{ "api_version": "1", "request": { "url": "https://clinicaltrialsfind.com/api/v1/search.json?intervention=Fluoride+free+toothpaste", "query": { "intervention": "Fluoride free toothpaste" }, "page_size": 10 }, "pagination": { "page": 1, "page_size": 10, "total_count": 18, "total_pages": 2, "next_page_url": "https://clinicaltrialsfind.com/api/v1/search.json?intervention=Fluoride+free+toothpaste&page=2&page_size=10", "previous_page_url": null }, "source": "remote", "last_synced_at": "2026-09-03T09:20:11.179Z", "attribution": "Data derived from public ClinicalTrials.gov records. The official record at https://clinicaltrials.gov/ remains the source of truth for current availability, contacts, and full study details.", "notes": [ "This endpoint exposes only public summary fields — no participant contact emails, phone numbers, or scraped investigator contact details.", "For contact information and full protocol detail, follow each trial's `official_url` to the ClinicalTrials.gov record.", "This API is a navigational aid. It does not provide medical advice, eligibility determinations, or compensation guarantees." ], "trials": [ { "nct_id": "NCT07029438", "title": "Comparative Efficacy of Floss and Essential Oil/CPC+Zn Mouthwashes in Reducing Dental Plaque and Gingivitis", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE4" ], "conditions": [ "Dental Plaque", "Gingivitis" ], "interventions": [ { "name": "Mouthwash", "type": "DRUG" }, { "name": "Floss", "type": "DEVICE" }, { "name": "Toothbrush", "type": "DEVICE" }, { "name": "Toothpaste", "type": "DRUG" } ], "intervention_types": [ "DRUG", "DEVICE" ], "sponsor": "Colgate Palmolive", "sponsor_class": "INDUSTRY", "healthy_volunteers": true, "eligibility": { "minimum_age": "18 Years", "maximum_age": null, "sex": "ALL", "summary": "18 Years and older" }, "enrollment_count": 228, "start_date": "2025-07-07", "completion_date": "2025-10-16", "has_results": false, "last_update_posted_date": "2025-10-30", "last_synced_at": "2026-09-03T09:20:11.179Z", "location_count": 1, "location_summary": "Fort Wayne, Indiana", "locations": [ { "city": "Fort Wayne", "state": "Indiana" } ], "official_url": "https://clinicaltrials.gov/study/NCT07029438" }, { "nct_id": "NCT00708305", "title": "Evaluation of Plaque Fluid Fluoride Retention From Fluoride Toothpastes", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE3" ], "conditions": [ "Dental Caries" ], "interventions": [ { "name": "Sodium Fluoride (NaF)", "type": "DRUG" }, { "name": "Placebo", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "GlaxoSmithKline", "sponsor_class": "INDUSTRY", "healthy_volunteers": true, "eligibility": { "minimum_age": "18 Years", "maximum_age": "65 Years", "sex": "ALL", "summary": "18 Years to 65 Years" }, "enrollment_count": 65, "start_date": "2008-06", "completion_date": "2008-10", "has_results": true, "last_update_posted_date": "2015-01-01", "last_synced_at": "2026-09-03T09:20:11.179Z", "location_count": 1, "location_summary": "Indianapolis, Indiana", "locations": [ { "city": "Indianapolis", "state": "Indiana" } ], "official_url": "https://clinicaltrials.gov/study/NCT00708305" }, { "nct_id": "NCT01901250", "title": "Xylitol for Caries Prevention in Inner-City Children", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "NA" ], "conditions": [ "Dental Caries" ], "interventions": [ { "name": "Xylitol gummy bears", "type": "DIETARY_SUPPLEMENT" }, { "name": "Sugar free fiber gummy bears", "type": "DIETARY_SUPPLEMENT" }, { "name": "Oral health education", "type": "BEHAVIORAL" }, { "name": "Fluoride varnish", "type": "DEVICE" }, { "name": "Dental sealant", "type": "DEVICE" } ], "intervention_types": [ "DIETARY_SUPPLEMENT", "BEHAVIORAL", "DEVICE" ], "sponsor": "Case Western Reserve University", "sponsor_class": "OTHER", "healthy_volunteers": false, "eligibility": { "minimum_age": "5 Years", "maximum_age": "6 Years", "sex": "ALL", "summary": "5 Years to 6 Years" }, "enrollment_count": 