{ "api_version": "1", "request": { "url": "https://clinicaltrialsfind.com/api/v1/search.json?intervention=Estradiol%2FNorethindrone+acetate&page=2", "query": { "intervention": "Estradiol/Norethindrone acetate", "page": 2 }, "page_size": 10 }, "pagination": { "page": 2, "page_size": 10, "total_count": 71, "total_pages": 8, "next_page_url": "https://clinicaltrialsfind.com/api/v1/search.json?intervention=Estradiol%2FNorethindrone+acetate&page=3&page_size=10", "previous_page_url": "https://clinicaltrialsfind.com/api/v1/search.json?intervention=Estradiol%2FNorethindrone+acetate&page=1&page_size=10" }, "source": "remote", "last_synced_at": "2026-10-01T05:32:31.495Z", "attribution": "Data derived from public ClinicalTrials.gov records. The official record at https://clinicaltrials.gov/ remains the source of truth for current availability, contacts, and full study details.", "notes": [ "This endpoint exposes only public summary fields — no participant contact emails, phone numbers, or scraped investigator contact details.", "For contact information and full protocol detail, follow each trial's `official_url` to the ClinicalTrials.gov record.", "This API is a navigational aid. It does not provide medical advice, eligibility determinations, or compensation guarantees." ], "trials": [ { "nct_id": "NCT01044498", "title": "A Study of Tocilizumab in Combination With an Oral Contraceptive in Patients With Rheumatoid Arthritis", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE3" ], "conditions": [ "Rheumatoid Arthritis" ], "interventions": [ { "name": "Tocilizumab", "type": "DRUG" }, { "name": "Ortho-Novum® 1/35", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "Hoffmann-La Roche", "sponsor_class": "INDUSTRY", "healthy_volunteers": true, "eligibility": { "minimum_age": "18 Years", "maximum_age": "44 Years", "sex": "FEMALE", "summary": "18 Years to 44 Years · Female only" }, "enrollment_count": 46, "start_date": "2009-12", "completion_date": "2012-02", "has_results": true, "last_update_posted_date": "2013-04-01", "last_synced_at": "2026-10-01T05:32:31.495Z", "location_count": 6, "location_summary": "Little Rock, Arkansas • Beverly Hills, California • Ormond Beach, Florida + 3 more", "locations": [ { "city": "Little Rock", "state": "Arkansas" }, { "city": "Beverly Hills", "state": "California" }, { "city": "Ormond Beach", "state": "Florida" }, { "city": "Port Orange", "state": "Florida" }, { "city": "Duncansville", "state": "Pennsylvania" } ], "official_url": "https://clinicaltrials.gov/study/NCT01044498" }, { "nct_id": "NCT03213457", "title": "A Clinical Study to Evaluate the Safety and Efficacy of Elagolix in Participants With Moderate to Severe Endometriosis-Associated Pain", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE3" ], "conditions": [ "Endometriosis" ], "interventions": [ { "name": "Estradiol/Norethindrone Acetate", "type": "DRUG" }, { "name": "Placebo for Elagolix", "type": "DRUG" }, { "name": "Elagolix", "type": "DRUG" }, { "name": "Placebo for E2/NETA", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "AbbVie", "sponsor_class": "INDUSTRY", "healthy_volunteers": false, "eligibility": { "minimum_age": "18 Years", "maximum_age": "49 Years", "sex": "FEMALE", "summary": "18 Years to 49 Years · Female only" }, "enrollment_count": 681, "start_date": "2017-07-07", "completion_date": "2023-12-06", "has_results": true, "last_update_posted_date": "2024-12-20", "last_synced_at": "2026-10-01T05:32:31.495Z", "location_count": 188, "location_summary": "Birmingham, Alabama • Fairhope, Alabama • Mobile, Alabama + 140 more", "locations": [ { "city": "Birmingham", "state": "Alabama" }, { "city": "Birmingham", "state": "Alabama" }, { "city": "Birmingham", "state": "Alabama" }, { "city": "Fairhope", "state": "Alabama" }, { "city": "Mobile", "state": "Alabama" } ], "official_url": "https://clinicaltrials.gov/study/NCT03213457" }, { "nct_id": "NCT02925494", "title": "An Extension Study to Evaluate the Efficacy and Safety of Elagolix in Premenopausal Women With Heavy Menstrual Bleeding Associated With Uterine Fibroids", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE3" ], "conditions": [ "Uterine Fibroids", "Heavy Menstrual Bleeding" ], "interventions": [ { "name": "Estradiol/Norethindrone Acetate", "type": "DRUG" }, { "name": "Elagolix", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "AbbVie", "sponsor_class": "INDUSTRY", "healthy_volunteers": false, "eligibility": { "minimum_age": "18 Years", "maximum_age": "51 Years", "sex": "FEMALE", "summary": "18 Years to 51 Years · Female only" }, "enrollment_count": 