{
  "api_version": "1",
  "request": {
    "url": "https://clinicaltrialsfind.com/api/v1/search.json?intervention=Essential+Amino+Acids+%2B+Leucine",
    "query": {
      "intervention": "Essential Amino Acids + Leucine"
    },
    "page_size": 10
  },
  "pagination": {
    "page": 1,
    "page_size": 10,
    "total_count": 42,
    "total_pages": 5,
    "next_page_url": "https://clinicaltrialsfind.com/api/v1/search.json?intervention=Essential+Amino+Acids+%2B+Leucine&page=2&page_size=10",
    "previous_page_url": null
  },
  "source": "remote",
  "last_synced_at": "2026-09-29T15:09:30.676Z",
  "attribution": "Data derived from public ClinicalTrials.gov records. The official record at https://clinicaltrials.gov/ remains the source of truth for current availability, contacts, and full study details.",
  "notes": [
    "This endpoint exposes only public summary fields — no participant contact emails, phone numbers, or scraped investigator contact details.",
    "For contact information and full protocol detail, follow each trial's `official_url` to the ClinicalTrials.gov record.",
    "This API is a navigational aid. It does not provide medical advice, eligibility determinations, or compensation guarantees."
  ],
  "trials": [
    {
      "nct_id": "NCT03557684",
      "title": "Leucine for Depression Study (L-DEP)",
      "overall_status": "TERMINATED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "EARLY_PHASE1"
      ],
      "conditions": [
        "Depression"
      ],
      "interventions": [
        {
          "name": "leucine",
          "type": "DIETARY_SUPPLEMENT"
        },
        {
          "name": "PO placebo",
          "type": "OTHER"
        },
        {
          "name": "lipopolysaccharide (LPS)",
          "type": "BIOLOGICAL"
        },
        {
          "name": "IV placebo",
          "type": "OTHER"
        }
      ],
      "intervention_types": [
        "DIETARY_SUPPLEMENT",
        "OTHER",
        "BIOLOGICAL"
      ],
      "sponsor": "University of California, Los Angeles",
      "sponsor_class": "OTHER",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": "65 Years",
        "sex": "ALL",
        "summary": "18 Years to 65 Years"
      },
      "enrollment_count": 59,
      "start_date": "2018-09-01",
      "completion_date": "2021-07-31",
      "has_results": true,
      "last_update_posted_date": "2023-06-08",
      "last_synced_at": "2026-09-29T15:09:30.676Z",
      "location_count": 1,
      "location_summary": "Los Angeles, California",
      "locations": [
        {
          "city": "Los Angeles",
          "state": "California"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT03557684"
    },
    {
      "nct_id": "NCT05400733",
      "title": "Prandial Metabolic Phenotype in Adults",
      "overall_status": "RECRUITING",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Protein Metabolism"
      ],
      "interventions": [
        {
          "name": "Total Amino Acids",
          "type": "DIETARY_SUPPLEMENT"
        },
        {
          "name": "Essential Amino Acids",
          "type": "DIETARY_SUPPLEMENT"
        },
        {
          "name": "Essential Amino Acids + Hydroxy-methylbutyric acid (HMB)",
          "type": "DIETARY_SUPPLEMENT"
        },
        {
          "name": "Essential Amino Acids + Leucine",
          "type": "DIETARY_SUPPLEMENT"
        },
        {
          "name": "Essential Amino Acids High",
          "type": "DIETARY_SUPPLEMENT"
        },
        {
          "name": "Placebo Water",
          "type": "DIETARY_SUPPLEMENT"
        }
      ],
      "intervention_types": [
        "DIETARY_SUPPLEMENT"
      ],
      "sponsor": "Texas A&M University",
      "sponsor_class": "OTHER",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "60 Years",
        "maximum_age": "80 Years",
        "sex": "ALL",
        "summary": "60 Years to 80 Years"
      },
      "enrollment_count": 50,
      "start_date": "2022-06-24",
      "completion_date": "2026-09",
      "has_results": false,
      "last_update_posted_date": "2025-10-01",
      "last_synced_at": "2026-09-29T15:09:30.676Z",
      "location_count": 1,
      "location_summary": "College Station, Texas",
      "locations": [
        {
          "city": "College Station",
          "state": "Texas"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT05400733"
    },
    {
      "nct_id": "NCT01172301",
      "title": "Leucine-enriched Essential Amino Acid Intake to Optimize Protein Anabolism in Children With Cystic Fibrosis",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Cystic Fibrosis"
      ],
      "interventions": [
        {
          "name": "Essential amino acid intake + Leucine vs total AA supplement",
          "type": "DIETARY_SUPPLEMENT"
        }
      ],
      "intervention_types": [
        "DIETARY_SUPPLEMENT"
      ],
      "sponsor": "Texas A&M University",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "10 Years",
        "maximum_age": "21 Years",
        "sex": "ALL",
        "summary": "10 Years to 21 Years"
      },
      "enrollment_count": 14,
