{
  "api_version": "1",
  "request": {
    "url": "https://clinicaltrialsfind.com/api/v1/search.json?intervention=HEC+gel",
    "query": {
      "intervention": "HEC gel"
    },
    "page_size": 10
  },
  "pagination": {
    "page": 1,
    "page_size": 10,
    "total_count": 32,
    "total_pages": 4,
    "next_page_url": "https://clinicaltrialsfind.com/api/v1/search.json?intervention=HEC+gel&page=2&page_size=10",
    "previous_page_url": null
  },
  "source": "remote",
  "last_synced_at": "2026-09-04T01:34:45.686Z",
  "attribution": "Data derived from public ClinicalTrials.gov records. The official record at https://clinicaltrials.gov/ remains the source of truth for current availability, contacts, and full study details.",
  "notes": [
    "This endpoint exposes only public summary fields — no participant contact emails, phone numbers, or scraped investigator contact details.",
    "For contact information and full protocol detail, follow each trial's `official_url` to the ClinicalTrials.gov record.",
    "This API is a navigational aid. It does not provide medical advice, eligibility determinations, or compensation guarantees."
  ],
  "trials": [
    {
      "nct_id": "NCT01575418",
      "title": "An Exploratory Rectal Safety Study of Three Tenofovir Gel Formulations",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE1"
      ],
      "conditions": [
        "HIV Prevention"
      ],
      "interventions": [
        {
          "name": "Rectal formulation (RF) of tenofovir 1% gel",
          "type": "DRUG"
        },
        {
          "name": "Vaginal formulation (VF) of tenofovir 1% gel",
          "type": "DRUG"
        },
        {
          "name": "Reduced glycerin vaginal formulation (RGVF) of tenofovir 1% gel",
          "type": "DRUG"
        },
        {
          "name": "Radiolabeling of study drugs and semen",
          "type": "RADIATION"
        }
      ],
      "intervention_types": [
        "DRUG",
        "RADIATION"
      ],
      "sponsor": "Ian McGowan",
      "sponsor_class": "OTHER",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": null,
        "sex": "MALE",
        "summary": "18 Years and older · Male only"
      },
      "enrollment_count": 9,
      "start_date": "2013-03",
      "completion_date": "2013-11",
      "has_results": false,
      "last_update_posted_date": "2014-05-08",
      "last_synced_at": "2026-09-04T01:34:45.686Z",
      "location_count": 1,
      "location_summary": "Baltimore, Maryland",
      "locations": [
        {
          "city": "Baltimore",
          "state": "Maryland"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT01575418"
    },
    {
      "nct_id": "NCT02569697",
      "title": "Development of Adherence Biomarkers for Multiple Microbicide and Multipurpose Prevention Technology (MPT) Dosage Forms",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE1"
      ],
      "conditions": [
        "HIV"
      ],
      "interventions": [
        {
          "name": "HEC Placebo gel",
          "type": "OTHER"
        },
        {
          "name": "Placebo Intravaginal Ring",
          "type": "OTHER"
        },
        {
          "name": "Placebo Vaginal Film",
          "type": "OTHER"
        },
        {
          "name": "Placebo Vaginal Insert",
          "type": "OTHER"
        }
      ],
      "intervention_types": [
        "OTHER"
      ],
      "sponsor": "CONRAD",
      "sponsor_class": "OTHER",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": "50 Years",
        "sex": "FEMALE",
        "summary": "18 Years to 50 Years · Female only"
      },
      "enrollment_count": 50,
      "start_date": "2015-10",
      "completion_date": "2016-05",
      "has_results": false,
      "last_update_posted_date": "2016-09-02",
      "last_synced_at": "2026-09-04T01:34:45.686Z",
      "location_count": 1,
      "location_summary": "Norfolk, Virginia",
      "locations": [
        {
          "city": "Norfolk",
          "state": "Virginia"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT02569697"
    },
    {
      "nct_id": "NCT01989663",
      "title": "A Phase I Trial to Assess the Safety of Tenofovir Gel and Film Formulations: FAME 04",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE1"
      ],
      "conditions": [
        "HIV"
      ],
      "interventions": [
        {
          "name": "1% vaginally applied tenofovir gel",
          "type": "DRUG"
        },
        {
          "name": "Tenofovir film- 10mg",
          "type": "DRUG"
        },
        {
          "name": "Tenofovir Film-40 mg",
          "type": "DRUG"
        },
        {
          "name": "HEC Placebo Gel",
          "type": "OTHER"
        },
        {
          "name": "Placebo Vaginal Film",
          "type": "OTHER"
        }
      ],
      "intervention_types": [
        "DRUG",
        "OTHER"
      ],
      "sponsor": "CONRAD",
      "sponsor_class": "OTHER",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": "45 Years",
