{ "api_version": "1", "request": { "url": "https://clinicaltrialsfind.com/api/v1/search.json?intervention=Folinic+Acid+and+placebo", "query": { "intervention": "Folinic Acid and placebo" }, "page_size": 10 }, "pagination": { "page": 1, "page_size": 10, "total_count": 109, "total_pages": 11, "next_page_url": "https://clinicaltrialsfind.com/api/v1/search.json?intervention=Folinic+Acid+and+placebo&page=2&page_size=10", "previous_page_url": null }, "source": "remote", "last_synced_at": "2026-09-26T17:07:25.712Z", "attribution": "Data derived from public ClinicalTrials.gov records. The official record at https://clinicaltrials.gov/ remains the source of truth for current availability, contacts, and full study details.", "notes": [ "This endpoint exposes only public summary fields — no participant contact emails, phone numbers, or scraped investigator contact details.", "For contact information and full protocol detail, follow each trial's `official_url` to the ClinicalTrials.gov record.", "This API is a navigational aid. It does not provide medical advice, eligibility determinations, or compensation guarantees." ], "trials": [ { "nct_id": "NCT02947750", "title": "Neurovascular Transduction During Exercise in Chronic Kidney Disease", "overall_status": "RECRUITING", "study_type": "INTERVENTIONAL", "phases": [ "PHASE2" ], "conditions": [ "Renal Insufficiency, Chronic" ], "interventions": [ { "name": "6R-BH4", "type": "DRUG" }, { "name": "6R-BH4 placebo", "type": "OTHER" }, { "name": "Folic acid", "type": "DIETARY_SUPPLEMENT" }, { "name": "Exercise training", "type": "OTHER" }, { "name": "Stretching", "type": "OTHER" }, { "name": "Histidine and beta-alanine supplementation", "type": "DIETARY_SUPPLEMENT" }, { "name": "Histidine and beta-alanine placebo", "type": "OTHER" } ], "intervention_types": [ "DRUG", "OTHER", "DIETARY_SUPPLEMENT" ], "sponsor": "Emory University", "sponsor_class": "OTHER", "healthy_volunteers": false, "eligibility": { "minimum_age": "18 Years", "maximum_age": "75 Years", "sex": "ALL", "summary": "18 Years to 75 Years" }, "enrollment_count": 150, "start_date": "2016-10", "completion_date": "2027-04-30", "has_results": false, "last_update_posted_date": "2026-05-18", "last_synced_at": "2026-09-26T17:07:25.712Z", "location_count": 3, "location_summary": "Atlanta, Georgia • Decatur, Georgia", "locations": [ { "city": "Atlanta", "state": "Georgia" }, { "city": "Atlanta", "state": "Georgia" }, { "city": "Decatur", "state": "Georgia" } ], "official_url": "https://clinicaltrials.gov/study/NCT02947750" }, { "nct_id": "NCT01099449", "title": "Calcium Gluconate and Magnesium Sulfate in Preventing Neurotoxicity in Patients With Colon Cancer or Rectal Cancer Receiving Oxaliplatin-Based Combination Chemotherapy", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE3" ], "conditions": [ "Chemotherapeutic Agent Toxicity", "Colorectal Cancer", "Neuropathy", "Neurotoxicity" ], "interventions": [ { "name": "calcium gluconate", "type": "DRUG" }, { "name": "magnesium sulfate", "type": "DRUG" }, { "name": "placebo", "type": "OTHER" }, { "name": "oxaliplatin", "type": "DRUG" } ], "intervention_types": [ "DRUG", "OTHER" ], "sponsor": "Alliance for Clinical Trials in Oncology", "sponsor_class": "OTHER", "healthy_volunteers": false, "eligibility": { "minimum_age": "18 Years", "maximum_age": null, "sex": "ALL", "summary": "18 Years and older" }, "enrollment_count": 362, "start_date": "2010-06", "completion_date": "2013-03", "has_results": true, "last_update_posted_date": "2022-11-03", "last_synced_at": "2026-09-26T17:07:25.712Z", "location_count": 404, "location_summary": "Fairbanks, Alaska • Antioch, California • Fairfield, California + 278 more", "locations": [ { "city": "Fairbanks", "state": "Alaska" }, { "city": "Antioch", "state": "California" }, { "city": "Fairfield", "state": "California" }, { "city": "Fremont", "state": "California" }, { "city": "Fresno", "state": "California" } ], "official_url": "https://clinicaltrials.gov/study/NCT01099449" }, { "nct_id": "NCT00815854", "title": "Examining Risk Factors for Atypical Antipsychotic Metabolic Side Effects", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "NA" ], "conditions": [ "Schizophrenia" ], "interventions": [ { "name": "Folic Acid", "type": "DIETARY_SUPPLEMENT" }, { "name": "Placebo", "type": "OTHER" } ], "intervention_types": [ "DIETARY_SUPPLEMENT", "OTHER" ], "sponsor": "University of