{
  "api_version": "1",
  "request": {
    "url": "https://clinicaltrialsfind.com/api/v1/search.json?intervention=Estradiol+or+Placebo&page=3",
    "query": {
      "intervention": "Estradiol or Placebo",
      "page": 3
    },
    "page_size": 10
  },
  "pagination": {
    "page": 3,
    "page_size": 10,
    "total_count": 71,
    "total_pages": 8,
    "next_page_url": "https://clinicaltrialsfind.com/api/v1/search.json?intervention=Estradiol+or+Placebo&page=4&page_size=10",
    "previous_page_url": "https://clinicaltrialsfind.com/api/v1/search.json?intervention=Estradiol+or+Placebo&page=2&page_size=10"
  },
  "source": "remote",
  "last_synced_at": "2026-10-09T09:06:35.651Z",
  "attribution": "Data derived from public ClinicalTrials.gov records. The official record at https://clinicaltrials.gov/ remains the source of truth for current availability, contacts, and full study details.",
  "notes": [
    "This endpoint exposes only public summary fields — no participant contact emails, phone numbers, or scraped investigator contact details.",
    "For contact information and full protocol detail, follow each trial's `official_url` to the ClinicalTrials.gov record.",
    "This API is a navigational aid. It does not provide medical advice, eligibility determinations, or compensation guarantees."
  ],
  "trials": [
    {
      "nct_id": "NCT03663543",
      "title": "Intravenous Estrogen in Kidney Transplant Study",
      "overall_status": "ACTIVE_NOT_RECRUITING",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE1",
        "PHASE2"
      ],
      "conditions": [
        "Ischemia Reperfusion Injury"
      ],
      "interventions": [
        {
          "name": "Conjugated Estrogen",
          "type": "DRUG"
        },
        {
          "name": "Normal saline",
          "type": "DRUG"
        }
      ],
      "intervention_types": [
        "DRUG"
      ],
      "sponsor": "University of Pennsylvania",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "21 Years",
        "maximum_age": null,
        "sex": "FEMALE",
        "summary": "21 Years and older · Female only"
      },
      "enrollment_count": 30,
      "start_date": "2016-08-26",
      "completion_date": "2027-05-01",
      "has_results": false,
      "last_update_posted_date": "2026-04-16",
      "last_synced_at": "2026-10-09T09:06:35.651Z",
      "location_count": 1,
      "location_summary": "Philadelphia, Pennsylvania",
      "locations": [
        {
          "city": "Philadelphia",
          "state": "Pennsylvania"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT03663543"
    },
    {
      "nct_id": "NCT06026553",
      "title": "Assessing Ketorolac (Toradol) at Oocyte Retrieval",
      "overall_status": "UNKNOWN",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE1"
      ],
      "conditions": [
        "Infertility",
        "Infertility, Female",
        "Oocyte Retrieval",
        "Postoperative Pain",
        "Embryo Transfer"
      ],
      "interventions": [
        {
          "name": "Ketorolac (Toradol)",
          "type": "DRUG"
        },
        {
          "name": "Placebo (saline)",
          "type": "OTHER"
        }
      ],
      "intervention_types": [
        "DRUG",
        "OTHER"
      ],
      "sponsor": "Shady Grove Fertility Reproductive Science Center",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": "45 Years",
        "sex": "FEMALE",
        "summary": "18 Years to 45 Years · Female only"
      },
      "enrollment_count": 400,
      "start_date": "2022-08-10",
      "completion_date": "2025-01",
      "has_results": false,
      "last_update_posted_date": "2023-09-07",
      "last_synced_at": "2026-10-09T09:06:35.651Z",
      "location_count": 2,
      "location_summary": "Rockville, Maryland • Fairfax, Virginia",
      "locations": [
        {
          "city": "Rockville",
          "state": "Maryland"
        },
        {
          "city": "Fairfax",
          "state": "Virginia"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT06026553"
    },
    {
      "nct_id": "NCT00066157",
      "title": "Alzheimer's Disease: Therapeutic Potential of Estrogen",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE2",
        "PHASE3"
      ],
      "conditions": [
        "Alzheimer Disease"
      ],
      "interventions": [
        {
          "name": "Transdermal estradiol",
          "type": "DRUG"
        },
        {
