression"
      ],
      "interventions": [
        {
          "name": "Active Transcranial Direct Current Stimulation (tDCS)",
          "type": "DEVICE"
        },
        {
          "name": "Sham Transcranial Direct Current Stimulation (tDCS)",
          "type": "DEVICE"
        }
      ],
      "intervention_types": [
        "DEVICE"
      ],
      "sponsor": "NYU Langone Health",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": "65 Years",
        "sex": "ALL",
        "summary": "18 Years to 65 Years"
      },
      "enrollment_count": 100,
      "start_date": "2025-01-02",
      "completion_date": "2027-11-01",
      "has_results": false,
      "last_update_posted_date": "2026-09-25",
      "last_synced_at": "2026-10-30T14:12:45.239Z",
      "location_count": 1,
      "location_summary": "New York, New York",
      "locations": [
        {
          "city": "New York",
          "state": "New York"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT06455527"
    },
    {
      "nct_id": "NCT06408246",
      "title": "ACE-D Aim 3 Clinical Cognitive Trial to Enhance Translation in Depression",
      "overall_status": "RECRUITING",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE2"
      ],
      "conditions": [
        "Depression"
      ],
      "interventions": [
        {
          "name": "Guanfacine",
          "type": "DRUG"
        },
        {
          "name": "Sertraline",
          "type": "DRUG"
        }
      ],
      "intervention_types": [
        "DRUG"
      ],
      "sponsor": "Stanford University",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": "60 Years",
        "sex": "ALL",
        "summary": "18 Years to 60 Years"
      },
      "enrollment_count": 162,
      "start_date": "2026-03-03",
      "completion_date": "2029-02-01",
      "has_results": false,
      "last_update_posted_date": "2026-03-05",
      "last_synced_at": "2026-10-30T14:12:45.239Z",
      "location_count": 2,
      "location_summary": "Palo Alto, California • Chicago, Illinois",
      "locations": [
        {
          "city": "Palo Alto",
          "state": "California"
        },
        {
          "city": "Chicago",
          "state": "Illinois"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT06408246"
    },
    {
      "nct_id": "NCT02329327",
      "title": "A Study in Participants With Acute Major Bleeding to Evaluate the Ability of Andexanet Alfa to Reverse the Anticoagulation Effect of Direct and Indirect Oral Anticoagulants (Extension Study)",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE3"
      ],
      "conditions": [
        "Bleeding"
      ],
      "interventions": [
        {
          "name": "Andexanet",
          "type": "BIOLOGICAL"
        }
      ],
      "intervention_types": [
        "BIOLOGICAL"
      ],
      "sponsor": "Alexion Pharmaceuticals, Inc.",
      "sponsor_class": "INDUSTRY",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "18 Years and older"
      },
      "enrollment_count": 479,
      "start_date": "2015-04-10",
      "completion_date": "2020-09-24",
      "has_results": true,
      "last_update_posted_date": "2022-02-16",
      "last_synced_at": "2026-10-30T14:12:45.239Z",
      "location_count": 23,
      "location_summary": "Long Beach, California • Los Angeles, California • Orange, California + 20 more",
      "locations": [
        {
          "city": "Long Beach",
          "state": "California"
        },
        {
          "city": "Los Angeles",
          "state": "California"
        },
        {
          "city": "Orange",
          "state": "California"
        },
        {
          "city": "Fort Lauderdale",
          "state": "Florida"
        },
        {
          "city": "Jacksonville",
          "state": "Florida"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT02329327"
    },
    {
      "nct_id": "NCT05535777",
      "title": "Patient Portal Flu Vaccine Reminders_RCT 5 (LADHS)",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Influenza",
        "Respiratory Tract Infections"
      ],
      "interventions": [
        {
          "name": "Enhanced texts with Callback by a Person",
          "type": "BEHAVIORAL"
        },
        {
          "name": "Enhanced Bidirectional Texts",
          "type": "BEHAVIORAL"
        }
      ],
      "intervention_types": [
        "BEHAVIORAL"
      ],
      "sponsor": "University of California, Los Angeles",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "6 Months",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "6 Months and older"
      },
      "enrollment_count": 246295,
      "start_date": "2022-09-13",
      "completion_date": "2023-03-31",
      "has_results": true,
      "last_update_posted_date": "2025-04-11",
      "last_synced_at": "2026-10-30T14:12:45.239Z",
