{
  "api_version": "1",
  "request": {
    "url": "https://clinicaltrialsfind.com/api/v1/search.json?intervention=High+Intraocular+Pressure+%28IOP%29&page=2",
    "query": {
      "intervention": "High Intraocular Pressure (IOP)",
      "page": 2
    },
    "page_size": 10
  },
  "pagination": {
    "page": 2,
    "page_size": 10,
    "total_count": 109,
    "total_pages": 11,
    "next_page_url": "https://clinicaltrialsfind.com/api/v1/search.json?intervention=High+Intraocular+Pressure+%28IOP%29&page=3&page_size=10",
    "previous_page_url": "https://clinicaltrialsfind.com/api/v1/search.json?intervention=High+Intraocular+Pressure+%28IOP%29&page=1&page_size=10"
  },
  "source": "remote",
  "last_synced_at": "2026-10-02T00:37:50.557Z",
  "attribution": "Data derived from public ClinicalTrials.gov records. The official record at https://clinicaltrials.gov/ remains the source of truth for current availability, contacts, and full study details.",
  "notes": [
    "This endpoint exposes only public summary fields — no participant contact emails, phone numbers, or scraped investigator contact details.",
    "For contact information and full protocol detail, follow each trial's `official_url` to the ClinicalTrials.gov record.",
    "This API is a navigational aid. It does not provide medical advice, eligibility determinations, or compensation guarantees."
  ],
  "trials": [
    {
      "nct_id": "NCT01076114",
      "title": "Comparison of Critical Flicker Fusion Versus Automated Visual Fields in the Detection of Early Glaucoma",
      "overall_status": "COMPLETED",
      "study_type": "OBSERVATIONAL",
      "phases": [],
      "conditions": [
        "Glaucoma"
      ],
      "interventions": [],
      "intervention_types": [],
      "sponsor": "Northwell Health",
      "sponsor_class": "OTHER",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "18 Years and older"
      },
      "enrollment_count": 58,
      "start_date": "2010-02",
      "completion_date": "2011-02",
      "has_results": false,
      "last_update_posted_date": "2011-03-15",
      "last_synced_at": "2026-10-02T00:37:50.557Z",
      "location_count": 1,
      "location_summary": "East Meadow, New York",
      "locations": [
        {
          "city": "East Meadow",
          "state": "New York"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT01076114"
    },
    {
      "nct_id": "NCT01037036",
      "title": "A Study of the L-PPDS With Adjunctive Xalatan® Eye Drops in Subjects With OH or OAG",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE2"
      ],
      "conditions": [
        "Ocular Hypertension",
        "Open-Angle Glaucoma"
      ],
      "interventions": [
        {
          "name": "Latanoprost Punctal Plug Delivery System",
          "type": "DRUG"
        },
        {
          "name": "Xalatan",
          "type": "DRUG"
        }
      ],
      "intervention_types": [
        "DRUG"
      ],
      "sponsor": "Mati Therapeutics Inc.",
      "sponsor_class": "INDUSTRY",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "18 Years and older"
      },
      "enrollment_count": 15,
      "start_date": "2009-12",
      "completion_date": "2010-07",
      "has_results": false,
      "last_update_posted_date": "2014-01-10",
      "last_synced_at": "2026-10-02T00:37:50.557Z",
      "location_count": 1,
      "location_summary": "Menlo Park, California",
      "locations": [
        {
          "city": "Menlo Park",
          "state": "California"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT01037036"
    },
    {
      "nct_id": "NCT01687426",
      "title": "Study Evaluating the Safety and Intraocular Pressure (IOP) Lowering Response of Brimonidine Tartrate Ophthalmic Solution in Subjects With Open Angle Glaucoma or Ocular Hypertension",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE1"
      ],
      "conditions": [
        "Glaucoma and Ocular Hypertension"
      ],
      "interventions": [
        {
          "name": "Brimonidine Tartrate 0.025%",
          "type": "DRUG"
        },
        {
          "name": "Vehicle",
          "type": "DRUG"
        }
      ],
      "intervention_types": [
        "DRUG"
      ],
      "sponsor": "Eye Therapies, LLC",
      "sponsor_class": "INDUSTRY",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "18 Years and older"
      },
      "enrollment_count": 15,
      "start_date": "2012-09",
      "completion_date": "2012-12",
      "has_results": false,
      "last_update_posted_date": "2012-12-25",
      "last_synced_at": "2026-10-02T00:37:50.557Z",
      "location_count": 1,
      "location_summary": "Winchester, Massachusetts",
      "locations": [
        {
          "city": "Winchester",
          "state": "Massachusetts"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT01687426"