      "start_date": "2008-07",
      "completion_date": "2013-02",
      "has_results": false,
      "last_update_posted_date": "2015-08-11",
      "last_synced_at": "2026-09-29T15:09:30.676Z",
      "location_count": 1,
      "location_summary": "Little Rock, Arkansas",
      "locations": [
        {
          "city": "Little Rock",
          "state": "Arkansas"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT01172301"
    },
    {
      "nct_id": "NCT06580145",
      "title": "Leucine in Midlife Depression",
      "overall_status": "RECRUITING",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE2"
      ],
      "conditions": [
        "Major Depression"
      ],
      "interventions": [
        {
          "name": "L-leucine",
          "type": "DRUG"
        },
        {
          "name": "L-lysine",
          "type": "DRUG"
        }
      ],
      "intervention_types": [
        "DRUG"
      ],
      "sponsor": "Emory University",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "35 Years",
        "maximum_age": "65 Years",
        "sex": "ALL",
        "summary": "35 Years to 65 Years"
      },
      "enrollment_count": 75,
      "start_date": "2025-02-01",
      "completion_date": "2029-06",
      "has_results": false,
      "last_update_posted_date": "2026-09-11",
      "last_synced_at": "2026-09-29T15:09:30.676Z",
      "location_count": 1,
      "location_summary": "Atlanta, Georgia",
      "locations": [
        {
          "city": "Atlanta",
          "state": "Georgia"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT06580145"
    },
    {
      "nct_id": "NCT00877812",
      "title": "Vitamin B6 Dependence of One-Carbon Metabolism",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Vitamin B6 Deficiency"
      ],
      "interventions": [
        {
          "name": "Arm 1 glycine and leucine",
          "type": "DIETARY_SUPPLEMENT"
        },
        {
          "name": "Arm 2 Intervention of Serine and methionine infusion",
          "type": "DIETARY_SUPPLEMENT"
        }
      ],
      "intervention_types": [
        "DIETARY_SUPPLEMENT"
      ],
      "sponsor": "University of Florida",
      "sponsor_class": "OTHER",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "20 Years",
        "maximum_age": "40 Years",
        "sex": "ALL",
        "summary": "20 Years to 40 Years"
      },
      "enrollment_count": 45,
      "start_date": "2008-01",
      "completion_date": "2010-09",
      "has_results": false,
      "last_update_posted_date": "2013-03-27",
      "last_synced_at": "2026-09-29T15:09:30.676Z",
      "location_count": 1,
      "location_summary": "Gainesville, Florida",
      "locations": [
        {
          "city": "Gainesville",
          "state": "Florida"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT00877812"
    },
    {
      "nct_id": "NCT02918981",
      "title": "Nutritional Strategies to Augment the Postprandial Muscle Protein Synthetic Response to the Ingestion of a Low Dose of Protein in Middle-aged Women",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Aging"
      ],
      "interventions": [
        {
          "name": "Resistance Exercise",
          "type": "BEHAVIORAL"
        },
        {
          "name": "14 g Whey protein",
          "type": "DIETARY_SUPPLEMENT"
        },
        {
          "name": "6.6 g Whey protein + 1.25 g leucine",
          "type": "DIETARY_SUPPLEMENT"
        },
        {
          "name": "4 g Whey protein + 1.25 g leucine + 2.6 g Whey peptides",
          "type": "DIETARY_SUPPLEMENT"
        },
        {
          "name": "6.6 g Whey protein + 1.25 g leucine + 0.8 g Citrulline",
          "type": "DIETARY_SUPPLEMENT"
        },
        {
          "name": "Water control",
          "type": "OTHER"
        }
      ],
      "intervention_types": [
        "BEHAVIORAL",
        "DIETARY_SUPPLEMENT",
        "OTHER"
      ],
      "sponsor": "University of Illinois at Urbana-Champaign",
      "sponsor_class": "OTHER",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "20 Years",
        "maximum_age": "79 Years",
        "sex": "FEMALE",
        "summary": "20 Years to 79 Years · Female only"
      },
      "enrollment_count": 50,
      "start_date": "2016-10",
      "completion_date": "2019-03-06",
      "has_results": false,
      "last_update_posted_date": "2020-11-03",
      "last_synced_at": "2026-09-29T15:09:30.676Z",
      "location_count": 1,
      "location_summary": "Urbana, Illinois",
      "locations": [
        {
          "city": "Urbana",
          "state": "Illinois"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT02918981"
    },
    {
      "nct_id": "NCT00014768",
      "title": "Study of Metabolic Effects of Pregnancy in Women With Cystic Fibrosis",
      "overall_status": "TERMINATED",
      "study_type": "OBSERVATIONAL",
      "phases": [],
      "conditions": [
        "Cystic Fibrosis"
      ],
      "interventions": [
        {
          "name": "glucose",
          "type": "DRUG"
        },
        {
          "name": "insulin",
          "type": "DRUG"
        },
        {
          "name": "leucine",