      "location_count": 2,
      "location_summary": "Los Angeles, California",
      "locations": [
        {
          "city": "Los Angeles",
          "state": "California"
        },
        {
          "city": "Los Angeles",
          "state": "California"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT05535777"
    },
    {
      "nct_id": "NCT00558259",
      "title": "Twice-daily Oral Direct Thrombin Inhibitor Dabigatran Etexilate in the Long Term Prevention of Recurrent Symptomatic VTE",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE3"
      ],
      "conditions": [
        "Venous Thromboembolism"
      ],
      "interventions": [
        {
          "name": "dabigatran etexilate 150 mg twice daily (BID)",
          "type": "DRUG"
        },
        {
          "name": "matching placebo twice daily (BID)",
          "type": "DRUG"
        }
      ],
      "intervention_types": [
        "DRUG"
      ],
      "sponsor": "Boehringer Ingelheim",
      "sponsor_class": "INDUSTRY",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "18 Years and older"
      },
      "enrollment_count": 1353,
      "start_date": "2007-11",
      "completion_date": null,
      "has_results": true,
      "last_update_posted_date": "2014-06-27",
      "last_synced_at": "2026-10-30T14:12:45.239Z",
      "location_count": 21,
      "location_summary": "Birmingham, Alabama • Huntsville, Alabama • Laguna Hills, California + 17 more",
      "locations": [
        {
          "city": "Birmingham",
          "state": "Alabama"
        },
        {
          "city": "Huntsville",
          "state": "Alabama"
        },
        {
          "city": "Laguna Hills",
          "state": "California"
        },
        {
          "city": "Colorado Springs",
          "state": "Colorado"
        },
        {
          "city": "Jacksonville",
          "state": "Florida"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT00558259"
    },
    {
      "nct_id": "NCT01795079",
      "title": "Effects of Transcranial Direct Current Stimulation (tDCS) on Neuropathic Symptoms Following Burn Injury",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Burn Injury",
        "Chronic Pain",
        "Pruritus",
        "Itching"
      ],
      "interventions": [
        {
          "name": "Transcranial direct current stimulation (tDCS)",
          "type": "DEVICE"
        }
      ],
      "intervention_types": [
        "DEVICE"
      ],
      "sponsor": "Spaulding Rehabilitation Hospital",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "18 Years and older"
      },
      "enrollment_count": 34,
      "start_date": "2013-01",
      "completion_date": "2020-04-15",
      "has_results": true,
      "last_update_posted_date": "2021-03-17",
      "last_synced_at": "2026-10-30T14:12:45.239Z",
      "location_count": 1,
      "location_summary": "Boston, Massachusetts",
      "locations": [
        {
          "city": "Boston",
          "state": "Massachusetts"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT01795079"
    },
    {
      "nct_id": "NCT06529159",
      "title": "H. Pylori Eradication With Argon Plasma During Endoscopy",
      "overall_status": "RECRUITING",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Helicobacter Pylori Infection",
        "Helicobacter Pylori",
        "Helicobacter Pylori Gastrointestinal Tract Infection",
        "H. Pylori Infection",
        "H. Pylori Gastrointestinal Disease"
      ],
      "interventions": [
        {
          "name": "HEAPE",
          "type": "PROCEDURE"
        },
        {
          "name": "Pre-HEAPE",
          "type": "PROCEDURE"
        }
      ],
      "intervention_types": [
        "PROCEDURE"
      ],
      "sponsor": "Christopher C. Thompson, MD, MSc",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "18 Years and older"
      },
      "enrollment_count": 20,
      "start_date": "2025-07-08",
      "completion_date": "2027-12",
      "has_results": false,
      "last_update_posted_date": "2026-03-02",
      "last_synced_at": "2026-10-30T14:12:45.239Z",
      "location_count": 1,
      "location_summary": "Boston, Massachusetts",
      "locations": [
        {
          "city": "Boston",
          "state": "Massachusetts"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT06529159"
    },
    {
      "nct_id": "NCT02178553",
      "title": "Study of Exparel Versus Epidural for Pain Control After Thoracotomy",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE4"
      ],
      "conditions": [
        "Pain Following Thoracotomy Surgery"
      ],
      "interventions": [
        {
          "name": "Epidural",
          "type": "DRUG"
        },
        {
          "name": "Intercostal Bupivicaine (Exparel)",