    },
    {
      "nct_id": "NCT07408154",
      "title": "Direct vs Standard SLT for Glaucoma: A Noninferiority Trial",
      "overall_status": "RECRUITING",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Open-angle Glaucoma (OAG)",
        "Ocular Hypertension (OHT)"
      ],
      "interventions": [
        {
          "name": "Direct Selective laser Trabeculoplasty",
          "type": "DEVICE"
        }
      ],
      "intervention_types": [
        "DEVICE"
      ],
      "sponsor": "Medical University of South Carolina",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "18 Years and older"
      },
      "enrollment_count": 172,
      "start_date": "2026-04-27",
      "completion_date": "2027-10",
      "has_results": false,
      "last_update_posted_date": "2026-05-06",
      "last_synced_at": "2026-10-02T00:37:50.557Z",
      "location_count": 1,
      "location_summary": "Charleston, South Carolina",
      "locations": [
        {
          "city": "Charleston",
          "state": "South Carolina"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT07408154"
    },
    {
      "nct_id": "NCT06325397",
      "title": "Less Discomfort and Less Pharmacology. Cataract Surgery at Physiologic Intraocular Pressure (IOP)",
      "overall_status": "COMPLETED",
      "study_type": "OBSERVATIONAL",
      "phases": [],
      "conditions": [
        "Nuclear Cataract"
      ],
      "interventions": [
        {
          "name": "High Intraocular Pressure (IOP)",
          "type": "OTHER"
        },
        {
          "name": "Low Intraocular Pressure (IOP)",
          "type": "OTHER"
        }
      ],
      "intervention_types": [
        "OTHER"
      ],
      "sponsor": "Matthew Rauen",
      "sponsor_class": "OTHER",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": null,
        "maximum_age": null,
        "sex": "ALL",
        "summary": "Not listed"
      },
      "enrollment_count": 65,
      "start_date": "2024-03-18",
      "completion_date": "2025-04-01",
      "has_results": false,
      "last_update_posted_date": "2025-05-21",
      "last_synced_at": "2026-10-02T00:37:50.557Z",
      "location_count": 1,
      "location_summary": "West Des Moines, Iowa",
      "locations": [
        {
          "city": "West Des Moines",
          "state": "Iowa"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT06325397"
    },
    {
      "nct_id": "NCT06016972",
      "title": "Qlaris Phase 2 Study of QLS-111 in POAG And/or OHT Patients",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE2"
      ],
      "conditions": [
        "Primary Open Angle Glaucoma (POAG)",
        "Primary Open Angle Glaucoma of Both Eyes",
        "Primary Open-Angle Glaucoma, Unspecified Eye",
        "Ocular Hypertension (OHT)"
      ],
      "interventions": [
        {
          "name": "Experimental: QLS-111 ophthalmic solution, (0.015%)",
          "type": "DRUG"
        },
        {
          "name": "Experimental: QLS-111 ophthalmic solution, (0.03%)",
          "type": "DRUG"
        },
        {
          "name": "Experimental: QLS-111 ophthalmic solution, (0.075%)",
          "type": "DRUG"
        },
        {
          "name": "QLS-111 ophthalmic vehicle solution",
          "type": "OTHER"
        }
      ],
      "intervention_types": [
        "DRUG",
        "OTHER"
      ],
      "sponsor": "Qlaris Bio, Inc.",
      "sponsor_class": "INDUSTRY",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "18 Years and older"
      },
      "enrollment_count": 63,
      "start_date": "2024-03-05",
      "completion_date": "2024-08-20",
      "has_results": false,
      "last_update_posted_date": "2025-01-20",
      "last_synced_at": "2026-10-02T00:37:50.557Z",
      "location_count": 1,
      "location_summary": "Roswell, Georgia",
      "locations": [
        {
          "city": "Roswell",
          "state": "Georgia"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT06016972"
    },
    {
      "nct_id": "NCT05451329",
      "title": "A Phase 2 Double-masked Study of VVN539 in Subjects With Elevated Intraocular Pressure",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE2"
      ],
      "conditions": [
        "Glaucoma, Open-Angle"
      ],
      "interventions": [
        {
          "name": "VVN539 Ophthalmic Solution 0.02%",
          "type": "DRUG"
        },
        {
          "name": "VVN539 Ophthalmic Solution 0.04%",
          "type": "DRUG"
        },
        {
          "name": "VVN539 Ophthalmic Solution Vehicle",
          "type": "DRUG"
        }
      ],
      "intervention_types": [
        "DRUG"
      ],
      "sponsor": "VivaVision Biotech, Inc",
      "sponsor_class": "INDUSTRY",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "18 Years and older"