          "type": "DRUG"
        }
      ],
      "intervention_types": [
        "DRUG"
      ],
      "sponsor": "National Center for Research Resources (NCRR)",
      "sponsor_class": "NIH",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "0 Years",
        "maximum_age": null,
        "sex": "FEMALE",
        "summary": "0 Years and older · Female only"
      },
      "enrollment_count": 36,
      "start_date": "2001-02",
      "completion_date": null,
      "has_results": false,
      "last_update_posted_date": "2005-06-24",
      "last_synced_at": "2026-09-29T15:09:30.676Z",
      "location_count": 1,
      "location_summary": "Salt Lake City, Utah",
      "locations": [
        {
          "city": "Salt Lake City",
          "state": "Utah"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT00014768"
    },
    {
      "nct_id": "NCT01211717",
      "title": "The Effects of Orally Ingesting Branched Chained Amino Acids on Delayed Onset Muscle Soreness in Diabetic Patients",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Type 2 Diabetes",
        "Healthy Individuals"
      ],
      "interventions": [
        {
          "name": "Branched Chained Amino Acids",
          "type": "DIETARY_SUPPLEMENT"
        },
        {
          "name": "Cellulose Placebo mix",
          "type": "OTHER"
        }
      ],
      "intervention_types": [
        "DIETARY_SUPPLEMENT",
        "OTHER"
      ],
      "sponsor": "Loma Linda University",
      "sponsor_class": "OTHER",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "20 Years",
        "maximum_age": "90 Years",
        "sex": "ALL",
        "summary": "20 Years to 90 Years"
      },
      "enrollment_count": 50,
      "start_date": "2010-10",
      "completion_date": "2011-04",
      "has_results": false,
      "last_update_posted_date": "2011-04-22",
      "last_synced_at": "2026-09-29T15:09:30.676Z",
      "location_count": 1,
      "location_summary": "Loma Linda, California",
      "locations": [
        {
          "city": "Loma Linda",
          "state": "California"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT01211717"
    },
    {
      "nct_id": "NCT02151461",
      "title": "Dose Comparisons of Leucine-Metformin Combinations on Blood Glucose Levels In Type 2 Diabetic Patients",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE2"
      ],
      "conditions": [
        "Type 2 Diabetes Mellitus"
      ],
      "interventions": [
        {
          "name": "Low Metformin",
          "type": "DRUG"
        },
        {
          "name": "Metformin",
          "type": "DRUG"
        },
        {
          "name": "Mid Metformin",
          "type": "DRUG"
        },
        {
          "name": "High Metformin",
          "type": "DRUG"
        }
      ],
      "intervention_types": [
        "DRUG"
      ],
      "sponsor": "NuSirt Biopharma",
      "sponsor_class": "INDUSTRY",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "18 Years and older"
      },
      "enrollment_count": 96,
      "start_date": "2014-07",
      "completion_date": "2016-01",
      "has_results": true,
      "last_update_posted_date": "2018-02-27",
      "last_synced_at": "2026-09-29T15:09:30.676Z",
      "location_count": 9,
      "location_summary": "Chino, California • Palm Beach, Florida • Tampa, Florida + 5 more",
      "locations": [
        {
          "city": "Chino",
          "state": "California"
        },
        {
          "city": "Palm Beach",
          "state": "Florida"
        },
        {
          "city": "Tampa",
          "state": "Florida"
        },
        {
          "city": "Blue Ridge",
          "state": "Georgia"
        },
        {
          "city": "Savannah",
          "state": "Georgia"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT02151461"
    },
    {
      "nct_id": "NCT04858412",
      "title": "Study of HMB-enriched Amino Acid Supplementation in Patients With Alcoholic Liver Disease and COVID-19",
      "overall_status": "RECRUITING",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Alcoholic Liver Disease",
        "COVID 19 Pneumonia"
      ],
      "interventions": [
        {
          "name": "β-hydroxy β-methyl butyrate (HMB) enriched amino acid",
          "type": "DIETARY_SUPPLEMENT"
        },
        {
          "name": "Balanced amino acid",
          "type": "DIETARY_SUPPLEMENT"
        }
      ],
      "intervention_types": [
        "DIETARY_SUPPLEMENT"
      ],
      "sponsor": "The Cleveland Clinic",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "21 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "21 Years and older"
      },
      "enrollment_count": 48,
      "start_date": "2021-04-01",
      "completion_date": "2028-12-31",
      "has_results": false,
      "last_update_posted_date": "2026-09-25",
      "last_synced_at": "2026-09-29T15:09:30.676Z",
      "location_count": 1,
      "location_summary": "Cleveland, Ohio",
      "locations": [
        {
          "city": "Cleveland",
          "state": "Ohio"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT04858412"
    }
  ]
}