{ "api_version": "1", "request": { "url": "https://clinicaltrialsfind.com/api/v1/search.json?intervention=Drospirenone%2Fethinylestradiol", "query": { "intervention": "Drospirenone/ethinylestradiol" }, "page_size": 10 }, "pagination": { "page": 1, "page_size": 10, "total_count": 29, "total_pages": 3, "next_page_url": "https://clinicaltrialsfind.com/api/v1/search.json?intervention=Drospirenone%2Fethinylestradiol&page=2&page_size=10", "previous_page_url": null }, "source": "remote", "last_synced_at": "2026-09-15T13:19:02.324Z", "attribution": "Data derived from public ClinicalTrials.gov records. The official record at https://clinicaltrials.gov/ remains the source of truth for current availability, contacts, and full study details.", "notes": [ "This endpoint exposes only public summary fields — no participant contact emails, phone numbers, or scraped investigator contact details.", "For contact information and full protocol detail, follow each trial's `official_url` to the ClinicalTrials.gov record.", "This API is a navigational aid. It does not provide medical advice, eligibility determinations, or compensation guarantees." ], "trials": [ { "nct_id": "NCT07074327", "title": "Effects of VX-407 on the Pharmacokinetics of Oral Contraceptives in Healthy Participants", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE1" ], "conditions": [ "Autosomal Dominant Polycystic Kidney Disease (ADPKD)" ], "interventions": [ { "name": "VX-407", "type": "DRUG" }, { "name": "LNG/EE", "type": "DRUG" }, { "name": "NGM/EE", "type": "DRUG" }, { "name": "NET/EE", "type": "DRUG" }, { "name": "DRSP/EE", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "Vertex Pharmaceuticals Incorporated", "sponsor_class": "INDUSTRY", "healthy_volunteers": true, "eligibility": { "minimum_age": "18 Years", "maximum_age": "50 Years", "sex": "FEMALE", "summary": "18 Years to 50 Years · Female only" }, "enrollment_count": 74, "start_date": "2025-07-11", "completion_date": "2026-02-27", "has_results": false, "last_update_posted_date": "2026-03-30", "last_synced_at": "2026-09-15T13:19:02.324Z", "location_count": 1, "location_summary": "Overland Park, Kansas", "locations": [ { "city": "Overland Park", "state": "Kansas" } ], "official_url": "https://clinicaltrials.gov/study/NCT07074327" }, { "nct_id": "NCT00722761", "title": "Safety and Efficacy Of Drospirenone and Ethinyl Estradiol vs Placebo in the Treatment of Truncal Acne", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE3" ], "conditions": [ "Acne Vulgaris" ], "interventions": [ { "name": "drospirenone and ethinyl estradiol", "type": "DRUG" }, { "name": "Placebo tablet", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "Massachusetts General Hospital", "sponsor_class": "OTHER", "healthy_volunteers": false, "eligibility": { "minimum_age": "18 Years", "maximum_age": "45 Years", "sex": "FEMALE", "summary": "18 Years to 45 Years · Female only" }, "enrollment_count": 30, "start_date": "2009-04", "completion_date": "2012-04", "has_results": true, "last_update_posted_date": "2013-03-05", "last_synced_at": "2026-09-15T13:19:02.324Z", "location_count": 1, "location_summary": "Boston, Massachusetts", "locations": [ { "city": "Boston", "state": "Massachusetts" } ], "official_url": "https://clinicaltrials.gov/study/NCT00722761" }, { "nct_id": "NCT06250205", "title": "Evaluate the Pharmacokinetics of a Combined Oral Contraceptive (COC) With and Without Obicetrapib", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE1" ], "conditions": [ "Healthy Volunteers" ], "interventions": [ { "name": "Obicetrapib", "type": "DRUG" }, { "name": "Obicetrapib + Drospirenone / Ethinyl Estradiol (COC)", "type": "DRUG" }, { "name": "Drospirenone / Ethinyl Estradiol (COC)", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "NewAmsterdam Pharma", "sponsor_class": "INDUSTRY", "healthy_volunteers": true, "eligibility": { "minimum_age": "18 Years", "maximum_age": "35 Years", "sex": "FEMALE", "summary": "18 Years to 35 Years · Female only" }, "enrollment_count": 30, "start_date": "2024-02-05", "completion_date": "2024-04-26", "has_results": false, "last_update_posted_date": "2024-09-19", "last_synced_at": "2026-09-15T13:19:02.324Z", "location_count": 