433, "start_date": "2016-09-14", "completion_date": "2019-03-22", "has_results": true, "last_update_posted_date": "2021-07-13", "last_synced_at": "2026-10-01T05:32:31.495Z", "location_count": 121, "location_summary": "Birmingham, Alabama • Dothan, Alabama • Fairhope, Alabama + 90 more", "locations": [ { "city": "Birmingham", "state": "Alabama" }, { "city": "Birmingham", "state": "Alabama" }, { "city": "Dothan", "state": "Alabama" }, { "city": "Fairhope", "state": "Alabama" }, { "city": "Mobile", "state": "Alabama" } ], "official_url": "https://clinicaltrials.gov/study/NCT02925494" }, { "nct_id": "NCT00000897", "title": "A Study to Evaluate the Effects of Different Methods of Birth Control on the Drug Actions of Zidovudine (an Anti-HIV Drug) in HIV-Positive Women and to Compare Zidovudine Metabolism in Men and Women", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "NA" ], "conditions": [ "HIV Infections" ], "interventions": [ { "name": "Zidovudine", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "National Institute of Allergy and Infectious Diseases (NIAID)", "sponsor_class": "NIH", "healthy_volunteers": false, "eligibility": { "minimum_age": "18 Years", "maximum_age": "45 Years", "sex": "ALL", "summary": "18 Years to 45 Years" }, "enrollment_count": 42, "start_date": null, "completion_date": null, "has_results": false, "last_update_posted_date": "2011-03-02", "last_synced_at": "2026-10-01T05:32:31.495Z", "location_count": 6, "location_summary": "San Francisco, California • Jacksonville, Florida • Albany, New York + 3 more", "locations": [ { "city": "San Francisco", "state": "California" }, { "city": "Jacksonville", "state": "Florida" }, { "city": "Albany", "state": "New York" }, { "city": "Buffalo", "state": "New York" }, { "city": "Chapel Hill", "state": "North Carolina" } ], "official_url": "https://clinicaltrials.gov/study/NCT00000897" }, { "nct_id": "NCT01209143", "title": "A Study of Pharmacokinetic Drug Interaction Study of the Hedgehog Pathway Inhibitor GDC-0449 in Combination With Rosiglitazone or Combined Oral Contraceptive in Patients With Locally Advanced or Metastatic Solid Tumors That Are Refractory to Standard Therapy or for Whom No Standard Therapy Exists", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE1" ], "conditions": [ "Solid Cancers" ], "interventions": [ { "name": "Vismodegib", "type": "DRUG" }, { "name": "Rosiglitazone", "type": "DRUG" }, { "name": "Norethindrone/ethinyl estradiol", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "Genentech, Inc.", "sponsor_class": "INDUSTRY", "healthy_volunteers": false, "eligibility": { "minimum_age": "18 Years", "maximum_age": null, "sex": "ALL", "summary": "18 Years and older" }, "enrollment_count": 52, "start_date": "2010-11", "completion_date": "2012-03", "has_results": true, "last_update_posted_date": "2015-06-29", "last_synced_at": "2026-10-01T05:32:31.495Z", "location_count": 3, "location_summary": "Stanford, California • Detroit, Michigan • Houston, Texas", "locations": [ { "city": "Stanford", "state": "California" }, { "city": "Detroit", "state": "Michigan" }, { "city": "Houston", "state": "Texas" } ], "official_url": "https://clinicaltrials.gov/study/NCT01209143" }, { "nct_id": "NCT02832180", "title": "The Effect of BMS-986142 on the Pharmacokinetics of a Combined Oral Contraceptive (OC) Containing Ethinyl Estradiol (EE) and Norethindrone Acetate (NET) in Healthy Female Subjects", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE1" ], "conditions": [ "Arthritis" ], "interventions": [ { "name": "OC containing EE and NET", "type": "DRUG" }, { "name": "BMS-986142", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "Bristol-Myers Squibb", "sponsor_class": "INDUSTRY", "healthy_volunteers": true, "eligibility": { "minimum_age": "18 Years", "maximum_age": "40 Years", "sex": "FEMALE", "summary": "18 Years to 40 Years · Female only" }, "enrollment_count": 25, "start_date": "2016-05", "completion_date": "2016-10", "has_results": false, "last_update_posted_date": "2016-12-26", "last_synced_at": "2026-10-01T05:32:31.495Z", "location_count": 2, "location_summary": "Miami, Florida • Evansville, Indiana", "locations": [ { "city": "Miami", "state": "Florida" }, { "city": "Evansville", "state": "Indiana" } ], "official_url": "https://clinicaltrials.gov/study/NCT02832180" }, { "nct_id": "NCT03412890", "title": "LIBERTY EXTENSION: Efficacy and Safety Extension Study of Relugolix in Women With Heavy Menstrual Bleeding Associated With Uterine Fibroids", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE3" ], "conditions": [ "Heavy