562, "start_date": "2007-08", "completion_date": "2011-12", "has_results": true, "last_update_posted_date": "2014-08-12", "last_synced_at": "2026-09-03T09:20:11.179Z", "location_count": 1, "location_summary": "Cleveland, Ohio", "locations": [ { "city": "Cleveland", "state": "Ohio" } ], "official_url": "https://clinicaltrials.gov/study/NCT01901250" }, { "nct_id": "NCT02940821", "title": "Assessing the Effects of Three Oral Care Regimens", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "NA" ], "conditions": [ "Dental Plaque", "Gingivitis" ], "interventions": [ { "name": "Toothbrushing", "type": "OTHER" }, { "name": "Fluoridated Dentifrice (.15% sodium monofluorophosphate)", "type": "OTHER" }, { "name": "Fluoridated Dentifrice Whitening System (.454% stannous fluoride with 2% hydrogen peroxide)", "type": "OTHER" }, { "name": "Whitening (4.5% hydrogen peroxide)", "type": "OTHER" }, { "name": "Other Fluoridated Dentifrice (.454% stannous fluoride)", "type": "OTHER" } ], "intervention_types": [ "OTHER" ], "sponsor": "Pearl Network", "sponsor_class": "NETWORK", "healthy_volunteers": true, "eligibility": { "minimum_age": "18 Years", "maximum_age": "70 Years", "sex": "ALL", "summary": "18 Years to 70 Years" }, "enrollment_count": 142, "start_date": "2016-05-30", "completion_date": "2017-07-27", "has_results": false, "last_update_posted_date": "2017-11-14", "last_synced_at": "2026-09-03T09:20:11.179Z", "location_count": 1, "location_summary": "Emerson, New Jersey", "locations": [ { "city": "Emerson", "state": "New Jersey" } ], "official_url": "https://clinicaltrials.gov/study/NCT02940821" }, { "nct_id": "NCT04449952", "title": "A Study of Mouth Rinses in Type 1 and Type 2 Diabetic Participants", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE4" ], "conditions": [ "Gingivits in Diabetics" ], "interventions": [ { "name": "Listerine Cool Mint", "type": "OTHER" }, { "name": "5% Hydroalcohol Mouth Rinse", "type": "OTHER" }, { "name": "Colgate Cavity Protection Toothpaste", "type": "OTHER" }, { "name": "Alcohol-Free Essential Oil Containing (AFEO) Mouth Rinse Lead Formula", "type": "OTHER" }, { "name": "Concept Curve Winter Series Toothbrush", "type": "DEVICE" }, { "name": "Listerine Cool Mint Floss", "type": "DEVICE" } ], "intervention_types": [ "OTHER", "DEVICE" ], "sponsor": "Johnson & Johnson Consumer Inc. (J&JCI)", "sponsor_class": "INDUSTRY", "healthy_volunteers": false, "eligibility": { "minimum_age": "18 Years", "maximum_age": null, "sex": "ALL", "summary": "18 Years and older" }, "enrollment_count": 154, "start_date": "2019-12-02", "completion_date": "2020-03-06", "has_results": false, "last_update_posted_date": "2023-08-07", "last_synced_at": "2026-09-03T09:20:11.179Z", "location_count": 1, "location_summary": "Fort Wayne, Indiana", "locations": [ { "city": "Fort Wayne", "state": "Indiana" } ], "official_url": "https://clinicaltrials.gov/study/NCT04449952" }, { "nct_id": "NCT07419685", "title": "Intraoral Appliance (IOA) Model Evaluating the Efficacy of a Whitening Toothpaste", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "NA" ], "conditions": [ "Dental Caries" ], "interventions": [ { "name": "Negative Control Toothpaste", "type": "DRUG" }, { "name": "Active Comparator", "type": "DRUG" }, { "name": "Test Toothpaste", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "Church & Dwight Company, Inc.", "sponsor_class": "INDUSTRY", "healthy_volunteers": true, "eligibility": { "minimum_age": "18 Years", "maximum_age": null, "sex": "ALL", "summary": "18 Years and older" }, "enrollment_count": 31, "start_date": "2024-10-08", "completion_date": "2025-01-17", "has_results": false, "last_update_posted_date": "2026-02-19", "last_synced_at": "2026-09-03T09:20:11.179Z", "location_count": 1, "location_summary": "Noblesville, Indiana", "locations": [ { "city": "Noblesville", "state": "Indiana" } ], "official_url": "https://clinicaltrials.gov/study/NCT07419685" }, { "nct_id": "NCT07419763", "title": "Intra Oral