{ "api_version": "1", "request": { "url": "https://clinicaltrialsfind.com/api/v1/search.json?intervention=Duloxetine+or+escitalopram", "query": { "intervention": "Duloxetine or escitalopram" }, "page_size": 10 }, "pagination": { "page": 1, "page_size": 10, "total_count": 37, "total_pages": 4, "next_page_url": "https://clinicaltrialsfind.com/api/v1/search.json?intervention=Duloxetine+or+escitalopram&page=2&page_size=10", "previous_page_url": null }, "source": "remote", "last_synced_at": "2026-10-07T20:34:11.475Z", "attribution": "Data derived from public ClinicalTrials.gov records. The official record at https://clinicaltrials.gov/ remains the source of truth for current availability, contacts, and full study details.", "notes": [ "This endpoint exposes only public summary fields — no participant contact emails, phone numbers, or scraped investigator contact details.", "For contact information and full protocol detail, follow each trial's `official_url` to the ClinicalTrials.gov record.", "This API is a navigational aid. It does not provide medical advice, eligibility determinations, or compensation guarantees." ], "trials": [ { "nct_id": "NCT01436162", "title": "Efficacy and Safety Study of SPD489 in Combination With an Antidepressant in the Treatment of Adults With Major Depressive Disorder", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE3" ], "conditions": [ "Major Depressive Disorder" ], "interventions": [ { "name": "Antidepressant + SPD489 (Lisdexamfetamine dimesylate )", "type": "DRUG" }, { "name": "Antidepressant + Placebo", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "Shire", "sponsor_class": "INDUSTRY", "healthy_volunteers": false, "eligibility": { "minimum_age": "18 Years", "maximum_age": "65 Years", "sex": "ALL", "summary": "18 Years to 65 Years" }, "enrollment_count": 1105, "start_date": "2011-10-19", "completion_date": "2013-12-10", "has_results": true, "last_update_posted_date": "2021-06-09", "last_synced_at": "2026-10-07T20:34:11.475Z", "location_count": 36, "location_summary": "Scottsdale, Arizona • Little Rock, Arkansas • Costa Mesa, California + 31 more", "locations": [ { "city": "Scottsdale", "state": "Arizona" }, { "city": "Little Rock", "state": "Arkansas" }, { "city": "Costa Mesa", "state": "California" }, { "city": "Downey", "state": "California" }, { "city": "Escondido", "state": "California" } ], "official_url": "https://clinicaltrials.gov/study/NCT01436162" }, { "nct_id": "NCT02422186", "title": "A Study to Evaluate the Efficacy, Safety, and Tolerability of Intranasal Esketamine Plus an Oral Antidepressant in Elderly Participants With Treatment-resistant Depression", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE3" ], "conditions": [ "Depressive Disorder, Treatment-Resistant" ], "interventions": [ { "name": "Esketamine", "type": "DRUG" }, { "name": "Placebo", "type": "DRUG" }, { "name": "Duloxetine (Oral Antidepressant)", "type": "DRUG" }, { "name": "Escitalopram (Oral Antidepressant)", "type": "DRUG" }, { "name": "Sertraline (Oral Antidepressant)", "type": "DRUG" }, { "name": "Venlafaxine Extended Release (XR) (New Antidepressant)", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "Janssen Research & Development, LLC", "sponsor_class": "INDUSTRY", "healthy_volunteers": false, "eligibility": { "minimum_age": "65 Years", "maximum_age": null, "sex": "ALL", "summary": "65 Years and older" }, "enrollment_count": 139, "start_date": "2015-08-20", "completion_date": "2017-08-10", "has_results": true, "last_update_posted_date": "2025-04-29", "last_synced_at": "2026-10-07T20:34:11.475Z", "location_count": 15, "location_summary": "San Diego, California • New Haven, Connecticut • Miami, Florida + 12 more", "locations": [ { "city": "San Diego", "state": "California" }, { "city": "New Haven", "state": "Connecticut" }, { "city": "Miami", "state": "Florida" }, { "city": "Marietta", "state": "Georgia" }, { "city": "Iowa City", "state": "Iowa" } ], "official_url": "https://clinicaltrials.gov/study/NCT02422186" }, { "nct_id": "NCT01436175", "title": "SPD489 Adult Major Depressive Disorder (MDD) Open-label Safety and Tolerability Rollover Extension Study", "overall_status": "TERMINATED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE3" ], "conditions": [ "Major Depressive Disorder" ], "interventions": [ { "name": "SPD489 (Lisdexamfetamine