{
  "api_version": "1",
  "request": {
    "url": "https://clinicaltrialsfind.com/api/v1/search.json?intervention=General+anesthesia+and+opioids",
    "query": {
      "intervention": "General anesthesia and opioids"
    },
    "page_size": 10
  },
  "pagination": {
    "page": 1,
    "page_size": 10,
    "total_count": 41,
    "total_pages": 5,
    "next_page_url": "https://clinicaltrialsfind.com/api/v1/search.json?intervention=General+anesthesia+and+opioids&page=2&page_size=10",
    "previous_page_url": null
  },
  "source": "remote",
  "last_synced_at": "2026-09-23T03:28:07.894Z",
  "attribution": "Data derived from public ClinicalTrials.gov records. The official record at https://clinicaltrials.gov/ remains the source of truth for current availability, contacts, and full study details.",
  "notes": [
    "This endpoint exposes only public summary fields — no participant contact emails, phone numbers, or scraped investigator contact details.",
    "For contact information and full protocol detail, follow each trial's `official_url` to the ClinicalTrials.gov record.",
    "This API is a navigational aid. It does not provide medical advice, eligibility determinations, or compensation guarantees."
  ],
  "trials": [
    {
      "nct_id": "NCT04377204",
      "title": "The Utility of Long-acting Local Anesthetic Agents in Reducing Post-operative Opioid Requirements Following Rhinoplasty",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "EARLY_PHASE1"
      ],
      "conditions": [
        "Pain, Postoperative",
        "Local Anesthetic"
      ],
      "interventions": [
        {
          "name": "marcaine bupivacaine",
          "type": "DRUG"
        },
        {
          "name": "Lidocaine",
          "type": "DRUG"
        }
      ],
      "intervention_types": [
        "DRUG"
      ],
      "sponsor": "Our Lady of the Lake Hospital",
      "sponsor_class": "OTHER",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": "100 Years",
        "sex": "ALL",
        "summary": "18 Years to 100 Years"
      },
      "enrollment_count": 5,
      "start_date": "2020-06-01",
      "completion_date": "2022-12-31",
      "has_results": false,
      "last_update_posted_date": "2023-03-23",
      "last_synced_at": "2026-09-23T03:28:07.894Z",
      "location_count": 1,
      "location_summary": "Baton Rouge, Louisiana",
      "locations": [
        {
          "city": "Baton Rouge",
          "state": "Louisiana"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT04377204"
    },
    {
      "nct_id": "NCT00684229",
      "title": "Regional Anesthesia in Colon Rectal Surgery",
      "overall_status": "WITHDRAWN",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Colon Cancer"
      ],
      "interventions": [
        {
          "name": "Regional anesthesia and analgesia",
          "type": "PROCEDURE"
        },
        {
          "name": "general anesthesia followed by opioid analgesia",
          "type": "DRUG"
        }
      ],
      "intervention_types": [
        "PROCEDURE",
        "DRUG"
      ],
      "sponsor": "The Cleveland Clinic",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": "85 Years",
        "sex": "ALL",
        "summary": "18 Years to 85 Years"
      },
      "enrollment_count": 0,
      "start_date": "2007-12",
      "completion_date": "2013-11",
      "has_results": false,
      "last_update_posted_date": "2016-09-15",
      "last_synced_at": "2026-09-23T03:28:07.894Z",
      "location_count": 1,
      "location_summary": "Cleveland, Ohio",
      "locations": [
        {
          "city": "Cleveland",
          "state": "Ohio"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT00684229"
    },
    {
      "nct_id": "NCT04017702",
      "title": "Detection of Postoperative Respiratory Depression in High Risk Patients Utilizing Minute Ventilation Monitoring",
      "overall_status": "COMPLETED",
      "study_type": "OBSERVATIONAL",
      "phases": [],
      "conditions": [
        "Respiratory Depression"
      ],
      "interventions": [
        {
          "name": "Expiron respirator",
          "type": "DEVICE"
        }
      ],
      "intervention_types": [
        "DEVICE"
      ],
      "sponsor": "Yale University",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": "80 Years",
        "sex": "ALL",
        "summary": "18 Years to 80 Years"
      },
      "enrollment_count": 86,
      "start_date": "2018-06-20",
      "completion_date": "2020-02-20",
      "has_results": false,
      "last_update_posted_date": "2022-04-01",
      "last_synced_at": "2026-09-23T03:28:07.894Z",
      "location_count": 1,
      "location_summary": "New Haven, Connecticut",
      "locations": [
        {
          "city": "New Haven",
          "state": "Connecticut"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT04017702"
    },
    {
      "nct_id": "NCT01449708",
      "title": "Effect of Intraoperative Anesthetic Management on Postoperative Nausea and Vomiting in Bariatric Surgery",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE4"