Appliance (IOA) Model Evaluating the Efficacy of Sensitive Toothpaste", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "NA" ], "conditions": [ "Dental Caries" ], "interventions": [ { "name": "Negative Control Toothpaste", "type": "DRUG" }, { "name": "Active Comparator", "type": "DRUG" }, { "name": "Test toothpaste", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "Church & Dwight Company, Inc.", "sponsor_class": "INDUSTRY", "healthy_volunteers": true, "eligibility": { "minimum_age": "18 Years", "maximum_age": null, "sex": "ALL", "summary": "18 Years and older" }, "enrollment_count": 30, "start_date": "2025-04-15", "completion_date": "2025-06-10", "has_results": false, "last_update_posted_date": "2026-02-19", "last_synced_at": "2026-09-03T09:20:11.179Z", "location_count": 1, "location_summary": "Noblesville, Indiana", "locations": [ { "city": "Noblesville", "state": "Indiana" } ], "official_url": "https://clinicaltrials.gov/study/NCT07419763" }, { "nct_id": "NCT01607411", "title": "A Clinical Study to Evaluate Experimental Children's Toothpastes in an In-Situ Caries Model", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE3" ], "conditions": [ "Dental Caries" ], "interventions": [ { "name": "Fluoride", "type": "DRUG" }, { "name": "Placebo", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "GlaxoSmithKline", "sponsor_class": "INDUSTRY", "healthy_volunteers": true, "eligibility": { "minimum_age": "11 Years", "maximum_age": "14 Years", "sex": "ALL", "summary": "11 Years to 14 Years" }, "enrollment_count": 55, "start_date": "2012-02", "completion_date": "2012-05", "has_results": true, "last_update_posted_date": "2014-08-11", "last_synced_at": "2026-09-03T09:20:11.179Z", "location_count": 1, "location_summary": "Indianapolis, Indiana", "locations": [ { "city": "Indianapolis", "state": "Indiana" } ], "official_url": "https://clinicaltrials.gov/study/NCT01607411" }, { "nct_id": "NCT01563172", "title": "Effect of Dentifrice Usage Regime on Delivery and Efficacy of Fluoride", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE4" ], "conditions": [ "Dental Caries" ], "interventions": [ { "name": "Sodium fluoride / silica and carbopol, 0.5g", "type": "DRUG" }, { "name": "Sodium fluoride / silica and carbopol, 1.5g", "type": "DRUG" }, { "name": "Fluoride free dentifrice", "type": "OTHER" } ], "intervention_types": [ "DRUG", "OTHER" ], "sponsor": "GlaxoSmithKline", "sponsor_class": "INDUSTRY", "healthy_volunteers": true, "eligibility": { "minimum_age": "18 Years", "maximum_age": "80 Years", "sex": "ALL", "summary": "18 Years to 80 Years" }, "enrollment_count": 65, "start_date": "2009-01-01", "completion_date": "2009-06-01", "has_results": true, "last_update_posted_date": "2018-02-07", "last_synced_at": "2026-09-03T09:20:11.179Z", "location_count": 1, "location_summary": "Indianapolis, Indiana", "locations": [ { "city": "Indianapolis", "state": "Indiana" } ], "official_url": "https://clinicaltrials.gov/study/NCT01563172" }, { "nct_id": "NCT07160166", "title": "Determination of the Oral Irritation Potential of Two Alcohol-Free Rinses", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "NA" ], "conditions": [ "Oral Health" ], "interventions": [ { "name": "Prototype 1", "type": "OTHER" }, { "name": "Prototype 2", "type": "OTHER" }, { "name": "Marketed Comparator", "type": "OTHER" } ], "intervention_types": [ "OTHER" ], "sponsor": "Kenvue Brands LLC", "sponsor_class": "INDUSTRY", "healthy_volunteers": true, "eligibility": { "minimum_age": "18 Years", "maximum_age": null, "sex": "ALL", "summary": "18 Years and older" }, "enrollment_count": 169, "start_date": "2025-07-11", "completion_date": "2025-07-30", "has_results": false, "last_update_posted_date": "2025-09-08", "last_synced_at": "2026-09-03T09:20:11.179Z", "location_count": 1, "location_summary": "Fort Wayne, Indiana", "locations": [ { "city": "Fort Wayne", "state": "Indiana" } ], "official_url": "https://clinicaltrials.gov/study/NCT07160166" } ] }