      },
      "enrollment_count": 68,
      "start_date": "2022-07-12",
      "completion_date": "2022-12-22",
      "has_results": true,
      "last_update_posted_date": "2024-01-17",
      "last_synced_at": "2026-10-02T00:37:50.557Z",
      "location_count": 1,
      "location_summary": "Durham, North Carolina",
      "locations": [
        {
          "city": "Durham",
          "state": "North Carolina"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT05451329"
    },
    {
      "nct_id": "NCT00523250",
      "title": "Ocular Hypotensive Efficacy of AR-102",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE2"
      ],
      "conditions": [
        "Glaucoma"
      ],
      "interventions": [
        {
          "name": "AR-102 0.003% Ophthalmic Solution",
          "type": "DRUG"
        },
        {
          "name": "AR-102 0.005% Ophthalmic Solution",
          "type": "DRUG"
        },
        {
          "name": "AR-102 0.01% Ophthalmic Solution",
          "type": "DRUG"
        },
        {
          "name": "AR-102 0.03% Ophthalmic Solution",
          "type": "DRUG"
        },
        {
          "name": "AR-102 Vehicle Ophthalmic Solution",
          "type": "DRUG"
        }
      ],
      "intervention_types": [
        "DRUG"
      ],
      "sponsor": "Aerie Pharmaceuticals",
      "sponsor_class": "INDUSTRY",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "18 Years and older"
      },
      "enrollment_count": 82,
      "start_date": "2007-09",
      "completion_date": "2008-03",
      "has_results": false,
      "last_update_posted_date": "2014-05-08",
      "last_synced_at": "2026-10-02T00:37:50.557Z",
      "location_count": 8,
      "location_summary": "Pasadena, California • Petaluma, California • Brooksville, Florida + 5 more",
      "locations": [
        {
          "city": "Pasadena",
          "state": "California"
        },
        {
          "city": "Petaluma",
          "state": "California"
        },
        {
          "city": "Brooksville",
          "state": "Florida"
        },
        {
          "city": "Louisville",
          "state": "Kentucky"
        },
        {
          "city": "Charlotte",
          "state": "North Carolina"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT00523250"
    },
    {
      "nct_id": "NCT00825396",
      "title": "An Open-Label Study of an Ophthalmic Solution to Reduce Intraocular Pressure in Patients With Ocular Hypertension",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Ocular Hypertension"
      ],
      "interventions": [
        {
          "name": "C-KAD Ophthalmic Solution",
          "type": "DRUG"
        }
      ],
      "intervention_types": [
        "DRUG"
      ],
      "sponsor": "Chakshu Research, Inc.",
      "sponsor_class": "INDUSTRY",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "50 Years",
        "maximum_age": "90 Years",
        "sex": "ALL",
        "summary": "50 Years to 90 Years"
      },
      "enrollment_count": 12,
      "start_date": "2007-04",
      "completion_date": "2009-04",
      "has_results": false,
      "last_update_posted_date": "2009-06-11",
      "last_synced_at": "2026-10-02T00:37:50.557Z",
      "location_count": 1,
      "location_summary": "Charlotte, North Carolina",
      "locations": [
        {
          "city": "Charlotte",
          "state": "North Carolina"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT00825396"
    },
    {
      "nct_id": "NCT05790408",
      "title": "Anterior-segment OCT (AS-OCT) and Intraoperative OCT (iOCT) for Trans- Conjunctival Needle Revision (TCNR)",
      "overall_status": "TERMINATED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Glaucoma",
        "Glaucoma Following Surgery"
      ],
      "interventions": [
        {
          "name": "Digital microscope integrated with intraoperative OCT (Zeiss Artevo 800, Carl Zeiss Meditec AG)",
          "type": "DEVICE"
        },
        {
          "name": "Spectralis Anterior-segment OCT (AS-OCT) (Heidelberg Engineering)",
          "type": "DEVICE"
        }
      ],
      "intervention_types": [
        "DEVICE"
      ],
      "sponsor": "Northwestern University",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "18 Years and older"
      },
      "enrollment_count": 10,
      "start_date": "2020-08-18",
      "completion_date": "2022-01-12",
      "has_results": true,
      "last_update_posted_date": "2023-11-15",
      "last_synced_at": "2026-10-02T00:37:50.557Z",
      "location_count": 1,
      "location_summary": "Chicago, Illinois",
      "locations": [
        {
          "city": "Chicago",
          "state": "Illinois"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT05790408"
    }
  ]
}