dimesylate) + Antidepressant", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "Shire", "sponsor_class": "INDUSTRY", "healthy_volunteers": false, "eligibility": { "minimum_age": "18 Years", "maximum_age": "65 Years", "sex": "ALL", "summary": "18 Years to 65 Years" }, "enrollment_count": 1570, "start_date": "2012-02-27", "completion_date": "2014-03-27", "has_results": true, "last_update_posted_date": "2021-06-14", "last_synced_at": "2026-10-07T20:34:11.475Z", "location_count": 140, "location_summary": "Birmingham, Alabama • Scottsdale, Arizona • Little Rock, Arkansas + 113 more", "locations": [ { "city": "Birmingham", "state": "Alabama" }, { "city": "Scottsdale", "state": "Arizona" }, { "city": "Little Rock", "state": "Arkansas" }, { "city": "Anaheim", "state": "California" }, { "city": "Carson", "state": "California" } ], "official_url": "https://clinicaltrials.gov/study/NCT01436175" }, { "nct_id": "NCT06965569", "title": "Multiple Ascending Dose Phase 1 Study of ALA-3000", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE1" ], "conditions": [ "Treatment Resistant Depression" ], "interventions": [ { "name": "ALA-3000", "type": "DRUG" }, { "name": "Placebo", "type": "DRUG" }, { "name": "escitalopram, sertraline, duloxetine or venlafaxine XR", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "Alar Pharmaceuticals Inc.", "sponsor_class": "INDUSTRY", "healthy_volunteers": false, "eligibility": { "minimum_age": "18 Years", "maximum_age": "65 Years", "sex": "ALL", "summary": "18 Years to 65 Years" }, "enrollment_count": 37, "start_date": "2025-04-21", "completion_date": "2025-12-30", "has_results": false, "last_update_posted_date": "2025-12-31", "last_synced_at": "2026-10-07T20:34:11.475Z", "location_count": 4, "location_summary": "Little Rock, Arkansas • St Louis, Missouri • Eatontown, New Jersey + 1 more", "locations": [ { "city": "Little Rock", "state": "Arkansas" }, { "city": "St Louis", "state": "Missouri" }, { "city": "Eatontown", "state": "New Jersey" }, { "city": "North Canton", "state": "Ohio" } ], "official_url": "https://clinicaltrials.gov/study/NCT06965569" }, { "nct_id": "NCT01436149", "title": "Efficacy and Safety Study of SPD489 in Combination With an Antidepressant in the Treatment of Adults With Major Depressive Disorder", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE3" ], "conditions": [ "Major Depressive Disorder" ], "interventions": [ { "name": "SPD489 (Lisdexamfetamine dimesylate )", "type": "DRUG" }, { "name": "Placebo", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "Shire", "sponsor_class": "INDUSTRY", "healthy_volunteers": false, "eligibility": { "minimum_age": "18 Years", "maximum_age": "65 Years", "sex": "ALL", "summary": "18 Years to 65 Years" }, "enrollment_count": 1262, "start_date": "2011-10-27", "completion_date": "2013-12-23", "has_results": true, "last_update_posted_date": "2021-06-09", "last_synced_at": "2026-10-07T20:34:11.475Z", "location_count": 47, "location_summary": "Birmingham, Alabama • Carson, California • Irvine, California + 42 more", "locations": [ { "city": "Birmingham", "state": "Alabama" }, { "city": "Carson", "state": "California" }, { "city": "Irvine", "state": "California" }, { "city": "Norwalk", "state": "California" }, { "city": "Oceanside", "state": "California" } ], "official_url": "https://clinicaltrials.gov/study/NCT01436149" }, { "nct_id": "NCT04245748", "title": "Determining Optimal Treatment Sequences in Anxious Depression (DOTS-AD)", "overall_status": "UNKNOWN", "study_type": "INTERVENTIONAL", "phases": [ "PHASE4" ], "conditions": [ "Anxious Depression", "Depression" ], "interventions": [ { "name": "Escitalopram", "type": "DRUG" }, { "name": "Duloxetine", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "University of Cincinnati", "sponsor_class": "OTHER", "healthy_volunteers": false, "eligibility": { "minimum_age": "18 Years", "maximum_age": "50 Years", "sex": "ALL", "summary": "18 Years to 50 Years" }, "enrollment_count": 84, "start_date": "2020-03-01", "completion_date": "2025-12-31", "has_results": false, "last_update_posted_date": "2024-08-29", "last_synced_at": "2026-10-07T20:34:11.475Z", "location_count": 1, "location_summary": "Cincinnati, Ohio", "locations": [ { "city": "Cincinnati", "state": "Ohio" } ], "official_url": "https://clinicaltrials.gov/study/NCT04245748" }, { "nct_id": "NCT00386243", "title": "Evaluation of Stepped Care for Chronic Pain