{
  "api_version": "1",
  "request": {
    "url": "https://clinicaltrialsfind.com/api/v1/search.json?intervention=E004+Placebo",
    "query": {
      "intervention": "E004 Placebo"
    },
    "page_size": 10
  },
  "pagination": {
    "page": 1,
    "page_size": 10,
    "total_count": 5,
    "total_pages": 1,
    "next_page_url": null,
    "previous_page_url": null
  },
  "source": "remote",
  "last_synced_at": "2026-09-05T19:33:02.282Z",
  "attribution": "Data derived from public ClinicalTrials.gov records. The official record at https://clinicaltrials.gov/ remains the source of truth for current availability, contacts, and full study details.",
  "notes": [
    "This endpoint exposes only public summary fields — no participant contact emails, phone numbers, or scraped investigator contact details.",
    "For contact information and full protocol detail, follow each trial's `official_url` to the ClinicalTrials.gov record.",
    "This API is a navigational aid. It does not provide medical advice, eligibility determinations, or compensation guarantees."
  ],
  "trials": [
    {
      "nct_id": "NCT01460511",
      "title": "Evaluation of Efficacy and Safety of E004 in Children With Asthma",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE3"
      ],
      "conditions": [
        "Asthma"
      ],
      "interventions": [
        {
          "name": "E004 (Epinephrine Inhalation Aerosol) HFA-MDI",
          "type": "DRUG"
        },
        {
          "name": "Placebo-HFA",
          "type": "DRUG"
        }
      ],
      "intervention_types": [
        "DRUG"
      ],
      "sponsor": "Amphastar Pharmaceuticals, Inc.",
      "sponsor_class": "INDUSTRY",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "4 Years",
        "maximum_age": "11 Years",
        "sex": "ALL",
        "summary": "4 Years to 11 Years"
      },
      "enrollment_count": 70,
      "start_date": "2011-10",
      "completion_date": "2012-07",
      "has_results": false,
      "last_update_posted_date": "2018-07-31",
      "last_synced_at": "2026-09-05T19:33:02.282Z",
      "location_count": 8,
      "location_summary": "Costa Mesa, California • Orange, California • Stockton, California + 5 more",
      "locations": [
        {
          "city": "Costa Mesa",
          "state": "California"
        },
        {
          "city": "Orange",
          "state": "California"
        },
        {
          "city": "Stockton",
          "state": "California"
        },
        {
          "city": "Medford",
          "state": "Oregon"
        },
        {
          "city": "Portland",
          "state": "Oregon"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT01460511"
    },
    {
      "nct_id": "NCT01737905",
      "title": "Evaluation of Efficacy and Safety for Single Dose of E004 in Children With Asthma",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE3"
      ],
      "conditions": [
        "Asthma"
      ],
      "interventions": [
        {
          "name": "Epinephrine HFA-MDI (E004)",
          "type": "DRUG"
        },
        {
          "name": "Placebo-HFA",
          "type": "DRUG"
        }
      ],
      "intervention_types": [
        "DRUG"
      ],
      "sponsor": "Amphastar Pharmaceuticals, Inc.",
      "sponsor_class": "INDUSTRY",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "4 Years",
        "maximum_age": "11 Years",
        "sex": "ALL",
        "summary": "4 Years to 11 Years"
      },
      "enrollment_count": 28,
      "start_date": "2012-10",
      "completion_date": "2013-12",
      "has_results": false,
      "last_update_posted_date": "2016-03-11",
      "last_synced_at": "2026-09-05T19:33:02.282Z",
      "location_count": 6,
      "location_summary": "Cypress, California • Medford, Oregon • Portland, Oregon + 3 more",
      "locations": [
        {
          "city": "Cypress",
          "state": "California"
        },
        {
          "city": "Medford",
          "state": "Oregon"
        },
        {
          "city": "Portland",
          "state": "Oregon"
        },
        {
          "city": "El Paso",
          "state": "Texas"
        },
        {
          "city": "San Antonio",
          "state": "Texas"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT01737905"
    },
    {
      "nct_id": "NCT01025648",
      "title": "Randomized, Placebo/Active Crossover Dose-ranging Study for Safety and Efficacy in Asthma Patients.",
      "overall_status": "TERMINATED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE1",
        "PHASE2"
      ],
      "conditions": [
        "Asthma"
      ],
      "interventions": [
        {
          "name": "E004 (epinephrine inhalation aerosol), 90 mcg/actuation",
          "type": "DRUG"
