{ "api_version": "1", "request": { "url": "https://clinicaltrialsfind.com/api/v1/search.json?intervention=Estradiol%2Fnorethindrone+acetate+placebo", "query": { "intervention": "Estradiol/norethindrone acetate placebo" }, "page_size": 10 }, "pagination": { "page": 1, "page_size": 10, "total_count": 17, "total_pages": 2, "next_page_url": "https://clinicaltrialsfind.com/api/v1/search.json?intervention=Estradiol%2Fnorethindrone+acetate+placebo&page=2&page_size=10", "previous_page_url": null }, "source": "remote", "last_synced_at": "2026-09-30T15:07:56.418Z", "attribution": "Data derived from public ClinicalTrials.gov records. The official record at https://clinicaltrials.gov/ remains the source of truth for current availability, contacts, and full study details.", "notes": [ "This endpoint exposes only public summary fields — no participant contact emails, phone numbers, or scraped investigator contact details.", "For contact information and full protocol detail, follow each trial's `official_url` to the ClinicalTrials.gov record.", "This API is a navigational aid. It does not provide medical advice, eligibility determinations, or compensation guarantees." ], "trials": [ { "nct_id": "NCT03049735", "title": "LIBERTY 1: Efficacy & Safety Study of Relugolix in Women With Heavy Menstrual Bleeding Associated With Uterine Fibroids", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE3" ], "conditions": [ "Heavy Menstrual Bleeding", "Uterine Fibroid" ], "interventions": [ { "name": "Relugolix", "type": "DRUG" }, { "name": "Estradiol/norethindrone acetate", "type": "DRUG" }, { "name": "Estradiol/norethindrone acetate placebo", "type": "DRUG" }, { "name": "Relugolix placebo", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "Myovant Sciences GmbH", "sponsor_class": "INDUSTRY", "healthy_volunteers": false, "eligibility": { "minimum_age": "18 Years", "maximum_age": "50 Years", "sex": "FEMALE", "summary": "18 Years to 50 Years · Female only" }, "enrollment_count": 388, "start_date": "2017-04-26", "completion_date": "2020-08-24", "has_results": true, "last_update_posted_date": "2022-04-19", "last_synced_at": "2026-09-30T15:07:56.418Z", "location_count": 76, "location_summary": "Andalusia, Alabama • Mobile, Alabama • Little Rock, Arkansas + 62 more", "locations": [ { "city": "Andalusia", "state": "Alabama" }, { "city": "Mobile", "state": "Alabama" }, { "city": "Little Rock", "state": "Arkansas" }, { "city": "La Mesa", "state": "California" }, { "city": "Lomita", "state": "California" } ], "official_url": "https://clinicaltrials.gov/study/NCT03049735" }, { "nct_id": "NCT00474851", "title": "The Effect of Hormonal Add-Back Therapy in Adolescents Treated With a GnRH Agonist for Endometriosis: A Randomized Trial", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE2" ], "conditions": [ "Endometriosis" ], "interventions": [ { "name": "Norethindrone acetate + estrogens", "type": "DRUG" }, { "name": "norethindrone acetate + placebo", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "Boston Children's Hospital", "sponsor_class": "OTHER", "healthy_volunteers": false, "eligibility": { "minimum_age": "13 Years", "maximum_age": "22 Years", "sex": "FEMALE", "summary": "13 Years to 22 Years · Female only" }, "enrollment_count": 53, "start_date": "2007-08", "completion_date": "2015-01", "has_results": true, "last_update_posted_date": "2015-03-30", "last_synced_at": "2026-09-30T15:07:56.418Z", "location_count": 1, "location_summary": "Boston, Massachusetts", "locations": [ { "city": "Boston", "state": "Massachusetts" } ], "official_url": "https://clinicaltrials.gov/study/NCT00474851" }, { "nct_id": "NCT02693002", "title": "Estrogen Diastolic Heart Failure", "overall_status": "TERMINATED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE4" ], "conditions": [ "Menopause" ], "interventions": [ { "name": "Estradiol/Norethindrone acetate", "type": "DRUG" }, { "name": "Placebo", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "Gretchen Wells", "sponsor_class": "OTHER", "healthy_volunteers": true, "eligibility": { "minimum_age": "45 Years", "maximum_age": "55 Years", "sex": "FEMALE", "summary": "45 Years to 55 Years · Female only" }, "enrollment_count": 4, "start_date": "2016-02", "completion_date": "2016-11", "has_results": true, "last_update_posted_date": "2018-08-08", "last_synced_at": "2026-09-30T15:07:56.418Z", "location_count": 1, "location_summary": "Lexington, Kentucky", "locations": [ { "city": "Lexington", "state": "Kentucky" } ], "official_url": "https://clinicaltrials.gov/study/NCT02693002" }, { "nct_id": "NCT03204331", "title": "SPIRIT 2: Efficacy and Safety Study of Relugolix in Women With Endometriosis-Associated Pain", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE3" ], "conditions": [ "Endometriosis Related Pain" ], "interventions": [ { "name": "Relugolix", "type": "DRUG" }, { "name": "Estradiol/norethindrone acetate", "type": "DRUG" }, { "name": "Estradiol/norethindrone acetate placebo", "type": "DRUG" }, { "name": "Relugolix placebo", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "Myovant Sciences GmbH", "sponsor_class": "INDUSTRY", "healthy_volunteers": false, "eligibility": { "minimum_age": "18 Years", "maximum_age": "50 Years", "sex": "FEMALE", "summary": "18 Years to 50 Years · Female only" }, "enrollment_count": 623, "start_date": "2017-11-01", "completion_date": "2021-05-31", "has_results": false, "last_update_posted_date": "2021-06-28", "last_synced_at": "2026-09-30T15:07:56.418Z", "location_count": 41, "location_summary": "Andalusia, Alabama • Washington D.C., District of Columbia • Aventura, Florida + 36 more", "locations": [ { "city": "Andalusia", "state": "Alabama" }, { "city": "Washington D.C.", "state": "District of Columbia" }, { "city": "Aventura", "state": "Florida" }, { "city": "DeLand", "state": "Florida" }, { "city": "Hialeah", "state": "Florida" } ], "official_url": "https://clinicaltrials.gov/study/NCT03204331" }, { "nct_id": "NCT03213457", "title": "A Clinical Study to Evaluate the Safety and Efficacy of Elagolix in Participants With Moderate to Severe Endometriosis-Associated Pain", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE3" ], "conditions": [ "Endometriosis" ], "interventions": [ { "name": "Estradiol/Norethindrone Acetate", "type": "DRUG" }, { "name": "Placebo for Elagolix", "type": "DRUG" }, { "name": "Elagolix", "type": "DRUG" }, { "name": "Placebo for E2/NETA", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "AbbVie", "sponsor_class": "INDUSTRY", "healthy_volunteers": false, "eligibility": { "minimum_age": "18 Years", "maximum_age": "49 Years", "sex": "FEMALE", "summary": "18 Years to 49 Years · Female only" }, "enrollment_count": 681, "start_date": "2017-07-07", "completion_date": "2023-12-06", "has_results": true, "last_update_posted_date": "2024-12-20", "last_synced_at": "2026-09-30T15:07:56.418Z", "location_count": 188, "location_summary": "Birmingham, Alabama • Fairhope, Alabama • Mobile, Alabama + 140 more", "locations": [ { "city": "Birmingham", "state": "Alabama" }, { "city": "Birmingham", "state": "Alabama" }, { "city": "Birmingham", "state": "Alabama" }, { "city": "Fairhope", "state": "Alabama" }, { "city": "Mobile", "state": "Alabama" } ], "official_url": "https://clinicaltrials.gov/study/NCT03213457" }, { "nct_id": "NCT02925494", "title": "An Extension Study to Evaluate the Efficacy and Safety of Elagolix in Premenopausal Women With Heavy Menstrual Bleeding Associated With Uterine Fibroids", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE3" ], "conditions": [ "Uterine Fibroids", "Heavy Menstrual Bleeding" ], "interventions": [ { "name": "Estradiol/Norethindrone Acetate", "type": "DRUG" }, { "name": "Elagolix", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "AbbVie", "sponsor_class": "INDUSTRY", "healthy_volunteers": false, "eligibility": { "minimum_age": "18 Years", "maximum_age": "51 Years", "sex": "FEMALE", "summary": "18 Years to 51 Years · Female only" }, "enrollment_count": 433, "start_date": "2016-09-14", "completion_date": "2019-03-22", "has_results": true, "last_update_posted_date": "2021-07-13", "last_synced_at": "2026-09-30T15:07:56.418Z", "location_count": 121, "location_summary": "Birmingham, Alabama • Dothan, Alabama • Fairhope, Alabama + 90 more", "locations": [ { "city": "Birmingham", "state": "Alabama" }, { "city": "Birmingham", "state": "Alabama" }, { "city": "Dothan", "state": "Alabama" }, { "city": "Fairhope", "state": "Alabama" }, { "city": "Mobile", "state": "Alabama" } ], "official_url": "https://clinicaltrials.gov/study/NCT02925494" }, { "nct_id": "NCT00932321", "title": "Study of Safety and Efficacy of an Oral Contraceptive", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE3" ], "conditions": [ "Prevention of Pregnancy" ], "interventions": [ { "name": "Norethindrone Acetate/Ethinyl Estradiol 24 Days", "type": "DRUG" }, { "name": "Norethindrone Acetate /Ethinyl Estradiol 21 Days", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "Warner