1, "location_summary": "Las Vegas, Nevada", "locations": [ { "city": "Las Vegas", "state": "Nevada" } ], "official_url": "https://clinicaltrials.gov/study/NCT06250205" }, { "nct_id": "NCT01254292", "title": "LCS12 vs Combined Oral Contraceptive (COC) User Satisfaction Study", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE3" ], "conditions": [ "Contraception" ], "interventions": [ { "name": "Levonorgestrel IUD (LCS, BAY86-5028)", "type": "DRUG" }, { "name": "Yasmin (EE30/DRSP, BAY86-5131)", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "Bayer", "sponsor_class": "INDUSTRY", "healthy_volunteers": false, "eligibility": { "minimum_age": "18 Years", "maximum_age": "29 Years", "sex": "FEMALE", "summary": "18 Years to 29 Years · Female only" }, "enrollment_count": 567, "start_date": "2011-01-06", "completion_date": "2014-05-28", "has_results": true, "last_update_posted_date": "2017-09-25", "last_synced_at": "2026-09-15T13:19:02.324Z", "location_count": 24, "location_summary": "Tucson, Arizona • La Mesa, California • San Diego, California + 8 more", "locations": [ { "city": "Tucson", "state": "Arizona" }, { "city": "Tucson", "state": "Arizona" }, { "city": "La Mesa", "state": "California" }, { "city": "La Mesa", "state": "California" }, { "city": "San Diego", "state": "California" } ], "official_url": "https://clinicaltrials.gov/study/NCT01254292" }, { "nct_id": "NCT00656981", "title": "Evaluate Safety and Efficacy of an Oral Contraceptive (OC) Preparation Versus Placebo for 6 Treatment Cycles in Women With Moderate Acne", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE3" ], "conditions": [ "Acne Vulgaris" ], "interventions": [ { "name": "YAZ (DRSP 3 mg/EE 0.02 mg, BAY86-5300)", "type": "DRUG" }, { "name": "Placebo", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "Bayer", "sponsor_class": "INDUSTRY", "healthy_volunteers": true, "eligibility": { "minimum_age": "14 Years", "maximum_age": "45 Years", "sex": "FEMALE", "summary": "14 Years to 45 Years · Female only" }, "enrollment_count": 541, "start_date": "2003-01", "completion_date": "2004-06", "has_results": false, "last_update_posted_date": "2014-12-30", "last_synced_at": "2026-09-15T13:19:02.324Z", "location_count": 22, "location_summary": "Mobile, Alabama • Kingman, Arizona • Encino, California + 18 more", "locations": [ { "city": "Mobile", "state": "Alabama" }, { "city": "Kingman", "state": "Arizona" }, { "city": "Encino", "state": "California" }, { "city": "San Diego", "state": "California" }, { "city": "San Diego", "state": "California" } ], "official_url": "https://clinicaltrials.gov/study/NCT00656981" }, { "nct_id": "NCT00468481", "title": "Efficacy and Safety Study for an Oral Contraceptive Containing Folate", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE3" ], "conditions": [ "Neural Tube Defects", "Contraception", "Oral Contraceptives (OC)" ], "interventions": [ { "name": "Drospirenone/Ethinylestradiol/Methyltetrahydrofolate", "type": "DRUG" }, { "name": "Drospirenone/Ethinylestradiol (Yaz)", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "Bayer", "sponsor_class": "INDUSTRY", "healthy_volunteers": true, "eligibility": { "minimum_age": "18 Years", "maximum_age": "40 Years", "sex": "FEMALE", "summary": "18 Years to 40 Years · Female only" }, "enrollment_count": 385, "start_date": "2007-04", "completion_date": "2008-09", "has_results": true, "last_update_posted_date": "2014-04-23", "last_synced_at": "2026-09-15T13:19:02.324Z", "location_count": 9, "location_summary": "Anaheim, California • San Diego, California • Baltimore, Maryland + 6 more", "locations": [ { "city": "Anaheim", "state": "California" }, { "city": "San Diego", "state": "California" }, { "city": "Baltimore", "state": "Maryland" }, { "city": "New York", "state": "New York" }, { "city": "Morrisville", "state": "North Carolina" } ], "official_url": "https://clinicaltrials.gov/study/NCT00468481" }, { "nct_id": "NCT01291004", "title": "A Study to Evaluate Ovarian Follicular Activity and Hormone Levels for DR-102 Compared to Two 28-Day Oral Contraceptives", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE1" ], "conditions": [ "Follicle Development", "Ovarian