Michigan", "sponsor_class": "OTHER", "healthy_volunteers": false, "eligibility": { "minimum_age": "18 Years", "maximum_age": "90 Years", "sex": "ALL", "summary": "18 Years to 90 Years" }, "enrollment_count": 88, "start_date": "2008-10", "completion_date": "2019-05", "has_results": false, "last_update_posted_date": "2019-06-21", "last_synced_at": "2026-09-26T17:07:25.712Z", "location_count": 1, "location_summary": "Ann Arbor, Michigan", "locations": [ { "city": "Ann Arbor", "state": "Michigan" } ], "official_url": "https://clinicaltrials.gov/study/NCT00815854" }, { "nct_id": "NCT00037180", "title": "For Prevention of Diarrhea in Patients Diagnosed With Metastatic Colorectal Cancer Treated With Chemotherapy", "overall_status": "TERMINATED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE2" ], "conditions": [ "Neoplasm Metastasis", "Colorectal Neoplasms" ], "interventions": [ { "name": "Celecoxib", "type": "DRUG" }, { "name": "Irinotecan", "type": "DRUG" }, { "name": "5-fluorouracil", "type": "DRUG" }, { "name": "Leucovorin", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "Pfizer", "sponsor_class": "INDUSTRY", "healthy_volunteers": false, "eligibility": { "minimum_age": "18 Years", "maximum_age": null, "sex": "ALL", "summary": "18 Years and older" }, "enrollment_count": 212, "start_date": "2002-04", "completion_date": "2003-01", "has_results": false, "last_update_posted_date": "2008-09-29", "last_synced_at": "2026-09-26T17:07:25.712Z", "location_count": 12, "location_summary": "Mobile, Alabama • Fort Lauderdale, Florida • Port Saint Lucie, Florida + 9 more", "locations": [ { "city": "Mobile", "state": "Alabama" }, { "city": "Fort Lauderdale", "state": "Florida" }, { "city": "Port Saint Lucie", "state": "Florida" }, { "city": "Chicago", "state": "Illinois" }, { "city": "Saint Joseph", "state": "Missouri" } ], "official_url": "https://clinicaltrials.gov/study/NCT00037180" }, { "nct_id": "NCT00655980", "title": "Vitamins in Nitrous Oxide Study", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "NA" ], "conditions": [ "Major Surgery", "Coronary Artery Disease" ], "interventions": [ { "name": "Vitamin B12 and folic acid", "type": "DRUG" }, { "name": "Nitrous oxide and placebo", "type": "DRUG" }, { "name": "standard of care", "type": "OTHER" } ], "intervention_types": [ "DRUG", "OTHER" ], "sponsor": "Washington University School of Medicine", "sponsor_class": "OTHER", "healthy_volunteers": false, "eligibility": { "minimum_age": "18 Years", "maximum_age": null, "sex": "ALL", "summary": "18 Years and older" }, "enrollment_count": 687, "start_date": "2008-02", "completion_date": "2016-12", "has_results": true, "last_update_posted_date": "2020-10-01", "last_synced_at": "2026-09-26T17:07:25.712Z", "location_count": 1, "location_summary": "St Louis, Missouri", "locations": [ { "city": "St Louis", "state": "Missouri" } ], "official_url": "https://clinicaltrials.gov/study/NCT00655980" }, { "nct_id": "NCT00197704", "title": "Nutrition, Immunology and Epidemiology of Tuberculosis", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE3" ], "conditions": [ "Tuberculosis" ], "interventions": [ { "name": "Multivitamins", "type": "DIETARY_SUPPLEMENT" }, { "name": "Placebo", "type": "OTHER" } ], "intervention_types": [ "DIETARY_SUPPLEMENT", "OTHER" ], "sponsor": "Harvard School of Public Health (HSPH)", "sponsor_class": "OTHER", "healthy_volunteers": false, "eligibility": { "minimum_age": "18 Years", "maximum_age": null, "sex": "ALL", "summary": "18 Years and older" }, "enrollment_count": 876, "start_date": "2000-03", "completion_date": "2004-05", "has_results": false, "last_update_posted_date": "2010-11-11", "last_synced_at": "2026-09-26T17:07:25.712Z", "location_count": 1, "location_summary": "Boston, Massachusetts", "locations": [ { "city": "Boston", "state": "Massachusetts" } ], "official_url": "https://clinicaltrials.gov/study/NCT00197704" }, { "nct_id": "NCT01602016", "title": "A Folinic Acid Intervention for Autism Spectrum Disorders", "overall_status": "TERMINATED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE2" ], "conditions": [ "Autism Spectrum Disorder", "Autistic Disorder", "Autism", "Asperger's Syndrome", "Pervasive Development Disorders" ], "interventions": [ { "name": "Folinic Acid and placebo", "type": "DRUG" }, { "name": "Folinic Acid", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "University of Arkansas", "sponsor_class": "OTHER", "healthy_volunteers": false, "eligibility": { "minimum_age": "3 Years", "maximum_age": "14 