      ],
      "conditions": [
        "Postoperative Nausea and Vomiting"
      ],
      "interventions": [
        {
          "name": "TIVA NoNarc",
          "type": "DRUG"
        }
      ],
      "intervention_types": [
        "DRUG"
      ],
      "sponsor": "Coastal Anesthesiology Consultants",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "18 Years and older"
      },
      "enrollment_count": 124,
      "start_date": "2011-11",
      "completion_date": "2012-10",
      "has_results": true,
      "last_update_posted_date": "2016-03-21",
      "last_synced_at": "2026-09-23T03:28:07.894Z",
      "location_count": 1,
      "location_summary": "Saint Augustine, Florida",
      "locations": [
        {
          "city": "Saint Augustine",
          "state": "Florida"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT01449708"
    },
    {
      "nct_id": "NCT04110080",
      "title": "Enhanced Recovery After Surgery in Kidney Transplant Donors",
      "overall_status": "UNKNOWN",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Opioid Use",
        "Kidney Diseases",
        "Pain, Postoperative",
        "Postoperative Complications",
        "Postoperative Nausea and Vomiting"
      ],
      "interventions": [
        {
          "name": "multimodal pain management",
          "type": "PROCEDURE"
        },
        {
          "name": "goal directed fluid management",
          "type": "OTHER"
        },
        {
          "name": "preoperative carbohydrate loading",
          "type": "OTHER"
        },
        {
          "name": "Donor nephrectomy",
          "type": "PROCEDURE"
        },
        {
          "name": "regional anesthesia",
          "type": "PROCEDURE"
        }
      ],
      "intervention_types": [
        "PROCEDURE",
        "OTHER"
      ],
      "sponsor": "Thomas Jefferson University",
      "sponsor_class": "OTHER",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "18 Years and older"
      },
      "enrollment_count": 42,
      "start_date": "2019-09-12",
      "completion_date": "2023-06-12",
      "has_results": false,
      "last_update_posted_date": "2023-04-18",
      "last_synced_at": "2026-09-23T03:28:07.894Z",
      "location_count": 1,
      "location_summary": "Philadelphia, Pennsylvania",
      "locations": [
        {
          "city": "Philadelphia",
          "state": "Pennsylvania"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT04110080"
    },
    {
      "nct_id": "NCT07552766",
      "title": "A Clinical Trial on the Use of Lidocaine Infusion During Surgery for Pediatric Upper Extremity Fractures and Its Impact on Total Perioperative Opioid Requirements",
      "overall_status": "RECRUITING",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE4"
      ],
      "conditions": [
        "Fracture Arm",
        "Fracture Closed of Lower End of Forearm, Unspecified",
        "Fracture Elbow",
        "Fracture Fixation",
        "Fracture Fixation, Internal",
        "Fracture Forearm",
        "Fracture Distal Radius"
      ],
      "interventions": [
        {
          "name": "Lidocaine Infusion",
          "type": "DRUG"
        },
        {
          "name": "Standard of Care (SOC)",
          "type": "OTHER"
        }
      ],
      "intervention_types": [
        "DRUG",
        "OTHER"
      ],
      "sponsor": "Nemours Children's Clinic",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "3 Years",
        "maximum_age": "18 Years",
        "sex": "ALL",
        "summary": "3 Years to 18 Years"
      },
      "enrollment_count": 90,
      "start_date": "2026-06-24",
      "completion_date": "2029-07",
      "has_results": false,
      "last_update_posted_date": "2026-07-06",
      "last_synced_at": "2026-09-23T03:28:07.894Z",
      "location_count": 1,
      "location_summary": "Wilmington, Delaware",
      "locations": [
        {
          "city": "Wilmington",
          "state": "Delaware"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT07552766"
    },
    {
      "nct_id": "NCT03133845",
      "title": "Shaping Anesthetic Techniques to Reduce Post-operative Delirium",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Delirium",
        "Lumbar Radiculopathy",
        "Lumbar Osteoarthritis",
        "Lumbar Spine Disc Degeneration"
      ],
      "interventions": [
        {
          "name": "Light sedation with propofol",
          "type": "PROCEDURE"
        },
        {
          "name": "Induction with propofol",
          "type": "PROCEDURE"
        },
        {
          "name": "Maintenance anesthetic using a volatile anesthetic",
          "type": "PROCEDURE"
        },
        {
          "name": "Muscle relaxant during maintenance anesthesia",
          "type": "PROCEDURE"
        },
        {
          "name": "Pain control with fentanyl",
          "type": "PROCEDURE"
        },
        {