          "name": "Medroxyprogesterone",
          "type": "DRUG"
        },
        {
          "name": "Placebo Patch",
          "type": "DRUG"
        },
        {
          "name": "Placebo",
          "type": "DRUG"
        }
      ],
      "intervention_types": [
        "DRUG"
      ],
      "sponsor": "University of Wisconsin, Madison",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "55 Years",
        "maximum_age": "90 Years",
        "sex": "FEMALE",
        "summary": "55 Years to 90 Years · Female only"
      },
      "enrollment_count": 42,
      "start_date": "2001-09",
      "completion_date": "2007-12",
      "has_results": false,
      "last_update_posted_date": "2018-08-23",
      "last_synced_at": "2026-10-09T09:06:35.651Z",
      "location_count": 1,
      "location_summary": "Madison, Wisconsin",
      "locations": [
        {
          "city": "Madison",
          "state": "Wisconsin"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT00066157"
    },
    {
      "nct_id": "NCT00480532",
      "title": "A Study of Continuous Oral Contraceptives and Doxycycline",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Contraceptives, Oral"
      ],
      "interventions": [
        {
          "name": "Lybrel",
          "type": "DRUG"
        },
        {
          "name": "Doxycycline",
          "type": "DRUG"
        },
        {
          "name": "Oracea",
          "type": "DRUG"
        },
        {
          "name": "Placebo",
          "type": "DRUG"
        },
        {
          "name": "Doxycycline 100bid x5 days at the time of bleeding",
          "type": "DRUG"
        },
        {
          "name": "Subantimicrobial doxycycline daily",
          "type": "DRUG"
        },
        {
          "name": "placebo daily",
          "type": "DRUG"
        }
      ],
      "intervention_types": [
        "DRUG"
      ],
      "sponsor": "Oregon Health and Science University",
      "sponsor_class": "OTHER",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": "45 Years",
        "sex": "FEMALE",
        "summary": "18 Years to 45 Years · Female only"
      },
      "enrollment_count": 131,
      "start_date": "2007-05",
      "completion_date": "2011-05",
      "has_results": true,
      "last_update_posted_date": "2014-10-22",
      "last_synced_at": "2026-10-09T09:06:35.651Z",
      "location_count": 2,
      "location_summary": "Honolulu, Hawaii • Portland, Oregon",
      "locations": [
        {
          "city": "Honolulu",
          "state": "Hawaii"
        },
        {
          "city": "Portland",
          "state": "Oregon"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT00480532"
    },
    {
      "nct_id": "NCT04043520",
      "title": "Bioenergetic Effects of Aging and Menopause (BEAM)",
      "overall_status": "RECRUITING",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE4"
      ],
      "conditions": [
        "Menopause",
        "Obesity, Abdominal",
        "Aging",
        "Weight Gain"
      ],
      "interventions": [
        {
          "name": "GnRH antagonist",
          "type": "DRUG"
        },
        {
          "name": "Estrogen Product",
          "type": "DRUG"
        },
        {
          "name": "Placebo estradiol",
          "type": "DRUG"
        },
        {
          "name": "Placebo GnRH antagonist",
          "type": "DRUG"
        }
      ],
      "intervention_types": [
        "DRUG"
      ],
      "sponsor": "University of Colorado, Denver",
      "sponsor_class": "OTHER",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "40 Years",
        "maximum_age": "65 Years",
        "sex": "FEMALE",
        "summary": "40 Years to 65 Years · Female only"
      },
      "enrollment_count": 57,
      "start_date": "2019-09-24",
      "completion_date": "2024-08-31",
      "has_results": false,
      "last_update_posted_date": "2023-12-18",
      "last_synced_at": "2026-10-09T09:06:35.651Z",
      "location_count": 1,
      "location_summary": "Aurora, Colorado",
      "locations": [
        {
          "city": "Aurora",
          "state": "Colorado"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT04043520"
    },
    {
      "nct_id": "NCT01437566",
      "title": "Study of GDC-0941 or GDC-0980 With Fulvestrant Versus Fulvestrant in Advanced or Metastatic Breast Cancer in Participants Resistant to Aromatase Inhibitor Therapy",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE2"
      ],
