{ "api_version": "1", "request": { "url": "https://clinicaltrialsfind.com/api/v1/search.json?intervention=HCTZ&page=2", "query": { "intervention": "HCTZ", "page": 2 }, "page_size": 10 }, "pagination": { "page": 2, "page_size": 10, "total_count": 10, "total_pages": 1, "next_page_url": null, "previous_page_url": "https://clinicaltrialsfind.com/api/v1/search.json?intervention=HCTZ&page=1&page_size=10" }, "source": "remote", "last_synced_at": "2026-09-09T17:09:59.945Z", "attribution": "Data derived from public ClinicalTrials.gov records. The official record at https://clinicaltrials.gov/ remains the source of truth for current availability, contacts, and full study details.", "notes": [ "This endpoint exposes only public summary fields — no participant contact emails, phone numbers, or scraped investigator contact details.", "For contact information and full protocol detail, follow each trial's `official_url` to the ClinicalTrials.gov record.", "This API is a navigational aid. It does not provide medical advice, eligibility determinations, or compensation guarantees." ], "trials": [ { "nct_id": "NCT00649441", "title": "Fasting Study of Quinapril HCl and Hydrochlorothiazide Tablets 20 mg/25 mg to Accuretic™ Tablets 20 mg/25 mg", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE1" ], "conditions": [ "Healthy" ], "interventions": [ { "name": "Quinapril HCl and Hydrochlorothiazide Tablets 20 mg/25 mg", "type": "DRUG" }, { "name": "Accuretic™ Tablets 20 mg/25 mg", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "Mylan Pharmaceuticals Inc", "sponsor_class": "INDUSTRY", "healthy_volunteers": true, "eligibility": { "minimum_age": "18 Years", "maximum_age": null, "sex": "ALL", "summary": "18 Years and older" }, "enrollment_count": 60, "start_date": "2003-08", "completion_date": "2003-09", "has_results": false, "last_update_posted_date": "2024-04-24", "last_synced_at": "2026-09-09T17:09:59.945Z", "location_count": 1, "location_summary": "Fargo, North Dakota", "locations": [ { "city": "Fargo", "state": "North Dakota" } ], "official_url": "https://clinicaltrials.gov/study/NCT00649441" }, { "nct_id": "NCT00698646", "title": "Efficacy and Safety of Valsartan/Hydrochlorothiazide Combination Compared to Valsartan Monotherapy or Hydrochlorothiazide Monotherapy in Elderly (>70) With Mild-moderate Hypertension.", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE4" ], "conditions": [ "Hypertension" ], "interventions": [ { "name": "Valsartan + HCTZ", "type": "DRUG" }, { "name": "Valsartan", "type": "DRUG" }, { "name": "HCTZ", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "Novartis Pharmaceuticals", "sponsor_class": "INDUSTRY", "healthy_volunteers": false, "eligibility": { "minimum_age": "70 Years", "maximum_age": null, "sex": "ALL", "summary": "70 Years and older" }, "enrollment_count": 384, "start_date": "2008-04", "completion_date": "2009-06", "has_results": true, "last_update_posted_date": "2011-04-19", "last_synced_at": "2026-09-09T17:09:59.945Z", "location_count": 20, "location_summary": "Birmingham, Alabama • Phoenix, Arizona • Escondido, California + 17 more", "locations": [ { "city": "Birmingham", "state": "Alabama" }, { "city": "Phoenix", "state": "Arizona" }, { "city": "Escondido", "state": "California" }, { "city": "Fresno", "state": "California" }, { "city": "Huntington Park", "state": "California" } ], "official_url": "https://clinicaltrials.gov/study/NCT00698646" }, { "nct_id": "NCT00478335", "title": "Pharmacologic Treatment of Congenital Nephrogenic Diabetes Insipidus", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "NA" ], "conditions": [ "Nephrogenic Diabetes Insipidus" ], "interventions": [ { "name": "sildenafil", "type": "DRUG" }, { "name": "calcitonin", "type": "DRUG" }, { "name": "hydrochlorothiazide/amiloride", "type": "DRUG" }, { "name": "indomethacin", "type": "DRUG" }, { "name": "Placebo for sildenafil", "type": "DRUG" }, { "name": "placebo for calcitonin", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "University of Colorado, Denver", "sponsor_class": "OTHER", "healthy_volunteers": false, "eligibility": { "minimum_age": "5 Years", "maximum_age": "25 Years", "sex": "MALE", "summary": "5 Years to 25 Years · Male only" }, "enrollment_count": 4, "start_date": "2007-05", "completion_date": "2012-10", "has_results": true, "last_update_posted_date": "2018-02-12", "last_synced_at": "2026-09-09T17:09:59.945Z", "location_count": 1, "location_summary": "Aurora, Colorado", "locations": [ { "city": "Aurora", "state": "Colorado" } ], "official_url": "https://clinicaltrials.gov/study/NCT00478335" }, { "nct_id": "NCT00223717", "title": "Treatment of Supine Hypertension in Autonomic Failure", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE1" ], "conditions": [ "Hypertension" ], "interventions": [ { "name": "Clonidine", "type": "DRUG" }, { "name": "Nitroglycerin transdermal", "type": "DRUG" }, { "name": "Dipyridamole/ Aspirin (Aggrenox)", "type": "DRUG" }, { "name": "Desmopressin (DDAVP)", "type": "DRUG" }, { "name": "Sildenafil", "type": "DRUG" }, { "name": "Nifedipine", "type": "DRUG" }, { "name": "Hydralazine", "type": "DRUG" }, { "name": "Hydrochlorothiazide", "type": "DRUG" }, { "name": "Placebo", "type": "DRUG" }, { "name": "Bosentan", "type": "DRUG" }, { "name": "Diltiazem", "type": "DRUG" }, { "name": "Eplerenone", "type": "DRUG" }, { "name": "guanfacine", "type": "DRUG" }, { "name": "L-arginine", "type": "DIETARY_SUPPLEMENT" }, { "name": "captopril", "type": "DRUG" }, { "name": "carbidopa", "type": "DRUG" }, { "name": "losartan", "type": "DRUG" }, { "name": "metoprolol tartrate", "type": "DRUG" }, { "name": "nebivolol hydrochloride", "type": "DRUG" }, { "name": "prazosin hydrochloride", "type": "DRUG" }, { "name": "tamsulosin hydrochloride", "type": "DRUG" }, { "name": "Head-up tilt.", "type": "OTHER" }, { "name": "aliskiren", "type": "DRUG" }, { "name": "Local heat stress", "type": "OTHER" } ], "intervention_types": [ "DRUG", "DIETARY_SUPPLEMENT", "OTHER" ], "sponsor": "Vanderbilt University", "sponsor_class": "OTHER", "healthy_volunteers": false, "eligibility": { "minimum_age": "18 Years", "maximum_age": "80 Years", "sex": "ALL", "summary": "18 Years to 80 Years" }, "enrollment_count": 152, "start_date": "2001-01", "completion_date": "2017-01", "has_results": false, "last_update_posted_date": "2017-10-13", "last_synced_at": "2026-09-09T17:09:59.945Z", "location_count": 1, "location_summary": "Nashville, Tennessee", "locations": [ { "city": "Nashville", "state": "Tennessee" } ], "official_url": "https://clinicaltrials.gov/study/NCT00223717" }, { "nct_id": "NCT00835042", "title": "Moexipril HCL/Hydrochlorothiazide 15/25 mg Tablets Under Fasting Conditions", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE1" ], "conditions": [ "Healthy" ], "interventions": [ { "name": "Moexipril HCl/hydrochlorothiazide 15/25 mg tablets", "type": "DRUG" }, { "name": "UNIRETIC® 15/25 mg tablets", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "Teva Pharmaceuticals USA", "sponsor_class": "INDUSTRY", "healthy_volunteers": true, "eligibility": { "minimum_age": "18 Years", "maximum_age": null, "sex": "ALL", "summary": "18 Years and older" }, "enrollment_count": 60, "start_date": "2003-10", "completion_date": "2003-11", "has_results": true, "last_update_posted_date": "2024-08-20", "last_synced_at": "2026-09-09T17:09:59.945Z", "location_count": 2, "location_summary": "Saint Charles, Missouri • Houston, Texas", "locations": [ { "city": "Saint Charles", "state": "Missouri" }, { "city": "Houston", "state": "Texas" } ], "official_url": "https://clinicaltrials.gov/study/NCT00835042" }, { "nct_id": "NCT00439738", "title": "Safety/Efficacy of Valsartan/Hydrochlorothiazide Combination Compared to Hydrochlorothiazide in Obese Hypertensive Adults", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE4" ], "conditions": [ "Hypertension" ], "interventions": [ { "name": "HCTZ + Amlodipine", "type": "DRUG" }, { "name": "Valsartan/HCTZ", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "Novartis Pharmaceuticals", "sponsor_class": "INDUSTRY", "healthy_volunteers": false, "eligibility": { "minimum_age": "40 Years", "maximum_age": null, "sex": "ALL", "summary": "40 Years and older" }, "enrollment_count": 412, "start_date": "2006-12", "completion_date": null, "has_results": true, "last_update_posted_date": "2017-05-16", "last_synced_at": "2026-09-09T17:09:59.945Z", "location_count": 5, "location_summary": "Muscle Shoals, Alabama • Westlake Village, California • Oklahoma City, Oklahoma + 2 more", "locations": [ { "city": "Muscle Shoals", "state": "Alabama" }, { "city": "Westlake Village", "state": "California" }, { "city": "Oklahoma City", "state": "Oklahoma" }, { "city": "Euless", "state": "Texas" }, { "city": "Port Orchard", "state": "Washington" } ], "official_url": "https://clinicaltrials.gov/study/NCT00439738" }, { "nct_id": "NCT05582837", "title": "Treatment of Meniere's Disease With Migraine