        "sex": "FEMALE",
        "summary": "18 Years to 45 Years · Female only"
      },
      "enrollment_count": 78,
      "start_date": "2013-11",
      "completion_date": "2015-01",
      "has_results": false,
      "last_update_posted_date": "2016-07-27",
      "last_synced_at": "2026-09-04T01:34:45.686Z",
      "location_count": 1,
      "location_summary": "Pittsburgh, Pennsylvania",
      "locations": [
        {
          "city": "Pittsburgh",
          "state": "Pennsylvania"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT01989663"
    },
    {
      "nct_id": "NCT00799058",
      "title": "A Safety Study of Two Dapivirine (TMC120) Vaginal Gels in the United States",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE1",
        "PHASE2"
      ],
      "conditions": [
        "HIV-1 Infections"
      ],
      "interventions": [
        {
          "name": "dapivirine 4789",
          "type": "DRUG"
        },
        {
          "name": "dapivirine gel 4759",
          "type": "DRUG"
        },
        {
          "name": "Drug placebo",
          "type": "DRUG"
        }
      ],
      "intervention_types": [
        "DRUG"
      ],
      "sponsor": "International Partnership for Microbicides, Inc.",
      "sponsor_class": "INDUSTRY",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": "40 Years",
        "sex": "FEMALE",
        "summary": "18 Years to 40 Years · Female only"
      },
      "enrollment_count": 128,
      "start_date": "2009-07-06",
      "completion_date": "2011-01-08",
      "has_results": true,
      "last_update_posted_date": "2022-10-25",
      "last_synced_at": "2026-09-04T01:34:45.686Z",
      "location_count": 5,
      "location_summary": "Birmingham, Alabama • Torrance, California • Chicago, Illinois + 2 more",
      "locations": [
        {
          "city": "Birmingham",
          "state": "Alabama"
        },
        {
          "city": "Torrance",
          "state": "California"
        },
        {
          "city": "Chicago",
          "state": "Illinois"
        },
        {
          "city": "Baltimore",
          "state": "Maryland"
        },
        {
          "city": "New York",
          "state": "New York"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT00799058"
    },
    {
      "nct_id": "NCT05386147",
      "title": "Flourish HEC to Prevent Recurrence of BV",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Bacterial Vaginosis"
      ],
      "interventions": [
        {
          "name": "Flourish HEC Vaginal Care System (contains a class II medical device plus other unregulated components)",
          "type": "DEVICE"
        }
      ],
      "intervention_types": [
        "DEVICE"
      ],
      "sponsor": "Vaginal Biome Science",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": "52 Years",
        "sex": "FEMALE",
        "summary": "18 Years to 52 Years · Female only"
      },
      "enrollment_count": 6,
      "start_date": "2021-12-22",
      "completion_date": "2022-11-15",
      "has_results": false,
      "last_update_posted_date": "2024-03-08",
      "last_synced_at": "2026-09-04T01:34:45.686Z",
      "location_count": 1,
      "location_summary": "Rosemont, Pennsylvania",
      "locations": [
        {
          "city": "Rosemont",
          "state": "Pennsylvania"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT05386147"
    },
    {
      "nct_id": "NCT02033109",
      "title": "Safety, Pharmacokinetics and Acceptability of PC-1005 for Vaginal Use",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE1"
      ],
      "conditions": [
        "HIV"
      ],
      "interventions": [
        {
          "name": "PC-1005",
          "type": "DRUG"
        },
        {
          "name": "HEC gel",
          "type": "DRUG"
        }
      ],
      "intervention_types": [
        "DRUG"
      ],
      "sponsor": "Population Council",
      "sponsor_class": "OTHER",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "19 Years",
        "maximum_age": "49 Years",
        "sex": "FEMALE",
        "summary": "19 Years to 49 Years · Female only"
      },
      "enrollment_count": 35,
      "start_date": "2014-05",
      "completion_date": "2015-06",
      "has_results": false,
      "last_update_posted_date": "2017-08-15",
      "last_synced_at": "2026-09-04T01:34:45.686Z",
      "location_count": 1,
      "location_summary": "Birmingham, Alabama",
      "locations": [
        {
          "city": "Birmingham",
          "state": "Alabama"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT02033109"
    },
    {
      "nct_id": "NCT05701722",
      "title": "Effect of Flourish HEC Vaginal Care System on BV Recurrence and the Vaginal Microbiome",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Bacterial Vaginosis"
      ],
      "interventions": [
        {
          "name": "Flourish HEC Vaginal Care System",
          "type": "DEVICE"
        }
      ],
      "intervention_types": [
