{
  "api_version": "1",
  "request": {
    "url": "https://clinicaltrialsfind.com/api/v1/search.json?intervention=Fentanyl%2FHydromorphone",
    "query": {
      "intervention": "Fentanyl/Hydromorphone"
    },
    "page_size": 10
  },
  "pagination": {
    "page": 1,
    "page_size": 10,
    "total_count": 44,
    "total_pages": 5,
    "next_page_url": "https://clinicaltrialsfind.com/api/v1/search.json?intervention=Fentanyl%2FHydromorphone&page=2&page_size=10",
    "previous_page_url": null
  },
  "source": "remote",
  "last_synced_at": "2026-09-14T17:12:55.921Z",
  "attribution": "Data derived from public ClinicalTrials.gov records. The official record at https://clinicaltrials.gov/ remains the source of truth for current availability, contacts, and full study details.",
  "notes": [
    "This endpoint exposes only public summary fields — no participant contact emails, phone numbers, or scraped investigator contact details.",
    "For contact information and full protocol detail, follow each trial's `official_url` to the ClinicalTrials.gov record.",
    "This API is a navigational aid. It does not provide medical advice, eligibility determinations, or compensation guarantees."
  ],
  "trials": [
    {
      "nct_id": "NCT02625181",
      "title": "Real-time Decision Support for Postoperative Nausea and Vomiting (PONV) Prophylaxis",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Postoperative Nausea and Vomiting"
      ],
      "interventions": [
        {
          "name": "Automated recommendation at the start of the case",
          "type": "PROCEDURE"
        },
        {
          "name": "Automated notification at the start of surgery",
          "type": "PROCEDURE"
        },
        {
          "name": "Preoperative recommendations: by email",
          "type": "PROCEDURE"
        },
        {
          "name": "Automated notification at the end of surgery",
          "type": "PROCEDURE"
        },
        {
          "name": "Anesthesia Information Management System (AIMS)",
          "type": "DEVICE"
        },
        {
          "name": "Perioperative Data Warehouse (PDW)",
          "type": "DEVICE"
        },
        {
          "name": "General anesthesia",
          "type": "PROCEDURE"
        },
        {
          "name": "Elective surgery",
          "type": "PROCEDURE"
        },
        {
          "name": "Propofol",
          "type": "DRUG"
        },
        {
          "name": "Sevoflurane",
          "type": "DRUG"
        },
        {
          "name": "Isoflurane",
          "type": "DRUG"
        },
        {
          "name": "Desflurane",
          "type": "DRUG"
        },
        {
          "name": "Scopolamine",
          "type": "DRUG"
        },
        {
          "name": "Droperidol",
          "type": "DRUG"
        },
        {
          "name": "Haloperidol",
          "type": "DRUG"
        },
        {
          "name": "Dexamethasone",
          "type": "DRUG"
        },
        {
          "name": "Promethazine",
          "type": "DRUG"
        },
        {
          "name": "Meclizine",
          "type": "DRUG"
        },
        {
          "name": "Aprepitant",
          "type": "DRUG"
        },
        {
          "name": "Metoclopramide",
          "type": "DRUG"
        },
        {
          "name": "Fentanyl",
          "type": "DRUG"
        },
        {
          "name": "Sufentanil",
          "type": "DRUG"
        },
        {
          "name": "Alfentanil",
          "type": "DRUG"
        },
        {
          "name": "Remifentanil",
          "type": "DRUG"
        },
        {
          "name": "Morphine",
          "type": "DRUG"
        },
        {
          "name": "Meperidine",
          "type": "DRUG"
        },
        {
          "name": "Hydromorphone",
          "type": "DRUG"
        },
        {
          "name": "Methadone",
          "type": "DRUG"
        },
        {
          "name": "Oxycodone",
          "type": "DRUG"
        },
        {
          "name": "Oxymorphone",
          "type": "DRUG"
        },
        {
          "name": "Hydrocodone",
          "type": "DRUG"
        },
        {
          "name": "Ketamine",
          "type": "DRUG"
        },
        {
          "name": "Ondansetron",
          "type": "DRUG"
        },
        {
          "name": "Granisetron",
          "type": "DRUG"
        },
        {
          "name": "Dolasetron mesylate",
          "type": "DRUG"