Menstrual Bleeding", "Uterine Fibroid" ], "interventions": [ { "name": "Relugolix", "type": "DRUG" }, { "name": "Estradiol/norethindrone acetate", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "Myovant Sciences GmbH", "sponsor_class": "INDUSTRY", "healthy_volunteers": false, "eligibility": { "minimum_age": "18 Years", "maximum_age": "50 Years", "sex": "FEMALE", "summary": "18 Years to 50 Years · Female only" }, "enrollment_count": 477, "start_date": "2017-10-19", "completion_date": "2021-01-13", "has_results": true, "last_update_posted_date": "2024-05-09", "last_synced_at": "2026-10-01T05:32:31.495Z", "location_count": 104, "location_summary": "Andalusia, Alabama • Birmingham, Alabama • Mobile, Alabama + 84 more", "locations": [ { "city": "Andalusia", "state": "Alabama" }, { "city": "Birmingham", "state": "Alabama" }, { "city": "Mobile", "state": "Alabama" }, { "city": "Mesa", "state": "Arizona" }, { "city": "Tucson", "state": "Arizona" } ], "official_url": "https://clinicaltrials.gov/study/NCT03412890" }, { "nct_id": "NCT07074327", "title": "Effects of VX-407 on the Pharmacokinetics of Oral Contraceptives in Healthy Participants", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE1" ], "conditions": [ "Autosomal Dominant Polycystic Kidney Disease (ADPKD)" ], "interventions": [ { "name": "VX-407", "type": "DRUG" }, { "name": "LNG/EE", "type": "DRUG" }, { "name": "NGM/EE", "type": "DRUG" }, { "name": "NET/EE", "type": "DRUG" }, { "name": "DRSP/EE", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "Vertex Pharmaceuticals Incorporated", "sponsor_class": "INDUSTRY", "healthy_volunteers": true, "eligibility": { "minimum_age": "18 Years", "maximum_age": "50 Years", "sex": "FEMALE", "summary": "18 Years to 50 Years · Female only" }, "enrollment_count": 74, "start_date": "2025-07-11", "completion_date": "2026-02-27", "has_results": false, "last_update_posted_date": "2026-03-30", "last_synced_at": "2026-10-01T05:32:31.495Z", "location_count": 1, "location_summary": "Overland Park, Kansas", "locations": [ { "city": "Overland Park", "state": "Kansas" } ], "official_url": "https://clinicaltrials.gov/study/NCT07074327" }, { "nct_id": "NCT03343067", "title": "A Study to Evaluate Safety and Efficacy of Elagolix in Participants With Endometriosis With Associated Moderate to Severe Pain", "overall_status": "TERMINATED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE3" ], "conditions": [ "Endometriosis" ], "interventions": [ { "name": "elagolix", "type": "DRUG" }, { "name": "estradiol/norethindrone acetate (E2/NETA)", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "AbbVie", "sponsor_class": "INDUSTRY", "healthy_volunteers": false, "eligibility": { "minimum_age": "18 Years", "maximum_age": "49 Years", "sex": "FEMALE", "summary": "18 Years to 49 Years · Female only" }, "enrollment_count": 11, "start_date": "2017-12-27", "completion_date": "2018-10-23", "has_results": true, "last_update_posted_date": "2019-11-27", "last_synced_at": "2026-10-01T05:32:31.495Z", "location_count": 37, "location_summary": "Anniston, Alabama • Tucson, Arizona • Little Rock, Arkansas + 30 more", "locations": [ { "city": "Anniston", "state": "Alabama" }, { "city": "Tucson", "state": "Arizona" }, { "city": "Little Rock", "state": "Arkansas" }, { "city": "Garden Grove", "state": "California" }, { "city": "Huntington Beach", "state": "California" } ], "official_url": "https://clinicaltrials.gov/study/NCT03343067" }, { "nct_id": "NCT01597986", "title": "Drug Interaction Study of Isavuconazole and Oral Contraceptive Containing Ethinyl Estradiol and Norethindrone", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE1" ], "conditions": [ "Pharmacokinetics of Isavuconazole", "Pharmacokinetics of Ethinyl Estradiol and Norethindrone", "Healthy Volunteers" ], "interventions": [ { "name": "isavuconazole", "type": "DRUG" }, { "name": "Oral Contraceptive (ethinyl estradiol / norethindrone)", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "Astellas Pharma Global Development, Inc.", "sponsor_class": "INDUSTRY", "healthy_volunteers": true, "eligibility": { "minimum_age": "50 Years", "maximum_age": "65 Years", "sex": "FEMALE", "summary": "50 Years to 65 Years · Female only" }, "enrollment_count": 24, "start_date": "2012-04", "completion_date": "2012-06", "has_results": false, "last_update_posted_date": "2012-07-16", "last_synced_at": "2026-10-01T05:32:31.495Z", "location_count": 1, "location_summary": "Miami, Florida", "locations": [ { "city": "Miami", "state": "Florida" } ], "official_url": "https://clinicaltrials.gov/study/NCT01597986" } ] }