      "conditions": [
        "Breast Cancer"
      ],
      "interventions": [
        {
          "name": "Fulvestrant",
          "type": "DRUG"
        },
        {
          "name": "GDC-0941",
          "type": "DRUG"
        },
        {
          "name": "GDC-0941 Matching Placebo",
          "type": "DRUG"
        },
        {
          "name": "GDC-0980",
          "type": "DRUG"
        },
        {
          "name": "GDC-0980 Matching Placebo",
          "type": "DRUG"
        }
      ],
      "intervention_types": [
        "DRUG"
      ],
      "sponsor": "Genentech, Inc.",
      "sponsor_class": "INDUSTRY",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": null,
        "sex": "FEMALE",
        "summary": "18 Years and older · Female only"
      },
      "enrollment_count": 318,
      "start_date": "2011-10",
      "completion_date": "2016-04",
      "has_results": false,
      "last_update_posted_date": "2016-11-02",
      "last_synced_at": "2026-10-09T09:06:35.651Z",
      "location_count": 41,
      "location_summary": "Birmingham, Alabama • Hayward, California • Oakland, California + 35 more",
      "locations": [
        {
          "city": "Birmingham",
          "state": "Alabama"
        },
        {
          "city": "Hayward",
          "state": "California"
        },
        {
          "city": "Oakland",
          "state": "California"
        },
        {
          "city": "Roseville",
          "state": "California"
        },
        {
          "city": "Sacramento",
          "state": "California"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT01437566"
    },
    {
      "nct_id": "NCT00283816",
      "title": "Impact of Metformin in Teens With Polycystic Ovary Syndrome (PCOS) on Oral Contraceptive Therapy",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE3"
      ],
      "conditions": [
        "Polycystic Ovary Syndrome"
      ],
      "interventions": [
        {
          "name": "Metformin",
          "type": "DRUG"
        },
        {
          "name": "Oral Contraceptive Pill",
          "type": "DRUG"
        },
        {
          "name": "Lifestyle Management Program",
          "type": "BEHAVIORAL"
        },
        {
          "name": "Quality of Life Questionnaire",
          "type": "BEHAVIORAL"
        },
        {
          "name": "Oral Glucose Tolerance Test",
          "type": "PROCEDURE"
        },
        {
          "name": "Blood work",
          "type": "PROCEDURE"
        },
        {
          "name": "Abdominal Ultra Sound",
          "type": "PROCEDURE"
        },
        {
          "name": "Dual-energy x-ray absorptiometry (DEXA scan)",
          "type": "PROCEDURE"
        },
        {
          "name": "placebo",
          "type": "DRUG"
        }
      ],
      "intervention_types": [
        "DRUG",
        "BEHAVIORAL",
        "PROCEDURE"
      ],
      "sponsor": "University of Rochester",
      "sponsor_class": "OTHER",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "12 Years",
        "maximum_age": "18 Years",
        "sex": "FEMALE",
        "summary": "12 Years to 18 Years · Female only"
      },
      "enrollment_count": 36,
      "start_date": "2006-01",
      "completion_date": "2008-01",
      "has_results": true,
      "last_update_posted_date": "2015-05-15",
      "last_synced_at": "2026-10-09T09:06:35.651Z",
      "location_count": 1,
      "location_summary": "Rochester, New York",
      "locations": [
        {
          "city": "Rochester",
          "state": "New York"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT00283816"
    },
    {
      "nct_id": "NCT00154180",
      "title": "Kronos Early Estrogen Prevention Study (KEEPS)",
      "overall_status": "UNKNOWN",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE4"
      ],
      "conditions": [
        "Menopause",
        "Arteriosclerosis"
      ],
      "interventions": [
        {
          "name": "Conjugated equine estrogens 0.45 mg/day",
          "type": "DRUG"
        },
        {
          "name": "Transdermal estradiol, 50 mcg/day",
          "type": "DRUG"
        },
        {
          "name": "Micronized progesterone, 200 mg/day x 12 d/month",
          "type": "DRUG"
        },
        {
          "name": "CEE , progesterone, estradiol patch or placebo for each",
          "type": "DRUG"
        },
        {
          "name": "CEE, progesterone, transdermal patch or the placebo",
