{ "api_version": "1", "request": { "url": "https://clinicaltrialsfind.com/api/v1/search.json?intervention=Diltiazem+Hydrochloride&page=3", "query": { "intervention": "Diltiazem Hydrochloride", "page": 3 }, "page_size": 10 }, "pagination": { "page": 3, "page_size": 10, "total_count": 59, "total_pages": 6, "next_page_url": "https://clinicaltrialsfind.com/api/v1/search.json?intervention=Diltiazem+Hydrochloride&page=4&page_size=10", "previous_page_url": "https://clinicaltrialsfind.com/api/v1/search.json?intervention=Diltiazem+Hydrochloride&page=2&page_size=10" }, "source": "remote", "last_synced_at": "2026-10-07T00:52:40.461Z", "attribution": "Data derived from public ClinicalTrials.gov records. The official record at https://clinicaltrials.gov/ remains the source of truth for current availability, contacts, and full study details.", "notes": [ "This endpoint exposes only public summary fields — no participant contact emails, phone numbers, or scraped investigator contact details.", "For contact information and full protocol detail, follow each trial's `official_url` to the ClinicalTrials.gov record.", "This API is a navigational aid. It does not provide medical advice, eligibility determinations, or compensation guarantees." ], "trials": [ { "nct_id": "NCT05661942", "title": "Diltiazem in the Treatment of Atrial Fibrillation or Atrial Flutter With Rapid Ventricular Rate", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE4" ], "conditions": [ "Atrial Fibrillation With Rapid Ventricular Response", "Hypotension Drug-Induced" ], "interventions": [ { "name": "Calcium pre-treatment", "type": "DRUG" }, { "name": "Placebo", "type": "OTHER" } ], "intervention_types": [ "DRUG", "OTHER" ], "sponsor": "Wake Forest University Health Sciences", "sponsor_class": "OTHER", "healthy_volunteers": false, "eligibility": { "minimum_age": "18 Years", "maximum_age": null, "sex": "ALL", "summary": "18 Years and older" }, "enrollment_count": 92, "start_date": "2022-11-30", "completion_date": "2024-11-20", "has_results": true, "last_update_posted_date": "2025-11-10", "last_synced_at": "2026-10-07T00:52:40.461Z", "location_count": 1, "location_summary": "Oak Lawn, Illinois", "locations": [ { "city": "Oak Lawn", "state": "Illinois" } ], "official_url": "https://clinicaltrials.gov/study/NCT05661942" }, { "nct_id": "NCT05391893", "title": "Effect of Oral and Intravenous Diltiazem Protocol for Emergency Department Atrial Fibrillation", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE4" ], "conditions": [ "Atrial Fibrillation", "Atrial Flutter" ], "interventions": [ { "name": "Oral", "type": "DRUG" }, { "name": "Intravenous drug", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "Corewell Health South", "sponsor_class": "OTHER", "healthy_volunteers": false, "eligibility": { "minimum_age": "18 Years", "maximum_age": null, "sex": "ALL", "summary": "18 Years and older" }, "enrollment_count": 444, "start_date": "2020-06-19", "completion_date": "2023-04-01", "has_results": true, "last_update_posted_date": "2024-12-27", "last_synced_at": "2026-10-07T00:52:40.461Z", "location_count": 1, "location_summary": "Saint Joseph, Michigan", "locations": [ { "city": "Saint Joseph", "state": "Michigan" } ], "official_url": "https://clinicaltrials.gov/study/NCT05391893" }, { "nct_id": "NCT00223717", "title": "Treatment of Supine Hypertension in Autonomic Failure", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE1" ], "conditions": [ "Hypertension" ], "interventions": [ { "name": "Clonidine", "type": "DRUG" }, { "name": "Nitroglycerin transdermal", "type": "DRUG" }, { "name": "Dipyridamole/ Aspirin (Aggrenox)", "type": "DRUG" }, { "name": "Desmopressin (DDAVP)", "type": "DRUG" }, { "name": "Sildenafil", "type": "DRUG" }, { "name": "Nifedipine", "type": "DRUG" }, { "name": "Hydralazine", "type": "DRUG" }, { "name": "Hydrochlorothiazide", "type": "DRUG" }, { "name": "Placebo", "type": "DRUG" }, { "name": "Bosentan", "type": "DRUG" }, { "name": "Diltiazem", "type": "DRUG" }, { "name": "Eplerenone", "type": "DRUG" }, { "name": "guanfacine", "type": "DRUG" }, { "name": "L-arginine", "type": "DIETARY_SUPPLEMENT" }, { "name": "captopril", "type": "DRUG" }, { "name": "carbidopa", "type": "DRUG" }, { "name": "losartan", "type": "DRUG" }, { "name": "metoprolol tartrate", "type": "DRUG" }, { "name": "nebivolol