        "DEVICE"
      ],
      "sponsor": "Vaginal Biome Science",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": "52 Years",
        "sex": "FEMALE",
        "summary": "18 Years to 52 Years · Female only"
      },
      "enrollment_count": 7,
      "start_date": "2023-03-29",
      "completion_date": "2024-02-15",
      "has_results": false,
      "last_update_posted_date": "2024-03-07",
      "last_synced_at": "2026-09-04T01:34:45.686Z",
      "location_count": 1,
      "location_summary": "Tulsa, Oklahoma",
      "locations": [
        {
          "city": "Tulsa",
          "state": "Oklahoma"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT05701722"
    },
    {
      "nct_id": "NCT02693418",
      "title": "Duration of Effect of Acidform Gel on Vaginal pH",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE1"
      ],
      "conditions": [
        "Healthy"
      ],
      "interventions": [
        {
          "name": "Acidform 5 g",
          "type": "DRUG"
        },
        {
          "name": "Placebo 4 g",
          "type": "DRUG"
        },
        {
          "name": "Acidform 4 g",
          "type": "DRUG"
        },
        {
          "name": "Acidform 3 g",
          "type": "DRUG"
        }
      ],
      "intervention_types": [
        "DRUG"
      ],
      "sponsor": "Evofem Inc.",
      "sponsor_class": "INDUSTRY",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": "45 Years",
        "sex": "FEMALE",
        "summary": "18 Years to 45 Years · Female only"
      },
      "enrollment_count": 105,
      "start_date": "2016-08-24",
      "completion_date": "2016-12-12",
      "has_results": true,
      "last_update_posted_date": "2020-11-20",
      "last_synced_at": "2026-09-04T01:34:45.686Z",
      "location_count": 2,
      "location_summary": "Baltimore, Maryland • Cleveland, Ohio",
      "locations": [
        {
          "city": "Baltimore",
          "state": "Maryland"
        },
        {
          "city": "Cleveland",
          "state": "Ohio"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT02693418"
    },
    {
      "nct_id": "NCT00850837",
      "title": "Safety of Acidform Lubricant in HIV-Uninfected Women",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE1"
      ],
      "conditions": [
        "HIV Infections"
      ],
      "interventions": [
        {
          "name": "Acidform Lubricant",
          "type": "DRUG"
        },
        {
          "name": "HEC gel",
          "type": "DRUG"
        }
      ],
      "intervention_types": [
        "DRUG"
      ],
      "sponsor": "National Institute of Allergy and Infectious Diseases (NIAID)",
      "sponsor_class": "NIH",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": "50 Years",
        "sex": "FEMALE",
        "summary": "18 Years to 50 Years · Female only"
      },
      "enrollment_count": 35,
      "start_date": "2009-02",
      "completion_date": null,
      "has_results": false,
      "last_update_posted_date": "2013-12-03",
      "last_synced_at": "2026-09-04T01:34:45.686Z",
      "location_count": 1,
      "location_summary": "The Bronx, New York",
      "locations": [
        {
          "city": "The Bronx",
          "state": "New York"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT00850837"
    },
    {
      "nct_id": "NCT01849965",
      "title": "Phase 3 Study Evaluating Efficacy and Safety of DSC127 Compared With Vehicle and With Standard-of-care in Diabetic Foot Ulcers",
      "overall_status": "TERMINATED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE3"
      ],
      "conditions": [
        "Diabetic Foot Ulcers"
      ],
      "interventions": [
        {
          "name": "DSC127",
          "type": "DRUG"
        },
        {
          "name": "placebo vehicle gel",
          "type": "DRUG"
        },
        {
          "name": "Standard of Care gel, Aquasite",
          "type": "DRUG"
        }
      ],
      "intervention_types": [
        "DRUG"
      ],
      "sponsor": "Integra LifeSciences Corporation",
      "sponsor_class": "INDUSTRY",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "18 Years and older"
      },
      "enrollment_count": 396,
      "start_date": "2013-04",
      "completion_date": "2015-12",
      "has_results": false,
      "last_update_posted_date": "2017-12-12",
      "last_synced_at": "2026-09-04T01:34:45.686Z",
      "location_count": 33,
      "location_summary": "Mesa, Arizona • Phoenix, Arizona • Castro Valley, California + 25 more",
      "locations": [
        {
          "city": "Mesa",
          "state": "Arizona"
        },
        {
          "city": "Phoenix",
          "state": "Arizona"
        },
        {
          "city": "Phoenix",
          "state": "Arizona"
        },
        {
          "city": "Phoenix",
          "state": "Arizona"
        },
        {
          "city": "Phoenix",
          "state": "Arizona"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT01849965"
    }
  ]
}