          "type": "DRUG"
        }
      ],
      "intervention_types": [
        "DRUG"
      ],
      "sponsor": "Kronos Longevity Research Institute",
      "sponsor_class": "OTHER",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "42 Years",
        "maximum_age": "58 Years",
        "sex": "FEMALE",
        "summary": "42 Years to 58 Years · Female only"
      },
      "enrollment_count": 728,
      "start_date": "2005-09",
      "completion_date": "2012-07",
      "has_results": false,
      "last_update_posted_date": "2009-09-14",
      "last_synced_at": "2026-10-09T09:06:35.651Z",
      "location_count": 9,
      "location_summary": "Phoenix, Arizona • San Francisco, California • New Haven, Connecticut + 6 more",
      "locations": [
        {
          "city": "Phoenix",
          "state": "Arizona"
        },
        {
          "city": "San Francisco",
          "state": "California"
        },
        {
          "city": "New Haven",
          "state": "Connecticut"
        },
        {
          "city": "Boston",
          "state": "Massachusetts"
        },
        {
          "city": "Rochester",
          "state": "Minnesota"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT00154180"
    },
    {
      "nct_id": "NCT01195974",
      "title": "A Study to Evaluate the Pharmacokinetics of an Oral Contraceptive When Co-administered With GSK2248761 in Healthy Adult Female Subjects.",
      "overall_status": "TERMINATED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE1"
      ],
      "conditions": [
        "Infection, Human Immunodeficiency Virus",
        "HIV Infections"
      ],
      "interventions": [
        {
          "name": "YASMIN",
          "type": "DRUG"
        },
        {
          "name": "GSK2248761",
          "type": "DRUG"
        },
        {
          "name": "Placebo",
          "type": "OTHER"
        }
      ],
      "intervention_types": [
        "DRUG",
        "OTHER"
      ],
      "sponsor": "ViiV Healthcare",
      "sponsor_class": "INDUSTRY",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": "40 Years",
        "sex": "FEMALE",
        "summary": "18 Years to 40 Years · Female only"
      },
      "enrollment_count": 13,
      "start_date": "2010-09-14",
      "completion_date": "2011-02-09",
      "has_results": false,
      "last_update_posted_date": "2019-02-20",
      "last_synced_at": "2026-10-09T09:06:35.651Z",
      "location_count": 1,
      "location_summary": "Fargo, North Dakota",
      "locations": [
        {
          "city": "Fargo",
          "state": "North Dakota"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT01195974"
    },
    {
      "nct_id": "NCT02107703",
      "title": "A Study of Abemaciclib (LY2835219) Combined With Fulvestrant in Women With Hormone Receptor Positive HER2 Negative Breast Cancer",
      "overall_status": "ACTIVE_NOT_RECRUITING",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE3"
      ],
      "conditions": [
        "Breast Neoplasms"
      ],
      "interventions": [
        {
          "name": "Abemaciclib",
          "type": "DRUG"
        },
        {
          "name": "Fulvestrant",
          "type": "DRUG"
        },
        {
          "name": "Placebo",
          "type": "DRUG"
        }
      ],
      "intervention_types": [
        "DRUG"
      ],
      "sponsor": "Eli Lilly and Company",
      "sponsor_class": "INDUSTRY",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": null,
        "sex": "FEMALE",
        "summary": "18 Years and older · Female only"
      },
      "enrollment_count": 669,
      "start_date": "2014-07-22",
      "completion_date": "2027-12",
      "has_results": true,
      "last_update_posted_date": "2025-10-21",
      "last_synced_at": "2026-10-09T09:06:35.651Z",
      "location_count": 43,
      "location_summary": "Jonesboro, Arkansas • Springdale, Arkansas • La Jolla, California + 36 more",
      "locations": [
        {
          "city": "Jonesboro",
          "state": "Arkansas"
        },
        {
          "city": "Springdale",
          "state": "Arkansas"
        },
        {
          "city": "La Jolla",
          "state": "California"
        },
        {
          "city": "Riverside",
          "state": "California"
        },
        {
          "city": "San Francisco",
          "state": "California"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT02107703"
    }
  ]
}