{
  "api_version": "1",
  "request": {
    "url": "https://clinicaltrialsfind.com/api/v1/search.json?intervention=Flavor+additive&page=2",
    "query": {
      "intervention": "Flavor additive",
      "page": 2
    },
    "page_size": 10
  },
  "pagination": {
    "page": 2,
    "page_size": 10,
    "total_count": 10,
    "total_pages": 1,
    "next_page_url": null,
    "previous_page_url": "https://clinicaltrialsfind.com/api/v1/search.json?intervention=Flavor+additive&page=1&page_size=10"
  },
  "source": "remote",
  "last_synced_at": "2026-09-30T01:47:18.635Z",
  "attribution": "Data derived from public ClinicalTrials.gov records. The official record at https://clinicaltrials.gov/ remains the source of truth for current availability, contacts, and full study details.",
  "notes": [
    "This endpoint exposes only public summary fields — no participant contact emails, phone numbers, or scraped investigator contact details.",
    "For contact information and full protocol detail, follow each trial's `official_url` to the ClinicalTrials.gov record.",
    "This API is a navigational aid. It does not provide medical advice, eligibility determinations, or compensation guarantees."
  ],
  "trials": [
    {
      "nct_id": "NCT02664012",
      "title": "Comparison of Nicotine Plasma Concentrations and Subjective Effects for Three Menthol Electronic Cigarettes vs Combustible Menthol Cigarettes and Nicotine Gum",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Smoking"
      ],
      "interventions": [
        {
          "name": "Own Brand Menthol Cigarette",
          "type": "OTHER"
        },
        {
          "name": "Electronic Menthol Cigarette #1",
          "type": "OTHER"
        },
        {
          "name": "Electronic Menthol Cigarette #2",
          "type": "OTHER"
        },
        {
          "name": "Electronic Menthol Cigarette #3",
          "type": "OTHER"
        },
        {
          "name": "Leading U.S. Nicotine Gum",
          "type": "OTHER"
        }
      ],
      "intervention_types": [
        "OTHER"
      ],
      "sponsor": "R.J. Reynolds Vapor Company",
      "sponsor_class": "INDUSTRY",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "21 Years",
        "maximum_age": "60 Years",
        "sex": "ALL",
        "summary": "21 Years to 60 Years"
      },
      "enrollment_count": 71,
      "start_date": "2016-01",
      "completion_date": "2016-05",
      "has_results": false,
      "last_update_posted_date": "2018-06-04",
      "last_synced_at": "2026-09-30T01:47:18.635Z",
      "location_count": 1,
      "location_summary": "Lincoln, Nebraska",
      "locations": [
        {
          "city": "Lincoln",
          "state": "Nebraska"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT02664012"
    },
    {
      "nct_id": "NCT06301113",
      "title": "This Research Study Examines the Effects of Cannabidiol-infused Candy on Reducing the Bacteria Causing Tooth Decay, When Comparing it to a Sugar Free Candy on Adults.",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Tooth Decay"
      ],
      "interventions": [
        {
          "name": "CBD infused candy",
          "type": "DIETARY_SUPPLEMENT"
        },
        {
          "name": "Sugar free Candy",
          "type": "DIETARY_SUPPLEMENT"
        }
      ],
      "intervention_types": [
        "DIETARY_SUPPLEMENT"
      ],
      "sponsor": "West Coast University",
      "sponsor_class": "OTHER",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "18 Years and older"
      },
      "enrollment_count": 30,
      "start_date": "2023-01-27",
      "completion_date": "2023-02-11",
      "has_results": false,
      "last_update_posted_date": "2024-03-08",
      "last_synced_at": "2026-09-30T01:47:18.635Z",
      "location_count": 1,
      "location_summary": "Anaheim, California",
      "locations": [
        {
          "city": "Anaheim",
          "state": "California"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT06301113"
    },
    {
      "nct_id": "NCT05447325",
      "title": "Neuroimaging Approaches to Improve Prediction of Smoking Initiation and Nicotine Escalation in Young Adult ENDS Users",
      "overall_status": "RECRUITING",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Message Exposure (Sequence: Regular Then Flavor)",
        "Message Exposure (Sequence: Flavor Then Regular)",
        "No Message Exposure (Control Condition)"
      ],
      "interventions": [
        {
          "name": "Exposure to Anti-Vaping Messages (generic themes then flavor-specific themes)",
          "type": "BEHAVIORAL"
        },
        {
          "name": "Exposure to Anti-Vaping Messages (flavor-specific themes then generic themes)",
          "type": "BEHAVIORAL"
        },
        {
          "name": "Exposure to Anti-Vaping Messages (no message exposure)",