        },
        {
          "name": "Palonosetron",
          "type": "DRUG"
        },
        {
          "name": "Tropisetron",
          "type": "DRUG"
        },
        {
          "name": "Ramosetron",
          "type": "DRUG"
        }
      ],
      "intervention_types": [
        "PROCEDURE",
        "DEVICE",
        "DRUG"
      ],
      "sponsor": "Vanderbilt University",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "18 Years and older"
      },
      "enrollment_count": 27034,
      "start_date": "2016-07",
      "completion_date": "2017-11-30",
      "has_results": true,
      "last_update_posted_date": "2019-03-07",
      "last_synced_at": "2026-09-14T17:12:55.921Z",
      "location_count": 1,
      "location_summary": "Nashville, Tennessee",
      "locations": [
        {
          "city": "Nashville",
          "state": "Tennessee"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT02625181"
    },
    {
      "nct_id": "NCT06868589",
      "title": "Reducing Pain With Methadone and Ketamine in Liver Transplant",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE4"
      ],
      "conditions": [
        "Liver Transplantation"
      ],
      "interventions": [
        {
          "name": "Methadone",
          "type": "DRUG"
        },
        {
          "name": "ketamine",
          "type": "DRUG"
        },
        {
          "name": "Hydromorphone",
          "type": "DRUG"
        },
        {
          "name": "fentanyl",
          "type": "DRUG"
        }
      ],
      "intervention_types": [
        "DRUG"
      ],
      "sponsor": "Lahey Clinic",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "18 Years and older"
      },
      "enrollment_count": 50,
      "start_date": "2025-06-30",
      "completion_date": "2026-06-01",
      "has_results": false,
      "last_update_posted_date": "2026-08-11",
      "last_synced_at": "2026-09-14T17:12:55.921Z",
      "location_count": 2,
      "location_summary": "Burlington, Massachusetts",
      "locations": [
        {
          "city": "Burlington",
          "state": "Massachusetts"
        },
        {
          "city": "Burlington",
          "state": "Massachusetts"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT06868589"
    },
    {
      "nct_id": "NCT07672301",
      "title": "Total Intravenous Anesthesia vs Spinal Anesthesia in Patients Undergoing Unilateral Primary Total Knee Arthroplasty",
      "overall_status": "RECRUITING",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE1",
        "PHASE2"
      ],
      "conditions": [
        "Total Knee Arthroplasty (TKA)"
      ],
      "interventions": [
        {
          "name": "Total IntraVenous Anesthesia (TIVA)",
          "type": "COMBINATION_PRODUCT"
        },
        {
          "name": "Spinal-Block",
          "type": "COMBINATION_PRODUCT"
        },
        {
          "name": "Electroencephalogram (EEG)",
          "type": "DEVICE"
        }
      ],
      "intervention_types": [
        "COMBINATION_PRODUCT",
        "DEVICE"
      ],
      "sponsor": "University of Chicago",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "18 Years and older"
      },
      "enrollment_count": 150,
      "start_date": "2026-03-11",
      "completion_date": "2028-06",
      "has_results": false,
      "last_update_posted_date": "2026-06-26",
      "last_synced_at": "2026-09-14T17:12:55.921Z",
      "location_count": 1,
      "location_summary": "Chicago, Illinois",
      "locations": [
        {
          "city": "Chicago",
          "state": "Illinois"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT07672301"
    },
    {
      "nct_id": "NCT04230681",
      "title": "Hydromorphone vs Fentanyl in Children Undergoing Tonsillectomy Surgery",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "EARLY_PHASE1"
      ],
      "conditions": [
        "Obstructive Sleep Apnea",
        "Tonsillitis"
      ],
      "interventions": [
        {
          "name": "Hydromorphone",
          "type": "DRUG"
        },
        {
          "name": "Fentanyl",
          "type": "DRUG"
        }
      ],
      "intervention_types": [
        "DRUG"
      ],
      "sponsor": "Washington University School of Medicine",
      "sponsor_class": "OTHER",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "2 Years",
        "maximum_age": "15 Years",
        "sex": "ALL",
        "summary": "2 Years to 15 Years"
      },
      "enrollment_count": 189,