Years", "sex": "ALL", "summary": "3 Years to 14 Years" }, "enrollment_count": 99, "start_date": "2012-05", "completion_date": "2015-11", "has_results": true, "last_update_posted_date": "2017-10-17", "last_synced_at": "2026-09-26T17:07:25.712Z", "location_count": 1, "location_summary": "Little Rock, Arkansas", "locations": [ { "city": "Little Rock", "state": "Arkansas" } ], "official_url": "https://clinicaltrials.gov/study/NCT01602016" }, { "nct_id": "NCT00069095", "title": "A Study of Capecitabine (Xeloda) and Bevacizumab as a First-line Therapy in Patients With Metastatic Colorectal Cancer", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE3" ], "conditions": [ "Colorectal Cancer" ], "interventions": [ { "name": "Oxaliplatin 130 mg/m^2", "type": "DRUG" }, { "name": "Capecitabine 1000 mg/m^2", "type": "DRUG" }, { "name": "Bevacizumab 7.5 mg/kg", "type": "DRUG" }, { "name": "Placebo for bevacizumab 7.5 mg/kg", "type": "DRUG" }, { "name": "Oxaliplatin 85 mg/m^2", "type": "DRUG" }, { "name": "Leucovorin 200 mg/m^2", "type": "DRUG" }, { "name": "Fluorouracil 400 mg/m^2", "type": "DRUG" }, { "name": "Bevacizumab 5 mg/kg", "type": "DRUG" }, { "name": "Placebo for bevacizumab 5 mg/kg", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "Hoffmann-La Roche", "sponsor_class": "INDUSTRY", "healthy_volunteers": false, "eligibility": { "minimum_age": "18 Years", "maximum_age": null, "sex": "ALL", "summary": "18 Years and older" }, "enrollment_count": 2035, "start_date": "2003-07", "completion_date": "2009-04", "has_results": true, "last_update_posted_date": "2016-10-06", "last_synced_at": "2026-09-26T17:07:25.712Z", "location_count": 49, "location_summary": "Berkeley, California • Fountain Valley, California • Fullerton, California + 44 more", "locations": [ { "city": "Berkeley", "state": "California" }, { "city": "Fountain Valley", "state": "California" }, { "city": "Fullerton", "state": "California" }, { "city": "Gilroy", "state": "California" }, { "city": "Greenbrae", "state": "California" } ], "official_url": "https://clinicaltrials.gov/study/NCT00069095" }, { "nct_id": "NCT04723134", "title": "Evaluation of a Folic Acid Wound Treatment (FAWT) for Chronic, Early-Stage Diabetic Foot Ulcer (DFU) Healing", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE2" ], "conditions": [ "Diabetic Foot Ulcer" ], "interventions": [ { "name": "Folinic acid calcium salt", "type": "COMBINATION_PRODUCT" } ], "intervention_types": [ "COMBINATION_PRODUCT" ], "sponsor": "Joseph Boykin, MD", "sponsor_class": "FED", "healthy_volunteers": false, "eligibility": { "minimum_age": "18 Years", "maximum_age": null, "sex": "ALL", "summary": "18 Years and older" }, "enrollment_count": 15, "start_date": "2021-12-01", "completion_date": "2024-09-24", "has_results": false, "last_update_posted_date": "2024-10-04", "last_synced_at": "2026-09-26T17:07:25.712Z", "location_count": 1, "location_summary": "Richmond, Virginia", "locations": [ { "city": "Richmond", "state": "Virginia" } ], "official_url": "https://clinicaltrials.gov/study/NCT04723134" }, { "nct_id": "NCT04354428", "title": "Treatment for COVID-19 in High-Risk Adult Outpatients", "overall_status": "TERMINATED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE2", "PHASE3" ], "conditions": [ "COVID-19", "SARS-CoV-2" ], "interventions": [ { "name": "Ascorbic Acid", "type": "DRUG" }, { "name": "Hydroxychloroquine Sulfate", "type": "DRUG" }, { "name": "Azithromycin", "type": "DRUG" }, { "name": "Folic Acid", "type": "DRUG" }, { "name": "Lopinavir 200 MG / Ritonavir 50 MG [Kaletra]", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "University of Washington", "sponsor_class": "OTHER", "healthy_volunteers": true, "eligibility": { "minimum_age": "18 Years", "maximum_age": "80 Years", "sex": "ALL", "summary": "18 Years to 80 Years" }, "enrollment_count": 289, "start_date": "2020-04-16", "completion_date": "2020-11-30", "has_results": true, "last_update_posted_date": "2022-08-08", "last_synced_at": "2026-09-26T17:07:25.712Z", "location_count": 6, "location_summary": "Chicago, Illinois • New Orleans, Louisiana • Boston, Massachusetts + 2 more", "locations": [ { "city": "Chicago", "state": "Illinois" }, { "city": "New Orleans", "state": "Louisiana" }, { "city": "Boston", "state": "Massachusetts" }, { "city": "Syracuse", "state": "New York" }, { "city": "Seattle", "state": "Washington" } ], "official_url": "https://clinicaltrials.gov/study/NCT04354428" } ] }