          "type": "BEHAVIORAL"
        }
      ],
      "intervention_types": [
        "BEHAVIORAL"
      ],
      "sponsor": "University of Georgia",
      "sponsor_class": "OTHER",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": "29 Years",
        "sex": "ALL",
        "summary": "18 Years to 29 Years"
      },
      "enrollment_count": 180,
      "start_date": "2022-07-15",
      "completion_date": "2026-07-31",
      "has_results": false,
      "last_update_posted_date": "2026-04-03",
      "last_synced_at": "2026-09-30T01:47:18.635Z",
      "location_count": 1,
      "location_summary": "Athens, Georgia",
      "locations": [
        {
          "city": "Athens",
          "state": "Georgia"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT05447325"
    },
    {
      "nct_id": "NCT00950976",
      "title": "Dose-response Enteral Citrulline for Normal Healthy Volunteers and Surgery Patients",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Nutritional Deficiency"
      ],
      "interventions": [
        {
          "name": "citrulline",
          "type": "OTHER"
        },
        {
          "name": "Lemonade",
          "type": "OTHER"
        }
      ],
      "intervention_types": [
        "OTHER"
      ],
      "sponsor": "Société des Produits Nestlé (SPN)",
      "sponsor_class": "INDUSTRY",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "18 Years and older"
      },
      "enrollment_count": 14,
      "start_date": "2008-03",
      "completion_date": "2010-08",
      "has_results": false,
      "last_update_posted_date": "2012-04-25",
      "last_synced_at": "2026-09-30T01:47:18.635Z",
      "location_count": 1,
      "location_summary": "Pittsburgh, Pennsylvania",
      "locations": [
        {
          "city": "Pittsburgh",
          "state": "Pennsylvania"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT00950976"
    },
    {
      "nct_id": "NCT00661947",
      "title": "Pharmacokinetics and Pharmacodynamics of Fructose",
      "overall_status": "COMPLETED",
      "study_type": "OBSERVATIONAL",
      "phases": [],
      "conditions": [
        "Healthy"
      ],
      "interventions": [
        {
          "name": "Dr Pepper sweetened with sucrose or high fructose corn syrup",
          "type": "OTHER"
        }
      ],
      "intervention_types": [
        "OTHER"
      ],
      "sponsor": "University of Florida",
      "sponsor_class": "OTHER",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "18 Years and older"
      },
      "enrollment_count": 40,
      "start_date": "2008-03",
      "completion_date": "2010-08",
      "has_results": false,
      "last_update_posted_date": "2012-02-16",
      "last_synced_at": "2026-09-30T01:47:18.635Z",
      "location_count": 1,
      "location_summary": "Gainesville, Florida",
      "locations": [
        {
          "city": "Gainesville",
          "state": "Florida"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT00661947"
    },
    {
      "nct_id": "NCT04188197",
      "title": "Assisting Smokers to Switch to a JUUL E-Cigarette by Devaluing Combustible Cigarettes",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Smoking Cessation",
        "Harm Reduction",
        "E-Cig Use",
        "Cigarette Smoking",
        "Tobacco Dependence",
        "Tobacco Use Cessation"
      ],
      "interventions": [
        {
          "name": "JUUL",
          "type": "OTHER"
        }
      ],
      "intervention_types": [
        "OTHER"
      ],
      "sponsor": "Rose Research Center, LLC",
      "sponsor_class": "INDUSTRY",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "21 Years",
        "maximum_age": "65 Years",
        "sex": "ALL",
        "summary": "21 Years to 65 Years"
      },
      "enrollment_count": 50,
      "start_date": "2019-08-26",
      "completion_date": "2021-06-22",
      "has_results": true,
      "last_update_posted_date": "2025-04-20",
      "last_synced_at": "2026-09-30T01:47:18.635Z",
      "location_count": 2,
      "location_summary": "Charlotte, North Carolina • Raleigh, North Carolina",
      "locations": [
        {
          "city": "Charlotte",
          "state": "North Carolina"
        },
        {
          "city": "Raleigh",
          "state": "North Carolina"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT04188197"
    },
    {
      "nct_id": "NCT01677169",
      "title": "Effect of Noni Juice on Lipid Peroxidation-derived DNA Adducts in Heavy Smokers",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE2"
      ],
      "conditions": [
        "DNA Damage"
      ],
      "interventions": [
        {
          "name": "Noni juice",
          "type": "DIETARY_SUPPLEMENT"
        },
        {
          "name": "Placebo",
          "type": "DIETARY_SUPPLEMENT"
        }
      ],
      "intervention_types": [