Medications", "overall_status": "RECRUITING", "study_type": "INTERVENTIONAL", "phases": [ "PHASE4" ], "conditions": [ "Ménière" ], "interventions": [ { "name": "nortriptyline + topiramate", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "University of California, Irvine", "sponsor_class": "OTHER", "healthy_volunteers": false, "eligibility": { "minimum_age": "25 Years", "maximum_age": "85 Years", "sex": "ALL", "summary": "25 Years to 85 Years" }, "enrollment_count": 40, "start_date": "2022-08-01", "completion_date": "2027-12-30", "has_results": false, "last_update_posted_date": "2026-06-22", "last_synced_at": "2026-09-09T17:09:59.945Z", "location_count": 1, "location_summary": "Orange, California", "locations": [ { "city": "Orange", "state": "California" } ], "official_url": "https://clinicaltrials.gov/study/NCT05582837" }, { "nct_id": "NCT00931710", "title": "Valsartan/Amlodipine As Compared to Losartan Treatment in Stage 2 Systolic Hypertension", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE4" ], "conditions": [ "Stage 2 Systolic Hypertension" ], "interventions": [ { "name": "valsartan, amlodipine, HCTZ", "type": "DRUG" }, { "name": "Losartan, HCTZ followed by valsartan, amlodipine, HCTZ", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "Novartis", "sponsor_class": "INDUSTRY", "healthy_volunteers": false, "eligibility": { "minimum_age": "18 Years", "maximum_age": null, "sex": "ALL", "summary": "18 Years and older" }, "enrollment_count": 488, "start_date": "2009-07", "completion_date": "2010-01", "has_results": true, "last_update_posted_date": "2011-03-07", "last_synced_at": "2026-09-09T17:09:59.945Z", "location_count": 1, "location_summary": "East Hanover, New Jersey", "locations": [ { "city": "East Hanover", "state": "New Jersey" } ], "official_url": "https://clinicaltrials.gov/study/NCT00931710" }, { "nct_id": "NCT00283686", "title": "HALT Progression of Polycystic Kidney Disease Study A", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE3" ], "conditions": [ "Kidney, Polycystic" ], "interventions": [ { "name": "Lisinopril", "type": "DRUG" }, { "name": "Telmisartan", "type": "DRUG" }, { "name": "Placebo", "type": "DRUG" }, { "name": "Standard Blood Pressure Control", "type": "OTHER" }, { "name": "Low Blood Pressure Control", "type": "OTHER" } ], "intervention_types": [ "DRUG", "OTHER" ], "sponsor": "National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)", "sponsor_class": "NIH", "healthy_volunteers": false, "eligibility": { "minimum_age": "15 Years", "maximum_age": "64 Years", "sex": "ALL", "summary": "15 Years to 64 Years" }, "enrollment_count": 558, "start_date": "2006-01", "completion_date": "2014-06", "has_results": true, "last_update_posted_date": "2020-04-21", "last_synced_at": "2026-09-09T17:09:59.945Z", "location_count": 7, "location_summary": "Aurora, Colorado • Atlanta, Georgia • Kansas City, Kansas + 3 more", "locations": [ { "city": "Aurora", "state": "Colorado" }, { "city": "Atlanta", "state": "Georgia" }, { "city": "Kansas City", "state": "Kansas" }, { "city": "Boston", "state": "Massachusetts" }, { "city": "Boston", "state": "Massachusetts" } ], "official_url": "https://clinicaltrials.gov/study/NCT00283686" }, { "nct_id": "NCT01033071", "title": "Efficacy and Safety of Azilsartan Medoxomil and Chlorthalidone Compared to Olmesartan Medoxomil and Hydrochlorothiazide in Participants With Moderate to Severe Hypertension.", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE3" ], "conditions": [ "Essential Hypertension" ], "interventions": [ { "name": "Azilsartan medoxomil and chlorthalidone", "type": "DRUG" }, { "name": "Olmesartan medoxomil and hydrochlorothiazide", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "Takeda", "sponsor_class": "INDUSTRY", "healthy_volunteers": false, "eligibility": { "minimum_age": "18 Years", "maximum_age": null, "sex": "ALL", "summary": "18 Years and older" }, "enrollment_count": 1071, "start_date": "2010-01", "completion_date": "2010-11", "has_results": true, "last_update_posted_date": "2012-02-07", "last_synced_at": "2026-09-09T17:09:59.945Z", "location_count": 84, "location_summary": "Gulf Shores, Alabama • Litchfield Park, Arizona • Mesa, Arizona + 81 more", "locations": [ { "city": "Gulf Shores", "state": "Alabama" }, { "city": "Litchfield Park", "state": "Arizona" }, { "city": "Mesa", "state": "Arizona" }, { "city": "Scottsdale", "state": "Arizona" }, { "city": "Tucson", "state": "Arizona" } ], "official_url": "https://clinicaltrials.gov/study/NCT01033071" } ] }