hydrochloride", "type": "DRUG" }, { "name": "prazosin hydrochloride", "type": "DRUG" }, { "name": "tamsulosin hydrochloride", "type": "DRUG" }, { "name": "Head-up tilt.", "type": "OTHER" }, { "name": "aliskiren", "type": "DRUG" }, { "name": "Local heat stress", "type": "OTHER" } ], "intervention_types": [ "DRUG", "DIETARY_SUPPLEMENT", "OTHER" ], "sponsor": "Vanderbilt University", "sponsor_class": "OTHER", "healthy_volunteers": false, "eligibility": { "minimum_age": "18 Years", "maximum_age": "80 Years", "sex": "ALL", "summary": "18 Years to 80 Years" }, "enrollment_count": 152, "start_date": "2001-01", "completion_date": "2017-01", "has_results": false, "last_update_posted_date": "2017-10-13", "last_synced_at": "2026-10-07T00:52:40.461Z", "location_count": 1, "location_summary": "Nashville, Tennessee", "locations": [ { "city": "Nashville", "state": "Tennessee" } ], "official_url": "https://clinicaltrials.gov/study/NCT00223717" }, { "nct_id": "NCT00578617", "title": "Ablation vs Drug Therapy for Atrial Fibrillation - Pilot Trial", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "NA" ], "conditions": [ "Atrial Fibrillation", "Arrhythmia" ], "interventions": [ { "name": "Rate Control", "type": "DRUG" }, { "name": "Ablation Therapy", "type": "DEVICE" }, { "name": "Rhythm control", "type": "DRUG" } ], "intervention_types": [ "DRUG", "DEVICE" ], "sponsor": "Mayo Clinic", "sponsor_class": "OTHER", "healthy_volunteers": false, "eligibility": { "minimum_age": "18 Years", "maximum_age": "90 Years", "sex": "ALL", "summary": "18 Years to 90 Years" }, "enrollment_count": 60, "start_date": "2006-09", "completion_date": "2010-06", "has_results": true, "last_update_posted_date": "2013-01-04", "last_synced_at": "2026-10-07T00:52:40.461Z", "location_count": 10, "location_summary": "Birminham, Alabama • Los Angeles, California • Maywood, Illinois + 7 more", "locations": [ { "city": "Birminham", "state": "Alabama" }, { "city": "Los Angeles", "state": "California" }, { "city": "Maywood", "state": "Illinois" }, { "city": "Des Moines", "state": "Iowa" }, { "city": "Baltimore", "state": "Maryland" } ], "official_url": "https://clinicaltrials.gov/study/NCT00578617" }, { "nct_id": "NCT01505179", "title": "The Effects of Ranolazine on Exercise Capacity in Patients With Heart Failure With Preserved Ejection Fraction", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "NA" ], "conditions": [ "Heart Failure With Preserved Ejection Fraction" ], "interventions": [ { "name": "Ranolazine", "type": "DRUG" }, { "name": "Placebo", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "University of California, San Diego", "sponsor_class": "OTHER", "healthy_volunteers": false, "eligibility": { "minimum_age": "18 Years", "maximum_age": null, "sex": "ALL", "summary": "18 Years and older" }, "enrollment_count": 10, "start_date": "2011-02", "completion_date": "2015-01", "has_results": true, "last_update_posted_date": "2020-01-18", "last_synced_at": "2026-10-07T00:52:40.461Z", "location_count": 1, "location_summary": "San Diego, California", "locations": [ { "city": "San Diego", "state": "California" } ], "official_url": "https://clinicaltrials.gov/study/NCT01505179" }, { "nct_id": "NCT01645826", "title": "Efficacy Study of Cardizem in Pulmonary Arterial Hypertension", "overall_status": "WITHDRAWN", "study_type": "INTERVENTIONAL", "phases": [ "NA" ], "conditions": [ "Idiopathic Pulmonary Arterial Hypertension", "Primary Pulmonary Hypertension", "Pulmonary Arterial Hypertension", "Familial Primary Pulmonary Hypertension" ], "interventions": [ { "name": "Diltiazem Hydrochloride", "type": "DRUG" }, { "name": "Sugar Pill", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "University of South Florida", "sponsor_class": "OTHER", "healthy_volunteers": false, "eligibility": { "minimum_age": "18 Years", "maximum_age": null, "sex": "ALL", "summary": "18 Years and older" }, "enrollment_count": 0, "start_date": "2012-07", "completion_date": "2014-09", "has_results": false, "last_update_posted_date": "2018-11-20", "last_synced_at": "2026-10-07T00:52:40.461Z", "location_count": 1, "location_summary": "Tampa, Florida", "locations": [ { "city": "Tampa", "state": "Florida" } ], "official_url": "https://clinicaltrials.gov/study/NCT01645826" }, { "nct_id": "NCT03070470", "title": "CiPA Phase 1 ECG Biomarker Validation