        "DIETARY_SUPPLEMENT"
      ],
      "sponsor": "Tahitian Noni International, Inc.",
      "sponsor_class": "INDUSTRY",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": "65 Years",
        "sex": "ALL",
        "summary": "18 Years to 65 Years"
      },
      "enrollment_count": 317,
      "start_date": "2000-09",
      "completion_date": "2006-08",
      "has_results": false,
      "last_update_posted_date": "2019-09-11",
      "last_synced_at": "2026-09-30T01:47:18.635Z",
      "location_count": 1,
      "location_summary": "Rockford, Illinois",
      "locations": [
        {
          "city": "Rockford",
          "state": "Illinois"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT01677169"
    },
    {
      "nct_id": "NCT02612129",
      "title": "Arimoclomol Prospective Study in Participants Diagnosed With Niemann-Pick Disease Type C",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE2",
        "PHASE3"
      ],
      "conditions": [
        "Niemann-Pick Disease, Type C"
      ],
      "interventions": [
        {
          "name": "arimoclomol",
          "type": "DRUG"
        },
        {
          "name": "Placebo",
          "type": "DRUG"
        }
      ],
      "intervention_types": [
        "DRUG"
      ],
      "sponsor": "ZevraDenmark",
      "sponsor_class": "INDUSTRY",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "2 Years",
        "maximum_age": "18 Years",
        "sex": "ALL",
        "summary": "2 Years to 18 Years"
      },
      "enrollment_count": 50,
      "start_date": "2016-06-14",
      "completion_date": "2024-10-31",
      "has_results": true,
      "last_update_posted_date": "2024-11-29",
      "last_synced_at": "2026-09-30T01:47:18.635Z",
      "location_count": 2,
      "location_summary": "Oakland, California • Rochester, Minnesota",
      "locations": [
        {
          "city": "Oakland",
          "state": "California"
        },
        {
          "city": "Rochester",
          "state": "Minnesota"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT02612129"
    },
    {
      "nct_id": "NCT00763048",
      "title": "Collection of Gingival Crevicular Fluid From Periodontitis Patients",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE3"
      ],
      "conditions": [
        "Gingival Diseases"
      ],
      "interventions": [
        {
          "name": "Fluoride",
          "type": "DRUG"
        },
        {
          "name": "Fluoride, triclosan",
          "type": "DRUG"
        }
      ],
      "intervention_types": [
        "DRUG"
      ],
      "sponsor": "Colgate Palmolive",
      "sponsor_class": "INDUSTRY",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "26 Years",
        "maximum_age": "68 Years",
        "sex": "ALL",
        "summary": "26 Years to 68 Years"
      },
      "enrollment_count": 39,
      "start_date": "2008-03",
      "completion_date": "2008-04",
      "has_results": true,
      "last_update_posted_date": "2011-06-14",
      "last_synced_at": "2026-09-30T01:47:18.635Z",
      "location_count": 1,
      "location_summary": "Boston, Massachusetts",
      "locations": [
        {
          "city": "Boston",
          "state": "Massachusetts"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT00763048"
    },
    {
      "nct_id": "NCT02548767",
      "title": "Adverse Metabolic Effects of Dietary Sugar",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Chronic Disease of Cardiovascular System",
        "Type 2 Diabetes",
        "Obesity"
      ],
      "interventions": [
        {
          "name": "high fructose corn syrup",
          "type": "OTHER"
        },
        {
          "name": "aspartame",
          "type": "OTHER"
        },
        {
          "name": "Energy-balanced diet",
          "type": "OTHER"
        },
        {
          "name": "Ad libitum diet",
          "type": "OTHER"
        }
      ],
      "intervention_types": [
        "OTHER"
      ],
      "sponsor": "University of California, Davis",
      "sponsor_class": "OTHER",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": "40 Years",
        "sex": "ALL",
        "summary": "18 Years to 40 Years"
      },
      "enrollment_count": 36,
      "start_date": "2016-02",
      "completion_date": "2020-03-13",
      "has_results": false,
      "last_update_posted_date": "2021-09-16",
      "last_synced_at": "2026-09-30T01:47:18.635Z",
      "location_count": 3,
      "location_summary": "Davis, California • Sacramento, California • Vallejo, California",
      "locations": [
        {
          "city": "Davis",
          "state": "California"
        },
        {
          "city": "Sacramento",
          "state": "California"
        },
        {
          "city": "Vallejo",
          "state": "California"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT02548767"
    }
  ]
}