{ "api_version": "1", "request": { "url": "https://clinicaltrialsfind.com/api/v1/search.json?intervention=Diphenhydramine+25+mg&page=2", "query": { "intervention": "Diphenhydramine 25 mg", "page": 2 }, "page_size": 10 }, "pagination": { "page": 2, "page_size": 10, "total_count": 130, "total_pages": 13, "next_page_url": "https://clinicaltrialsfind.com/api/v1/search.json?intervention=Diphenhydramine+25+mg&page=3&page_size=10", "previous_page_url": "https://clinicaltrialsfind.com/api/v1/search.json?intervention=Diphenhydramine+25+mg&page=1&page_size=10" }, "source": "remote", "last_synced_at": "2026-10-10T19:51:35.525Z", "attribution": "Data derived from public ClinicalTrials.gov records. The official record at https://clinicaltrials.gov/ remains the source of truth for current availability, contacts, and full study details.", "notes": [ "This endpoint exposes only public summary fields — no participant contact emails, phone numbers, or scraped investigator contact details.", "For contact information and full protocol detail, follow each trial's `official_url` to the ClinicalTrials.gov record.", "This API is a navigational aid. It does not provide medical advice, eligibility determinations, or compensation guarantees." ], "trials": [ { "nct_id": "NCT00887640", "title": "Impact of Temsirolimus Therapy on Circulating Tumor Cell Biology In Men With Castration Resistant Metastatic Prostate Cancer", "overall_status": "TERMINATED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE2" ], "conditions": [ "Prostate Cancer" ], "interventions": [ { "name": "Temsirolimus", "type": "DRUG" }, { "name": "Diphenhydramine", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "Duke University", "sponsor_class": "OTHER", "healthy_volunteers": false, "eligibility": { "minimum_age": "18 Years", "maximum_age": null, "sex": "MALE", "summary": "18 Years and older · Male only" }, "enrollment_count": 11, "start_date": "2009-07", "completion_date": "2012-08", "has_results": true, "last_update_posted_date": "2014-02-26", "last_synced_at": "2026-10-10T19:51:35.525Z", "location_count": 2, "location_summary": "Durham, North Carolina • Norfolk, Virginia", "locations": [ { "city": "Durham", "state": "North Carolina" }, { "city": "Norfolk", "state": "Virginia" } ], "official_url": "https://clinicaltrials.gov/study/NCT00887640" }, { "nct_id": "NCT01666678", "title": "Compare Pharmacokinetic (PK) Profiles of Naproxen Sodium, Diphenhydramine Hydrochloride, and Naproxen Sodium and Diphenhydramine Hydrochloride Combination", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE1" ], "conditions": [ "Therapeutic Equivalence" ], "interventions": [ { "name": "BAY98-7111", "type": "DRUG" }, { "name": "Naproxen Sodium (Aleve, BAYH6689)", "type": "DRUG" }, { "name": "Diphenhydramine HCl", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "Bayer", "sponsor_class": "INDUSTRY", "healthy_volunteers": false, "eligibility": { "minimum_age": "18 Years", "maximum_age": "55 Years", "sex": "ALL", "summary": "18 Years to 55 Years" }, "enrollment_count": 32, "start_date": "2012-01", "completion_date": "2012-03", "has_results": false, "last_update_posted_date": "2014-08-21", "last_synced_at": "2026-10-10T19:51:35.525Z", "location_count": 1, "location_summary": "Hackensack, New Jersey", "locations": [ { "city": "Hackensack", "state": "New Jersey" } ], "official_url": "https://clinicaltrials.gov/study/NCT01666678" }, { "nct_id": "NCT02235909", "title": "An Efficacy and Safety Study in Children 6 to Less Than 18 Years of Age With Hypertension", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE3" ], "conditions": [ "Hypertension" ], "interventions": [ { "name": "Azilsartan Medoxomil Low-dose", "type": "DRUG" }, { "name": "Losartan", "type": "DRUG" }, { "name": "Placebo for Azilsartan Medoxomil", "type": "DRUG" }, { "name": "Placebo for Losartan", "type": "DRUG" }, { "name": "Azilsartan Medoxomil Medium-dose (20 mg)", "type": "DRUG" }, { "name": "Azilsartan Medoxomil High-dose (40 mg)", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "Arbor Pharmaceuticals, Inc.", "sponsor_class": "INDUSTRY", "healthy_volunteers": false, "eligibility": { "minimum_age": "6 Years", "maximum_age": "18 Years", "sex": "ALL", "summary": "6 Years to 18 Years" }, "enrollment_count": 377, "start_date": "2015-03-30", "completion_date": "2019-11-11", "has_results": true, "last_update_posted_date": "2025-02-25", "last_synced_at": "2026-10-10T19:51:35.525Z", "location_count": 