Chilcott", "sponsor_class": "INDUSTRY", "healthy_volunteers": true, "eligibility": { "minimum_age": "18 Years", "maximum_age": "45 Years", "sex": "FEMALE", "summary": "18 Years to 45 Years · Female only" }, "enrollment_count": 938, "start_date": "2004-01", "completion_date": "2004-11", "has_results": true, "last_update_posted_date": "2013-04-22", "last_synced_at": "2026-09-30T15:07:56.418Z", "location_count": 34, "location_summary": "Birmingham, Alabama • Phoenix, Arizona • Chico, California + 28 more", "locations": [ { "city": "Birmingham", "state": "Alabama" }, { "city": "Phoenix", "state": "Arizona" }, { "city": "Phoenix", "state": "Arizona" }, { "city": "Chico", "state": "California" }, { "city": "Los Angeles", "state": "California" } ], "official_url": "https://clinicaltrials.gov/study/NCT00932321" }, { "nct_id": "NCT00600106", "title": "Data Analyses for Ancillary WISE Femhrt Hormone Replacement Study", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "NA" ], "conditions": [ "Myocardial Ischemia" ], "interventions": [ { "name": "1/10 NA/EE", "type": "DRUG" }, { "name": "Placebo", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "Cedars-Sinai Medical Center", "sponsor_class": "OTHER", "healthy_volunteers": false, "eligibility": { "minimum_age": null, "maximum_age": null, "sex": "FEMALE", "summary": "Female only" }, "enrollment_count": 37, "start_date": "1999-12", "completion_date": "2010-03", "has_results": true, "last_update_posted_date": "2019-04-24", "last_synced_at": "2026-09-30T15:07:56.418Z", "location_count": 1, "location_summary": "Los Angeles, California", "locations": [ { "city": "Los Angeles", "state": "California" } ], "official_url": "https://clinicaltrials.gov/study/NCT00600106" }, { "nct_id": "NCT01466114", "title": "Estriol Treatment in Multiple Sclerosis (MS): Effect on Cognition", "overall_status": "UNKNOWN", "study_type": "INTERVENTIONAL", "phases": [ "PHASE2" ], "conditions": [ "Relapsing-remitting Multiple Sclerosis", "Secondary-progressive Multiple Sclerosis", "Primary-progressive Multiple Sclerosis" ], "interventions": [ { "name": "estriol", "type": "DRUG" }, { "name": "Placebo", "type": "OTHER" }, { "name": "Norethindrone", "type": "DRUG" }, { "name": "Progestin Placebo", "type": "OTHER" } ], "intervention_types": [ "DRUG", "OTHER" ], "sponsor": "University of California, Los Angeles", "sponsor_class": "OTHER", "healthy_volunteers": false, "eligibility": { "minimum_age": "18 Years", "maximum_age": "55 Years", "sex": "FEMALE", "summary": "18 Years to 55 Years · Female only" }, "enrollment_count": 64, "start_date": "2011-10", "completion_date": "2022-04", "has_results": false, "last_update_posted_date": "2019-11-06", "last_synced_at": "2026-09-30T15:07:56.418Z", "location_count": 4, "location_summary": "Los Angeles, California • Aurora, Colorado • Albuquerque, New Mexico + 1 more", "locations": [ { "city": "Los Angeles", "state": "California" }, { "city": "Aurora", "state": "Colorado" }, { "city": "Albuquerque", "state": "New Mexico" }, { "city": "Philadelphia", "state": "Pennsylvania" } ], "official_url": "https://clinicaltrials.gov/study/NCT01466114" }, { "nct_id": "NCT03751124", "title": "Study of Relugolix With Estradiol and Norethindrone Acetate in Women With Heavy Menstrual Bleeding Associated With Uterine Fibroids", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE3" ], "conditions": [ "Uterine Leiomyoma", "Uterine Fibroids" ], "interventions": [ { "name": "Relugolix", "type": "DRUG" }, { "name": "Estradiol/norethindrone acetate", "type": "DRUG" }, { "name": "Placebo for relugolix", "type": "DRUG" }, { "name": "Placebo for E2/NETA", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "Myovant Sciences GmbH", "sponsor_class": "INDUSTRY", "healthy_volunteers": false, "eligibility": { "minimum_age": "18 Years", "maximum_age": "51 Years", "sex": "FEMALE", "summary": "18 Years to 51 Years · Female only" }, "enrollment_count": 229, "start_date": "2018-10-16", "completion_date": "2021-10-20", "has_results": true, "last_update_posted_date": "2024-06-25", "last_synced_at": "2026-09-30T15:07:56.418Z", "location_count": 72, "location_summary": "Birmingham, Alabama • Mesa, Arizona • Tucson, Arizona + 61 more", "locations": [ { "city": "Birmingham", "state": "Alabama" }, { "city": "Mesa", "state": "Arizona" }, { "city": "Tucson", "state": "Arizona" }, { "city": "Canoga Park", "state": "California" }, { "city": "Huntington Beach", "state": "California" } ], "official_url": "https://clinicaltrials.gov/study/NCT03751124" } ] }