{
  "api_version": "1",
  "request": {
    "url": "https://clinicaltrialsfind.com/api/v1/search.json?intervention=High+Flow+Nasal+Cannula",
    "query": {
      "intervention": "High Flow Nasal Cannula"
    },
    "page_size": 10
  },
  "pagination": {
    "page": 1,
    "page_size": 10,
    "total_count": 110,
    "total_pages": 11,
    "next_page_url": "https://clinicaltrialsfind.com/api/v1/search.json?intervention=High+Flow+Nasal+Cannula&page=2&page_size=10",
    "previous_page_url": null
  },
  "source": "remote",
  "last_synced_at": "2026-09-23T05:50:49.410Z",
  "attribution": "Data derived from public ClinicalTrials.gov records. The official record at https://clinicaltrials.gov/ remains the source of truth for current availability, contacts, and full study details.",
  "notes": [
    "This endpoint exposes only public summary fields — no participant contact emails, phone numbers, or scraped investigator contact details.",
    "For contact information and full protocol detail, follow each trial's `official_url` to the ClinicalTrials.gov record.",
    "This API is a navigational aid. It does not provide medical advice, eligibility determinations, or compensation guarantees."
  ],
  "trials": [
    {
      "nct_id": "NCT04517344",
      "title": "High Flow Nasal Cannula (HFNC) Initiation Flow Rate Study",
      "overall_status": "TERMINATED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Bronchiolitis"
      ],
      "interventions": [
        {
          "name": "Initial Flow Rate",
          "type": "OTHER"
        }
      ],
      "intervention_types": [
        "OTHER"
      ],
      "sponsor": "University of Texas Southwestern Medical Center",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "7 Days",
        "maximum_age": "12 Months",
        "sex": "ALL",
        "summary": "7 Days to 12 Months"
      },
      "enrollment_count": 21,
      "start_date": "2020-12-01",
      "completion_date": "2025-04-01",
      "has_results": false,
      "last_update_posted_date": "2025-05-16",
      "last_synced_at": "2026-09-23T05:50:49.410Z",
      "location_count": 1,
      "location_summary": "Dallas, Texas",
      "locations": [
        {
          "city": "Dallas",
          "state": "Texas"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT04517344"
    },
    {
      "nct_id": "NCT03738345",
      "title": "The Effects of Flow Settings During High Flow Nasal Cannula for Adult Hypoxemia Patients",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Hypoxemia"
      ],
      "interventions": [
        {
          "name": "HFNC flow",
          "type": "OTHER"
        }
      ],
      "intervention_types": [
        "OTHER"
      ],
      "sponsor": "Rush University Medical Center",
      "sponsor_class": "OTHER",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": "90 Years",
        "sex": "ALL",
        "summary": "18 Years to 90 Years"
      },
      "enrollment_count": 49,
      "start_date": "2018-12-26",
      "completion_date": "2021-03-30",
      "has_results": false,
      "last_update_posted_date": "2021-04-23",
      "last_synced_at": "2026-09-23T05:50:49.410Z",
      "location_count": 1,
      "location_summary": "Chicago, Illinois",
      "locations": [
        {
          "city": "Chicago",
          "state": "Illinois"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT03738345"
    },
    {
      "nct_id": "NCT03221387",
      "title": "Sleep and Daytime Use of Humidified Nasal High-flow Oxygen in COPD Outpatients",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Pulmonary Disease, Chronic Obstructive",
        "Hypercapnia",
        "Hypoxia"
      ],
      "interventions": [
        {
          "name": "Humidified nasal high flow with oxygen",
          "type": "DEVICE"
        }
      ],
      "intervention_types": [
        "DEVICE"
      ],
      "sponsor": "Temple University",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "40 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "40 Years and older"
      },
      "enrollment_count": 30,
      "start_date": "2017-09-10",
      "completion_date": "2019-12-15",
      "has_results": true,
      "last_update_posted_date": "2021-06-07",
      "last_synced_at": "2026-09-23T05:50:49.410Z",
      "location_count": 1,
      "location_summary": "Philadelphia, Pennsylvania",
      "locations": [
        {
          "city": "Philadelphia",