17, "location_summary": "Anaheim, California • Hialeah, Florida • Miami, Florida + 12 more", "locations": [ { "city": "Anaheim", "state": "California" }, { "city": "Hialeah", "state": "Florida" }, { "city": "Miami", "state": "Florida" }, { "city": "Miami", "state": "Florida" }, { "city": "Miami", "state": "Florida" } ], "official_url": "https://clinicaltrials.gov/study/NCT02235909" }, { "nct_id": "NCT02062710", "title": "Antitussive Effect of a Naturally Flavored Syrup Containing Diphenhydramine, Compared With Dextromethorphan and Placebo", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE4" ], "conditions": [ "Cough Reflex Sensitivity" ], "interventions": [ { "name": "diphenhydramine/phenylephrine/cocoa; dextromethorophan; placebo", "type": "DRUG" }, { "name": "diphenhydramine/phenylephrine/cocoa; placebo; dextromethorphan", "type": "DRUG" }, { "name": "dextromethorphan; diphenhydramine/phenylephrine/cocoa; placebo", "type": "DRUG" }, { "name": "dextromethorophan; placebo; diphenhydramine/phenylephrine/cocoa", "type": "DRUG" }, { "name": "placebo; diphenhydramine/phenylephrine/cocoa; dextromethorphan", "type": "DRUG" }, { "name": "placebo; dextromethorphan; diphenhydramine/phenylephrine/cocoa", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "Montefiore Medical Center", "sponsor_class": "OTHER", "healthy_volunteers": false, "eligibility": { "minimum_age": "18 Years", "maximum_age": null, "sex": "ALL", "summary": "18 Years and older" }, "enrollment_count": 22, "start_date": "2014-01", "completion_date": "2014-06", "has_results": true, "last_update_posted_date": "2018-02-28", "last_synced_at": "2026-10-10T19:51:35.525Z", "location_count": 1, "location_summary": "The Bronx, New York", "locations": [ { "city": "The Bronx", "state": "New York" } ], "official_url": "https://clinicaltrials.gov/study/NCT02062710" }, { "nct_id": "NCT00505531", "title": "Pain Study to See if Ultram ER Will Provide Relief to Subjects Whose Pain is Not Well Controlled by Narcotics", "overall_status": "TERMINATED", "study_type": "OBSERVATIONAL", "phases": [], "conditions": [ "Chronic Pain" ], "interventions": [ { "name": "Tramadol Extended Release Oral Capsule", "type": "DRUG" }, { "name": "Benadryl", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "Massachusetts General Hospital", "sponsor_class": "OTHER", "healthy_volunteers": false, "eligibility": { "minimum_age": "18 Years", "maximum_age": "65 Years", "sex": "ALL", "summary": "18 Years to 65 Years" }, "enrollment_count": 7, "start_date": "2007-06", "completion_date": "2007-12", "has_results": false, "last_update_posted_date": "2020-07-22", "last_synced_at": "2026-10-10T19:51:35.525Z", "location_count": 1, "location_summary": "Boston, Massachusetts", "locations": [ { "city": "Boston", "state": "Massachusetts" } ], "official_url": "https://clinicaltrials.gov/study/NCT00505531" }, { "nct_id": "NCT01280591", "title": "Evaluate Analgesic/Sedative Efficacy of Naproxen Sodium and Diphenhydramine in Patients With Postsurgical Dental Pain", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE3" ], "conditions": [ "Pain, Postoperative" ], "interventions": [ { "name": "Naproxen sodium 440 mg / DPH 50 mg (BAY98-7111)", "type": "DRUG" }, { "name": "Naproxen sodium 220 mg / DPH 50 mg (BAY98-7111)", "type": "DRUG" }, { "name": "Naproxen sodium 440 mg (BAYH6689)", "type": "DRUG" }, { "name": "DPH 50 mg", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "Bayer", "sponsor_class": "INDUSTRY", "healthy_volunteers": false, "eligibility": { "minimum_age": "12 Years", "maximum_age": "45 Years", "sex": "ALL", "summary": "12 Years to 45 Years" }, "enrollment_count": 712, "start_date": "2010-10", "completion_date": "2011-02", "has_results": true, "last_update_posted_date": "2015-06-08", "last_synced_at": "2026-10-10T19:51:35.525Z", "location_count": 2, "location_summary": "Austin, Texas • Salt Lake City, Utah", "locations": [ { "city": "Austin", "state": "Texas" }, { "city": "Salt Lake City", "state": "Utah" } ], "official_url": "https://clinicaltrials.gov/study/NCT01280591" }, { "nct_id": "NCT04580121", "title": "A Dose Escalation and Expansion Study Evaluating the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of RO7283420.", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE1" ], "conditions": [ "Acute Myeloid Leukemia" ], "interventions": [ { "name": "RO7283420", "type": "DRUG" }, { "name": "Tocilizumab", "type": "DRUG" }, { "name": "Dasatinib", "type": "DRUG" }, { "name": "Dexamethasone", "type": "DRUG" }, { "name": "Paracetamol/acetaminophen", "type": "DRUG" }, { "name": "Diphenhydramine", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "Hoffmann-La Roche", "sponsor_class": "INDUSTRY", "healthy_volunteers": false, "eligibility": { "minimum_age": "18 Years", "maximum_age": null, "sex": "ALL", "summary": "18 Years and older" }, "enrollment_count": 59, "start_date": "2020-11-04", "completion_date": "2023-08-09", "has_results": false, "last_update_posted_date": "2024-06-03", "last_synced_at": "2026-10-10T19:51:35.525Z", "location_count": 2, "location_summary": "Sacramento, California • Houston, Texas", "locations": [ { "city": "Sacramento", "state": "California" }, { "city": "Houston", "state": "Texas" } ], "official_url": "https://clinicaltrials.gov/study/NCT04580121" }, { "nct_id": "NCT04840615", "title": "Intratumor Injection of Anti-Mesothelin Immunotoxin LMB-100 With Ipilimumab in Malignant Mesothelioma", "overall_status": "TERMINATED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE1" ], "conditions": [ "Mesothelioma" ], "interventions": [ { "name": "LMB-100", "type": "BIOLOGICAL" }, { "name": "ipilimumab", "type": "DRUG" }, { "name": "Diphenhydramine", "type": "DRUG" }, { "name": "Famotidine", "type": "DRUG" }, { "name": "Acetaminophen", "type": "DRUG" }, { "name": "Dexamethasone", "type": "DRUG" }, { "name": "Biopsy", "type": "PROCEDURE" }, { "name": "FDG-PET", "type": "DIAGNOSTIC_TEST" }, { "name": "CT CAP", "type": "DIAGNOSTIC_TEST" }, { "name": "MRI", "type": "DIAGNOSTIC_TEST" }, { "name": "ECG", "type": "DIAGNOSTIC_TEST" }, { "name": "Echocardiogram", "type": "DIAGNOSTIC_TEST" } ], "intervention_types": [ "BIOLOGICAL", "DRUG", "PROCEDURE", "DIAGNOSTIC_TEST" ], "sponsor": "National Cancer Institute (NCI)", "sponsor_class": "NIH", "healthy_volunteers": false, "eligibility": { "minimum_age": "18 Years", "maximum_age": "120 Years", "sex": "ALL", "summary": "18 Years to 120 Years" }, "enrollment_count": 2, "start_date": "2021-06-11", "completion_date": "2022-01-12", "has_results": true, "last_update_posted_date": "2024-02-02", "last_synced_at": "2026-10-10T19:51:35.525Z", "location_count": 1, "location_summary": "Bethesda, Maryland", "locations": [ { "city": "Bethesda", "state": "Maryland" } ], "official_url": "https://clinicaltrials.gov/study/NCT04840615" }, { "nct_id": "NCT06070649", "title": "The Potential Therapeutic Effects of Psychedelic, N, N-dimethyltryptamine (DMT), on Alcohol Use Disorder (AUD)", "overall_status": "RECRUITING", "study_type": "INTERVENTIONAL", "phases": [ "PHASE1" ], "conditions": [ "Alcohol Use Disorder (AUD)", "Alcohol-Related Disorders", "Alcohol Use" ], "interventions": [ { "name": "0.3mg/kg/min Dimethyltryptamine + Normal Saline infusion", "type": "DRUG" }, { "name": "0.2 mg/kg/min + Dimethyltryptamine 0.01mg/kg/min infusion", "type": "DRUG" }, { "name": "25 mg Diphenhydramine (5 min) + Normal Saline", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "Yale University", "sponsor_class": "OTHER", "healthy_volunteers": false, "eligibility": { "minimum_age": "21 Years", "maximum_age": "65 Years", "sex": "ALL", "summary": "21 Years to 65 Years" }, "enrollment_count": 63, "start_date": "2025-08-04", "completion_date": "2027-08-01", "has_results": false, "last_update_posted_date": "2026-09-10", "last_synced_at": "2026-10-10T19:51:35.525Z", "location_count": 1, "location_summary": "New Haven, Connecticut", "locations": [ { "city": "New Haven", "state": "Connecticut" } ], "official_url": "https://clinicaltrials.gov/study/NCT06070649" }, { "nct_id": "NCT02552394", "title": "J591 in Patients With Advanced Prostate Cancer and Unfavorable Circulating Tumor Cell Counts", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE1" ], "conditions": [ "Prostate Cancer" ], "interventions": [ { "name": "huJ591", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "Weill Medical College of Cornell University", "sponsor_class": "OTHER", "healthy_volunteers": false, "eligibility": { "minimum_age": "18 Years", "maximum_age": null, "sex": "MALE", "summary": "18 Years and older · Male only" }, "enrollment_count": 10, "start_date": "2015-07", "completion_date": "2021-01-03", "has_results": false, "last_update_posted_date": "2023-04-06", "last_synced_at": "2026-10-10T19:51:35.525Z", "location_count": 1, "location_summary": "New York, New York", "locations": [ { "city": "New York", "state": "New York" } ], "official_url": "https://clinicaltrials.gov/study/NCT02552394" } ] }