Study", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE1" ], "conditions": [ "Drug-induced QT Prolongation", "Pharmacokinetics", "Pharmacodynamics" ], "interventions": [ { "name": "Ranolazine", "type": "DRUG" }, { "name": "Verapamil", "type": "DRUG" }, { "name": "Lopinavir / Ritonavir", "type": "DRUG" }, { "name": "Chloroquine", "type": "DRUG" }, { "name": "Placebo", "type": "DRUG" }, { "name": "Dofetilide and Diltiazem", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "Food and Drug Administration (FDA)", "sponsor_class": "FED", "healthy_volunteers": true, "eligibility": { "minimum_age": "18 Years", "maximum_age": "50 Years", "sex": "ALL", "summary": "18 Years to 50 Years" }, "enrollment_count": 60, "start_date": "2017-03-14", "completion_date": "2017-06-26", "has_results": true, "last_update_posted_date": "2020-01-18", "last_synced_at": "2026-10-07T00:52:40.461Z", "location_count": 1, "location_summary": "West Bend, Wisconsin", "locations": [ { "city": "West Bend", "state": "Wisconsin" } ], "official_url": "https://clinicaltrials.gov/study/NCT03070470" }, { "nct_id": "NCT00911508", "title": "Catheter Ablation vs Anti-arrhythmic Drug Therapy for Atrial Fibrillation Trial", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "NA" ], "conditions": [ "Atrial Fibrillation", "Arrhythmia" ], "interventions": [ { "name": "Left atrial ablation", "type": "DEVICE" }, { "name": "Rate or Rhythm Control Therapy", "type": "DRUG" } ], "intervention_types": [ "DEVICE", "DRUG" ], "sponsor": "Mayo Clinic", "sponsor_class": "OTHER", "healthy_volunteers": false, "eligibility": { "minimum_age": "18 Years", "maximum_age": "90 Years", "sex": "ALL", "summary": "18 Years to 90 Years" }, "enrollment_count": 2204, "start_date": "2009-11-13", "completion_date": "2017-12-31", "has_results": true, "last_update_posted_date": "2021-04-21", "last_synced_at": "2026-10-07T00:52:40.461Z", "location_count": 76, "location_summary": "Little Rock, Arkansas • Los Angeles, California • Sacramento, California + 66 more", "locations": [ { "city": "Little Rock", "state": "Arkansas" }, { "city": "Los Angeles", "state": "California" }, { "city": "Los Angeles", "state": "California" }, { "city": "Sacramento", "state": "California" }, { "city": "San Francisco", "state": "California" } ], "official_url": "https://clinicaltrials.gov/study/NCT00911508" }, { "nct_id": "NCT01914926", "title": "Comparison of Diltiazem and Metoprolol in the Management of Acute Atrial Fibrillation or Atrial Flutter", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE4" ], "conditions": [ "Heart Rate and Rhythm Disorders" ], "interventions": [ { "name": "Metoprolol", "type": "DRUG" }, { "name": "Diltiazem", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "Antonios Likourezos", "sponsor_class": "OTHER", "healthy_volunteers": false, "eligibility": { "minimum_age": "18 Years", "maximum_age": null, "sex": "ALL", "summary": "18 Years and older" }, "enrollment_count": 54, "start_date": "2009-06", "completion_date": "2010-11", "has_results": true, "last_update_posted_date": "2014-05-15", "last_synced_at": "2026-10-07T00:52:40.461Z", "location_count": 1, "location_summary": "Brooklyn, New York", "locations": [ { "city": "Brooklyn", "state": "New York" } ], "official_url": "https://clinicaltrials.gov/study/NCT01914926" }, { "nct_id": "NCT01352416", "title": "Suppression Of Atrial Fibrillation With Ranolazine After Cardiac Surgery", "overall_status": "TERMINATED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE3" ], "conditions": [ "Heart; Dysfunction Postoperative, Cardiac Surgery" ], "interventions": [ { "name": "Ranolazine", "type": "DRUG" }, { "name": "Placebo", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "Corewell Health East", "sponsor_class": "OTHER", "healthy_volunteers": false, "eligibility": { "minimum_age": "22 Years", "maximum_age": null, "sex": "ALL", "summary": "22 Years and older" }, "enrollment_count": 15, "start_date": "2010-09", "completion_date": "2012-11", "has_results": true, "last_update_posted_date": "2017-01-06", "last_synced_at": "2026-10-07T00:52:40.461Z", "location_count": 2, "location_summary": "Royal Oak, Michigan • Troy, Michigan", "locations": [ { "city": "Royal Oak", "state": "Michigan" }, { "city": "Troy", "state": "Michigan" } ], "official_url": "https://clinicaltrials.gov/study/NCT01352416" } ] }