          "state": "Pennsylvania"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT03221387"
    },
    {
      "nct_id": "NCT02357134",
      "title": "High-Flow Oxygen in Reducing Shortness of Breath Caused by Exercise in Patients With Cancer",
      "overall_status": "UNKNOWN",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE2"
      ],
      "conditions": [
        "Dyspnea",
        "Malignant Neoplasm"
      ],
      "interventions": [
        {
          "name": "Oxygen Therapy",
          "type": "PROCEDURE"
        },
        {
          "name": "Quality-of-Life Assessment",
          "type": "OTHER"
        },
        {
          "name": "Questionnaire Administration",
          "type": "OTHER"
        },
        {
          "name": "Respiratory Therapy",
          "type": "PROCEDURE"
        }
      ],
      "intervention_types": [
        "PROCEDURE",
        "OTHER"
      ],
      "sponsor": "M.D. Anderson Cancer Center",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "18 Years and older"
      },
      "enrollment_count": 74,
      "start_date": "2015-03-17",
      "completion_date": "2023-05-31",
      "has_results": true,
      "last_update_posted_date": "2022-12-07",
      "last_synced_at": "2026-09-23T05:50:49.410Z",
      "location_count": 1,
      "location_summary": "Houston, Texas",
      "locations": [
        {
          "city": "Houston",
          "state": "Texas"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT02357134"
    },
    {
      "nct_id": "NCT02689531",
      "title": "CTTI Risk Factors for HABP/VABP Study",
      "overall_status": "COMPLETED",
      "study_type": "OBSERVATIONAL",
      "phases": [],
      "conditions": [
        "Pneumonia, Ventilator-Associated",
        "Pneumonia, Bacterial",
        "Pneumonia, Hospital-Acquired"
      ],
      "interventions": [],
      "intervention_types": [],
      "sponsor": "Duke University",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": null,
        "maximum_age": null,
        "sex": "ALL",
        "summary": "Not listed"
      },
      "enrollment_count": 7530,
      "start_date": "2016-02",
      "completion_date": "2018-02",
      "has_results": false,
      "last_update_posted_date": "2023-06-15",
      "last_synced_at": "2026-09-23T05:50:49.410Z",
      "location_count": 15,
      "location_summary": "Birmingham, Alabama • Los Angeles, California • Chicago, Illinois + 12 more",
      "locations": [
        {
          "city": "Birmingham",
          "state": "Alabama"
        },
        {
          "city": "Los Angeles",
          "state": "California"
        },
        {
          "city": "Chicago",
          "state": "Illinois"
        },
        {
          "city": "Louisville",
          "state": "Kentucky"
        },
        {
          "city": "New Orleans",
          "state": "Louisiana"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT02689531"
    },
    {
      "nct_id": "NCT04995562",
      "title": "Use of Hyperpolarized 129Xe MR Lung Imaging in Infants",
      "overall_status": "RECRUITING",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE4"
      ],
      "conditions": [
        "Lungs; Developmental Disorder"
      ],
      "interventions": [
        {
          "name": "129Xe",
          "type": "DRUG"
        }
      ],
      "intervention_types": [
        "DRUG"
      ],
      "sponsor": "Children's Hospital Medical Center, Cincinnati",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": null,
        "maximum_age": "6 Months",
        "sex": "ALL",
        "summary": "Up to 6 Months"
      },
      "enrollment_count": 12,
      "start_date": "2020-05-06",
      "completion_date": "2028-05-01",
      "has_results": false,
      "last_update_posted_date": "2026-01-07",
      "last_synced_at": "2026-09-23T05:50:49.410Z",
      "location_count": 1,
      "location_summary": "Cincinnati, Ohio",
      "locations": [
        {
          "city": "Cincinnati",
          "state": "Ohio"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT04995562"
    },
    {
      "nct_id": "NCT04170062",
      "title": "Oxygen Savings With Administered Oxygen and High Flow Ambient Air At Rest",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Pulmonary Disease, Chronic Obstructive",
        "Lung Diseases, Interstitial",
        "Pulmonary Fibrosis",
        "Hypoxemia",
        "Dyspnea",
        "Oxygen Inhalation Therapy"
      ],