          "type": "DRUG"
        }
      ],
      "intervention_types": [
        "DRUG"
      ],
      "sponsor": "Mayo Clinic",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "18 Years and older"
      },
      "enrollment_count": 102,
      "start_date": "2014-10-15",
      "completion_date": "2019-01-25",
      "has_results": true,
      "last_update_posted_date": "2020-01-09",
      "last_synced_at": "2026-10-30T14:12:45.239Z",
      "location_count": 1,
      "location_summary": "Rochester, Minnesota",
      "locations": [
        {
          "city": "Rochester",
          "state": "Minnesota"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT02178553"
    },
    {
      "nct_id": "NCT04908631",
      "title": "Safety and Feasibility of tDCS to Enhance Auditory Rehabilitation in Cochlear Implant Recipients",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Hearing Loss"
      ],
      "interventions": [
        {
          "name": "Transcranial Direct Stimulation",
          "type": "DEVICE"
        },
        {
          "name": "Auditory Training Program",
          "type": "OTHER"
        }
      ],
      "intervention_types": [
        "DEVICE",
        "OTHER"
      ],
      "sponsor": "Duke University",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "18 Years and older"
      },
      "enrollment_count": 8,
      "start_date": "2023-03-15",
      "completion_date": "2024-07-29",
      "has_results": true,
      "last_update_posted_date": "2025-08-22",
      "last_synced_at": "2026-10-30T14:12:45.239Z",
      "location_count": 1,
      "location_summary": "Durham, North Carolina",
      "locations": [
        {
          "city": "Durham",
          "state": "North Carolina"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT04908631"
    },
    {
      "nct_id": "NCT06294431",
      "title": "Radicle Clarity 24: A Study of Health and Wellness Products on Cognitive Function and Related Health Outcomes",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Cognitive Function"
      ],
      "interventions": [
        {
          "name": "Placebo Control Form 1",
          "type": "DIETARY_SUPPLEMENT"
        },
        {
          "name": "Clarity Active Study Product 1.1 Usage",
          "type": "DIETARY_SUPPLEMENT"
        },
        {
          "name": "Placebo Control Form 2",
          "type": "DIETARY_SUPPLEMENT"
        },
        {
          "name": "Clarity Active Study Product 2.1 Usage",
          "type": "DIETARY_SUPPLEMENT"
        },
        {
          "name": "Placebo Control Form 3",
          "type": "DIETARY_SUPPLEMENT"
        },
        {
          "name": "Clarity Active Study Product 3.1 Usage",
          "type": "DIETARY_SUPPLEMENT"
        },
        {
          "name": "Clarity Active Study Product 3.2 Usage",
          "type": "DIETARY_SUPPLEMENT"
        },
        {
          "name": "Placebo Control Form 4",
          "type": "DIETARY_SUPPLEMENT"
        },
        {
          "name": "Clarity Active Study Product 4.1 Usage",
          "type": "DIETARY_SUPPLEMENT"
        },
        {
          "name": "Placebo Control Form 5",
          "type": "DIETARY_SUPPLEMENT"
        },
        {
          "name": "Clarity Active Study Product 5.1 Usage",
          "type": "DIETARY_SUPPLEMENT"
        },
        {
          "name": "Clarity Active Study Product 5.2 Usage",
          "type": "DIETARY_SUPPLEMENT"
        },
        {
          "name": "Placebo Control Form 6",
          "type": "DIETARY_SUPPLEMENT"
        },
        {
          "name": "Clarity Active Study Product 6.1 Usage",
          "type": "DIETARY_SUPPLEMENT"
        },
        {
          "name": "Placebo Control 6.1.0",
          "type": "DIETARY_SUPPLEMENT"
        },
        {
          "name": "Clarity Active Study Product 6.1.1 Usage",
          "type": "DIETARY_SUPPLEMENT"
        },
        {
          "name": "Clarity Active Study Product 6.1.2 Usage",
          "type": "DIETARY_SUPPLEMENT"
        }
      ],
      "intervention_types": [
        "DIETARY_SUPPLEMENT"
      ],
      "sponsor": "Radicle Science",
      "sponsor_class": "INDUSTRY",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "21 Years",
        "maximum_age": "105 Years",
        "sex": "ALL",
        "summary": "21 Years to 105 Years"
      },
      "enrollment_count": 4794,
      "start_date": "2024-03-04",
      "completion_date": "2025-08-15",
      "has_results": false,
      "last_update_posted_date": "2025-10-02",
      "last_synced_at": "2026-10-30T14:12:45.239Z",
      "location_count": 1,
      "location_summary": "Del Mar, California",
      "locations": [
        {
          "city": "Del Mar",
          "state": "California"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT06294431"
    }
  ]
}