        },
        {
          "name": "E004 Placebo",
          "type": "DRUG"
        },
        {
          "name": "E004 (epinephrine inhalation aerosol), 125 mcg",
          "type": "DRUG"
        },
        {
          "name": "E004 (epinephrine inhalation aerosol), 220 mcg",
          "type": "DRUG"
        },
        {
          "name": "epinephrine inhalation aerosol, CFC propelled",
          "type": "DRUG"
        },
        {
          "name": "E004 (epinephrine inhalation aerosol), 160 mcg",
          "type": "DRUG"
        }
      ],
      "intervention_types": [
        "DRUG"
      ],
      "sponsor": "Amphastar Pharmaceuticals, Inc.",
      "sponsor_class": "INDUSTRY",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": "55 Years",
        "sex": "ALL",
        "summary": "18 Years to 55 Years"
      },
      "enrollment_count": 9,
      "start_date": "2009-12",
      "completion_date": "2009-12",
      "has_results": false,
      "last_update_posted_date": "2018-05-16",
      "last_synced_at": "2026-09-05T19:33:02.282Z",
      "location_count": 2,
      "location_summary": "San Jose, California • Stockton, California",
      "locations": [
        {
          "city": "San Jose",
          "state": "California"
        },
        {
          "city": "Stockton",
          "state": "California"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT01025648"
    },
    {
      "nct_id": "NCT01357642",
      "title": "Epinephrine Inhalation Aerosol USP: For Evaluation Of Efficacy And Safety In Asthma Patients",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE3"
      ],
      "conditions": [
        "Asthma"
      ],
      "interventions": [
        {
          "name": "epinephrine inhalation aerosol",
          "type": "DRUG"
        },
        {
          "name": "Placebo",
          "type": "DRUG"
        }
      ],
      "intervention_types": [
        "DRUG"
      ],
      "sponsor": "Amphastar Pharmaceuticals, Inc.",
      "sponsor_class": "INDUSTRY",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "12 Years",
        "maximum_age": "75 Years",
        "sex": "ALL",
        "summary": "12 Years to 75 Years"
      },
      "enrollment_count": 373,
      "start_date": "2011-07",
      "completion_date": "2011-12",
      "has_results": false,
      "last_update_posted_date": "2016-03-11",
      "last_synced_at": "2026-09-05T19:33:02.282Z",
      "location_count": 33,
      "location_summary": "Costa Mesa, California • Los Angeles, California • Mission Viejo, California + 30 more",
      "locations": [
        {
          "city": "Costa Mesa",
          "state": "California"
        },
        {
          "city": "Los Angeles",
          "state": "California"
        },
        {
          "city": "Mission Viejo",
          "state": "California"
        },
        {
          "city": "Orange",
          "state": "California"
        },
        {
          "city": "San Jose",
          "state": "California"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT01357642"
    },
    {
      "nct_id": "NCT01476904",
      "title": "Safety Study in Adolescent and Adult Patients With Asthma",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE3"
      ],
      "conditions": [
        "Asthma"
      ],
      "interventions": [
        {
          "name": "Placebo",
          "type": "DRUG"
        },
        {
          "name": "Primatene Mist",
          "type": "DRUG"
        },
        {
          "name": "Epinephrine inhalation",
          "type": "DRUG"
        }
      ],
      "intervention_types": [
        "DRUG"
      ],
      "sponsor": "Amphastar Pharmaceuticals, Inc.",
      "sponsor_class": "INDUSTRY",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "12 Years",
        "maximum_age": "75 Years",
        "sex": "ALL",
        "summary": "12 Years to 75 Years"
      },
      "enrollment_count": 208,
      "start_date": "2011-11",
      "completion_date": "2012-07",
      "has_results": false,
      "last_update_posted_date": "2017-02-13",
      "last_synced_at": "2026-09-05T19:33:02.282Z",
      "location_count": 27,
      "location_summary": "Costa Mesa, California • Los Angeles, California • Orange, California + 24 more",
      "locations": [
        {
          "city": "Costa Mesa",
          "state": "California"
        },
        {
          "city": "Los Angeles",
          "state": "California"
        },
        {
          "city": "Orange",
          "state": "California"
        },
        {
          "city": "San Jose",
          "state": "California"
        },
        {
          "city": "Stockton",
          "state": "California"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT01476904"
    }
  ]
}