Follicle", "Follicle Count", "Follicle Size", "Oral Contraceptive" ], "interventions": [ { "name": "Desogestrel/ethinyl estradiol and ethinyl estradiol", "type": "DRUG" }, { "name": "28-day drospirenone oral contraceptive", "type": "DRUG" }, { "name": "28-day levonorgestrel oral contraceptive", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "Teva Branded Pharmaceutical Products R&D, Inc.", "sponsor_class": "INDUSTRY", "healthy_volunteers": true, "eligibility": { "minimum_age": "18 Years", "maximum_age": "35 Years", "sex": "FEMALE", "summary": "18 Years to 35 Years · Female only" }, "enrollment_count": 206, "start_date": "2011-01-31", "completion_date": "2012-03-31", "has_results": false, "last_update_posted_date": "2021-12-08", "last_synced_at": "2026-09-15T13:19:02.324Z", "location_count": 2, "location_summary": "Philadelphia, Pennsylvania • Seattle, Washington", "locations": [ { "city": "Philadelphia", "state": "Pennsylvania" }, { "city": "Seattle", "state": "Washington" } ], "official_url": "https://clinicaltrials.gov/study/NCT01291004" }, { "nct_id": "NCT03126097", "title": "A Study to Investigate the Interaction Between JNJ-64155806 and Ethinylestradiol/Drospirenone in Healthy Females", "overall_status": "TERMINATED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE1" ], "conditions": [ "Healthy" ], "interventions": [ { "name": "JNJ-64155806 150 mg", "type": "DRUG" }, { "name": "Ethinylestradiol/drospirenone 0.02 mg/3 mg", "type": "DRUG" }, { "name": "COCP Placebo", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "Janssen Research & Development, LLC", "sponsor_class": "INDUSTRY", "healthy_volunteers": true, "eligibility": { "minimum_age": "18 Years", "maximum_age": "45 Years", "sex": "FEMALE", "summary": "18 Years to 45 Years · Female only" }, "enrollment_count": 18, "start_date": "2017-04-13", "completion_date": "2017-05-26", "has_results": false, "last_update_posted_date": "2017-09-01", "last_synced_at": "2026-09-15T13:19:02.324Z", "location_count": 1, "location_summary": "Tempe, Arizona", "locations": [ { "city": "Tempe", "state": "Arizona" } ], "official_url": "https://clinicaltrials.gov/study/NCT03126097" }, { "nct_id": "NCT03418363", "title": "How DHEA Supplements Affect Coagulation in Women Using Birth Control Pills", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE4" ], "conditions": [ "Contraceptive Usage", "Coagulation" ], "interventions": [ { "name": "DHEA Oral Capsule", "type": "DIETARY_SUPPLEMENT" }, { "name": "Placebo Oral Capsule", "type": "OTHER" } ], "intervention_types": [ "DIETARY_SUPPLEMENT", "OTHER" ], "sponsor": "Oregon Health and Science University", "sponsor_class": "OTHER", "healthy_volunteers": true, "eligibility": { "minimum_age": "18 Years", "maximum_age": "44 Years", "sex": "FEMALE", "summary": "18 Years to 44 Years · Female only" }, "enrollment_count": 15, "start_date": "2018-01-16", "completion_date": "2019-12-11", "has_results": false, "last_update_posted_date": "2020-01-23", "last_synced_at": "2026-09-15T13:19:02.324Z", "location_count": 1, "location_summary": "Portland, Oregon", "locations": [ { "city": "Portland", "state": "Oregon" } ], "official_url": "https://clinicaltrials.gov/study/NCT03418363" }, { "nct_id": "NCT00633360", "title": "The Oral Contraceptive Pill for Premenstrual Worsening of Depression", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "NA" ], "conditions": [ "Premenstrual Syndrome", "Depression" ], "interventions": [ { "name": "Drospirenone and ethinyl estradiol", "type": "DRUG" }, { "name": "Placebo", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "Massachusetts General Hospital", "sponsor_class": "OTHER", "healthy_volunteers": false, "eligibility": { "minimum_age": "18 Years", "maximum_age": "45 Years", "sex": "FEMALE", "summary": "18 Years to 45 Years · Female only" }, "enrollment_count": 32, "start_date": "2008-02", "completion_date": "2011-05", "has_results": true, "last_update_posted_date": "2017-03-20", "last_synced_at": "2026-09-15T13:19:02.324Z", "location_count": 1, "location_summary": "Boston, Massachusetts", "locations": [ { "city": "Boston", "state": "Massachusetts" } ], "official_url": "https://clinicaltrials.gov/study/NCT00633360" } ] }