{
  "api_version": "1",
  "request": {
    "url": "https://clinicaltrialsfind.com/api/v1/search.json?intervention=Grape+seed+polyphenol+extract",
    "query": {
      "intervention": "Grape seed polyphenol extract"
    },
    "page_size": 10
  },
  "pagination": {
    "page": 1,
    "page_size": 10,
    "total_count": 7,
    "total_pages": 1,
    "next_page_url": null,
    "previous_page_url": null
  },
  "source": "remote",
  "last_synced_at": "2026-09-10T08:06:23.945Z",
  "attribution": "Data derived from public ClinicalTrials.gov records. The official record at https://clinicaltrials.gov/ remains the source of truth for current availability, contacts, and full study details.",
  "notes": [
    "This endpoint exposes only public summary fields — no participant contact emails, phone numbers, or scraped investigator contact details.",
    "For contact information and full protocol detail, follow each trial's `official_url` to the ClinicalTrials.gov record.",
    "This API is a navigational aid. It does not provide medical advice, eligibility determinations, or compensation guarantees."
  ],
  "trials": [
    {
      "nct_id": "NCT02502253",
      "title": "BDPP Treatment for Mild Cognitive Impairment (MCI) and Prediabetes or Type 2 Diabetes Mellitus (T2DM)",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE1"
      ],
      "conditions": [
        "Mild Cognitive Impairment",
        "Alzheimer's Disease"
      ],
      "interventions": [
        {
          "name": "grape seed polyphenolic extract, resveratrol",
          "type": "DRUG"
        }
      ],
      "intervention_types": [
        "DRUG"
      ],
      "sponsor": "Johns Hopkins University",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "50 Years",
        "maximum_age": "90 Years",
        "sex": "ALL",
        "summary": "50 Years to 90 Years"
      },
      "enrollment_count": 14,
      "start_date": "2015-06",
      "completion_date": "2022-06-01",
      "has_results": false,
      "last_update_posted_date": "2022-07-22",
      "last_synced_at": "2026-09-10T08:06:23.945Z",
      "location_count": 1,
      "location_summary": "Baltimore, Maryland",
      "locations": [
        {
          "city": "Baltimore",
          "state": "Maryland"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT02502253"
    },
    {
      "nct_id": "NCT01995643",
      "title": "Acute Effects of Grape Seed Extract on Insulin Sensitivity and Oxidative Stress and Inflammation Markers.",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Polyphenolic Compounds and Metabolism"
      ],
      "interventions": [
        {
          "name": "Active Capsule",
          "type": "DIETARY_SUPPLEMENT"
        },
        {
          "name": "Placebo Capsule",
          "type": "DIETARY_SUPPLEMENT"
        }
      ],
      "intervention_types": [
        "DIETARY_SUPPLEMENT"
      ],
      "sponsor": "Clinical Nutrition Research Center, Illinois Institute of Technology",
      "sponsor_class": "INDUSTRY",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "20 Years",
        "maximum_age": "65 Years",
        "sex": "ALL",
        "summary": "20 Years to 65 Years"
      },
      "enrollment_count": 13,
      "start_date": "2013-10-01",
      "completion_date": "2014-08-30",
      "has_results": false,
      "last_update_posted_date": "2021-07-27",
      "last_synced_at": "2026-09-10T08:06:23.945Z",
      "location_count": 1,
      "location_summary": "Chicago, Illinois",
      "locations": [
        {
          "city": "Chicago",
          "state": "Illinois"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT01995643"
    },
    {
      "nct_id": "NCT01185067",
      "title": "Physiological Effects of Grape Seed Extract in Diastolic Heart Failure",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE1"
      ],
      "conditions": [
        "Diastolic Heart Failure",
        "Hypertensive Heart Disease",
        "Heart Failure With Preserved Ejection Fraction",
        "Hypertension",
        "Oxidative Stress"
      ],
      "interventions": [
        {
          "name": "grape seed extract (MegaNatural BP, Polyphenolics, Inc.)",
          "type": "DRUG"
        }
      ],
      "intervention_types": [
        "DRUG"
      ],
      "sponsor": "University of Michigan",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "50 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "50 Years and older"
      },
      "enrollment_count": 15,
      "start_date": "2010-10",
      "completion_date": "2014-02-24",
      "has_results": false,
      "last_update_posted_date": "2017-06-06",
      "last_synced_at": "2026-09-10T08:06:23.945Z",
      "location_count": 1,
      "location_summary": "Ann Arbor, Michigan",
      "locations": [
        {
          "city": "Ann Arbor",
          "state": "Michigan"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT01185067"
    },
    {
      "nct_id": "NCT03203915",
      "title": "Metabolic Response to Chardonnay Grape Marc Powder",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Dyslipidemia",
        "Obesity"
      ],
      "interventions": [
        {
