{ "api_version": "1", "request": { "url": "https://clinicaltrialsfind.com/api/v1/search.json?intervention=HCTZ+%2B+Amlodipine&page=2", "query": { "intervention": "HCTZ + Amlodipine", "page": 2 }, "page_size": 10 }, "pagination": { "page": 2, "page_size": 10, "total_count": 45, "total_pages": 5, "next_page_url": "https://clinicaltrialsfind.com/api/v1/search.json?intervention=HCTZ+%2B+Amlodipine&page=3&page_size=10", "previous_page_url": "https://clinicaltrialsfind.com/api/v1/search.json?intervention=HCTZ+%2B+Amlodipine&page=1&page_size=10" }, "source": "remote", "last_synced_at": "2026-10-03T23:00:29.274Z", "attribution": "Data derived from public ClinicalTrials.gov records. The official record at https://clinicaltrials.gov/ remains the source of truth for current availability, contacts, and full study details.", "notes": [ "This endpoint exposes only public summary fields — no participant contact emails, phone numbers, or scraped investigator contact details.", "For contact information and full protocol detail, follow each trial's `official_url` to the ClinicalTrials.gov record.", "This API is a navigational aid. It does not provide medical advice, eligibility determinations, or compensation guarantees." ], "trials": [ { "nct_id": "NCT01432106", "title": "The Study of Novel Dual Renin Angiotensin Aldosterone System (RAAS) Blockade; Valsartan/Aliskiren in African American Patients With Hypertension and the Metabolic Syndrome", "overall_status": "WITHDRAWN", "study_type": "INTERVENTIONAL", "phases": [ "PHASE1" ], "conditions": [ "Hypertension", "Metabolic Syndrome" ], "interventions": [ { "name": "Aliskerin/Valsartan and Rampiril", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "University of Michigan", "sponsor_class": "OTHER", "healthy_volunteers": true, "eligibility": { "minimum_age": "18 Years", "maximum_age": "80 Years", "sex": "ALL", "summary": "18 Years to 80 Years" }, "enrollment_count": 0, "start_date": "2011-02", "completion_date": "2012-12", "has_results": false, "last_update_posted_date": "2013-11-18", "last_synced_at": "2026-10-03T23:00:29.274Z", "location_count": 1, "location_summary": "Ann Arbor, Michigan", "locations": [ { "city": "Ann Arbor", "state": "Michigan" } ], "official_url": "https://clinicaltrials.gov/study/NCT01432106" }, { "nct_id": "NCT00667719", "title": "A Long Term Safety Study to Test the Combination of Aliskiren/ Amlodipine / Hydrochlorothiazide in Participants With Essential Hypertension", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE3" ], "conditions": [ "Essential Hypertension" ], "interventions": [ { "name": "Aliskiren", "type": "DRUG" }, { "name": "Amlodipine", "type": "DRUG" }, { "name": "Hydrochlorothiazide", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "Novartis", "sponsor_class": "INDUSTRY", "healthy_volunteers": false, "eligibility": { "minimum_age": "18 Years", "maximum_age": null, "sex": "ALL", "summary": "18 Years and older" }, "enrollment_count": 564, "start_date": "2008-06-05", "completion_date": "2009-10-05", "has_results": true, "last_update_posted_date": "2021-06-07", "last_synced_at": "2026-10-03T23:00:29.274Z", "location_count": 1, "location_summary": "Houston, Texas", "locations": [ { "city": "Houston", "state": "Texas" } ], "official_url": "https://clinicaltrials.gov/study/NCT00667719" }, { "nct_id": "NCT01259297", "title": "A Randomized Controlled Trial of Aliskiren in the Prevention of Major Cardiovascular Events in Elderly People", "overall_status": "TERMINATED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE3" ], "conditions": [ "Cardiovascular Events" ], "interventions": [ { "name": "Aliskiren", "type": "DRUG" }, { "name": "Amlodipine", "type": "DRUG" }, { "name": "Hydrochlorothiazide (HCTZ)", "type": "DRUG" }, { "name": "Placebo for Aliskiren", "type": "DRUG" }, { "name": "Placebo for Amlodipine", "type": "DRUG" }, { "name": "Placebo for Hydrochlorothiazide (HCTZ)", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "Novartis Pharmaceuticals", "sponsor_class": "INDUSTRY", "healthy_volunteers": false, "eligibility": { "minimum_age": "65 Years", "maximum_age": null, "sex": "ALL", "summary": "65 Years and older" }, "enrollment_count": 2336, "start_date": "2011-01", "completion_date": "2012-11", "has_results": true, "last_update_posted_date": "2014-04-08", "last_synced_at": "2026-10-03T23:00:29.274Z", "location_count": 14, "location_summary": "Birmingham, Alabama • Los Angeles, California • Northridge, California + 11 more", "locations": [ { "city": "Birmingham", "state": "Alabama" }, { "city": "Los Angeles", "state": "California" }, { "city": "Northridge", "state": "California" }, { "city": "Sylmar", "state": "California" }, { "city": "Tucker", "state": "Georgia" } ], "official_url": "https://clinicaltrials.gov/study/NCT01259297" }, { "nct_id": "NCT00787605", "title": "Aliskiren HCTZ Compared to Amlodipine in Patients With Stage 2 Systolic Hypertension and Diabetes Mellitus", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE4" ], "conditions": [ "Hypertension", "Diabetes Mellitus" ], "interventions": [ { "name": "Amlodipine", "type": "DRUG" }, { "name": "Hydrochlorothiazide (HCTZ)", "type": "DRUG" }, { "name": "Aliskiren", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "Novartis", "sponsor_class": "INDUSTRY", "healthy_volunteers": false, "eligibility": { "minimum_age": "18 Years", "maximum_age": null, "sex": "ALL", "summary": "18 Years and older" }, "enrollment_count": 860, "start_date": "2008-11", "completion_date": "2010-01", "has_results": true, "last_update_posted_date": "2016-10-27", "last_synced_at": "2026-10-03T23:00:29.274Z", "location_count": 1, "location_summary": "East Hanover, New Jersey", "locations": [ { "city": "East Hanover", "state": "New Jersey" } ], "official_url": "https://clinicaltrials.gov/study/NCT00787605" }, { "nct_id": "NCT00185120", "title": "Treatment of High Blood Pressure Using Olmesartan With Hydrochlorothiazide Compared to an ACE Inhibitor With a Calcium Channel Blocker", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE4" ], "conditions": [ "Hypertension" ], "interventions": [ { "name": "Olmesartan medoxomil", "type": "DRUG" }, { "name": "Hydroclorothiazide", "type": "DRUG" }, { "name": "Benazepril", "type": "DRUG" }, { "name": "Amlodipine", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "Daiichi Sankyo", "sponsor_class": "INDUSTRY", "healthy_volunteers": false, "eligibility": { "minimum_age": "18 Years", "maximum_age": null, "sex": "ALL", "summary": "18 Years and older" }, "enrollment_count": 152, "start_date": "2005-09", "completion_date": "2006-09", "has_results": false, "last_update_posted_date": "2012-01-18", "last_synced_at": "2026-10-03T23:00:29.274Z", "location_count": 20, "location_summary": "Mobile, Alabama • Long Beach, California • Los Angeles, California + 17 more", "locations": [ { "city": "Mobile", "state": "Alabama" }, { "city": "Long Beach", "state": "California" }, { "city": "Los Angeles", "state": "California" }, { "city": "Roseville", "state": "California" }, { "city": "Santa Ana", "state": "California" } ], "official_url": "https://clinicaltrials.gov/study/NCT00185120" }, { "nct_id": "NCT00000620", "title": "Action to Control Cardiovascular Risk in Diabetes (ACCORD)", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE3" ], "conditions": [ "Atherosclerosis", "Cardiovascular Diseases", "Hypercholesterolemia", "Hypertension", "Diabetes Mellitus, Type 2", "Diabetes Mellitus", "Coronary Disease" ], "interventions": [ { "name": "Anti-hyperglycemic Agents", "type": "DRUG" }, { "name": "Anti-hypertensive Agents", "type": "DRUG" }, { "name": "Blinded fenofibrate or placebo plus simvastatin", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "National Heart, Lung, and Blood Institute (NHLBI)", "sponsor_class": "NIH", "healthy_volunteers": false, "eligibility": { "minimum_age": "40 Years", "maximum_age": "79 Years", "sex": "ALL", "summary": "40 Years to 79 Years" }, "enrollment_count": 10251, "start_date": "1999-09", "completion_date": "2012-12", "has_results": true, "last_update_posted_date": "2016-11-22", "last_synced_at": "2026-10-03T23:00:29.274Z", "location_count": 6, "location_summary": "Minneapolis, Minnesota • New York, New York • Winston-Salem, North Carolina + 3 more", "locations": [ { "city": "Minneapolis", "state": "Minnesota" }, { "city": "New York", "state": "New York" }, { "city": "Winston-Salem", "state": "North Carolina" }, { "city": "Cleveland", "state": "Ohio" }, { "city": "Memphis", "state": "Tennessee" } ], "official_url": "https://clinicaltrials.gov/study/NCT00000620" }, { "nct_id": "NCT02744456", "title": "N-of-1 Trials for Blood Pressure Medications in Adults", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "EARLY_PHASE1" ], "conditions": [ "Hypertension", "High Blood Pressure" ], "interventions": [ { "name": "Losartan", "type": "DRUG" }, { "name": "Amlodipine", "type": "DRUG" }, { "name": "Hydrochlorothiazide", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "Columbia