      "start_date": "2020-02-26",
      "completion_date": "2022-04-01",
      "has_results": true,
      "last_update_posted_date": "2024-12-18",
      "last_synced_at": "2026-09-14T17:12:55.921Z",
      "location_count": 1,
      "location_summary": "St Louis, Missouri",
      "locations": [
        {
          "city": "St Louis",
          "state": "Missouri"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT04230681"
    },
    {
      "nct_id": "NCT06429657",
      "title": "Ketamine for Sedation in Severe Traumatic Brain Injury",
      "overall_status": "SUSPENDED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE4"
      ],
      "conditions": [
        "Severe Traumatic Brain Injury",
        "Intracranial Hypertension",
        "Intracranial Hemorrhage, Hypertensive"
      ],
      "interventions": [
        {
          "name": "Ketamine with propofol",
          "type": "DRUG"
        },
        {
          "name": "Standard of Care propofol, fentanyl, dexmedetomidine, morphine, hydromorphone, midazolam, or lorazepam",
          "type": "OTHER"
        }
      ],
      "intervention_types": [
        "DRUG",
        "OTHER"
      ],
      "sponsor": "Henry M. Jackson Foundation for the Advancement of Military Medicine",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": "65 Years",
        "sex": "ALL",
        "summary": "18 Years to 65 Years"
      },
      "enrollment_count": 50,
      "start_date": "2024-09-23",
      "completion_date": "2027-06-30",
      "has_results": false,
      "last_update_posted_date": "2025-07-14",
      "last_synced_at": "2026-09-14T17:12:55.921Z",
      "location_count": 1,
      "location_summary": "Fort Sam Houston, Texas",
      "locations": [
        {
          "city": "Fort Sam Houston",
          "state": "Texas"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT06429657"
    },
    {
      "nct_id": "NCT02086123",
      "title": "Randomized Study Comparing the Use of Epidural Analgesia to Intravenous Narcotics for Laparoscopic Colorectal Resection.",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Pain, Postoperative"
      ],
      "interventions": [
        {
          "name": "Epidural Analgesia",
          "type": "PROCEDURE"
        },
        {
          "name": "Parenteral Analgesia (Intravenous)",
          "type": "PROCEDURE"
        }
      ],
      "intervention_types": [
        "PROCEDURE"
      ],
      "sponsor": "University of California, Irvine",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "18 Years and older"
      },
      "enrollment_count": 87,
      "start_date": "2012-05",
      "completion_date": "2015-04",
      "has_results": false,
      "last_update_posted_date": "2023-08-14",
      "last_synced_at": "2026-09-14T17:12:55.921Z",
      "location_count": 1,
      "location_summary": "Orange, California",
      "locations": [
        {
          "city": "Orange",
          "state": "California"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT02086123"
    },
    {
      "nct_id": "NCT03133845",
      "title": "Shaping Anesthetic Techniques to Reduce Post-operative Delirium",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Delirium",
        "Lumbar Radiculopathy",
        "Lumbar Osteoarthritis",
        "Lumbar Spine Disc Degeneration"
      ],
      "interventions": [
        {
          "name": "Light sedation with propofol",
          "type": "PROCEDURE"
        },
        {
          "name": "Induction with propofol",
          "type": "PROCEDURE"
        },
        {
          "name": "Maintenance anesthetic using a volatile anesthetic",
          "type": "PROCEDURE"
        },
        {
          "name": "Muscle relaxant during maintenance anesthesia",
          "type": "PROCEDURE"
        },
        {
          "name": "Pain control with fentanyl",
          "type": "PROCEDURE"
        },
        {
          "name": "Bispectral Index (BIS) monitoring for depth of anesthesia",
          "type": "PROCEDURE"
        },
        {
          "name": "Spinal Anesthesia",
          "type": "PROCEDURE"
        },
        {
          "name": "Midazolam administered during spinal anesthesia",
          "type": "PROCEDURE"
        },
        {
          "name": "Cerebrospinal fluid collection",
          "type": "PROCEDURE"
        },
        {
          "name": "Administration of intrathecal morphine",
          "type": "PROCEDURE"
        }
      ],