          "name": "Bispectral Index (BIS) monitoring for depth of anesthesia",
          "type": "PROCEDURE"
        },
        {
          "name": "Spinal Anesthesia",
          "type": "PROCEDURE"
        },
        {
          "name": "Midazolam administered during spinal anesthesia",
          "type": "PROCEDURE"
        },
        {
          "name": "Cerebrospinal fluid collection",
          "type": "PROCEDURE"
        },
        {
          "name": "Administration of intrathecal morphine",
          "type": "PROCEDURE"
        }
      ],
      "intervention_types": [
        "PROCEDURE"
      ],
      "sponsor": "Johns Hopkins University",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "65 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "65 Years and older"
      },
      "enrollment_count": 218,
      "start_date": "2015-10",
      "completion_date": "2020-05-25",
      "has_results": false,
      "last_update_posted_date": "2020-06-18",
      "last_synced_at": "2026-09-23T03:28:07.894Z",
      "location_count": 1,
      "location_summary": "Baltimore, Maryland",
      "locations": [
        {
          "city": "Baltimore",
          "state": "Maryland"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT03133845"
    },
    {
      "nct_id": "NCT05766891",
      "title": "Opioid-Sparing Effects of Nurse-Delivered Hypnosis During Breast Cancer Surgery",
      "overall_status": "RECRUITING",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE2",
        "PHASE3"
      ],
      "conditions": [
        "Breast Cancer"
      ],
      "interventions": [
        {
          "name": "Group 1",
          "type": "BEHAVIORAL"
        },
        {
          "name": "Group 2",
          "type": "BEHAVIORAL"
        },
        {
          "name": "Group 3",
          "type": "BEHAVIORAL"
        }
      ],
      "intervention_types": [
        "BEHAVIORAL"
      ],
      "sponsor": "M.D. Anderson Cancer Center",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "18 Years and older"
      },
      "enrollment_count": 225,
      "start_date": "2023-10-12",
      "completion_date": "2028-12-31",
      "has_results": false,
      "last_update_posted_date": "2026-03-16",
      "last_synced_at": "2026-09-23T03:28:07.894Z",
      "location_count": 1,
      "location_summary": "Houston, Texas",
      "locations": [
        {
          "city": "Houston",
          "state": "Texas"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT05766891"
    },
    {
      "nct_id": "NCT07227389",
      "title": "Timing of Opioid Administration and Postoperative Respiratory Depression.",
      "overall_status": "RECRUITING",
      "study_type": "OBSERVATIONAL",
      "phases": [],
      "conditions": [
        "Respiratory Complications",
        "Opioid Induced Respiratory Depression",
        "Postoperative Respiratory Complications"
      ],
      "interventions": [
        {
          "name": "Respiratory volume monitoring",
          "type": "DIAGNOSTIC_TEST"
        }
      ],
      "intervention_types": [
        "DIAGNOSTIC_TEST"
      ],
      "sponsor": "Wayne State University",
      "sponsor_class": "OTHER",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": "85 Years",
        "sex": "ALL",
        "summary": "18 Years to 85 Years"
      },
      "enrollment_count": 52,
      "start_date": "2026-02-01",
      "completion_date": "2029-02-01",
      "has_results": false,
      "last_update_posted_date": "2026-07-16",
      "last_synced_at": "2026-09-23T03:28:07.894Z",
      "location_count": 1,
      "location_summary": "Detroit, Michigan",
      "locations": [
        {
          "city": "Detroit",
          "state": "Michigan"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT07227389"
    },
    {
      "nct_id": "NCT07565870",
      "title": "Methadone for Enhanced Postoperative Analgesia in Intermediate-Risk Noncardiac Surgery (MELODY)",
      "overall_status": "NOT_YET_RECRUITING",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE3"
      ],
      "conditions": [
        "Postoperative Pain",
        "Recovery"
      ],
      "interventions": [
        {
          "name": "Intravenous Methadone",
          "type": "DRUG"
        },
        {
          "name": "Short-acting Opioids Intraoperative analgesia",
          "type": "DRUG"
        }
      ],
      "intervention_types": [
        "DRUG"
      ],
      "sponsor": "Alexandre P. Joosten",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "18 Years and older"
      },
      "enrollment_count": 400,
      "start_date": "2026-07-01",
      "completion_date": "2027-03-30",
      "has_results": false,
      "last_update_posted_date": "2026-05-04",
      "last_synced_at": "2026-09-23T03:28:07.894Z",
      "location_count": 1,
      "location_summary": "Irvine, California",
      "locations": [
        {
          "city": "Irvine",
          "state": "California"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT07565870"
    }
  ]
}