      "interventions": [
        {
          "name": "Nasal Delivery of High-Flow Air and Oxygen Therapy",
          "type": "DEVICE"
        },
        {
          "name": "Nasal Delivery of Oxygen Therapy",
          "type": "DEVICE"
        }
      ],
      "intervention_types": [
        "DEVICE"
      ],
      "sponsor": "Johns Hopkins University",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "30 Years",
        "maximum_age": "100 Years",
        "sex": "ALL",
        "summary": "30 Years to 100 Years"
      },
      "enrollment_count": 11,
      "start_date": "2020-12-15",
      "completion_date": "2024-12-16",
      "has_results": false,
      "last_update_posted_date": "2024-12-24",
      "last_synced_at": "2026-09-23T05:50:49.410Z",
      "location_count": 2,
      "location_summary": "Baltimore, Maryland",
      "locations": [
        {
          "city": "Baltimore",
          "state": "Maryland"
        },
        {
          "city": "Baltimore",
          "state": "Maryland"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT04170062"
    },
    {
      "nct_id": "NCT03333174",
      "title": "Prematurity Related Ventilatory Control (PRE-VENT) - Specific Aim 3",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Infant,Premature"
      ],
      "interventions": [
        {
          "name": "Cardiorespiratory monitoring",
          "type": "DIAGNOSTIC_TEST"
        }
      ],
      "intervention_types": [
        "DIAGNOSTIC_TEST"
      ],
      "sponsor": "University of Alabama at Birmingham",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "1 Day",
        "maximum_age": "98 Days",
        "sex": "ALL",
        "summary": "1 Day to 98 Days"
      },
      "enrollment_count": 25,
      "start_date": "2018-04-09",
      "completion_date": "2021-07-01",
      "has_results": false,
      "last_update_posted_date": "2021-09-21",
      "last_synced_at": "2026-09-23T05:50:49.410Z",
      "location_count": 1,
      "location_summary": "Birmingham, Alabama",
      "locations": [
        {
          "city": "Birmingham",
          "state": "Alabama"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT03333174"
    },
    {
      "nct_id": "NCT06228703",
      "title": "The Effects of Different Flow Settings on Lung Impedance",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Healthy"
      ],
      "interventions": [
        {
          "name": "High-flow nasal cannula device with flow setting at 40 L/min or higher",
          "type": "DEVICE"
        }
      ],
      "intervention_types": [
        "DEVICE"
      ],
      "sponsor": "Rush University Medical Center",
      "sponsor_class": "OTHER",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "21 Years",
        "maximum_age": "65 Years",
        "sex": "ALL",
        "summary": "21 Years to 65 Years"
      },
      "enrollment_count": 26,
      "start_date": "2024-05-19",
      "completion_date": "2024-10-26",
      "has_results": true,
      "last_update_posted_date": "2025-12-19",
      "last_synced_at": "2026-09-23T05:50:49.410Z",
      "location_count": 1,
      "location_summary": "Forest Park, Illinois",
      "locations": [
        {
          "city": "Forest Park",
          "state": "Illinois"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT06228703"
    },
    {
      "nct_id": "NCT04707729",
      "title": "ROX Index for the Timing of Intubation in Nasal High Flow",
      "overall_status": "UNKNOWN",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Acute Hypoxemic Respiratory Failure"
      ],
      "interventions": [
        {
          "name": "ROX index algorithm",
          "type": "DIAGNOSTIC_TEST"
        }
      ],
      "intervention_types": [
        "DIAGNOSTIC_TEST"
      ],
      "sponsor": "Hospital Universitari Vall d'Hebron Research Institute",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": "120 Years",
        "sex": "ALL",
        "summary": "18 Years to 120 Years"
      },
      "enrollment_count": 630,
      "start_date": "2020-12-09",
      "completion_date": "2025-06-30",
      "has_results": false,
      "last_update_posted_date": "2024-08-15",
      "last_synced_at": "2026-09-23T05:50:49.410Z",
      "location_count": 1,
      "location_summary": "Chicago, Illinois",
      "locations": [
        {
          "city": "Chicago",
          "state": "Illinois"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT04707729"
    }
  ]
}