University", "sponsor_class": "OTHER", "healthy_volunteers": false, "eligibility": { "minimum_age": "21 Years", "maximum_age": "80 Years", "sex": "ALL", "summary": "21 Years to 80 Years" }, "enrollment_count": 10, "start_date": "2014-08-01", "completion_date": "2017-12-31", "has_results": false, "last_update_posted_date": "2019-03-26", "last_synced_at": "2026-10-03T23:00:29.274Z", "location_count": 1, "location_summary": "New York, New York", "locations": [ { "city": "New York", "state": "New York" } ], "official_url": "https://clinicaltrials.gov/study/NCT02744456" }, { "nct_id": "NCT01692301", "title": "Study of the Safety and Efficacy of LCZ696 on Arterial Stiffness in Elderly Patients With Hypertension", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE2" ], "conditions": [ "Hypertension" ], "interventions": [ { "name": "LCZ696", "type": "DRUG" }, { "name": "Olmesartan", "type": "DRUG" }, { "name": "LCZ696 matching placebo", "type": "DRUG" }, { "name": "Olmesartan matching placebo", "type": "DRUG" }, { "name": "amlodipine", "type": "DRUG" }, { "name": "hydrochlorothiazide", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "Novartis Pharmaceuticals", "sponsor_class": "INDUSTRY", "healthy_volunteers": false, "eligibility": { "minimum_age": "60 Years", "maximum_age": null, "sex": "ALL", "summary": "60 Years and older" }, "enrollment_count": 454, "start_date": "2012-12", "completion_date": "2015-04", "has_results": true, "last_update_posted_date": "2016-05-04", "last_synced_at": "2026-10-03T23:00:29.274Z", "location_count": 11, "location_summary": "Clearwater, Florida • Chicago, Illinois • Baltimore, Maryland + 8 more", "locations": [ { "city": "Clearwater", "state": "Florida" }, { "city": "Chicago", "state": "Illinois" }, { "city": "Baltimore", "state": "Maryland" }, { "city": "Belzoni", "state": "Mississippi" }, { "city": "Jackson", "state": "Mississippi" } ], "official_url": "https://clinicaltrials.gov/study/NCT01692301" }, { "nct_id": "NCT00439738", "title": "Safety/Efficacy of Valsartan/Hydrochlorothiazide Combination Compared to Hydrochlorothiazide in Obese Hypertensive Adults", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE4" ], "conditions": [ "Hypertension" ], "interventions": [ { "name": "HCTZ + Amlodipine", "type": "DRUG" }, { "name": "Valsartan/HCTZ", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "Novartis Pharmaceuticals", "sponsor_class": "INDUSTRY", "healthy_volunteers": false, "eligibility": { "minimum_age": "40 Years", "maximum_age": null, "sex": "ALL", "summary": "40 Years and older" }, "enrollment_count": 412, "start_date": "2006-12", "completion_date": null, "has_results": true, "last_update_posted_date": "2017-05-16", "last_synced_at": "2026-10-03T23:00:29.274Z", "location_count": 5, "location_summary": "Muscle Shoals, Alabama • Westlake Village, California • Oklahoma City, Oklahoma + 2 more", "locations": [ { "city": "Muscle Shoals", "state": "Alabama" }, { "city": "Westlake Village", "state": "California" }, { "city": "Oklahoma City", "state": "Oklahoma" }, { "city": "Euless", "state": "Texas" }, { "city": "Port Orchard", "state": "Washington" } ], "official_url": "https://clinicaltrials.gov/study/NCT00439738" }, { "nct_id": "NCT00654745", "title": "18 Week Study Evaluating Safety and Efficacy of Olmesartan, Amlodipine, and Hydrochlorothiazide, in Type 2 Diabetics", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE4" ], "conditions": [ "Type 2 Diabetes", "Hypertension" ], "interventions": [ { "name": "Amlodipine", "type": "DRUG" }, { "name": "amlodipine / olmesartan medoxomil combination", "type": "DRUG" }, { "name": "Hydrochlorothiazide", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "Daiichi Sankyo", "sponsor_class": "INDUSTRY", "healthy_volunteers": false, "eligibility": { "minimum_age": "18 Years", "maximum_age": "80 Years", "sex": "ALL", "summary": "18 Years to 80 Years" }, "enrollment_count": 207, "start_date": "2008-05", "completion_date": "2009-06", "has_results": true, "last_update_posted_date": "2010-07-13", "last_synced_at": "2026-10-03T23:00:29.274Z", "location_count": 21, "location_summary": "Los Angeles, California • Sylmar, California • Tustin, California + 18 more", "locations": [ { "city": "Los Angeles", "state": "California" }, { "city": "Sylmar", "state": "California" }, { "city": "Tustin", "state": "California" }, { "city": "Aventura", "state": "Florida" }, { "city": "DeLand", "state": "Florida" } ], "official_url": "https://clinicaltrials.gov/study/NCT00654745" } ] }