in Iraq/Afghanistan Veterans (ESCAPE)", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "NA" ], "conditions": [ "Low Back Pain", "Pain", "Pain, Intractable" ], "interventions": [ { "name": "Cognitive behavioral therapy", "type": "BEHAVIORAL" }, { "name": "Pain self-management program", "type": "BEHAVIORAL" }, { "name": "Co-Analgesic Therapy", "type": "DRUG" }, { "name": "Opioid Analgesics", "type": "DRUG" } ], "intervention_types": [ "BEHAVIORAL", "DRUG" ], "sponsor": "VA Office of Research and Development", "sponsor_class": "FED", "healthy_volunteers": false, "eligibility": { "minimum_age": "18 Years", "maximum_age": null, "sex": "ALL", "summary": "18 Years and older" }, "enrollment_count": 242, "start_date": "2007-12", "completion_date": "2012-09", "has_results": true, "last_update_posted_date": "2019-07-05", "last_synced_at": "2026-10-07T20:34:11.475Z", "location_count": 1, "location_summary": "Indianapolis, Indiana", "locations": [ { "city": "Indianapolis", "state": "Indiana" } ], "official_url": "https://clinicaltrials.gov/study/NCT00386243" }, { "nct_id": "NCT04748276", "title": "Tracking Response to Antidepressants in Advance of Investigational Trials", "overall_status": "UNKNOWN", "study_type": "OBSERVATIONAL", "phases": [], "conditions": [ "Major Depressive Disorder" ], "interventions": [ { "name": "FDA-approved selective-serotonin reuptake inhibitors (SSRIs) and selective-norepinephrine reuptake inhibitors (SNRIs)", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "Adams Clinical", "sponsor_class": "NETWORK", "healthy_volunteers": false, "eligibility": { "minimum_age": "18 Years", "maximum_age": null, "sex": "ALL", "summary": "18 Years and older" }, "enrollment_count": 400, "start_date": "2019-01-02", "completion_date": "2023-12-31", "has_results": false, "last_update_posted_date": "2023-03-27", "last_synced_at": "2026-10-07T20:34:11.475Z", "location_count": 1, "location_summary": "Watertown, Massachusetts", "locations": [ { "city": "Watertown", "state": "Massachusetts" } ], "official_url": "https://clinicaltrials.gov/study/NCT04748276" }, { "nct_id": "NCT01838876", "title": "Long-term Safety and Tolerability of Cariprazine as an Adjunctive Treatment to Antidepressant Therapy in Patients With Major Depressive Disorder", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE3" ], "conditions": [ "Major Depressive Disorder" ], "interventions": [ { "name": "Cariprazine", "type": "DRUG" }, { "name": "Antidepressant Therapy (ADT)", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "Forest Laboratories", "sponsor_class": "INDUSTRY", "healthy_volunteers": false, "eligibility": { "minimum_age": "18 Years", "maximum_age": "65 Years", "sex": "ALL", "summary": "18 Years to 65 Years" }, "enrollment_count": 442, "start_date": "2013-04-29", "completion_date": "2015-07-27", "has_results": true, "last_update_posted_date": "2019-08-21", "last_synced_at": "2026-10-07T20:34:11.475Z", "location_count": 88, "location_summary": "Tucson, Arizona • Fayetteville, Arkansas • Little Rock, Arkansas + 74 more", "locations": [ { "city": "Tucson", "state": "Arizona" }, { "city": "Tucson", "state": "Arizona" }, { "city": "Fayetteville", "state": "Arkansas" }, { "city": "Little Rock", "state": "Arkansas" }, { "city": "Little Rock", "state": "Arkansas" } ], "official_url": "https://clinicaltrials.gov/study/NCT01838876" }, { "nct_id": "NCT01973283", "title": "Antidepressant Response in the Treatment of Depressive Symptoms and Frailty Characteristics in Older Adults", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE4" ], "conditions": [ "Major Depressive Disorder", "Dysthymic Disorder", "Depressive Disorder, NOS" ], "interventions": [ { "name": "Antidepressant Medication", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "New York State Psychiatric Institute", "sponsor_class": "OTHER", "healthy_volunteers": false, "eligibility": { "minimum_age": "60 Years", "maximum_age": "95 Years", "sex": "ALL", "summary": "60 Years to 95 Years" }, "enrollment_count": 100, "start_date": "2014-02-19", "completion_date": "2020-12-05", "has_results": true, "last_update_posted_date": "2021-01-29", "last_synced_at": "2026-10-07T20:34:11.475Z", "location_count": 1, "location_summary": "New York, New York", "locations": [ { "city": "New York", "state": "New York" } ], "official_url": "https://clinicaltrials.gov/study/NCT01973283" } ] }