          "name": "Chardonnay grape marc marc high polyphenol dose (120mg)",
          "type": "DIETARY_SUPPLEMENT"
        },
        {
          "name": "Chardonnay grape marc powder low polyphenol dose (75mg)",
          "type": "DIETARY_SUPPLEMENT"
        },
        {
          "name": "Placebo (0mg)",
          "type": "DIETARY_SUPPLEMENT"
        }
      ],
      "intervention_types": [
        "DIETARY_SUPPLEMENT"
      ],
      "sponsor": "USDA, Western Human Nutrition Research Center",
      "sponsor_class": "FED",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "35 Years",
        "maximum_age": "65 Years",
        "sex": "ALL",
        "summary": "35 Years to 65 Years"
      },
      "enrollment_count": 31,
      "start_date": "2017-08-01",
      "completion_date": "2019-06-28",
      "has_results": false,
      "last_update_posted_date": "2021-07-16",
      "last_synced_at": "2026-09-10T08:06:23.945Z",
      "location_count": 1,
      "location_summary": "Davis, California",
      "locations": [
        {
          "city": "Davis",
          "state": "California"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT03203915"
    },
    {
      "nct_id": "NCT04421079",
      "title": "Metabolism of Bioactive Dietary Polyphenol Preparation (BDPP)",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE1"
      ],
      "conditions": [
        "Healthy Control"
      ],
      "interventions": [
        {
          "name": "Trans-resveratrol",
          "type": "DIETARY_SUPPLEMENT"
        },
        {
          "name": "Concord grape juice",
          "type": "DIETARY_SUPPLEMENT"
        },
        {
          "name": "Grape seed polyphenol extract",
          "type": "DIETARY_SUPPLEMENT"
        },
        {
          "name": "Placebo",
          "type": "DRUG"
        }
      ],
      "intervention_types": [
        "DIETARY_SUPPLEMENT",
        "DRUG"
      ],
      "sponsor": "Icahn School of Medicine at Mount Sinai",
      "sponsor_class": "OTHER",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": "55 Years",
        "sex": "ALL",
        "summary": "18 Years to 55 Years"
      },
      "enrollment_count": 84,
      "start_date": "2021-01-19",
      "completion_date": "2024-12-02",
      "has_results": false,
      "last_update_posted_date": "2025-03-03",
      "last_synced_at": "2026-09-10T08:06:23.945Z",
      "location_count": 1,
      "location_summary": "New York, New York",
      "locations": [
        {
          "city": "New York",
          "state": "New York"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT04421079"
    },
    {
      "nct_id": "NCT06309914",
      "title": "The Effects of Mirtoselect®, Virtiva®, and Enovita® on Cognitive Performance and Mood States",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Mental Processes",
        "Cognitive Change",
        "Mood Change"
      ],
      "interventions": [
        {
          "name": "Placebo",
          "type": "DIETARY_SUPPLEMENT"
        },
        {
          "name": "Enovita Grape Seed Extract",
          "type": "DIETARY_SUPPLEMENT"
        },
        {
          "name": "Mirtoselect Bilberry Extract",
          "type": "DIETARY_SUPPLEMENT"
        },
        {
          "name": "Virtiva Plus Ginko Biloba Extract",
          "type": "DIETARY_SUPPLEMENT"
        }
      ],
      "intervention_types": [
        "DIETARY_SUPPLEMENT"
      ],
      "sponsor": "Applied Science & Performance Institute",
      "sponsor_class": "INDUSTRY",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "25 Years",
        "maximum_age": "55 Years",
        "sex": "ALL",
        "summary": "25 Years to 55 Years"
      },
      "enrollment_count": 76,
      "start_date": "2024-02-21",
      "completion_date": "2024-07-08",
      "has_results": false,
      "last_update_posted_date": "2024-07-30",
      "last_synced_at": "2026-09-10T08:06:23.945Z",
      "location_count": 1,
      "location_summary": "Tampa, Florida",
      "locations": [
        {
          "city": "Tampa",
          "state": "Florida"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT06309914"
    },
    {
      "nct_id": "NCT01751750",
      "title": "Grape Polyphenol Kinetics in Humans",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Healthy Volunteers"
      ],
      "interventions": [
        {
          "name": "Grape",
          "type": "OTHER"
        }
      ],
      "intervention_types": [
        "OTHER"
      ],
      "sponsor": "Janet Novotny",
      "sponsor_class": "FED",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": null,
        "maximum_age": "59 Years",
        "sex": "ALL",
        "summary": "Up to 59 Years"
      },
      "enrollment_count": 16,
      "start_date": "2011-09",
      "completion_date": "2011-09",
      "has_results": false,
      "last_update_posted_date": "2017-05-25",
      "last_synced_at": "2026-09-10T08:06:23.945Z",
      "location_count": 1,
      "location_summary": "Beltsville, Maryland",
      "locations": [
        {
          "city": "Beltsville",
          "state": "Maryland"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT01751750"
    }
  ]
}