      "intervention_types": [
        "PROCEDURE"
      ],
      "sponsor": "Johns Hopkins University",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "65 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "65 Years and older"
      },
      "enrollment_count": 218,
      "start_date": "2015-10",
      "completion_date": "2020-05-25",
      "has_results": false,
      "last_update_posted_date": "2020-06-18",
      "last_synced_at": "2026-09-14T17:12:55.921Z",
      "location_count": 1,
      "location_summary": "Baltimore, Maryland",
      "locations": [
        {
          "city": "Baltimore",
          "state": "Maryland"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT03133845"
    },
    {
      "nct_id": "NCT02459964",
      "title": "Compare Fentanyl Nasal Spray With Intravenous Opioids to Treat Severe Pain",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE4"
      ],
      "conditions": [
        "Advanced Cancers",
        "Pain"
      ],
      "interventions": [
        {
          "name": "Fentanyl Nasal Spray",
          "type": "DRUG"
        },
        {
          "name": "Hydromorphone Hydrochloride",
          "type": "DRUG"
        },
        {
          "name": "Phone Call",
          "type": "BEHAVIORAL"
        }
      ],
      "intervention_types": [
        "DRUG",
        "BEHAVIORAL"
      ],
      "sponsor": "M.D. Anderson Cancer Center",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": null,
        "maximum_age": null,
        "sex": "ALL",
        "summary": "Not listed"
      },
      "enrollment_count": 84,
      "start_date": "2015-09-14",
      "completion_date": "2020-06-21",
      "has_results": true,
      "last_update_posted_date": "2021-06-16",
      "last_synced_at": "2026-09-14T17:12:55.921Z",
      "location_count": 1,
      "location_summary": "Houston, Texas",
      "locations": [
        {
          "city": "Houston",
          "state": "Texas"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT02459964"
    },
    {
      "nct_id": "NCT06576830",
      "title": "Optimization of Pediatric Tonsillectomy to IMprove AnaLgesia",
      "overall_status": "RECRUITING",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE4"
      ],
      "conditions": [
        "Pain, Postoperative",
        "Tonsillar Hypertrophy",
        "Tonsillitis",
        "Pediatric Sleep Apnea",
        "Sleep-Disordered Breathing"
      ],
      "interventions": [
        {
          "name": "Methadone",
          "type": "DRUG"
        },
        {
          "name": "Fentanyl/Hydromorphone",
          "type": "DRUG"
        }
      ],
      "intervention_types": [
        "DRUG"
      ],
      "sponsor": "Duke University",
      "sponsor_class": "OTHER",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "3 Years",
        "maximum_age": "17 Years",
        "sex": "ALL",
        "summary": "3 Years to 17 Years"
      },
      "enrollment_count": 440,
      "start_date": "2024-11-21",
      "completion_date": "2029-06-01",
      "has_results": false,
      "last_update_posted_date": "2025-12-05",
      "last_synced_at": "2026-09-14T17:12:55.921Z",
      "location_count": 1,
      "location_summary": "Durham, North Carolina",
      "locations": [
        {
          "city": "Durham",
          "state": "North Carolina"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT06576830"
    },
    {
      "nct_id": "NCT03313115",
      "title": "Sleep/Wake Protocol Implementation to Improve Sleep Quality in the ICU",
      "overall_status": "COMPLETED",
      "study_type": "OBSERVATIONAL",
      "phases": [],
      "conditions": [
        "Sleep Deprivation",
        "Delirium"
      ],
      "interventions": [
        {
          "name": "Sleep/Wake Protocol",
          "type": "BEHAVIORAL"
        }
      ],
      "intervention_types": [
        "BEHAVIORAL"
      ],
      "sponsor": "University of Utah",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "18 Years and older"
      },
      "enrollment_count": 685,
      "start_date": "2017-10-11",
      "completion_date": "2018-03-14",
      "has_results": false,
      "last_update_posted_date": "2023-04-25",
      "last_synced_at": "2026-09-14T17:12:55.921Z",
      "location_count": 1,
      "location_summary": "Salt Lake City, Utah",
      "locations": [
        {
          "city": "Salt Lake City",
          "state": "Utah"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT03313115"
    }
  ]
}